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Öğe Agomelatine Protection in an LPS-Induced Psychosis-Relevant Behavior Model(Int Scientific Information, Inc, 2015) Inanir, Sema; Copoglu, Umit Sertan; Kokacya, Hanifi; Dokuyucu, Recep; Erbas, Oytun; Inanir, AhmetBackground: The aim of this study was to investigate the effect of agomelatine in a psychosis-relevant behavior model. Material/Methods: We used 18 adult male Wistar rats in this study. Twelve rats given LPS for endotoxemia were randomly divided into 2 groups (n=6). Group I was treated with 1 mL/kg 0.9% NaCl i. p. and Group II was treated with 40 mg/kg agomelatine. Six normal rats served as the control group and were not given LPS for endotoxemia. Cylindrical steel cages containing vertical and horizontal metal bars with top cover were used. Rats were put in these cages for the purpose of orientation for 10 min. Apomorphine was given to rats removed from cages, and then they were immediately put back in the cages for the purpose of observing stereotyped conduct. Brain HVA levels and plasma TNF-alpha levels were evaluated in tissue homogenates using ELISA. The proportion of malondialdehyde (MDA) was measured in samples taken from plasma for detection of lipid peroxidation similar to thiobarbituric acid reactive substances. Results: LPS induced-plasma TNF-alpha, brain TNF-alpha, and plasma MDA levels were significantly lower in the LPS+ agomelatine group compared to the LPS+ saline group (p< 0.05). HVA levels and stereotype scores were significantly lower in the LPS+ agomelatine group compared to the LPS+ saline group (p < 0.001). Conclusions: Agomelatine reduced TNF-alpha, HVA, MDA levels, and the stereotype score in relevant models of psychosis. Our results suggest that the anti-inflammatory effect of agomelatine involved oxidant cleansing properties and that its effects on the metabolism of dopamine can play an important role in the model of psychosis.Öğe Ameliorating effect of quercetin on acute pentylenetetrazole induced seizures in rats(E-Century Publishing Corp, 2014) Sefil, Fatih; Kahraman, Ibrahim; Dokuyucu, Recep; Gokce, Hasan; Ozturk, Atakan; Tutuk, Okan; Aydin, MehmetObjective: The aim of the study to elicit effects of pure quercetin in pentylenetetrazole (PTZ) and picrotoxin induced seizures. Materials and methods: Each animal group was divided into six groups and composed of six rats. Rats were assigned to the following experiments and groups (G): (G1) PTZ 45 mg/kg + DMSO; (G2) PTZ 45 mg/kg + 5 mg/kg quercetin; (G3) PTZ 45 mg/kg + 10 mg/kg quercetin; (G4) PTZ 45 mg/kg + 20 mg/kg quercetin; (G5) PTZ 45 mg/kg + 40 mg/kg quercetin; (G6) Picrotoxin 5 mg/kg + DMSO; (G7) Picrotoxin 5 mg/kg + 10 mg/kg quercetin; (G8) Picrotoxin 5 mg/kg + 20 mg/kg quercetin. In all groups quercetin were injected 30 min before PTZ and picrotoxin applications. Results: Compared to PTZ, quercetin significantly prolonged onset of the seizure in 10 mg/kg (P < 0.05) and reduced the seizure stage in 10 mg/kg quercetin injected group (P < 0.01). Compared to PTZ, quercetin also declined the generalized seizure duration at 10 mg/kg (P < 0.01) and 20 mg/kg (P < 0.05) doses. At the doses of 5 mg/kg and 40 mg/kg quercetin there were no significant changes in seizure parameters. Development of picrotoxin induced seizures is slower than in PTZ. Quercetin was found to be unable to prevent seizure in picrotoxin induced seizures. Surprisingly, quercetin also significantly reduced the onset of seizures at the dose of 20 mg/kg (P < 0.05). Conclusion: quercetin (at doses of 10 and 20 mg/kg i.p) prevented seizures in PTZ (45 mg/kg i.p) induced seizures. Especially, 10 mg/kg PTZ prolonged onset of seizures, reduced the seizure duration and seizure severity score in comparison with control group. At a higher (40 mg/kg) dose quercetin failed to prevent PTZ induced seizures. In addition 20 mg/kg quercetin significantly reduced the onset of seizures that suggest a preconvulsive effect. 20 mg/kg quercetin reduced the onset of picrotoxin induced seizures. In picrotoxin model, it may be claimed that quercetin at higher doses accelerate the epileptic activity owing to its antagonistic effect on GABAA. Further investigations are needed to explore the mechanisms of the antiepileptic and preconvulsant effects of quercetin.Öğe The Amelorative Role of Caffeic Acid Phenethyl Ester (Cape) in a Rat Model of Liver Ischemia/Reperfusion Model(Wiley-Blackwell, 2015) Dokuyucu, Recep; Oruc, Cem; Ozcan, Oguzhan; Gokce, Hasan; Bayraktaroglu, Suphi; Dogan, Hatice; Sefil, Fatih[Abstract Not Available]Öğe The Amelorative Role of Thymoquinone on a Rat Model of Letrozole-Induced Polycystic Ovary Syndrome(Wiley-Blackwell, 2015) Dokuyucu, Recep; Ozgur, Tumay; Dogan, Hatice; Tutuk, Okan; Tas, Zeynel Abidin[Abstract Not Available]Öğe Analysis of methanol and its derivatives in illegally produced alcoholic beverages(Elsevier Sci Ltd, 2015) Arslan, M. Mustafa; Zeren, Cem; Aydin, Zeki; Akcan, Ramazan; Dokuyucu, Recep; Keten, Alper; Cekin, NecmiIntroduction: Illegal alcohol production remains as a common issue worldwide. Methanol poisoning mostly occurs because of the methanol used in production of counterfeit alcohol instead of ethyl alcohol due to its low price or by drinking the liquids containing methyl alcohol. Pectolytic enzymes results in an increase of methanol levels in many fermentation products such as ciders or wines. Methanol poisonings are infrequently encountered in forensic medicine practice. However, sporadic cases due to methanol intoxication as well as epidemic cases have been reported. In this study, we aimed to identify existence of methanol and its metabolites in illegally produced alcoholic beverages used in Antakya region. Material and methods: Twelve legally produced alcohol samples and Fifty-six different illegally produced alcohol samples were collected from the markets and local producers. Existence of methanol, formic acid, methyl amine, methyl formate and trioxan were determined using GC-MS method in these samples. Results: Fifty-six different illegal alcohol samples were analyzed in this study and methanol was detected in 39 (75%) of samples. Formic acid was detected in 3, formamide in 1, methyl amine in 6, methyl formate in 10 and trioxan in 2 samples. Conclusion: Overwhelming majority of illegal alcoholic beverages was detected to contain methanol. Interestingly this study also revealed the presence of trioxane, which has not previously reported among toxic agents in illegal alcohol samples. (C) 2015 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.Öğe Antioxidant effect of erdosteine and lipoic acid in ovarian ischemia-reperfusion injury(Elsevier Science Bv, 2014) Dokuyucu, Recep; Karateke, A.; Gokce, H.; Kurt, R. K.; Ozcan, O.; Ozturk, S.; Tas, Z. A.Objective: To investigate the effects of erdosteine and alpha lipoic acid (ALA) in a rat model of ovarian ischaemia-reperfusion injury. Study design: Forty-eight female Wistar albino rats were separated, at random, into six groups of eight rats. The groups were classified as: sham, torsion, detorsion, detorsion + erdosteine 100 mg/kg, detorsion + alpha lipoic acid (ALA) 100 mg/kg, and detorsion + erdosteine + ALA. The investigators executing the biochemical and histological analyses were blinded to the randomization until the end of the study. Results: The TOS (Total Oxidant Status) and OSI (Oxidative Stress Index) levels are higher in the Torsion and Detorsion groups when compared with the ones in the Sham group (p < 0.05). Strong correlation was found between OSI and total histological score in the sham, torsion and detorsion groups (r = 0.765, p < 0.001). The mean levels of TOS and OSI in the rats that received erdosteine and/or ALA were significantly lower compared with the sham, torsion and detorsion groups (p < 0.05). Mean TOS and mean OSI were lower in the detorsion + erdosteine + ALA group compared with the detorsion + erdosteine and detorsion + ALA groups (p < 0.05). In comparison with the detorsion group, the numbers of primordial follicles (p = 0.006) and primary follicles (p = 0.036) were increased in the groups that received erdosteine and/or ALA. Conclusions: Erdosteine and ALA decreased ischaemia-reperfusion injury in an experimental rat ovarian torsion model; combination treatment had a greater effect than either agent alone. Treatment with erdosteine and/or ALA was found to preserve the loss of reproductive capacity normally observed after ovarian torsion. (C) 2014 Elsevier Ireland Ltd. All rights reserved.Öğe The Antipsychotic Effects of Omega-3 Fatty Acids in Rats(Elsevier Science Inc, 2015) Kokacya, Mehmet Hanifi; Inanir, Sema; Copoglu, Umit Sertan; Dokuyucu, Recep; Erbas, OytunBackground: In humans, omega-3 fatty acids are necessary for cell membranes, brain function and nerve transmission continuation. When animals are exposed to a new environment-or as a result of an apomorphine application that creates an agonistic effect on D1 and D2 receptors-they display behavioral reactions like rearing and stereotypy. This study aims to reveal the possible antipsychotic and oxidative effects of omega-3 fatty acids by comparing with chlorpromazine, a conventional antipsychotic drug, through evaluating the novelty-induced rearing and apomorphine-induced stereotypic behaviors, as well as malondialdehyde and glutathione levels in rats. Methods: Twenty-eight, adult, male, Wistar rats were used in the study. Briefly, 4 groups of rats (n = 7) were administered docosahexaenoic acid (DHA) + eicosapentaenoic acid (EPA) (300 mg/kg; DHA: 120 mg/kg + EPA: 180 mg/kg intraperitoneally [IP]), DHA + EPA (150 mg/kg; DHA: 60 mg/kg + EPA: 90 mg/kg IP), chlorpromazine (1 mg/kg, IP) and isotonic saline (1 mL/kg, IP). One hour later, apomorphine (2 mg/kg, subcutaneously) was administered to each rat. After the apomorphine administration, rats were observed for stereotypic behavior. Results: This study shows that omega-3 fatty acids, similar to antipsychotics, reversed the psychotic like effects, increase of oxidants and decrease of antioxidants that are composed experimentally in rats. Conclusions: The application of omega-3 fatty acids has antipsychotic effects and causes an oxidative imbalance. This study adds new evidence to the current literature regarding the possible antipsychotic effects of omega-3 fatty acids.Öğe Antipsychotic-like effect of minocycline in a rat model(E-Century Publishing Corp, 2014) Dokuyucu, Recep; Kokacya, Hanifi; Inanir, Sema; Copoglu, Umit Sertan; Erbas, OytunObjectives: Tetracycline antibiotic drug minocycline has strongly neuroprotective and anti-inflammatory effects. Minocycline has also remarkable brain tissue penetration, is clinically entirely tolerated and properly absorbed when taken orally. In our study, we class with the effects of minocycline and chlorpromazine, a conventional antipsychotic drug, by evaluating the novelty-induced rearing, apomorphine-induced stereotypic behavior, and brain MDA levels in rats. Materials and Methods: Four groups of rat (n = 7) were applied with minocycline (50 and 100 mg/kg, i.p.), chlorpromazine (1 mg/kg, i.p.), or isotonic saline (1 mL/kg, i.p.). One hour later, apomorphine (2 mg/kg, s.c.) was applied to each rat. Result: Our results showed that both doses of minocycline significantly decreased the rearing behavior in rats, whereas the decrease with chlorpromazine was higher. Minocycline also decreased the stereotypy scores in a dose-dependent manner. Conclusion: We concluded that minocycline has beneficial effects on rearing behavior and stereotypy, which are accepted to be indicators of antipsychotic effect. Taken together, minocycline, as an anti-oxidant and cytoprotective agent, can be useful in neuroprotection especially on early stages of psychosis or prepsychotic patients with insignificant symptoms. Minocycline is worthy of being investigated for its anti-psychotic effects as a primary or an adjunctive drug.Öğe Assessment of Sensitivity to the Anesthesia in a Diabetic Rat Model(Wiley-Blackwell, 2015) Dokuyucu, Recep; Dogan, Hatice; Agturk, Gokhan; Cay, Emrah; Bilgic, Yasemin; Egeli, Duygu; Tutuk, Okan[Abstract Not Available]Öğe ATTENUATING EFFECTS OF CAFFEIC ACID PHENETHYL ESTER WITH INTRALIPID ON HEPATOTOXICITY OF CHLORPYRIFOS IN THE CASE OF RATS(Nofer Inst Occupational Medicine, Poland, 2016) Dokuyucu, Recep; Bilgili, Ali; Hanedan, Basak; Dogan, Hatice; Dokuyucu, Ahmet; Celik, Muhammet MuratBackground: Chlorpyrifos (CPF), insecticide widely used in agriculture, may cause poisonings in the case of humans. As a result, there is a large amount of treatment research underway to focus on the possibility of chlorpyrifos induced poisonings. The aim of this study has been to evaluate the effects of caffeic acid phenethyl ester (CAPE) and intralipid (IL) on hepatotoxicity induced by chlorpyrifos in the case of rats. Material and Methods: The rats in this study were treated with CPF (10 mg/kg body weight (b.w.), orally), CAPE (10 mu mol/kg b.w., intraperitoneally), IL (18.6 ml/kg b.w., orally), CPF+CAPE, CPF+IL, and CPF+CAPE+IL. The plasma total oxidant capacity (TOC), total antioxidant capacity (TAC) were measured and the oxidative stress index (OSI) was calculated. Liver histopathology and immunohistochemical staining were performed. Results: Chlorpyrifos statistically significantly decreased the TAC levels in the rats' plasma and increased the apoptosis and the TOC and OSI levels. In the chlorpyrifos induced liver injury, CAPE and CAPE+IL significantly decreased the plasma OSI levels and the apoptosis, and significantly increased the plasma TAC levels. Conclusions: This study revealed that CAPE and CAPE+IL attenuate chlorpyrifos induced liver injuries by decreasing oxidative stress and apoptosis.Öğe Can the ductus venosus doppler predict the hemoglobinopathies?(E-Century Publishing Corp, 2015) Karateke, Atilla; Silfeler, Dilek Benk; Gungoren, Arif; Kurt, Raziye Keskin; Okyay, Ayse Guler; Dokuyucu, Recep; Ulutas, TurkerObjective: The aim of our study was to investigate the ductus venosus doppler between 11-13+6 (weekday) in pregnant women with hemoglobinopaties and its relation with fetal outcomes. Material and methods: A total of 100 pregnant women with hemoglobinopathies and 100 healthy pregnant women were included in our study. Ultrasonography (USG) was performed to all pregnant women and the ductus venosus doppler (DVD) flows were evaluated. The results were statistically analyzed. Results: The mean hemoglobin level was significantly lower in hemoglobinopathy group (9.7 +/- 0.7) than control group (10.67 +/- 0.82) (P<0.001). There was a significant relationship between Vmax, Vmin, S/D and reverse 'a' wave in fetuses with hemoglobinopathies. Vmax, Vmin and S/D parameters were higher in the group of hemoglobinopathies (respectively mean value, 31.3 +/- 1.66, 8.90 +/- 0.81, 2.97 +/- 0.49). Reverse 'a' wave was detected especially in all fetuses with sickle cell anemia. There was no significantly relationship between the groups in terms of PI, RI and HR. In a logistic regression analyses, fetal hemoglobinopathy was independently associated with Vmin (beta = 1.07, P = 0.001), S/D (beta = 2.61, P = 0.001) and reverse 'a' wave (beta = 2.46, P = 0.004). Conclusion: Pregnant women with hemoglobinopathies had changed ductus venosus doppler values in compared to normal pregnant women. Maternal anemia may cause this doppler changes. Furthermore all fetuses with sickle cell anemia (n = 5) had abnormal ductus venosus doppler findings. Further studies are needed to investigate the relationship between abnormal ductus venosus doppler findings and fetuses diagnosed with sickle cell anemia.Öğe Comparison of reaction time and Body Mass Index in football training children and sedentary children(Edizioni Minerva Medica, 2015) Dokuyucu, Recep; Demir, T.; Bilgic, M.; Saglik, M.; Punduk, Z.; Daglioglu, O.; Gur, A.Aim. Reaction time (RT) is a term that is used to explain the interval time between the appearance of a stimulus and the initiation of the muscular response to that any expected and unexpected stimulus. The RT is varies depending on such factors as type of the stimulus, type of the response, age, gender, education, training status, warming, fatigue condition. In this study, RT and Body Mass Index (BMI) of students playing football and not playing football (sedentary) is investigated. Methods. Total number of 76 eligible children that is playing football for a regularly 6 months (2 days a week) in the football school and total number of 43 sedentary children in Gaziantep is included. Children's weight and height measurements were recorded and body mass index percentiles were calculated. With ten times in a row, not rhythmic sound stimuli were given to children in both groups and average values were recorded. The relationship between RT and age, BMI percentiles were investigated. Average values were compared statistically. Results. RT was significantly short in training children (right foot: P<0.0004 and left foot: P<0.0002). In addition, BMI percentiles in training children is highly significant when compared to sedentary children (P<0.006). Conclusion. Based on these results we demonstrated that a regular fitness training and nutritional status have important contribution to RT. In particular, starting sport at an early age is very important for health.Öğe CORRESPONDING ERDOSTEINE CHANGES AUTOPHAGY GENES EXPRESSION IN HIPPOCAMPUS ON RHINITIS MEDICAMENTOSA MODEL(Serbian Genetics Soc, 2015) Dokuyucu, Recep; Gogebakan, Bulent; Cevik, CengizIn our study, rats were subjected to Oxymetazoline hydrochloride treatment and Rhinitis medicamentosa (RM) was formed and then autophagy gene expression levels were determined after the application of an antioxidant agent erdosteine (ED). The rats were divided into three groups; Group 1 was the control group. Group 2 (RM) and group 3 (RM+ED) rats received two spray puffs of 0.05% oxymetazoline into the nasal cavities three times daily for eight weeks. After determination of RM in the rats, the RM group were killed. The ED+RM group received 10 mg/kg of an ED suspension. At the end of seven days, these rats were also killed. All groups' hippocampus tissues were obtained for the measurement of autophagy gene expressions. In rhinitis medicamentosa group Atg5, Atg7 and Atg10 gene expressions in the left hippocampus were reduced as compared to control group (p=0.01, p>0.05, p=0.01, respectively). Also, erdosteine treatments were restored mRNA expression of autophagy genes. In right hippocampus of rhinitis medicamentosa group, Atg5 and Atg10 gene expressions was found to be down-regulated as compared to control group (p>0.05, p<0.05, respectively). Both BECN1 and ULK genes expression were found to be reduced in left hippocampus of rhinitis medicamentosa group. Erdosteine applications was restored the expression of these genes (p=0.03, p=0.03, respectively). Additionally, in right hippocampus, Erdosteine application was restored the expression of ULK gene (p=0.01). This is the first report that evaluated the expression autophagy genes in RM rat models and the changes observed after erdosteine applications.Öğe The Dermal Internal Brassiere Flap, A New Modification of Inferior Pedicle Breast Reduction Technic(Springer, 2015) Temel, Metin; Karakas, Ali O.; Dokuyucu, Recep; Turkmen, ArifThe inferior pedicle mammaplasty is particularly applied to large breasts with a long sternal notch to nipple distance. The present study reports modifications developed to solve the bottoming-out deformity, the lack of upper pole fullness and the wound healing problems seen at the reverse T-zone, known disadvantages of the inferior pedicle reduction mammaplasty, and evaluates postoperative sensation. A total of 110 patients with a mean age of 32 underwent the same technique. In this technique, two pairs of quadrangular and triangular flaps were planned from the skin of resection sites. The triangular dermal flaps and quadrangular flaps were suspended from the periosteum of the 2nd and 4th ribs, respectively. The distance from the nipple to inframammary fold was measured at the postoperative 1st month and 1st year. In the postoperative period, a nipple-inframammary fold distance increase of over 2 cm was determined as bottoming-out deformity. Sensation evaluations were performed by subjective and objective tests. The mean sternal notch to nipple distance was 35.00 cm. After operation, the mean distance between the sternal notch and the nipple was 20.00 cm. NAC examination revealed normal sensation in all patients. Whereas the preoperative mean areolar threshold value was 36.70 g/mm(2), the postoperative first-year mean areolar pressure threshold value was 35.50 g/mm(2) (p < 0.0001). The preoperative mean nipple pressure threshold value was 25.30 g/mm(2), whereas the postoperative first-year mean nipple pressure threshold value was 26.00 g/mm(2) (p = 0.5471). The postoperative first-month mean sternal notch to nipple distance value of the patients was 20.00 cm, whereas the postoperative first-year mean sternal notch to nipple distance value of the patients was 20.00 cm, (p = 0.0648). The postoperative first-month mean nipple to submammary fold distance value of the patients was 10.50 cm, the postoperative first-year mean nipple to submammary fold distance value of the patients was 11.00 cm (p < 0.0001) There were no patients determined as having bottoming-out deformity. No breast asymmetry was encountered at the late follow-up period. All patients, except the scarred ones, were satisfied with the results. In this study, we achieved an internal fascial reconstruction using a pair of triangular and quadrangular dermal flaps suspended to the rib periosteum. We believe that our modifications will contribute to decreasing the disadvantages of the inferior pedicle breast reduction technique. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.Öğe Determination of oxidative stress and effect of erdosteine on rhinitis medicamentosa in a rat model(Elsevier Science Bv, 2014) Dokuyucu, Recep; Cevik, Cengiz; Ozler, Gul Soylu; Ozgur, Tumay; Arli, Cengiz; Sefil, Fatih; Yonden, ZaferWe aimed to determine the presence of oxidative stress in rhinitis medicamentosa (RM) and to evaluate the effect of erdosteine (ED) on mucosal changes in a rat model. Twenty-four male rats were used in this experimental study. Three groups were created. Group 1 (n=8) was the control group. Two puffs of 0.05% oxymetazolin were sprayed into the nasal cavities of the remaining rats (n = 16) three times daily for eight weeks. One of these 16 rats was scarified at the end of the eight weeks and examined to confirm the presence of RM. Seven of the remaining 16 rats were killed, and venous blood samples were taken (Group 2). Group 3 (n=8) received 10 mg/kg of an ED suspension orally for seven days. All rats were put on formalin for light microscopy. The total antioxidant status (TAS) was similar in all groups (p = 0.073). The total oxidative status (TOS) of the RM group was significantly higher than that of the control group and RM + ED group (Group 3) (p = 0.003 and p = 0.011, respectively). The pathological recovery of the nasal mucosa of the rats was similar in the RM + ED and control groups. The TOS was high in this RM rat model, and oxidative stress was associated with RM. ED significantly ameliorated nasal mucosal changes induced by RM, suggesting that oxidative stress may play an important role in the pathophysiology of this condition. (C) 2014 Elsevier B.V. All rights reserved.Öğe Diabetes mellituslu hemodiyaliz hastalarında HbA1c ile kan glukozu düzeyleri arasındaki ilişki(2013) Motor, Sedat; Dokuyucu, Recep; Sefil, Fatih; Rifaioğlu, Mehmet Murat; Erhan Yengil; Kemal Türker Ulutaş; Ahmet Taner Sümbül; Rızaoğlu, Hatice; Üstün, İhsan; Gökçe, CumaliAmaç: Bu çalışmada Diabetes mellitus (DM)’lu, kronik böbrek yetmezliği olan ve diyalize giren hastalarda HbA1c düzeyleri ile kan glukozu düzeyleri arasındaki ilişkinin incelenmesi amaçlanmıştır. Yöntemler: 1 Ocak 2009-31 Temmuz 2010 tarihleri arasında, özel bir diyaliz merkezinde diyalize giren 131 (53 kadın, 78 erkek) hastanın aylık kan glukozu ve 3 aylık HbA1c sonuçları geriye dönük olarak incelendi. Bulgular: 131 olgunun yaş ortalaması 63,3±11,2 yıl (30- 91 yaş arası) idi. Bu olguların 53’ü kadın (%40,5), 78’i erkek (%59.5) idi. Kadınların yaş ortalaması 62,2±11,2 iken erkeklerin yaş ortalaması 64,1±11,2 idi. Kadınların ve erkeklerin ortalama glukoz değeri ile ortalama HbA1c de- ğeri arasında korelasyon vardı (Kadın: p<0,001, r=0.761, Erkek: p<0.001, r=0.743). Tüm gruplar arası ortalama glukoz değeri ile ortalama HbA1c arasında korelasyon vardı (p<0.001, r=755). İncelenen HbA1c sonuçlarının %32.8’ i %6.5 değerinin altında tespit edilirken, % 67,2’ si %6.5 değerinin üzerinde tespit edildi. Açlık kan glukozu değerlerinin %18,3’ ü 126 mg/dl değerinin altında tespit edilirken, %81,3’ ü 126 mg/dl değerinin üzerinde tespit edilmiştir. Ortalama kan glukozu değeri ile HbA1c değerleri arasında korelasyon bulundu. Sonuç: Açlık, tokluk kan glukozu ve HbA1c ölçümleri kötü glisemik kontrolün tanı, izlem ve tedavisinde önemlidir. Dolayısıyla diyabetik nefropatili diyaliz hastalarında, HbA1c ve kan glukozu (açlık ve tokluk) ölçümü ve bunlar arasındaki korelasyon, kardiyovasküler mortalite ve morbidite açısından ve DM’nin izlemi açısından son derece önemlidir.Öğe Disinfectant Effect of Thyme Oil in Diabetic Wound Model(Wiley-Blackwell, 2015) Temel, Metin; Dokuyucu, Recep; Gokce, Hasan; Agturk, Gokhan; Dogan, Hatice[Abstract Not Available]Öğe DNA Methylation of BDNF Gene in Schizophrenia(Int Scientific Information, Inc, 2016) Copoglu, Umit Sertan; Igci, Mehri; Bozgeyik, Esra; Kokacya, M. Hanifi; Igci, Yusuf Ziya; Dokuyucu, Recep; Ari, MustafaBackground: Although genetic factors are risk factors for schizophrenia, some environmental factors are thought to be required for the manifestation of disease. Epigenetic mechanisms regulate gene functions without causing a change in the nucleotide sequence of DNA. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that regulates synaptic transmission and plasticity. It has been suggested that BDNF may play a role in the pathophysiology of schizophrenia. It is established that methylation status of the BDNF gene is associated with fear learning, memory, and stressful social interactions. In this study, we aimed to investigate the DNA methylation status of BDNF gene in patients with schizophrenia. Material/Methods: The study included 49 patients (33 male and 16 female) with schizophrenia and 65 unrelated healthy controls (46 male and 19 female). Determination of methylation pattern of CpG islands was based on the principle that bisulfite treatment of DNA results in conversion of unmethylated cytosine residues into uracil, whereas methylated cytosine residues remain unmodified. Methylation-specific PCR was performed with primers specific for either methylated or unmethylated DNA. Results: There was no significant difference in methylated or un-methylated status for BDNF promoters between schizophrenia patients and controls. The mean duration of illness was significantly lower in the hemi-methylated group compared to the non-methylated group for BDNF gene CpG island-1 in schizophrenia patients. Conclusions: Although there were no differences in BDNF gene methylation status between schizophrenia patients and healthy controls, there was an association between duration of illness and DNA methylation.Öğe Does helicobacter pylori cause psychiatric symptoms in dyspeptic patients?(Acta Medica Mediterranea, 2014) Kivrak, Yuksel; Kokacya, Hanifi; Copoglu, Umit Sertan; Dokuyucu, Recep; Ari, Mustafa; Sulu, Barlas; Atalay, ErayObjective: A good deal of researches regarding dyspepsia and Helicobacter Pylori (Hp), which are among the most important health problems, have been held. Both Hp and psychiatric symptoms can affect dyspepsia. However, it has not been researched whether Hp causes the psychiatric symptoms or not. In this study, it has been researched whether HP causes the psychiatric symptoms or not. Method: of the patients who applied with the problem of dyspepsia and were directed for endoscopy, 118 were evaluated. Scl-90 scale was applied. Those who proved biochemically and histopatologically HP and those who do not were compared. Results: It has been established that there is no meaningful difference in both groups in terms of somatization, obsessive-compulsive features, sensibility in interpersonal relations, anxiety, anger and hostility, phobic anxiety, paranoid thinking and psychoticism. While HP group got higher scores from the sub-groups of anxiety, obsession, depression, interpersonal sensibility, psychotic, paranoid and General Symptom Index , the HP (-) group got higher scores from sub-scales of somatization, anger and from additional ones. The scores that the both groups have obtained from the somatization sub-scale are above eleven, which is cutoff score. Besides the group with HP (+) has been detected to get a score over 1 from the subscales of anxiety, obsession, depression and interpersonal sensibility. Conclusion: HP does not cause psychiatric symptoms. Individuals who suffer from dyspepsia had better get examined.Öğe DOES HELICOBACTER PYLORI CAUSE PSYCHIATRIC SYMPTOMS IN DYSPEPTIC PATIENTS?(Carbone Editore, 2014) Kivrak, Yuksel; Kokacya, Hanifi; Copoglu, Umit Sertan; Dokuyucu, Recep; Ari, Mustafa; Sulu, Barlas; Atalay, ErayObjective: A good deal of researches regarding dyspepsia and Helicobacter Pylori (Hp), which are among the most important health problems, have been held. Both Hp and psychiatric symptoms can affect dyspepsia. However, it has not been researched whether Hp causes the psychiatric symptoms or not In this study, it has been researched whether HP causes the psychiatric symptoms or not. Method: of the patients who applied with the problem of dyspepsia and were directed for endoscopy, 118 were evaluated. Scl-90 scale was applied. Those who proved biochemically and histopatologically HP and those who do not were compared. Results: It has been established that there is no meaningful difference in both groups in terms of somatization, obsessive-coin. pulsive features, sensibility in interpersonal relations anxiety anger and hostility, phobic anxiety, paranoid thinking and psychoticism. While HP group :got higher scores from the sub groups of anxiety, Obsession, depression, interpersonal sensibility, psychotic, paranoid and General Symptom Index, the HP (-) group got higher scores from sub scales of somatization, anger and from additional ones. The scores that the both groups have obtained from the somatization sub scale are above eleven;. which is cutoff score. Besides the group with Hp (+) has been detected to get a score. over I from the subscales of anxiety, obsession, depression and interpersonal sensibility. Conclusion: HP does not cause psychiatric symptoms: Individuals who suffer from dyspepsia had better get examined.
