Yazar "Ege, Hismiogullari Sahver" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    The Effects of Chloramphenicol on Some Biochemical Parameters in Mice
    (Medwell Online, 2008) Ege, Hismiogullari Sahver; Tunay, Kontas; Adil, Hismiogullari Adnan; Dinc, Essiz; Gokhan, Eraslan
    The aim of the study was to investigate the effects of some dose regimens of chloramphenicol on some biochemical parameters in mice for acute and subacute periods. Chloramphenicol was given to the experimental groups at the doses of 100 mg kg(-1) bw (group 2) and 200 mg kg(-1) bw (group 3) in drinking water for 7 days. Blood samples were taken from all animals on day 0, 1, 7 and 14 of the study. The hepatotoxic effect of cloramphenicol occurred in groups 2 and 3 with increasing doses of cloramphenicol. Hepatotoxicity in groups 2 and 3 was determined based on the levels of increased activity of ALP, AST and ALT.
  • Küçük Resim
    Öğe
    Spectral Classical Least Square Calibration Approach for the Simultaneous Determination and Stability Test of Sulphadiazine and Trimethoprim in Bolus
    (Medwell Online, 2010) Ege, Hismiogullari Sahver; Ender, Yarsan; Dinc, Erdal
    A simple spectral classical least square calibration approach were proposed for the simultaneous quantitative evaluation and stability testing of sulphadiazine and trimethoprim in an animal commercial preparation, bolus without requiring a priory separation step. Stability tests of sulphadiazine and trimethoprim in bolus were performed by using the following conditions: Room temperature, refrigerator and etuve (37 degrees C) for each 3 month during 12 months. A spectral classical least square calibration based on the use of absorptivities at three-wavelength set (241, 257 and 288 nm) was computed by using the linear concentration range of 4.0-22.0 mu g mL(-1) for sulphadiazine and 3.0-18.0 mu g mL(-1) for trimethoprim. The proposed spectral least square calibration was validated by using various synthetic binary mixtures containing the above veterinary drugs. Simultaneous analysis and stability test of sulphadiazine and trimethoprim in commercial veterinary bolus was established by the spectral classical calibration method.