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Öğe Anti-inflammatory and antioxidant activity of thymoquinone in a rat model of acute bacterial prostatitis(Sage Publications Ltd, 2013) Inci, M.; Davarci, M.; Inci, M.; Motor, S.; Yalcinkaya, F. R.; Nacar, E.; Aydin, M.Prostatitis plays a major role in morbidity and mortality related to prostate diseases. The aim of this study was to detect whether thymoquinone (TQ) could ameliorate oxidative damage and the proliferative response induced by Escherichia coli (E. coli) in rats. A total of 42 adult male Wistar rats were used. The rats were randomly divided into seven groups (three treatment groups, three infected groups and one control group). Control group received saline and was killed 24 h after saline administration. Infected rats were killed after 24, 48 and 72 h following direct injection of E coli into the prostate. Treatment groups were administered with 10 mg/kg dose of TQ intraperitoneally following E. coli injection and after 24 and 48 h following E. coli injection. The rats were killed at 24, 48 and 72 h after the first drug administration. Each group was compared with each other and with the control group. In addition, infected groups were compared with treatment groups. Our findings show that the treatment with TQ has a protective effect against bacterial prostatitis-induced tissue injury. Increase in malondialdehyde levels and histological damage caused by E. coli were improved markedly with TQ treatment. TQ treatment particularly increased the activity of glutathione peroxidase and decreased the activities of catalase and superoxide dismutase. These observations might be attributed, at least in part, to the antioxidant effect of TQ and suggest that it could be a clinically valuable agent in the prevention of acute prostatitis caused by E. coli.Öğe BENEFICIAL EFFECT OF ERDOSTEINE ON METHOTREXATE-INDUCED TESTICULAR TOXICITY IN MICE(Elsevier Science Bv, 2010) Oktar, S.; Gokce, A.; Aydin, M.; Davarci, M.; Meydan, S.; Ozturk, O. H.; Koc, A.[Abstract Not Available]Öğe The effect of ankaferd to stop bleeding in experimental partial nephrectomy(Comenius Univ, 2011) Yalcinkaya, F. R.; Kerem, M.; Guven, E. O.; Gokce, A.; Davarci, M.Aims: In kidney surgery, bleeding is one of the most important issues. In partial nephrectomy, as a blood stopper, we used surgycell and ankaferd which is used traditionally in Turkish medicine. Material and methods: 24 Wistar-Albino rats were grouped randomly. Laparotomy was performed in the first group, sham group. In the second group, partial nephrectomy was performed to lower-kidney pole and then, serum physiology was given to the lower part of the kidney. In the third group, partial nephrectomy was performed and surgycell was given over the kidney. In the fourth group, partial nephrectomy was performed and then ABS was applied. In all groups, the gauze was weighted on sensitive lift before and after the operation in order to determine the amount of bleeding. After the subjects were left alive for 5 hours, the levels of blood urea, and creatinine and kidney histopathology were evaluated. Results: No meaningful difference between the groups was found as for the levels of blood urea, and creatinine and the kidney histopathology. Bleeding amount was diminished significantly in the group 4, to which ankaferd was applied. Conclusion: Ankaferd is a substance which can be used effectively for controlling acute bleeding in kidney surgery (Tab. 2, Ref. 19). Full Text in free PDF www.bmj.sk.Öğe IMPROVEMENT OF NOCTURNAL ENURESIS AFTER ADENOTONSILLECTOMY IN CHILDREN WITH OBSTRUCTIVE SLEEP APNEA SYNDROME(Elsevier Science Bv, 2010) Goekce, A.; Aslan, S.; Yalcinkaya, F. R.; Davarci, M.; Kaya, Y. S.; Savas, N.; Gorur, S.[Abstract Not Available]Öğe Improvement of nocturnal enuresis after adenotonsillectomy in children with obstructive sleep apnea syndrome(Elsevier Science Bv, 2009) Gokce, A.; Aslan, S.; Yalcinkaya, F. R.; Davarci, M.; Kaya, Y. S.; Savas, N.; Gorur, S.[Abstract Not Available]Öğe Protective effect of caffeic acid phenethyl ester on cyclosporine A-induced nephrotoxicity in rats(Elsevier Science Bv, 2009) Gokce, A.; Oktar, S.; Aydin, M.; Ilhan, S.; Yonden, Z.; Ozkan, O. V.; Davarci, M.[Abstract Not Available]Öğe Protective effect of ebselen on experimental testicular torsion and detorsion injury(Wiley, 2014) Rifaioglu, M. M.; Motor, S.; Davarci, I.; Tuzcu, K.; Sefil, F.; Davarci, M.; Nacar, A.Ebselen is used as a drug in clinical trials against stroke, reperfusion injury with anti-atherosclerotic and renoprotective effects. The aim of this study is to investigate the protective effect of ebselen, on torsion/detorsion (T/D)-induced biochemical and histopathological changes in experimental testicular ischaemia/reperfusion injury. A total of 28 male Wistar Albino rats were divided into four groups: group 1(sham-operated group, n=7), group 2(ebselen group, n=7), group 3(torsion/detorsion + saline, n=7) and group 4(T/D+10mgkg(-1) ebselen group, n=7). The tissue homogenate samples were used for immediate nitric oxide (NO), malondialdehyde (MDA), superoxide dismutase, catalase and glutathione measurement. Testes in all groups were evaluated for the biochemical assay and histopathological examinations. To evaluate spermatogenesis, Johnsen scoring system was used. Testicular tissue MDA and NO levels in group 3 were significantly higher than in group 1 and 4. In histological evaluation of the testicular tissues, ebselen administration improved tubular histology significantly compared with T/D group. Significant increase in histological score was observed in the testis of group 3 compared with group 1 and 2. Histological score in group 4 significantly decreased compared with group 3. Johnson score was significantly lower in T/D group compared with all other three groups, ebselen administration increased the score significantly compared with T/D group. Ebselen reduced oxidative biochemical and histopathological damage in our testicular T/D rat model.Öğe Protective Effect of Vitamin E and Melatonin Against Radiation Induced Damage in Testes of Rats(Medwell Online, 2009) Yalcinkaya, F. R.; Gokce, A.; Guven, E. O.; Davarci, M.; Cikim, G.; Yekeler, H.; Balbay, M. D.To investigate the effects of vitamin E and melatonin on gamma ray induced damage in testes of rats. A total of 40 Wistar type rats were divided into 4 groups, each including 10 rats. Total body radiation was applied to the first 3 groups with 90 cm, 90% isodose curve using Cobalt 60 apparatus. The period of exposure time was 11 min 30 see and a total of 360 cGy gamma radiation was administered in each session. Following radiation exposure, intraperitoneal injection of vitamin E (100 mg/kg/day), melatonin (100 mg/kg/day), 0.9% saline (100 mg/kg/day) were done in group 1-3, respectively. Group 4 was the control group and intraperitoneal 0.9% saline (100 mg/kg/day) was administered without any radiation. Five days after the procedure testes were removed and analyzed to measure Malondialdehyde (MDA) levels and degree of histopathological injury. Tissue MDA level measured in rats receiving melatonin did not show significant difference when compared to control group (p>0.05). Similarly, there was no significant tissue injury on histopathological examination between melatonin administered and control groups. However, compared to the control group both tissue MDA level and tissue injury were found to be significantly increased in groups, which received vitamin E and 0.9% saline solution (p<0.05). Melatonin displays a remarkable tissue protective effect by inhibiting the damage mediated by free radicals after radiation. The same effect could not be obtained with Vitamin E. Thus, the cytoprotective effect of melatonin can be of value in preserving testicular functions after radiation exposure.Öğe Protective effect of vitamin e and melatonin against radiation induced damage in testes of rats(2009) Yalcmkaya, F.R.; Gokce, A.; Guven, E.O.; Davarci, M.; Cikim, G.; Yekeler, H.; Balbay, M.D.To investigate the effects of vitamin E and melatonin on gamma ray induced damage in testes of rats. A total of 40 Wistar type rats were divided into 4 groups, each including 10 rats. Total body radiation was applied to the first 3 groups with 90 cm, 90% isodose curve using Cobalt 60 apparatus. The period of exposure time was 11 min 30 sec and a total of 360 cGy gamma radiation was administered in each session. Following radiation exposure, intraperitoneal injection of vitamin E (100 mg/kg/day), melatonin (100 mg/kg/day), 0.9% saline (100 mg/kg/day) were done in group 1 -3, respectively. Group 4 was the control group and intraperitoneal 0.9% saline (100 ml/kg/day) was administered without any radiation. Five days after the procedure testes were removed and analyzed to measure Malondialdehyde (MDA) levels and degree of histopathological injury. Tissue MDA level measured in rats receiving melatonin did not show significant difference when compared to control group (p>0.05). Similarly, there was no significant tissue injury on histopathological examination between melatonin administered and control groups. However, compared to the control group both tissue MDA level and tissue injury were found to be significantly increased in groups, which received vitamin E and 0.9% saline solution (p<0.05). Melatonin displays a remarkable tissue protective effect by inhibiting the damage mediated by free radicals after radiation. The same effect could not be obtained with Vitamin E. Thus, the cytoprotective effect of melatonin can be of value in preserving testicular functions after radiation exposure. © Medwell Journals, 2009.Öğe Protective effect of vitamine E and melatonin against radiation induced damage in testis of rat(Elsevier Science Bv, 2009) Yalcinkaya, F. R.; Gokce, A.; Guven, E. O.; Davarci, M.; Cikim, G.; Yekeler, H.; Balbay, M. D.[Abstract Not Available]Öğe Relationship of varicocele with height and obesity in men presenting with infertility(Elsevier Science Bv, 2009) Gokce, A.; Davarci, M.; Yalcinkaya, F. R.; Guven, E. O.; Balbay, M. D.[Abstract Not Available]Öğe What is the relationship between type 2 diabetes mellitus and urolithiasis?(Comenius Univ, 2011) Davarci, M.; Helvaci, M. R.; Aydin, M.Aim: Despite the high incidence of urolithiasis in general population, the exact underlying pathology is unknown. Possible association between urolithiasis and parameters of physical health were assesed in the presented study. Material and methods: The study was performed at an Internal Medicine out patient unit during routine check ups. Patients between the ages of 20 and 70 years were studied to prevent debility induced weight loss in elderly. Patients with devastating illnesses were excluded to avoid their possible effects on weight. Cases with urolithiasis were collected in one group, and age and sex-matched cases without urolithiasis were collected in other group. Results: Eighty cases with urolithiasis and 120 cases without were studied. Mean age of urolithiasis cases was 49.0 years, and 52.5 % of them were female. Mean weight of the urolithiasis cases was 76.0 kg, whereas it was 80.8 kg in the group without urolithiasis (p=0.013). The prevalence of type 2 diabetes mellitus (DM) was significantly higher in the urolithiasis group with unknown reasons (17.5 % vs 7.5 %, p<0.01). There was no significant difference as for the height, body mass index, prevalence of hypertension, and mean values of low density lipoprotein cholesterol, high density lipoprotein cholesterol, and triglyceride between the groups. Conclusion: In spite of several terrible effects of excess weight on health, we could not detect any association with urolithiasis, but there is a highly significant association between urolithiasis and type 2 DM, and it may have hundreds of mechanisms with variable priorities, which must be explained with further studies (Tab. 1, Ref. 21). Full Text in free PDF www.bmj.sk.
