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    The effect of obesity on inflammatory markers in patients with PCOS: a BMI-matched case-control study
    (Springer Heidelberg, 2014) Kurt, Raziye Keskin; Okyay, Ayse Guler; Hakverdi, Ali Ulvi; Gungoren, Arif; Dolapcioglu, Kenan Serdar; Karateke, Atilla; Dogan, Mustafa Ozcil
    Previous studies have shown increased inflammatory activity in patients with polycystic ovary syndrome (PCOS); however, it remains uncertain whether this increased inflammatory activity is a consequence of the disorder itself or of the accompanying obesity. We therefore aimed to test the inflammatory marker levels in obese and lean patients with PCOS by using two separate control groups with matching body mass index (BMI). A total of 120 women in reproductive age with (n = 62) and without (n = 60) PCOS were recruited for the study. Patients with PCOS were divided into two groups as obese (n = 32) and lean (n = 30) PCOS groups according to BMI. Two BMI-matched control groups were created. Furthermore, high sensitive CRP protein (hsCRP), neutrophils, lymphocytes, white blood cell count (WBC) and neutrophil to lymphocyte ratio (NLR) were evaluated with complete blood count. The hsCRP (5.5 +/- A 0.8 vs. 3.1 +/- A 0.7, p < 0.001), neutrophil count (3.8 +/- A 0.4 vs. 2.9 +/- A 0.7, p < 0.001), leukocyte count (7.2 +/- A 1.8 vs. 5.6 +/- A 1.6, p < 0.001), and NLR (2.6 +/- A 1.4 vs. 1.5 +/- A 0.4, p < 0.001) were higher in patients with PCOS compared to the control group while lymphocyte count was lower (1.71 +/- A 0.65 vs. 1.98 +/- A 0.39, p = 0.008). Similarly, both obese and lean patients with PCOS had higher levels of hsCRP, neutrophils, leukocytes and NLR ratios compared to BMI-matched controls. The correlation analysis revealed a moderate correlation between NLR and hsCRP (r 0.459, p < 0.001), and between HOMA-IR (r 0.476 p < 0.001) and BMI (r 0.310, p 0.001). Our study results demonstrated that both lean and obese patients with PCOS have increased inflammatory markers compared to BMI-matched control groups indicating that the inflammation seen in PCOS might be related with the presence of the disorder rather than with obesity.
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    Evaluation of vaginal agenesis treated with the modified McIndoe technique: A retrospective study
    (Galenos Yayincilik, 2016) Karapinar, Oya Soylu; Ozkan, Mustafa; Okyay, Ayse Guler; Sahin, Hanifi; Dolapcioglu, Kenan Serdar
    Objective: Retrospective analysis of cases that have undergone neovagina operation because of congenital vaginal agenesis was objected. Material and Methods: Seven cases applying with the complaints of primary amenorrhea or inability to have sexual intercourse were in the study. The cases were diagnosed with congenital vaginal agenesis and operated at Mustafa Kemal University Training and Research Hospital between 2011 and 2014. Vaginoplasty by the modified McIndoe method was performed in all cases. The main complaint, chromosomal analysis, duration of operation, preoperative and postoperative vaginal length, complications, postoperative treatment, and satisfaction from the sexual intercourse were all evaluated. Results: Average age of our patients was 28.14 +/- 8.61 (19-39) years. One patient was 46XX-45X0 mosaic Turner syndrome), 1 patient was 46XY (testicular feminization), and other 5 patients were 46XX. The average duration of operation was 2.7 +/- 0.56 (2-3.5 h). Postoperative infection was observed in 1 patient. In this infected patient, graft failure occurred and debridement was performed in reoperation. No early complications were seen in the others. Preoperative and postoperative average vaginal lengths were 1.85 +/- 0.62 (1-3 cm) and 8.71 +/- 1.11 (7-10 cm), respectively. Dyspareunia occurred in 2 cases that were not able to use dilatator regularly: 1 because of cancelation of marriage and the other because of postoperative infection; regular sexual life was achieved in remaining 5 (71%) cases. Conclusion: Although there is no consensus about the ideal method of making a functioning vagina among different specialties. The modified McIndoe technique is the most applied method by gynecologists and simple, minimally invasive and with low morbidity.
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    Postpartum Ovarian Vein Thrombosis Due to COVID-19 in Pregnancy: A Case Report
    (Springernature, 2023) Beyazit, Ahmet; Karapinar, Oya Soylu; Dolapcioglu, Kenan Serdar; Beyazit, Selen
    Ovarian vein thrombosis is a clinic condition that is generally seen in the postpartum period and can mimic acute appendicitis with acute abdomen. The incidence of occurrence has increased further in cases predisposing to thrombosis. Coronavirus disease 2019 (COVID-19) during pregnancy causes increased thromboembolic events. Here we examined a case of ovarian vein thrombosis after stopping enoxoparin in a postpartum patient who had COVID-19 during pregnancy.
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    Utility of intravaginal ultrasound gel for local staging of cervical carcinoma on MRI
    (Elsevier Science Inc, 2016) Atci, Nesrin; Ozgur, Tumay; Ozturk, Fatma; Dolapcioglu, Kenan Serdar
    Purpose: The aim of this study is to evaluate the utility of intravaginal ultrasound gel for the staging of cervical carcinoma on magnetic resonance imaging (MRI) and to confirm the results with pathological staging. Methods: Nine patients were included in the study. T2-weighted images were compared without and with vaginal gel (VG). Results: Five patients were evaluated as overstaged on MRI without VG. After VG, the results were compatible with the pathological stages in all patients. Conclusions: We suggest that this technique is easy, well tolerated, and effective, and it increases the accuracy rate of MRI staging in early cervical cancer. (C) 2016 Elsevier Inc. All rights reserved.