Yazar "Deveci, Mehmet Zeki Yilmaz" seçeneğine göre listele
Listeleniyor 1 - 10 / 10
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Bisphenol AF Caused Reproductive Toxicity in Rats and Cineole Co-Treatment Exhibited Protective Effect(Springer Heidelberg, 2024) Uyar, Ahmet; Cellat, Mustafa; Kanat, Ozgur; Etyemez, Muhammed; Kutlu, Tuncer; Deveci, Mehmet Zeki Yilmaz; Yavas, IlkerBisphenol AF (BPAF) is increasingly used and now found in products intended for human consumption. The protective effect of 1,8-cineole (CIN) against BPAF-induced reproductive toxicity was investigated. Four groups were created, with each group consisting of eight rats: control, BPAF (200 mg/kg), CIN (200 mg/kg), and BPAF + CIN groups. The results demonstrated that the BPAF group exhibited a decline in testosterone levels and a decrease in sperm parameters compared with the control. Additionally, higher levels of MDA were observed, along with lower levels of GSH and GPx activity. CAT activity also decreased slightly. Tnf-alpha, Nf-kappa B levels were significantly higher, and caspase-3 expression was elevated, while PCNA expression decreased. BPAF significantly increased tissue degeneration compared with the control. However, the BPAF + CIN group showed statistically significant improvements in sperm parameters, except for concentration. They also exhibited an increase in testosterone levels and an improvement in MDA and GSH levels compared with the BPAF group. However, GPx activity partially enhanced. Tnf-alpha and Nf-kappa B levels were significantly reduced, and caspase-3 levels declined while PCNA and Bcl-2 levels increased. The Johnsen Testicular Biopsy score showed a substantial increase. Overall, these results suggest that CIN co-treatment in rats enhanced reproductive health and exhibited antioxidant, antiapoptotic, and anti-inflammatory properties against BPAF-induced testicular damage.Öğe Comparison of azithromycin and a combination of trypsin, chymotrypsin and papain proteolytic enzymes for the treatment of bovine cutaneous papillomatosis(Univ Nacional Autonoma Mexico Facultad Medicina Veterinaria Zootecnia, 2022) Deveci, Mehmet Zeki Yilmaz; Altus, Muhammed Enes; Alaku, Halil; Ozsoy, Sule YurdagulAlthough various methods have been used in the treatment of bovine cutaneous papillomatosis (BCP), no definite treatment has yet been established. There are no studies regarding the efficacy of azithromycin (AZ) and of any combination of trypsin, chymotrypsin, and papain proteolytic enzymes (PEC) in the treatment of BCP. The objective of this study was to investigate the efficacy of AZ and PEC in the treatment of BCP. A total of 24 female Holstein cattle of 6-17 months of age with spontaneous BCP were used for this study. In addition to the clinical findings, the diagnosis was confirmed with histopathological examinations. The animals were divided at random into three groups (n = 8). The AZ group received 10 mg/kg/day PO for 10 days. In the PEC group, an injectable suspension of proteolytic enzymes was applied IM at 0.4 mL/10 kg dose, 3 times with 8-10 days interval and the spray was used topically once a day for 10 days. The control group (CO) was not treated. The mean in papilloma warts decreased 92.4 % in the AZ group, 83.38 % in the PEC group, and 59.48 % in the CO. There were statistically significant differences in warts presence decreases between the three groups (P < 0.05). Both AZ and PEC were considered successful for the BCP treatment. However, AZ was found more effective than PEC.Öğe Determination of dynamic thiol-disulfide levels in dairy cattle with foot disease(Univ Zagreb Vet Faculty, 2022) Deveci, Mehmet Zeki Yilmaz; Erdal, HuseyinFoot diseases are among the top three causes of economic loss in dairy cattle. Recent studies show that oxidative stress plays a critical role in the pathogenesis of foot diseases. There is no study determining the dynamic thioldisulfide levels in dairy cattle with foot disease. This study aimed to determine dynamic thiol-disulfide levels in foot diseased and healthy dairy cattle. Demographic information about the animals, and clinical findings of foot diseases and lameness were presented. In the Foot Disease Group, native thiol (P<0.01), total thiol (P<0.05), disulfide (P<0.01), disulfide/native thiol (P<0.01) and disulfide/total thiol (P<0.01) results were found to be significantly higher than in the Control Group. Native thiol/total thiol (P<0.01) was found to be significantly higher in the Control Group than in the Foot Disease Group. As a result, statistically significant increases in thiol-disulfide levels were determined in foot diseased dairy cattle. It was shown that the thiol-disulfide balance was impaired. This study is the first to determine thiol-disulfide levels and thus changes in thiol-disulfide homeostasis in healthy and foot diseased dairy cattle. With further studies, oxidative stress changes that occur as a result of foot diseases can be better understood and the use of antioxidants as a part of treatment evaluated.Öğe Eucalyptol alleviates cisplatin-induced kidney damage in rats(Taylor & Francis Ltd, 2024) Kazak, Filiz; Deveci, Mehmet Zeki Yilmaz; Akcakavak, GoekhanThis study was aimed to explore the therapeutic effect of eucalyptol on cisplatin induced kidney damage in Wistar albino rats. The animals were divided into four groups: sham (S), eucalyptol (E), cisplatin (C), and cisplatin + eucalyptol (CE) randomly, six animals in each group. Groups C and CE were received cisplatin (12 mg/kg, a single dose, intraperitoneally (i.p.)). Groups E and CE were treated with eucalyptol (100 mg/kg, for seven days, orally). The blood samples and kidney tissues were collected following sacrification and analyzed histopathologically and biochemically. Histopathological results revealed tubular degeneration and necrosis, inflammatory cell infiltration, tubular lumen dilatation, enlargement of bowman's space and hyaline cast were significantly irregular in the group C than group S. However, eucalyptol treatment (CE) modulated the alterations in the group C. Serum levels of blood urea nitrogen (BUN) and creatinine (CRE) were considerably higher in the group C compared to the other groups. There was no significant difference among the other groups statistically (except group C) in terms of BUN and CRE values. Eucalyptol treatment (at 100 mg/kg, for seven days) decreased the cisplatin induced increase in serum BUN and CRE levels and restored the reduced Vit C level and CAT activity of kidneys caused by cisplatin. Thus, eucalyptol's antioxidative, nephroprotective, and curative effects indicated the potential for future drug development.Öğe Eucalyptol Protects against Cisplatin-Induced Liver Injury in Rats(Pleiades Publishing Inc, 2023) Akcakavak, Gokhan; Kazak, Filiz; Deveci, Mehmet Zeki YilmazEucalyptol (1,8-cineole), a terpenoid oxide, is known as the main component of eucalyptus essential oils. The antimicrobial, anti-inflammatory and antioxidant activities of eucalyptol have been reported in many studies. We investigated the possible effects of eucalyptol (EUC) against hepatotoxicity induced by cisplatin (CIS) in Wistar albino rats. A total of 24 rats were divided into 4 equal groups; Control (C), Eucalyptol (EUC), Cisplatin (CIS), and Cisplatin + Eucalyptol (CIS + EUC). CIS and CIS + EUC groups received cisplatin (12 mg/kg, in a single dose, intraperitoneally (i.p.)). EUC and CIS + EUC groups were treated with eucalyptol (100 mg/kg, seven days, orally). The rats were euthanised under appropriate conditions, and samples were taken. Histopathologically, hepatocyte degeneration and necrosis, sinusoidal dilatation, inflammatory cell infiltration and bile duct proliferation were significantly irregular in the CIS group compared to the C group. However, EUC treatment modulated changes in group CIS. Biochemically, EUC (100 mg/kg) treatment reduced oxidative stress against increased liver hepatotoxicity by decreasing MDA levels and increasing Glutathione (GSH), Glucose-6-phosphate dehydrogenase (G6PD) and Catalase (CAT) levels. EUC treatment down-regulated 8-hydroxy-2-deoxyguanosine (8-OHdG) levels, resulting in reductions DNA damage. It also significantly down-regulated inducible nitric oxide synthase (iNOS) expression. In conclusion, eucalyptol exerts protective effects on cisplatin-induced experimental liver toxicity in rats by improving oxidative stress and oxidative DNA damage and iNOS expressions.Öğe HERNIORRHAPHY AND SURGICAL OUTCOMES OF DIAPHRAGMATIC HERNIA IN CATS(Univ Ljubljana, Veterinary Faculty, 2022) Deveci, Mehmet Zeki Yilmaz; Yurtal, Ziya; Isler, Cafer Tayer; Emiroglu, Sara Busra; Alakus, Ibrahim; Altug, Muhammed EnesThe aim of this study was to evaluate the surgical outcome and mortality of diaphragmatic hernia in cats and present herniorrhaphy results. Diagnostic and surgical data from 25 cats with diaphragmatic hernias were analyzed retrospectively. The cats were between the ages of 2 months and 4 years, included 9 cases of males (5/9 neutered) and 16 cases of females (9/16 spayed). Acute cases were 12/25 and chronic cases were 13/25. Diaphragmatic rupture locations were defined according to the pointsthatare determined based on a clockwise scale. Location was classified as multiple in 10 (40%), ventral in 7 (28 %), right in 5 (20%), and left in 3 (12 %) cases. The three most frequently herniated organs were small intestine (20,80%), liver(16, 64 %), and omentum (15, 60 %). Postoperative survival rates were 83.3 % for acute cases and 69.2 % for chronic. Full recovery was achieved in 19 (76 %) of the cats. Results suggest that the location and size of diaphragm ruptures, the organs herniated, and the presence of concurrent pathologies directly affect mortality. Mortality is higher in cases with concurrent injuries, large diaphragmatic ruptures, and excessively herniated organs.Öğe The Matrix Metalloproteinase Inhibitor Batimastat Reduces Epidural Fibrosis After Laminectomy in Rats(Turkish Neurosurgical Soc, 2023) Yurtal, Ziya; Ozkan, Huseyin; Kutlu, Tuncer; Deveci, Mehmet Zeki Yilmaz; Urfali, Boran; Urfali, SenemAIM: To investigate the efficacy of locally applied batimastat after laminectomy in preventing postoperative epidural fibrosis. MATERIAL and METHODS: Thirty-two Wistar albino male rats weighing 200-250 g were used. The rats were assigned to four different groups (I-Control group, II-sham group, III-Laminectomy+Batimastat group, and IV-Laminectomy+Spongostan (TM) group). The rats were euthanized 28 days after surgery before TNF-alpha, IL6, IL-1 beta, IL10, TGF-beta 1, and MMP9 gene expression levels of tissue in the surgical area were determined with qPCR. TNF-alpha, IL6, and IL10 protein levels were also measured in both tissue and plasma. In addition, the surgical area was evaluated by histopathological and immunohistochemical methods. RESULTS: TNF-alpha, IL6, and IL-1 beta gene expression levels were higher in the batimastat group than in the control group. Whereas IL10 gene expression levels increased about two-fold in the sham and Spongostan (TM) groups, in the batimastat group, it was similar to that in the control group. TGF-beta 1 gene expression was three-fold higher in the sham group but was similar to that in the control group in both batimastat and Spongostan (TM) groups. MMP9 gene expression levels significantly decreased only in the batimastat group. In addition, fibrosis score, fibroblast cell count, inflammatory cell count, and CD105 expression decreased in the batimastat group relative to the control. CONCLUSION: Molecular and pathological examination results suggested that batimastat is an effective agent in reducing the occurrence of epidural fibrosis after laminectomy.Öğe Multifunctional hernia repair biopatch: Development, characterization, in vitro and in vivo evaluation(Editions de Sante, 2024) Deveci, Mehmet Zeki Yilmaz; Enguven, Gozde; Ege, Hasan; Alakus, Ibrahim; Agturk, Gokhan; Yontem, Fulya Dal; Yilmaz, SenanurIncisional hernia, a prevalent postoperative complication, is characterized by the protrusion of organs or tissues through damaged abdominal wall. Predisposing factors for hernias include obesity, wound infections, immunosuppression, and comorbidities. However, hernia patches currently in use, including the commercial polypropylene (PP) patch, still have limitations in providing the mechanical and biological properties necessary for abdominal wall regeneration. In this study, three dimensional (3D) printing and coaxial electrospinning methods were combined to create a multifunctional double layered hernia repair biopatch to overcome these limitations. The double-layer design of the biopatch serves a multifunctional role in addressing incisional hernia models, with 3D printed ciprofloxacin (CIP) loaded polycaprolactone (PCL)/gelatin (Ge) scaffold (3DCIP) layer and coaxially electrospun PCL/Ge/?-carrageenan (?-C) nanofiber (NF) layers. While 3DCIP layers provides temporary mechanical reinforcement to the damaged abdominal wall, prevention of adhesions to internal organs, and reduction of surgical site infections, NF layer serves as tissue regeneration and fast wound healing. The developed multifunctional hernia biopatches underwent comprehensive physical and chemical characterization, followed by in vitro and in vivo evaluations. These evaluations included comparisons with a commercial PP patch, which was used as the control in the experiments. The study successfully fabricated multifunctional hernia biopatches with excellent antibacterial properties, high mechanical robustness, and strong biocompatibility. © 2024 Elsevier B.V.Öğe Proanthocyanidin alleviates testicular torsion/detorsion-induced ischemia/ reperfusion injury in rats(Churchill Livingstone, 2024) Kazak, Filiz; Akcakavak, Gokhan; Alakus, Ibrahim; Alakus, Halil; Kirgiz, Omer; Karatas, Ozhan; Deveci, Mehmet Zeki YilmazTesticular torsion is an urological emergency and can lead to ischemia damage and testicular loss if not diagnosed in time. Proanthocyanidin is reported to have anti-inflammatory and antioxidant properties. The current study aimed to examine the possible effects of proanthocyanidin (P) on the testis in torsion/detorsion (T/D)induced testicular ischemia/reperfusion (I/R) injury in rats. Forty rats were divided into four groups (n=10 for each): sham-operated (sham), I/R, I/R + P100 (100 mg/kg, 30 min before torsion), and I/R + P200 (200 mg/kg, 30 min before torsion). Testicular T/D was performed on the left testicle by 3 hours of torsion at 720 degrees clockwise, followed by 3 hours of detorsion. In the I/R group, an increase in malondialdehyde (MDA) levels and a decrease in glutathione (GSH), vitamin C (Vit C), glutathione peroxidase (GPx), glucose-6-phosphate dehydrogenase (G6PD) values were determined compared to the sham group (p <0.001). Moreover, an increase in the expression of cleaved caspase-3 and Bcl2-associated X protein (Bax), a decrease in the expression of B-cell lymphoma 2 (Bcl2) and proliferating cell nuclear antigen (PCNA) were detected in the I/R group (p <0.001). Histopathologically, it was determined that the Johnsen and Cosentino scores of the testicles were irregular in the I/R group (p <0.001). Proanthocyanidin treatment caused a decrease in MDA, cleaved caspase-3 and Bax levels and an increase in GSH, Vit C, GPx, G6PD, Bcl-2 and PCNA values. Additionally, Johnsen and Cosentino rearranged the scores. The present findings revealed the protective and curative effects of proanthocyanidin in organ damage due to testicular torsion/detorsion-induced ischemia/reperfusion with their antioxidative and antiapoptotic properties.Öğe Sacroiliac luxations in cats: Surgery or conservative treatment?(Univ Zulia, Facultad Ciencias Veterinarias, 2022) Yurtal, Ziya; Altug, Muhammed Enes; Isler, Cafer Tayer; Deveci, Mehmet Zeki Yilmaz; Alakus, Ibrahim; Kirgiz, Omer; Alakus, HalilSacroiliac luxations constitute an important part of hip fractures. In the treatment phase, a choice should be made between surgical and conservative treatment. Which treatment option will yield more effective results depends on many variable factors. In the present study, some of these factors were mentioned and their effects on treatment and outcomes were evaluated. A total of 61 cats, 26 female and 35 male, of various breeds and ages, were included in the study. The mean age of the cats included in the study was 16 months. The mean weight of the cats was 2.87 kg. Cases were categorized as ages, <= 6, 7-12, and >= 13 months of age. In addition, the success criteria of etiological causes, luxation type, and concomitant traumas on decision and outcomes were evaluated. Conservative treatment was preferred more in all age groups and success rates were higher than those of surgery. Conservative treatment was preferred in both genders, and the recovery rate was higher in males than that in females. Regardless of the cause of the trauma, more conservative treatment was preferred, and the rate of good recovery was higher in high-rise falls. Even if there was traumatic injury in addition to sacroiliac luxation, conservative treatment was preferred and the rate of good recovery was higher in cases without concomitant traumatic injury. As a result; age, gender, luxation type and concomitant traumatic injury were not statistically significant on treatment choice. However, good recovery was statistically significant in cases without concomitant traumatic injury.
