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    Demonstration of ethyl glucuronide in dental tissue samples by liquid chromatography/electro-spray tandem mass spectrometry
    (Elsevier Sci Ltd, 2013) Zeren, Cem; Keten, Alper; Celik, Salih; Damlar, Ibrahim; Daglioglu, Nebile; Celiker, Adnan; Karaarslan, Bekir
    Introduction: Ethyl glucuronide (EtG) has been studied in various tissues and body fluid for determination of alcohol intake. However, no study, dealing with EtG analysis in dental tissue, was performed so far. In this study, we aimed to demonstrate EtG levels in dental tissue. Materials and methods: Michigan Alcohol Screening Test (MAST) was performed to 29 participants. Following the test, cases were divided into three groups as non-hazardous alcohol users, alcohol abusers and 6 controls who verbally declared that they were abstainers. A total of 29 tooth specimens, obtained from participants, Was included in the study. These specimens were analyzed using LC/MS/MS. Results: All of the participants included in the study were male. According to the MAST outcomes 14 of the participants were non-hazardous alcohol users, and 9 were alcohol abusers, while 6 patients verbally declared that they were abstainers. Dental tissue analyses revealed EtG levels ranging between EtG < LOD and 23.39 pg/mg. EtG levels were observed to be
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    Determination of ethyl glucuronide in fingernails by LC/MS-MS
    (Romanian Legal Med Soc, 2013) Keten, Alper; Zeren, Cem; Arslan, M. Mustafa; Daglioglu, Nebile; Karanfil, Ramazan; Sen, Bilge Bulbul
    Introduction: Ethyl glucuronide (EtG) is a biomarker used for detection of alcohol consumption. Fingernail is a keratinous tissue capable of accumulating a number of biomarkers and metabolites of toxic agents. Therefore, nails are used especially for determination toxic exposure in forensic analyses. In this study, we aimed to demonstrate EtG in fingernail tissue and show its correlation with alcohol intake behavior. Materials and Methods: Michigan Alcohol Screening Test (MAST) was performed to the individuals participated in the study. Sixteen fingernails were obtained from each individual. Afterwards, EtG analysis was carried out in fingernail tissue using LC/MS/MS. Results: Michigan Alcohol Screening Test revealed that 4 participants showed non-hazardous drinking behavior and 8 cases were alcohol abusers, while 4 cases verbally stated they were abstainers. On the analyses, EtG was found between EtG level of