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    Polymer – flufenamic acid delivery systems for injured skin
    (2022) Marin, Maria Minodora; Ghıca, Mihaela Violeta; Kaya, Durmuş Alpaslan; Udeanu, Denisa Ioana; Kaya, Madalina Albu; Dinu-Pirvu, Cristina-Elena; Popa, Lacramıoara
    Collagen, the main protein of the body, is extracted in different forms and used as reservoir for drug delivery. The aim of this work was to obtain a drug delivery system based on collagen-dextran matrices cross-linked with glutaraldehyde as support and flufenamic acid and/or microcapsules with flufenamic acid as drug. The flufenamic acid was encapsulated in polymeric microcapsules consisting in gelatin, alginate, and sodium carboxymethyl cellulose. The morphology of matrices was determined by water absorption and contact angle. The biodegradation was performed in collagenase solution. In vitroflufenamic acid release profiles were built and the kinetic mechanism was set according to different mathematical models. The pharmacological studies followed the effect of collagen formulations treatment on the healing process of Wistar rats which were induced experimental wounds. The studied matrices proved that flufenamic acid delivery can be controlled, and the healing can be completed using the designed spongious matrices.
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    Selection of Optimal Operating Conditions for Extraction of Myrtus Communis L. Essential Oil by the Steam Distillation Method
    (Mdpi, 2020) Kaya, Durmus Alpaslan; Ghica, Mihaela Violeta; Danila, Elena; Ozturk, Sevket; Turkmen, Musa; Albu Kaya, Madalina Georgiana; Dinu-Pirvu, Cristina-Elena
    Myrtus communis L. is one of the important aromatic and medicinal species from the Mediterranean area. It is used in various fields such as culinary, cosmetic, pharmaceutical, therapeutic, and industrial applications. Thus, a Box-Wilson experimental plan was used in this study to select the optimal operating conditions in order to obtain high volumes of essential oils. The factorial design method was applied to evaluate at an industrial scale the effect of major process variables on the essential oil extraction from Myrtus communis L. herbs by the steam distillation method. The input variables considered as significant operating conditions were: X-1-boiler occupancy rate (boilers were filled to 50%, 75%, and 100%), X-2-distillation duration (distillation was continued 60, 75, and 90 min), and X-3-particle size (herbs were cut in sizes of 10, 20, and 30 mm via guillotine). The dependent variable selected, coded as Y, was the essential oil volume obtained (mL). The steps of the classical statistical experimental design technique were complemented with the Taguchi method to improve the extraction efficacy of essential oil from Myrtus communis L., and the optimum parameter conditions were selected: boiler occupancy rate 100%, distillation duration 75 min, and particle size 20 mm. Following the optimum parameters, the GC-MS assay revealed for the Myrtus communis L. essential oil two predominant components, alpha -pinene-33.14% and eucalyptol-55.09%.