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  • Küçük Resim
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    Cytogenetic biomonitoring of primary school children exposed to air pollutants: micronuclei analysis of buccal epithelial cells
    (Springer Heidelberg, 2014) Demircigil, Gonca Cakmak; Erdem, Onur; Gaga, Eftade O.; Altug, Hicran; Demirel, Gulcin; Ozden, Ozlem; Ari, Akif
    There is an increasing attempt in the world to determine the exposures of children to environmental chemicals. To analyze the genotoxic effect of air pollution, micronucleus (MN) assay was carried out in buccal epithelial cells (BECs) of children living in an urban city of Turkey. Children from two schools at urban-traffic and suburban sites were investigated in summer and winter seasons for the determination of BEC-MN frequency (per mille) and frequency of BEC with MN (per mille). The same children were also recruited for lung function measurements within a MATRA project (Together Towards Clean Air in Eskisehir and Iskenderun) Measured NO2 and SO2 concentrations did not exceed the European Union (EU) limit levels either in urban-traffic or suburban regions. Higher O-3 concentrations were measured in the suburban site especially in the summer period. Particulate matter (PM2.5 and PM10) levels which did not differ statistically between two regions were above the EU limits in general. Although BEC-MN frequencies of children living in the suburban sites were higher in general, the difference between two regions was not significant either in the summer or winter periods. BEC-MN frequencies of the urban-traffic children were found to be significantly higher in summer period (mean +/- SD, 2.68 +/- 1.99) when compared to winter period (1.64 +/- 1.59; p = 0.004). On the other hand, no seasonality was observed for the suburban children. Similar results have been obtained in the BEC frequency with MN in our study. In summer, BEC-MN frequencies were significantly increased with the decrease in pulmonary function levels based on forced expiratory flow between 25 and 75 % of vital capacity (FEF25-75 %) levels (p < 0.05). As a conclusion, children living in urban-traffic and suburban areas in the city of EskiAYehir exhibited similar genotoxicity. Seasonal variation in genotoxicity may be interpreted as relatively high ozone levels and increasing time spent at outdoors in the summer.
  • Küçük Resim
    Öğe
    Determination of exposure to benzene, toluene and xylenes in Turkish primary school children by analysis of breath and by environmental passive sampling
    (Elsevier Science Bv, 2010) Scheepers, Paul T. J.; Konings, Joke; Demirel, Gulcin; Gaga, Eftade O.; Anzion, Rob; Peer, Petronella G. M.; Dogeroglu, Tuncay
    Benzene, toluene, m/p-xylene and o-xylene (BTX) are toxic volatile organic compounds and ubiquitous air pollutants. Smoking and consumer products are indoor sources of BTX, whereas traffic and industrial activities are primary sources contributing to outdoor levels of BTX. The aim of this study was to characterize exposure of children to BTX by personal air sampling using diffusive samplers and by analysis of end-exhaled air. For this study, 101 children of 10-11 years of age were recruited from four primary schools in Southern Turkey during the warm season (May 2008). Two schools were situated in a residential area near primary and secondary iron and steel works (Payas) and two schools were located in a non-industrialized city (Iskenderun). The children and their parents were visited at home for an interview and to identify possible sources of BTX in the residence. Median concentrations of benzene determined by diffusive samplers were higher in Payas (4.1 mu g/m(3)) than in Iskenderun (2.7 mu g/m(3), p<0.001). For toluene, no differences were observed, whereas for xylene isomers air concentrations tended to be lower for children living in Payas. The median end-exhaled air concentrations were 8.2, 29, 3.8, and 5.7 pmol/L for benzene, toluene, m/p-xylene and o-xylene, respectively (Payas), and 6.9, 25, 4.9, and 6.0 pmol/L, respectively (Iskenderun). Concentrations of toluene in end-exhaled air were 50% higher in children living with household members who smoked indoors (p<0.05) and benzene in end-exhaled air was more than 3-fold higher for those children who were exposed to tobacco smoke inside a vehicle (p<0.001). End-exhaled concentrations of benzene were also higher in children living in a residence with an attached garage (p<0.05). These exposure modifying factors were not identified when using the results obtained with diffusive samplers. (C) 2010 Elsevier B.V. All rights reserved.