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    Chronic obstructive pulmonary disease may be one of the terminal endpoints of the sickle cell diseases
    (Medi+World Int, 2015) Helvaci, Mehmet Rami; Dogru, Sibel
    Background: Sickle cell diseases (SCDs) are chronic destructive processes on vascular endothelium initiating at birth all over the body. We tried to understand whether or not there is an association between chronic obstructive pulmonary disease (COPD) and severity of the SCDs. Methods: All patients with the SCDs were taken into the study. Results: The study included 411 patients with the SCDs (199 females and 212 males). There were 60 patients (14.5%) with the COPD. Mean age of the patients was significantly higher in the COPD group (33.0 versus 29.5 years, P=0.005). The male ratio was significantly higher in the COPD group, too (80.0% versus 46.7%, P<0.001). Smoking was also higher in the COPD group, significantly (36.6% versus 9.9%, P<0.001). Parallel to the smoking, alcoholism was also higher among the COPD cases, significantly (3.3% versus 0.8%, P<0.05). Beside these, transfused red blood cell units in their lives (69.1 versus 32.9, P=0.001), priapism (10.0% versus 1.9%, P<0.001), leg ulcers (26.6% versus 11.6%, P<0.001), digital clubbing (25.0% versus 7.1%, P<0.001), coronary heart disease (26.6% versus 13.1%, P<0.01), chronic renal disease (16.6% versus 7.1%, P<0.01), and stroke (20.0% versus 7.9%, P<0.001) were all higher among the COPD cases, significantly. Conclusion: SCDs are chronic catastrophic processes on vascular endothelium particularly at the capillary level, and terminate with accelerated atherosclerosis induced end-organ failures in early years of life. COPD may be one of the terminal endpoints of the diseases.
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    EVALUATION OF HEARING LOSS IN PATIENTS WITH OSAS AND THE RELATIONSHIP BETWEEN S100B AND NSE
    (2020) Arlı, Cengiz; Sarac, Elif Tugba; Babayıgıt, Cenk; Dıkmen, Nursel; Özcan, Oğuzhan; Dogru, Sibel; Okuyucu, Emine Esra
    Objective: The aim of the current study was to determine the relationship between serum S100B levels, NSE levels and hearing function in patients with OSAS. Material and Methods: Thirty-five subjects and 30 controls were included in the study. The study group included 35 patients with moderate and severe apnoea (AHI > 15) who were diagnosed by polysomnography (PSG). Control subjects were selected with ESS (Epworth Sleepiness Scale). Serum S100B and NSE levels in the study and control groups were analyzed by ELISA (enzyme-linked immunosorbent assay) and high-frequency audiometry was done for all subjects. Results: Mean S100B levels and NSE levels of the OSAS group were significantly higher than that of the controls (p = 0.039; p = 0.002, respectively). The hearing thresholds between 125-1,000 Hz and between 4,000-12,000 Hz in the study group were found to be significantly higher than the control group. Conclusion: We suggest that hearing function should be evaluated in OSAS patients and a professional consultation should be sought for OSAS treatment. In addition, serum S100B and NSE measurements may be valued as biochemical indicators in determining hearing loss risk caused by OSAS.
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    THE RELATIONSHIP BETWEEN DISEASE SEVERITY AND PREDICTORS OF DIFFICULT INTUBATION IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME
    (Carbone Editore, 2015) Akkurt, Buket Cagla Ozbakis; Dogru, Sibel; Koyuncu, Onur; Davarci, Isil; Genc, Sebahat
    Objectives: The objective of our study was to identify clinical and polysomnographic predictors of difficult intubation, through the correlation between commonly used measurements to predict difficult intubation. Methods: Consecutive patients diagnosed with moderate or severe obstructive sleep apnea syndrome (OSAS) using polysomnography (PSG), and sex and age matched normal controls were included in the study. The patient group was divided into two subgroups as mild/moderate and severe desease groups. Body mass index (BMI), neck circumference (NC), abdominal circumference (AC), Epworth Sleepiness Scale (ESS) score, Apnea/Hypopnea Index (AHI), Arousal Index (AI) were recorded. Predictive tests for difficult intubation were recorded for each subject. Records were compared between all groups. Results: Forty OSAS patients and 39 control subjects were enrolled in the study. Class III-IV Modified Mallampati Test (MMT) score was found in 37 (%92.5) OSAS patients, while in 10 (25.6 %) of the control subjects. There was statistically significant difference between two groups in terms of NC, AC, interincissor distance (IID). There was a significant inverse correlation between sternomental distance (SMD) and AHI in patients with OSAS. Conclusion: AHI is a reliable predictor of difficult intubation in patients with OSAS and is correlated with the sternomental distance.
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    The relationship between disease severity and predictors of difficult intubation in patients with obstructive sleep apnea syndrome
    (Acta Medica Mediterranea, 2015) Akkurt, Buket Cagla Ozbakis; Dogru, Sibel; Koyuncu, Onur; Davarci, Isil; Genc, Sebahat
    Objectives: The objective of our study was to identify clinical and polysomnographic predictors of difficult intubation, through the correlation between commonly used measurements to predict difficult intubation. Methods: Consecutive patients diagnosed with moderate or severe obstructive sleep apnea syndrome (OSAS) using polysomnography (PSG), and sex and age matched normal controls were included in the study. The patient group was divided into two subgroups as mild/moderate and severe desease groups. Body mass index (BMI), neck circumference (NC), abdominal circumference (AC), Epworth Sleepiness Scale (ESS) score, Apnea/Hypopnea Index (AHI), Arousal Index (AI) were recorded. Predictive tests for difficult intubation were recorded for each subject. Records were compared between all groups. Results: Forty OSAS patients and 39 control subjects were enrolled in the study. Class III-IV Modified Mallampati Test (MMT) score was found in 37 (%92,5) OSAS patients, while in 10 (25.6 %) of the control subjects. There was statistically significant difference between two groups in terms of NC, AC, interincissor distance (IID). There was a significant inverse correlation between sternomental distance (SMD) and AHI in patients with OSAS. Conclusion: AHI is a reliable predictor of difficult intubation in patients with OSAS and is correlated with the sternomental distance.
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    The Relationship between Patient Age and Sensitivity to Known Risk Factors for Asthma Attacks
    (Bilimsel Tip Publishing House, 2013) Dogru, Sibel; Kanat, Fikret; Ozer, Faruk; Maden, Emin; Akoglu, Sebahat; Babayigit, Cenk
    OBJECTIVE: The characteristics of patients hospitalised for an asthma attack were evaluated to delineate the impact of age on sensitivity to risk factors for this condition. MATERIAL AND METHODS: Eighty patients hospitalised for an asthma attack were included in this cross-sectional study. Patients were divided into two age groups; younger than 65-years-old (52.5 +/- 7.6 years, n= 36) and older than 65-years-old (72.5 +/- 5.2 years, n=44). A questionnaire was used to collect data on demographics, initial age and duration of asthma, atopy, atopic diseases, drug and food allergies, additional diseases, treatments during the previous 1 and 3 months, cause of attacks, duration of hospital stay, number of emergency visits and hospitalisation due to asthma over the last year, and all past hospital stays. Pulmonary function tests were performed upon admittance and discharge, and parameters of arterial blood gases were recorded. RESULTS : The severity of asthma attacks was greater in the older cohort of patients with risk factors including osteoporosis, positive skin test for mould, or theophylline use in the previous month. Independent of these variables, the severity of attacks was greater in patients over the age of 65. Irregular treatments in both age groups were noted over the previous one and three months. CONCLUSION: Theophylline use, mould sensitivity and biomass exposure in elderly patients with asthma should be questioned more carefully and protective measures taken to avoid these risks in keeping with the recommended guidelines.