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    Assessment of thyroid function and lipid profile in patients with postadolescent acne in a Mediterranean population from Turkey
    (Wiley-Blackwell, 2015) Ekiz, Ozlem; Balta, Ilknur; Unlu, Ezgi; Sen, Bilge Bulbul; Rifaioglu, Emine N.; Dogramaci, Asena C.
    BackgroundPostadolescent acne is defined as acne that is seen even after the age of 25years, regardless of the age at onset. The causes of postadolescent acne have not been completely clarified up to now. Androgens are considered to be the major factor involved in pathogenesis. ObjectiveWe aimed to investigate the status of thyroid functions and lipid levels in patients with postadolescent acne and determine the effects of lifestyle and environmental factors on postadolescent acne in a Turkish population. MethodsIn total, 184 patients and 82 healthy controls were enrolled in the study. Thyroid function and lipid profiles of all participants were analyzed. ResultsThe mean age of patients was 30.44.9years (25-50). The mean age of control group was 30.0 +/- 4.4years (25-40). Cigarette smoking was significantly associated with postadolescent acne (P<0.001). No significant differences were observed between patients with postadolescent acne and control subjects in triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels, thyroid hormone profiles, and thyroid ultrasound scans. High-density lipoprotein cholesterol levels were significantly decreased with postadolescent acne (P=0.01). ConclusionsTo our knowledge, this is the first study to investigate the thyroid functions and lipid profile in men and women with postadolescent acne. In this study, there was no relationship between thyroid functions and postadolescent acne. However, an association with low high-density lipoprotein cholesterol levels and postadolescent acne was detected. Further investigations with more patients in different populations are needed to determine the causes of postadolescent acne.
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    Dermatoglyphs in Patients with Beta-Thalassemia Major and Their Thalassemia Carrier Parents
    (Collegium Antropologicum, 2009) Dogramaci, Asena C.; Savas, Nazan; Bagriacik, Mehmet A.
    Dermatoglyphs are cutaneous ridges on the fingers, palms, and soles, formed during early intrauterine life. During this period, and only then, genetic and environmental factors can influence their formation. Beta-thalassemia major is an genetic disease. The aim of the present work was to analyze dermatoglyphs traits in subjects with beta-thalassemia major and their thalassemia carrier parents. The sample included 59 patients with beta-thalassemia major (39 males, 20 females). We also analyzed a total of 61 thalassemia carrier parents. There were 38 mothers and 23 fathers in the study. The control group comprised 120 healthy subjects (64 men, 56 women). All ten fingers and right hand palm prints of all participants were taken and statistically analyzed. The results of analyses showed that the frequency of loops on the fifth finger of left hand was significantly higher in female patients than that of carriers and controls (p<0.05). It was also significantly higher in female patients than that male patients (p=0.03). The increase in mean c-d ridge count was noticed in female patients only (p=0.04) compared to carriers and controls. In addition to that there was also differences according to the mean c-d ridge count between female and male patients (p=0.01). Our study showed that dermatoglyphs were helpful for the diagnosis of beta-thalassemia major. However; it does not help to detect thalassemia carriers. This study is the comprehensive dermatoglyphic research on thalassemia, and its dermatoglyphic data will be useful for future research in genetics and medicine.
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    Lipoid proteinosis in the eastern Mediterranean region of Turkey
    (Medknow Publications, 2012) Dogramaci, Asena C.; Celik, Murat M.; Celik, Ebru; Bayarogullari, Hanifi
    Background: Lipoid proteinosis (LP), also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease, is a rare autosomal recessive genodermatosis. Hyalin-like material is deposited in multiple organs, including the skin, oral mucosa, larynx, and brain. Only about 300 cases have been reported in the literature so far. Occurrence of LP in siblings is also rare. The reasons for relatively large number of cases, the clinical features of the patients, and the association of LP with other clinical conditions are described in this article. Aims: The aim of this study is to show that LP is not rare in Turkey and consanguineous marriage is still a social problem. Methods: We included patients between the years of 2008-2011 with lesions resembling LP. Based on the findings of clinical and histological examination of all cases, a diagnosis of LP was made. Results: We presented six different families with multiple family members suffered from LP. In total, we determined eight children and six adult patients. Three of eight children were from the same family (sisters), the other three children belonged to another family (brothers), two children were from another family (brother and sister), and the adult patients were from three different families. Conclusions: Patients with LP are likely to present first to a dermatologist because of the appearance of their skin; therefore, it is important that the dermatologic diagnosis is not to be missed. We described patients with LP and discuss the salient features of this disease.