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    Prevalence of abdominal ultrasonographic abnormalities in patients with sickle cell disease
    (Turkish Soc Radiology, 2008) Balcı, Ali; Karazincir, Sinem; Sanguen, Oezlem; Gali, Edip; Daplan, Turgay; Cingiz, Cihangir; Egilmez, Ertugrul
    PURPOSE The aim of this study was to evaluate the type and prevalence of abdominal ultrasonographic abnormalities in patients with sickle cell disease. MATERIALS AND METHODS A total of 102 patients with sickle cell disease at the Center of Hemoglobinopathy of the Antakya State Hospital were screened for intra-abdominal abnormalities by abdominal ultrasonography (US). Eighty-four patients were homozygous or sickle-cell disease (S/S), and 18 patients were compound heterozygotes for sickle cell-beta thalassemia (S/beta(thal)). At the time of examination, 15.7% (16/102) of patients had undergone gone splenectomy, and 18.6% (19/102) of patients had undergone cholecystectomy. RESULTS The most frequent US findings (expressed as percentages of all patients) were hepatomegaly (71.6%), renal enlargement (30.4%), autosplenectomy (33.3%), cholelithiasis (30.4%) and splenomegaly (17.4%). A bright liver was identified in 6 patients (5.9%), an echogenic pancreas in 4 patients (3.9%), and pancreatic punctate echogenic foci were identified in 5 patients (4.9%). Medullary or diffusely increased renal echogenicity was observed in 16 patients (15.7%). Sonographic findings typical of renal papillary necrosis were observed in one patient with S/S. Periportal lymphadenopathy was detected in 10 (11.9%) of 84 patients of the S/S group, and 2 (11.1%) of 18 patients of S/beta(thal) group. CONCLUSION Abdominal ultrasonographic imaging of patients with sickle cell disease revealed a high prevalence of abdominal abnormalities, especially in solid organs.
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    Thyroid Doppler indices in patients with sickle cell disease
    (Elsevier Science Inc, 2013) Karazincir, Sinem; Balcı, Ali; Yonden, Zafer; Gali, Edip; Daplan, Turgay; Beyoglu, Yeliz; Kaya, Hasan
    Objective: To evaluate the intrathyroidal hemodynamic changes and thyroidal volume in sickle cell disease (SCD) patients. Methods: Thirty-two patients with homozygous SCD and 32 control subjects were examined with color Doppler ultrasonography. None of the patients and control subjects had clinical or laboratory evidence of thyroid disease. Results: SCD patients had significantly higher resistance index (RI) and pulsatility index (PI) values and lower thyroid volume compared with control group. Conclusion: Increased intrathyroidal RI and PI and decreased thyroid volume may be due to impaired thyroidal microcirculation. Further and follow-up studies are needed to explain the relationship between Doppler parameters and thyroid functions. (C) 2013 Elsevier Inc. All rights reserved.