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    The effect of a multispecies synbiotic mixture on the duration of diarrhea and length of hospital stay in children with acute diarrhea in Turkey: Single blinded randomized study
    (Springer, 2013) Dinleyici, Ener Cagri; Dalgic, Nazan; Guven, Sirin; Ozen, Metehan; Kara, Ates; Arica, Vefik; Metin-Timur, Ozge
    Probiotics have been successfully used for the treatment of acute diarrhea in children and this effect depends on the strains and dose. The aim of this study was to assess the effect of a synbiotic mixture on the duration of diarrhea and the length of hospital stay in children with acute watery diarrhea. This is a prospective randomized, multicenter single blinded clinical trial in hospitalized children with acute watery diarrhea. All children were treated with conventional hydration therapy with or without a daily dose of a synbiotic (2.5 x 10(9) CFU live bacteria including Lactobacillus acidophilus, Lactobacillus rhamnosus, Bifidobacterium bifidum, Bifidobacterium longum, Enterococcus faecium, and 625 mg fructooligosaccharide) for 5 days. The primary endpoint was duration of diarrhea and duration of hospitalization was the secondary endpoint. Among 209 eligible children, 113 received the synbiotic mixture and 96 served as a control. The duration of diarrhea was significantly shorter (similar to 36 h) in children receiving the synbiotic group than the controls (77.9 +/- 30.5 vs. 114.6 +/- 37.4 h, p < 0.0001). The duration of hospitalization was shorter in children receiving the synbiotic group (4.94 +/- 1.7 vs. 5.77 +/- 1.97 days, p = 0.002). The effect of synbiotic mixture on diarrhea started after 24th hours and stool frequency significantly decreased after 24th and 48th hours. The percentage of diarrhea-free children is significantly higher in synbiotic group at 48th and 72nd hours of synbiotic group. In conclusion, this study showed a reduction in diarrhea duration by approximately 36 h and a reduction in the duration of hospitalization with approximately 1 day in children with acute diarrhea with this synbiotic mixture.
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    Invasive Streptococcal Infection Diagnosed With Group A Beta Hemolytic Streptococcus Positivity In Throat Culture
    (Aves Yayincilik, Ibrahim Kara, 2021) Eren, Elif Ece; Dalgic, Nazan; Sari, Ferhat; Girgic, Ugur
    Group A streptococcus (GAS) infections are often associated with pharyngitis, skin and soft tissue infection, but may have a variety of presentations that can lead to bacteremia, necrotizing fasciitis, and Streptococcal Toxic Shock Syndrome (STSS). Invasive GAS infections are seen most commonly in infancy and if they are not managed well, mortality is high. Therefore, they should be immediately diagnosed and treated successfully. In this study, it was aimed to report a patient admitted to our hospital complaining of high fever and rash, followed with an initial diagnosis of pneumonia and sepsis, and later diagnosed as invasive streptococcal infection. By presenting this case, we aimed to emphasize the wide range of GAS infections and their treatment properly.