Yazar "Dogan, Hatice" seçeneğine göre listele

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    The Amelorative Role of Caffeic Acid Phenethyl Ester (Cape) in a Rat Model of Liver Ischemia/Reperfusion Model
    (Wiley-Blackwell, 2015) Dokuyucu, Recep; Oruc, Cem; Ozcan, Oguzhan; Gokce, Hasan; Bayraktaroglu, Suphi; Dogan, Hatice; Sefil, Fatih
    [Abstract Not Available]
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    The Amelorative Role of Thymoquinone on a Rat Model of Letrozole-Induced Polycystic Ovary Syndrome
    (Wiley-Blackwell, 2015) Dokuyucu, Recep; Ozgur, Tumay; Dogan, Hatice; Tutuk, Okan; Tas, Zeynel Abidin
    [Abstract Not Available]
  • Küçük Resim
    Öğe
    Anticonvulsive and behavior modulating effects of sophoretin and rutoside
    (Akademiai Kiado Zrt, 2019) Demir, Enver Ahmet; Ozturk, Atakan; Tutuk, Okan; Dogan, Hatice; Tumer, Cemil
    Introduction: Seizures are the hallmarks of most types of epilepsies. Behavioral and cognitive impairments coincide with interictal periods even though it is not clear whether these impairments spring out of the seizure itself or accompanying sociopsychological burden of the disease. Materials and methods: In this study, we investigated behavioral and cognitive consequences of a single GABA receptor-related seizure in mice, and examined the potential anticonvulsive and behavior-modulating properties of sophoretin (quercetin) and rutoside (rutin). Results: The study demonstrated that sophoretin and rutoside, common flavonoids of the human diet, delay the seizure onset and reduce the seizure stage. Moreover, they exerted an antidepressant-like effect, which was independent of the seizure. Neither treatments nor seizure altered recognition and spatial memory performances of the mice. Conclusions: Behavioral or cognitive disturbances that are evident in epileptic patients did not appear following a single seizure. In addition, we suggest that both sophoretin and rutoside successfully alleviate the seizure severity without interfering in the behavioral stability and cognitive performance. Hence, these flavonoids may be of use as adjuncts to the current treatment options.
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    Assessment of Sensitivity to the Anesthesia in a Diabetic Rat Model
    (Wiley-Blackwell, 2015) Dokuyucu, Recep; Dogan, Hatice; Agturk, Gokhan; Cay, Emrah; Bilgic, Yasemin; Egeli, Duygu; Tutuk, Okan
    [Abstract Not Available]
  • Küçük Resim
    Öğe
    ATTENUATING EFFECTS OF CAFFEIC ACID PHENETHYL ESTER WITH INTRALIPID ON HEPATOTOXICITY OF CHLORPYRIFOS IN THE CASE OF RATS
    (Nofer Inst Occupational Medicine, Poland, 2016) Dokuyucu, Recep; Bilgili, Ali; Hanedan, Basak; Dogan, Hatice; Dokuyucu, Ahmet; Celik, Muhammet Murat
    Background: Chlorpyrifos (CPF), insecticide widely used in agriculture, may cause poisonings in the case of humans. As a result, there is a large amount of treatment research underway to focus on the possibility of chlorpyrifos induced poisonings. The aim of this study has been to evaluate the effects of caffeic acid phenethyl ester (CAPE) and intralipid (IL) on hepatotoxicity induced by chlorpyrifos in the case of rats. Material and Methods: The rats in this study were treated with CPF (10 mg/kg body weight (b.w.), orally), CAPE (10 mu mol/kg b.w., intraperitoneally), IL (18.6 ml/kg b.w., orally), CPF+CAPE, CPF+IL, and CPF+CAPE+IL. The plasma total oxidant capacity (TOC), total antioxidant capacity (TAC) were measured and the oxidative stress index (OSI) was calculated. Liver histopathology and immunohistochemical staining were performed. Results: Chlorpyrifos statistically significantly decreased the TAC levels in the rats' plasma and increased the apoptosis and the TOC and OSI levels. In the chlorpyrifos induced liver injury, CAPE and CAPE+IL significantly decreased the plasma OSI levels and the apoptosis, and significantly increased the plasma TAC levels. Conclusions: This study revealed that CAPE and CAPE+IL attenuate chlorpyrifos induced liver injuries by decreasing oxidative stress and apoptosis.
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    Behavioral and Cognitive Consequences of Obesity in Parents and Offspring in Female and Male Rats: Implications of Neuroinflammation and Neuromodulation
    (Springer, 2022) Demir, Enver Ahmet; Gulbol-Duran, Gulay; Urhan-Kucuk, Meral; Dogan, Hatice; Tutuk, Okan; Cimen, Funda; Bayirli, Mucella
    Obesity is a rapidly growing public health concern that can create a family-wise burden. This study was aimed to investigate behavioral, cognitive, neuroinflammatory, and neuromodulatory consequences of the diet and parental obesity. Female and male Wistar albino rats were fed on either an obesogenic or standard diet for 12 weeks, beginning with weaning. Thereafter, the animals were matched and allowed to mate. Pups born to obese or normal parents received either the diet or standard chow to the same age. The obesogenic diet and/or parental obesity increased the locomotor activity in both females and males. The diet exhibited anxiolytic-like and antidepressant-like properties, and impaired short-term object memory as well as spatial memory. Interestingly, the obesogenic diet resulted in neuroinflammation only in naive animals, but not in the ones with parental obesity. BDNF, SIRT1, and p53 expressions were decreased, whereas RelN expression was increased in the brain with the diet, regardless of parental obesity. Multi-factor analyses demonstrated that the obesogenic diet is the prominent influencer of cognitive, neuroinflammatory, and neuromodulatory results while parental obesity has an effect on spatial memory, neuroinflammation, and hippocampal RelN and p53 expressions. Here, we provided supporting evidence for detrimental cognitive and neuroinflammatory consequences of early life consumption of the obesogenic diet which accompanies alterations in neuromodulatory factors. Surprisingly, the diet was found beneficial against anxiety-like and depression-like behaviors, and additionally, parental obesity was demonstrated to impair some aspects of cognitive performance which appears unrelated to neuroinflammation.
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    Capparis Spinosa L. in an Animal Model of Sciatic Crush Injury
    (Wiley, 2019) Ishakoglu, Ozlem Kutlu; Tutuk, Okan; Dogan, Hatice; Demir, Enver Ahmet; Secinti, Ilke Evrim; Kara, Mikail; Kahraman, Ibrahim
    [Abstract Not Available]
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    The Comparison of Visceral Adiposity Measures Between Type 2 Diabetics and Healthy Individuals
    (Wiley, 2018) Egeli, Duygu; Demir, Enver Ahmet; Dogan, Hatice; Tutuk, Okan; Acik, Murat; Tumer, Cemil
    [Abstract Not Available]
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    Determining the Ideal Object Size in the Novel Object Recognition Test
    (Wiley, 2019) Kasirga, Busra; Demir, Enver Ahmet; Dogan, Hatice; Tutuk, Okan; Tumer, Cemil
    [Abstract Not Available]
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    Detrimental effects of chia (Salvia hispanica L.) seeds on learning and memory in aluminum chloride-induced experimental Alzheimer's disease
    (Nencki Inst Experimental Biology, 2018) Bilgic, Yasemin; Demir, Enver Ahmet; Bilgic, Nilufer; Dogan, Hatice; Tutuk, Okan; Turner, Cemil
    Polyphenols and omega-3 fatty acids are thought to have beneficial effects in Alzheimer's disease, the most common cause of dementia. Seeds of chia (Salvia hispanica L.) are highly rich in these nutrients, and thus, the present study investigated the effects of chia seeds on behavior and cognition in an aluminum-induced Alzheimer's disease model in rats. Experimental animals received chia supplementation either during the generation of the model (i.e., pretreatment) or after the model was established (i.e., treatment). A battery of behavioral and cognitive tests were performed, including open-field, elevated plus maze, Porsolt's forced swim, and Morris' water maze, to evaluate anxiety- and depression-like behaviors, and learning and memory. Results showed that chia supplementation was ineffective against Alzheimer's-related anxiety, whereas depression-like behaviors were attenuated with both pretreatment and treatment. There was no improvement in learning and memory with chia treatment. Rather, cognitive performance in chia-pretreated animals was remarkably worse as compared to their non-treated disease-induced counterparts. Hippocampal concentrations of amyloid-beta 42, amyloid precursor protein, and total tau protein were similarly increased in all disease-induced animals (despite chia supplementation), as compared to the controls. Based on these findings, chia supplementation during the progression of Alzheimer's disease may exacerbate the disease. Although the results presented here emerge from an experimental/preclinical study, we suggest cautious and careful use of chia, especially in early-stage Alzheimer's patients, until future research in different experimental settings is conducted.
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    Disinfectant Effect of Thyme Oil in Diabetic Wound Model
    (Wiley-Blackwell, 2015) Temel, Metin; Dokuyucu, Recep; Gokce, Hasan; Agturk, Gokhan; Dogan, Hatice
    [Abstract Not Available]
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    Effect of Alpha-LipoicAcid on TRPM7 Gene Expression in Experimental Varicocele Model
    (Wiley, 2018) Tutuk, Okan; Dogan, Hatice; Demir, Enver Ahmet; Tutuk, Sumeyye; Tumer, Cemil
    [Abstract Not Available]
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    The Effect of Caffeic Acid Phenethyl Ester (CAPE) on TRPM 2, 8 Channels in Hepatic Ischemia-Reperfusion Model
    (Wiley-Blackwell, 2016) Dokuyucu, Recep; Dogan, Hatice; Tutuk, Okan; Sefil, Fatih; Gogebakan, Bulent; Gokce, Hasan; Tumer, Cemil
    [Abstract Not Available]
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    The Effect of Chia (Salvia hispanica L.) Seed in an Experimental Alzheimer's Disease Model
    (Wiley, 2018) Bilgic, Yasemin; Demir, Enver Ahmet; Bilgic, Nilufer; Dogan, Hatice; Tutuk, Okan; Tumer, Cemil
    [Abstract Not Available]
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    The Effect of Thymoquinone in Hepatic Ischemia/Reperfusion Rat Model
    (Wiley-Blackwell, 2015) Caglar, Kerem; Gokce, Hasan; Ozcan, Oguzhan; Tas, Zeynel Abidin; Dogan, Hatice; Agturk, Gokhan; Sefil, Fatih
    [Abstract Not Available]
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    The Effect of Vitamin D in an Experimental Varicocele Model
    (Wiley, 2018) Agturk, Gokhan; Demir, Enver Ahmet; Tutuk, Okan; Dogan, Hatice; Ozgur, Tumay; Tumer, Cemil
    [Abstract Not Available]
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    Effects of Alpha-Lipoic Acid on Urotensin II and TGF-?1 on Steroid-induced Osteonecrosis in Rats
    (Wiley-Blackwell, 2016) Dokuyucu, Recep; Tutuk, Okan; Dogan, Hatice; Bilgic, Nilufer; Tas, Zeynel Abidin; Sefil, Fatih; Gogebakan, Bulent
    [Abstract Not Available]
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    Effects of Erdosteine and Vitamin D in Experimental Rat Kidney Ischemia/Reperfusion Model
    (Wiley, 2017) Dogan, Hatice; Demir, Enver Ahmet; Tutuk, Okan; Ozgur, Tumay; Kucuk, Meral Urhan; Ozcan, Oguzhan; Bayraktar, Suphi
    [Abstract Not Available]
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    The Effects of Erdosteine and Vitamin D on Liver Damage After Renal Ischemia Reperfusion
    (Wiley, 2017) Demir, Enver Ahmet; Dogan, Hatice; Tutuk, Okan; Ozcan, Oguzhan; Ozgur, Tumay; Tumer, Cemil
    [Abstract Not Available]
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    The Effects of Erdosteine and Vitamin D on TRPM 2 Ion Channel in Renal Ischemia Reperfusion Damage Model in Rats
    (Wiley, 2018) Dogan, Hatice; Tutuk, Okan; Demir, Enver Ahmet; Tumer, Cemil
    [Abstract Not Available]