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Öğe Anti-proliferative Effects of Trigonella foeniculum and Eucalyptus camaldulensis on Human Melanoma Cells(Wiley, 2017) Duran, Nizami; Duran, Gulay Gulbol; Kaya, D. Alpaslan; Ay, Emrah; Tumer, Cemil; Demir, Enver Ahmet[Abstract Not Available]Öğe Anticonvulsive and behavior modulating effects of sophoretin and rutoside(Akademiai Kiado Zrt, 2019) Demir, Enver Ahmet; Ozturk, Atakan; Tutuk, Okan; Dogan, Hatice; Tumer, CemilIntroduction: Seizures are the hallmarks of most types of epilepsies. Behavioral and cognitive impairments coincide with interictal periods even though it is not clear whether these impairments spring out of the seizure itself or accompanying sociopsychological burden of the disease. Materials and methods: In this study, we investigated behavioral and cognitive consequences of a single GABA receptor-related seizure in mice, and examined the potential anticonvulsive and behavior-modulating properties of sophoretin (quercetin) and rutoside (rutin). Results: The study demonstrated that sophoretin and rutoside, common flavonoids of the human diet, delay the seizure onset and reduce the seizure stage. Moreover, they exerted an antidepressant-like effect, which was independent of the seizure. Neither treatments nor seizure altered recognition and spatial memory performances of the mice. Conclusions: Behavioral or cognitive disturbances that are evident in epileptic patients did not appear following a single seizure. In addition, we suggest that both sophoretin and rutoside successfully alleviate the seizure severity without interfering in the behavioral stability and cognitive performance. Hence, these flavonoids may be of use as adjuncts to the current treatment options.Öğe Antidepressant-like effects of quercetin in diabetic rats are independent of hypothalamic-pituitary-adrenal axis(Cambridge Univ Press, 2016) Demir, Enver Ahmet; Gergerlioglu, Hasan Serdar; Oz, MehmetObjective Quercetin, one of the most potent flavonol in the family of flavonoids, has been shown to have benefits against diabetes and its complications. In the present study, we investigated effects of quercetin on depression-like behaviours and hypothalamic-pituitary-adrenal (HPA) axis in diabetic rats. Methods Experimental diabetes was induced by using streptozotocin, and either 50 or 100 mg/kg quercetin was intraperitoneally administered for 21 days. Following the last treatment, animals were subjected to the forced swim test, and subsequently, the blood was obtained by cardiac puncture to measure plasma adrenocorticotropic hormone (ACTH) and corticosterone (CORT) levels. Results A significant increase of the total immobile time, accompanied by a decrease in the immobility latency, which suggests a depressive status, was observed in diabetic animals that was reversed by the treatment of 50 mg/kg quercetin. However, the higher dose of quercetin (100 mg/kg) was ineffective in alleviating depression-like behaviours. The plasma concentrations of ACTH, and total- and free-CORT were not affected by both doses of quercetin. Conclusion Therefore, we concluded that the antidepressant-like effects of quercetin in diabetes are independent of the HPA axis.Öğe Behavioral and Cognitive Consequences of Obesity in Parents and Offspring in Female and Male Rats: Implications of Neuroinflammation and Neuromodulation(Springer, 2022) Demir, Enver Ahmet; Gulbol-Duran, Gulay; Urhan-Kucuk, Meral; Dogan, Hatice; Tutuk, Okan; Cimen, Funda; Bayirli, MucellaObesity is a rapidly growing public health concern that can create a family-wise burden. This study was aimed to investigate behavioral, cognitive, neuroinflammatory, and neuromodulatory consequences of the diet and parental obesity. Female and male Wistar albino rats were fed on either an obesogenic or standard diet for 12 weeks, beginning with weaning. Thereafter, the animals were matched and allowed to mate. Pups born to obese or normal parents received either the diet or standard chow to the same age. The obesogenic diet and/or parental obesity increased the locomotor activity in both females and males. The diet exhibited anxiolytic-like and antidepressant-like properties, and impaired short-term object memory as well as spatial memory. Interestingly, the obesogenic diet resulted in neuroinflammation only in naive animals, but not in the ones with parental obesity. BDNF, SIRT1, and p53 expressions were decreased, whereas RelN expression was increased in the brain with the diet, regardless of parental obesity. Multi-factor analyses demonstrated that the obesogenic diet is the prominent influencer of cognitive, neuroinflammatory, and neuromodulatory results while parental obesity has an effect on spatial memory, neuroinflammation, and hippocampal RelN and p53 expressions. Here, we provided supporting evidence for detrimental cognitive and neuroinflammatory consequences of early life consumption of the obesogenic diet which accompanies alterations in neuromodulatory factors. Surprisingly, the diet was found beneficial against anxiety-like and depression-like behaviors, and additionally, parental obesity was demonstrated to impair some aspects of cognitive performance which appears unrelated to neuroinflammation.Öğe Capparis Spinosa L. in an Animal Model of Sciatic Crush Injury(Wiley, 2019) Ishakoglu, Ozlem Kutlu; Tutuk, Okan; Dogan, Hatice; Demir, Enver Ahmet; Secinti, Ilke Evrim; Kara, Mikail; Kahraman, Ibrahim[Abstract Not Available]Öğe Chia seed (Salvia hispanica L.) supplementation may contribute to raising the levels of vitamin B12: An option for the vegan diet(Pontificia Universidade Catolica Campinas, 2019) Demir, Enver Ahmet; Bilgic, YaseminObjective The chia seed, an ancient pseudocereal, is rich in omega-3 fatty acids and polyphenols, and has been suggested to possess several health benefits. Although it has gained popularity among nutritionists, little is known about the systemic effects of chia and their interactions. Hence, hepatorenal indicators and plasma vitamin concentrations in chia-supplemented aluminum-exposed rats were investigated. Methods Wistar albino rats were either fed on a chia-rich- or standard-diet for 21 days and exposed to aluminum. Liver function tests (Alanine Aminotransferase, Aspartate Aminotransferase, Alkaline Phosphatase, Lactate Dehydrogenase), kidney function tests (Urea Nitrogen, Creatinine), and vitamin B-12 and folic acid measurements were performed by using an automated analyzer. Results Aluminum exposure had no influence on renal function, as did chia supplementation. However, liver function was disturbed with the exposure to Aluminum and chia was of no use against it. Surprisingly, it was found that the animals fed on a chia-rich diet displayed higher concentrations of vitamin B-12 which was not the case for folic acid. Conclusion It was deduced that a chia-rich diet has no effect on the renal function and is not able to reverse aluminum-induced hepatotoxicity; however, it may be of benefit against vitamin B-12 insufficiency and thus, it may offer a novel treatment option which is particularly important in the vegan diet.Öğe The Comparison of Visceral Adiposity Measures Between Type 2 Diabetics and Healthy Individuals(Wiley, 2018) Egeli, Duygu; Demir, Enver Ahmet; Dogan, Hatice; Tutuk, Okan; Acik, Murat; Tumer, Cemil[Abstract Not Available]Öğe CREB1 and PPAR-?/? Pathways in Hepatic Ischemia/Reperfusion: Route for Curcumin to Hepatoprotection(Briefland, 2022) Demir, Enver Ahmet; Tutuk, Okan; Dogan-Gocmen, Hatice; Ozyilmaz, Duygu Seren; Karagul, Meryem Ilkay; Kara, Mikail; Temiz, MuhyittinBackground: Hepatic ischemia/reperfusion injury is a major problem that can exacerbate complications, particularly in liver trans-plantations. Objectives: This study aimed to investigate the cellular mechanisms of ischemia/reperfusion injury and hepatoprotection by cur -cumin. Methods: Wistar albino rats were divided into four groups as Control, Sham, I/R, and Cur+I/R. Hepatic ischemia/reperfusion was induced in I/R and Cur+I/R animals, the latter of which was also given 50 mg/kg/day of curcumin for 14 days. Liver aminotransferases and the transcription regulators of inflammation (RelA, I & kappa;B, PPAR-& alpha;, PPAR-& gamma;, CREB1) were examined along with the histological examination. Results: Hepatic ischemia/reperfusion was found to disrupt hepatic microstructure and downregulate PPAR-& alpha;, PPAR-& gamma;, and CREB1 transcripts. Curcumin supplementation in hepatic ischemia/reperfusion recovered the structural organization and promoted the hepatocyte regeneration while increasing expressions of PPARs and CREB1. RelA and I & kappa;B were found unaltered, possibly due to the crosstalk between targeted transcripts by ischemia/reperfusion and curcumin. Conclusions: In sum, PPAR-& alpha;/& gamma; and CREB1 were involved in hepatic ischemia/reperfusion and, moreover, were detected to be stim-ulated by curcumin. PPAR and CREB pathways were found to provide a route to hepatoprotection for curcumin supplementation as evidenced by the microstructural improvement.Öğe Curcumin alleviates cisplatin-induced learning and memory impairments(Academic Press Inc Elsevier Science, 2015) Oz, Mehmet; Atalik, K. Esra Nurullahoglu; Yerlikaya, F. Humeyra; Demir, Enver AhmetThe present study has been designed to investigate the role of curcumin on cisplatin-inducedcognitive impairment and to reveal mechanisms of cisplatin's detrimental actions on cognition in rats. Animals were treated with cisplatin (5 mg/kg/week) and/or curcumin (300 mg/kg/day) for 5 weeks. Morris water maze test was used to assess spatial learning and memory. Enzymatic activities of acetylcholinesterase (AChE) and superoxide dismutase (SOD) were evaluated from hippocampus and plasma samples, and malondialdehyde (MDA), which is the end-product of lipid peroxidation, was determined by a colorimetric method. Our results showed that cisplatin (5 mg/kg/week, 5 weeks) caused learning and memory deficits, elevated MDA content, decreased SOD activity in the hippocampus and plasma, and AChE activity in the hippocampus. Curcumin improved learning and memory in rats with administration of cisplatin. In addition, curcumin significantly reduced the level of MDA and increased the activities of SOD and AChE. Taken together, our findings indicate that curcumin ameliorates cisplatin-induced spatial learning and memory impairment, possibly through restored cholinergic function and enhanced oxidative status. (C) 2015 Elsevier Inc. All rights reserved.Öğe Determining the Ideal Object Size in the Novel Object Recognition Test(Wiley, 2019) Kasirga, Busra; Demir, Enver Ahmet; Dogan, Hatice; Tutuk, Okan; Tumer, Cemil[Abstract Not Available]Öğe Detrimental effects of chia (Salvia hispanica L.) seeds on learning and memory in aluminum chloride-induced experimental Alzheimer's disease(Nencki Inst Experimental Biology, 2018) Bilgic, Yasemin; Demir, Enver Ahmet; Bilgic, Nilufer; Dogan, Hatice; Tutuk, Okan; Turner, CemilPolyphenols and omega-3 fatty acids are thought to have beneficial effects in Alzheimer's disease, the most common cause of dementia. Seeds of chia (Salvia hispanica L.) are highly rich in these nutrients, and thus, the present study investigated the effects of chia seeds on behavior and cognition in an aluminum-induced Alzheimer's disease model in rats. Experimental animals received chia supplementation either during the generation of the model (i.e., pretreatment) or after the model was established (i.e., treatment). A battery of behavioral and cognitive tests were performed, including open-field, elevated plus maze, Porsolt's forced swim, and Morris' water maze, to evaluate anxiety- and depression-like behaviors, and learning and memory. Results showed that chia supplementation was ineffective against Alzheimer's-related anxiety, whereas depression-like behaviors were attenuated with both pretreatment and treatment. There was no improvement in learning and memory with chia treatment. Rather, cognitive performance in chia-pretreated animals was remarkably worse as compared to their non-treated disease-induced counterparts. Hippocampal concentrations of amyloid-beta 42, amyloid precursor protein, and total tau protein were similarly increased in all disease-induced animals (despite chia supplementation), as compared to the controls. Based on these findings, chia supplementation during the progression of Alzheimer's disease may exacerbate the disease. Although the results presented here emerge from an experimental/preclinical study, we suggest cautious and careful use of chia, especially in early-stage Alzheimer's patients, until future research in different experimental settings is conducted.Öğe The Effect of Alpha Lipoic Acid on the Hypothalamic-pituitary-adrenal Axis and Cholinergic System in an Experimental Alzheimer's Model(Wiley-Blackwell, 2016) Oz, Mehmet; Demir, Enver Ahmet; Gergerlioglu, Hasan Serdar[Abstract Not Available]Öğe Effect of Alpha-LipoicAcid on TRPM7 Gene Expression in Experimental Varicocele Model(Wiley, 2018) Tutuk, Okan; Dogan, Hatice; Demir, Enver Ahmet; Tutuk, Sumeyye; Tumer, Cemil[Abstract Not Available]Öğe The Effect of Chia (Salvia hispanica L.) Seed in an Experimental Alzheimer's Disease Model(Wiley, 2018) Bilgic, Yasemin; Demir, Enver Ahmet; Bilgic, Nilufer; Dogan, Hatice; Tutuk, Okan; Tumer, Cemil[Abstract Not Available]Öğe The Effect of Vitamin D in an Experimental Varicocele Model(Wiley, 2018) Agturk, Gokhan; Demir, Enver Ahmet; Tutuk, Okan; Dogan, Hatice; Ozgur, Tumay; Tumer, Cemil[Abstract Not Available]Öğe Effects of Cisplatin and Curcumin on the Hypothalamic-Pituitary-Adrenal Axis(Wiley-Blackwell, 2015) Oz, Mehmet; Demir, Enver Ahmet; Gergerlioglu, Hasan Serdar; Atalik, Kismet Esra Nurullahoglu; Yerlikaya, Fatma Humeyra[Abstract Not Available]Öğe Effects of Erdosteine and Vitamin D in Experimental Rat Kidney Ischemia/Reperfusion Model(Wiley, 2017) Dogan, Hatice; Demir, Enver Ahmet; Tutuk, Okan; Ozgur, Tumay; Kucuk, Meral Urhan; Ozcan, Oguzhan; Bayraktar, Suphi[Abstract Not Available]Öğe The Effects of Erdosteine and Vitamin D on Liver Damage After Renal Ischemia Reperfusion(Wiley, 2017) Demir, Enver Ahmet; Dogan, Hatice; Tutuk, Okan; Ozcan, Oguzhan; Ozgur, Tumay; Tumer, Cemil[Abstract Not Available]Öğe The Effects of Erdosteine and Vitamin D on TRPM 2 Ion Channel in Renal Ischemia Reperfusion Damage Model in Rats(Wiley, 2018) Dogan, Hatice; Tutuk, Okan; Demir, Enver Ahmet; Tumer, Cemil[Abstract Not Available]Öğe The Effects of Essential Oils of Nigella sativa L. on p53 Gene Expression and Cell Apoptosis in HT-29 Colon Carcinoma Cells(Wiley, 2017) Duran, Nizami; Duran, Gulay Gulbol; Kaya, D. Alpaslan; Ay, Emrah; Demir, Enver Ahmet; Dogan, Hatice[Abstract Not Available]
