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    An Application of Cox Mixed Cure Model for Breast Cancer Patients
    (2021) Çetin, Şirin; Pasin, Özge; Dede, İsa; Ulgen, Ayse
    Objective: Survival analyses are used in cancer research in the selection of treatment methods that may be effective in survival time and in investigating prognostic factors. In the literature, Cox regression analysis was performed without investigating whether the assumptions were met in survival analysis. The aim of this study is; to give information about the features of Cox mixed cure models and to show its application for breast cancer patients. Material and Methods: In our study, it was observed that breast cancer data did not provide the proportional hazard assumption. In addition, since the survival curve has a flattened tail after 72 months, this study was analyzed with a mixed cure model. In the model, cured and uncured patients are modeled separately. Results: In our study, the median survival time of the patients was found to be 72 months (95% confidence interval; 51.88-92.12). Progesterone receptor, estrogen receptor, c-erbB-2, age and lymph node were found to be a significant risk factor for the survival of breast cancer patients in cured and uncured part (for all of them p<0.05). Conclusion: Nowadays, cancer patients are more likely to recover. For this reason, we think that it would be appropriate to evaluate the survival analyses of cured and uncured cancer patients separately with a mixed cure model instead of Cox regression analysis in modeling the survival analysis of cancer patients.
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    Evaluation of Attitudes and Behavioral Changes in Relatives of Patients with Breast Cancer
    (2021) Güner, Pınar; Aksoy, Hilal; Bölükbaşı, Hande; Dede, İsa
    Objective: The aim of this study was to determine the information and support needs of breast cancer patients’ relatives and to what extent they were met.Methods: This cross-sectional descriptive study was conducted with 177 participants whose relatives were followed up with breast-cancer diagnosis in the Oncology Department between May and September 2019. The questionnaire and sociodemographic characteristics and “Information and Support Needs Scale” were applied to the participants.Results: The mean age of the participants was 39.70±14.10. 66 (37.30%) were primary school graduates, 106 (59.90%) were housewives and 124 (70.10%) were married. The most common breast cancer screening methods for women were 68.40% (121) self-examination and 54.20% (96) mammography. The number of participants who had breast cancer screening was 78 (44.30%). The mean score of information requirements was 3.50±0.09 and the mean score of support requirements was 3.30±0.18. with Statistical analysis were performed with SPSS 21.0 program.Conclusion: It is necessary to determine the knowledge status, attitudes and needs of women who have breast cancer in their neighborhood by the health professionals about the causes, screening methods, treatment methods and prevention of breast cancer. In this way, it will increase the spread of breast cancer screening, the number of patients diagnosed early and the success of treatment.