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    Platelet and white blood cells in severity of sickle cell diseases
    (Prensa Medica Argentina, 2014) Helvaci, Mehmet Rami; Aydogan, Fusun; Sevinc, Alper; Camci, Celaletdin; Dilek, Imdat
    Background: We tried to understand whether or not there is an association between platelet (PLT) and white blood cell (WBC) counts of peripheric blood and severity of sickle cell diseases (SCDs). Methods: The SCDs patients with red blood cell transfusions of less than 50 units in their lives were put into the first and 50 units or higher were put into the second groups. Results: The study included 316 cases. There were 224 cases (70.8%) in the first and 92 cases (29.1%) in the second groups (p<0.001). Male ratio was significantly higher in the second group (45.5% versus 64.1%, respectively, p<0.001). Although both the WBC and PLT counts were higher in the second group, the difference was only significant for the PLT counts (p= 0.005) probably due to the small sample sizes. Although prevalences of smoking, avascular necrosis of bones, cirrhosis, and exitus were similar in the groups, mean number of painful crises per year, digital clubbing, chronic obstructive pulmonary disease, leg ulcers, stroke, chronic renal disease, and coronary heart disease were significantly higher in the second group (p<0.05 for all). Conclusion: Although the difference was statistically nonsignificant between the WBC count and severity of SCDs probably due to the small sample sizes of the study, there was a highly significant association between the PLT count and disease severity. So the higher PLT and WBC counts of the second group may indicate the significant roles of the cells for the chronic endothelial damage of the SCDs all over the body.