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Öğe Acne Vulgaris and Acne Rosacea: An Update in Etiopathogenesis(Derman Medical Publ, 2014) Ekiz, Ozlem; Balta, IlknurAcne vulgaris is a chronic inflammatory disease of the pilosebaceous unit, characterized by comedones, papules, pustules, nodules, and scars rarely. The major pathogenic factors are abnormal activity of sebaceous glands, microbial colonization. Rosacea is a common, chronic inflammatory relapsing skin disorder of the central area of the face characterized by transient or persistent erythema, telangiectasia, papules and pustules. Although several hypotheses have been suggested for the etiopathogenesis of rosacea, the exact etiology is still unknown. In this review, we tried to summarize up-to-date information about etiopathogenesis of acne vulgaris and rosocea.Öğe Aortic Arterial Stiffness is a Moderate Predictor of Cardiovascular Disease in Patients With Psoriasis Vulgaris(Sage Publications Inc, 2014) Balta, Ilknur; Balta, Sevket; Demirkol, Sait; Celik, Turgay; Ekiz, Ozlem; Cakar, Mustafa; Sarlak, HakanPsoriasis is associated with an increased risk of atherosclerosis. Endothelial dysfunction is the critical early step in the process of atherogenesis, and it is commonly investigated by measuring arterial stiffness. We aimed to investigate the relationship between arterial stiffness and high-sensitivity C-reactive protein (hsCRP) in patients with psoriasis. A total of 32 patients with psoriasis and 35 patients with other skin diseases were included in the study. The hsCRP levels and arterial stiffness measurements were compared. Arterial stiffness was significantly different between the 2 groups (P = .01). Arterial stiffness was not associated with the duration of the disease or the disease activity (P = .34 and .64, respectively). In patients with psoriasis, arterial stiffness correlated positively with age, sex, body mass index, diastolic blood pressure, and hsCRP level (P < .05). These findings provide further evidence of a link between inflammation, premature atherosclerosis, and psoriasis.Öğe Are plasma resistin and omentin levels different in patients with psoriasis with or without atherosclerosis?(Springer, 2013) Sen, Bilge Bulbul; Rifalioglu, Emine Nur; Ekiz, Ozlem; Buyukkaya, Eyup; Sen, Nihat[Abstract Not Available]Öğe Arterial Stiffness Parameters Should be Evaluated With Different Types of Psoriasis(Sage Publications Inc, 2014) Balta, Ilknur; Balta, Sevket; Demir, Mustafa; Demirkol, Sait; Ekiz, Ozlem; Unlu, Murat[Abstract Not Available]Öğe Assesment of the Retinal Nerve Fiber Layer Thickness with Optical Coherence Tomography in Patients with Psoriasis(Galenos Yayincilik, 2014) Rifaioglu, Emine Nur; Tuzcu, Esra Ayhan; Sen, Bilge Bubul; Ekiz, OzlemObjective: Psoriasis is an auto inflammatory disorder that affects the skin and joints. Psoriasis-related conditions that involve the eye are mainly blepharitis, conjunctivitis and keratitis and these conditions are seen in about 10% of psoriasis patients. However optic neuritis and pathologies of visual fields are rarely seen. Our study aims to investigate the mean retinal nerve fibres layer (RNFL) thickness using OCT in patient psoriasis. Methods: A total of 40 patients with psoriasis and 35 controls were included in our study. The average retinal nerve fibre layer thickness was measured using the optic disc cube protocol (200x200) and the Cirrus SD-OCT (Carl Zeiss Meditec, Dublin, CA) device. The statistical analyses were performed using the SPSS v 19 software programme. Results: The mean psoriasis area and severity index (PASI) was 8.04 and the mean disease duration was 8.9 years. The average RNFL thickness was not statistically different between the patients and the controls, and there was no correlation between the mean RNFL thickness and the severity and duration of the disease. Conclusion: To our knowledge this study is the first assessment of RNFL thickness in patient with psoriasis. However, of greater scope are needed to investigate possible retinal changes in such patients.Öğe Assessment of left ventricular dyssynchrony in patients with psoriasis(Wiley-Blackwell, 2014) Sen, Bilge Bulbul; Rifaioglu, Emine Nur; Ekiz, Ozlem; Buyukkaya, Eyup; Kurt, Mustafa; Karakas, Mehmet Fatih; Buyukkaya, SuleBackground Psoriasis is an inflammatory disorder, which has been reported to be associated with cardiovascular (CV) risks. Although increased CV risks in psoriasis are well established, there are no data about changes of contraction synchrony in psoriasis. Therefore, we aimed to study the left ventricular (LV) contraction synchrony in patients with psoriasis with narrow QRS and normal ejection fraction. Methods Fifty patients with psoriasis and 50 age- and sex-matched control subjects were included in the study. LV dyssynchrony was investigated by color-coded tissue Doppler imaging. Results In the psoriasis group, the mean high-sensitive C-reactive protein values were significantly higher compared with the controls. Peak A velocity, deceleration time, isovolumetric relaxation time, and E/E' values were higher in the psoriasis group; however, E/A ratio and average Em were higher in the control group. LV systolic dyssynchrony parameters [including standard deviation of Ts of the 12 LV segments (Ts-SD-12), maximal difference in Ts between any two of the 12 LV segments, standard deviation of Ts of the six basal LV segments, and maximal difference in Ts between any two of the six basal LV segments] were found to be higher in the psoriasis group. The patients with ventricular dyssynchrony (a Ts-SD-12 > 34.4 ms) were higher in the psoriasis group than the control group (34% vs. 6%, P < 0.01). Conclusion In patients with psoriasis with normal ejection fractions and narrow QRS, LV systolic dyssynchrony is an early manifestation of heart involvement and may coexist with diastolic dysfunction.Öğe Assessment of subclinical left ventricular dysfunction in patients with psoriasis by speckle tracking echocardiography: A Speckle Tracking Study(Wiley, 2016) Bulbul Sen, Bilge; Ekiz, Ozlem; Rifaioglu, Emine Nur; Buyukkaya, Eyup; Karakas, Mehmet Fatih; Buyukkaya, Sule; Bilen, PerihanBackgroundPsoriasis is a systemic inflammatory disease and is reportedly associated with adverse cardiovascular risks. Left ventricular (LV) function has not been studied comprehensively in psoriasis. ObjectivesThis study was conducted to study LV mechanics in patients with psoriasis by speckle tracking echocardiography. MethodsThe study population consisted of 40 patients with psoriasis and 35 age- and sex-matched control subjects. Two-dimensional echocardiography images were obtained from LV apical four-chamber (4C), long axis (LAX), and two-chamber (2C) views. Peak longitudinal strain and strain rate were obtained from 4C, LAX, and 2C views. Global strain and strain rate were calculated by averaging data for the three apical views. ResultsPatients with psoriasis had significantly lower meanstandard deviation (SD) 4C (17.1 +/- 1.7 vs. 19.2 +/- 2.3; P<0.01), LAX (16.6 +/- 1.5 vs. 19.5 +/- 2.3; P<0.01), and 2C (16.5 +/- 1.5 vs. 19.4 +/- 2.2; P<0.01) peak longitudinal strain values compared with the control group. Moreover, mean +/- SD LV global strain (16.6 +/- 1.5 vs. 19.9 +/- 2.1; P<0.01) and strain rate (1.39 +/- 0.30 vs. 1.51 +/- 0.20; P<0.01) values were found to be significantly lower in the psoriasis group. In a multiple regression model, global strain was independently associated with high-sensitivity C-reactive protein (=0.29, P=0.04), duration of disease (=0.35, P<0.01), ejection fraction (EF) (=0.38, P=0.01), and the ratio of early diastolic mitral inflow velocity to early diastolic annular velocity (E/E ratio) (=0.34, P=0.02). Also, in a multiple regression model, global strain rate was independently associated with duration of disease (=0.36, P<0.01), EF (=0.32, P=0.01), and E/E ratio (=0.35, P<0.01). ConclusionsUsing 2-D strain imaging, we have demonstrated that patients with psoriasis have lower LV functions.Öğe Assessment of thyroid function and lipid profile in patients with postadolescent acne in a Mediterranean population from Turkey(Wiley-Blackwell, 2015) Ekiz, Ozlem; Balta, Ilknur; Unlu, Ezgi; Sen, Bilge Bulbul; Rifaioglu, Emine N.; Dogramaci, Asena C.BackgroundPostadolescent acne is defined as acne that is seen even after the age of 25years, regardless of the age at onset. The causes of postadolescent acne have not been completely clarified up to now. Androgens are considered to be the major factor involved in pathogenesis. ObjectiveWe aimed to investigate the status of thyroid functions and lipid levels in patients with postadolescent acne and determine the effects of lifestyle and environmental factors on postadolescent acne in a Turkish population. MethodsIn total, 184 patients and 82 healthy controls were enrolled in the study. Thyroid function and lipid profiles of all participants were analyzed. ResultsThe mean age of patients was 30.44.9years (25-50). The mean age of control group was 30.0 +/- 4.4years (25-40). Cigarette smoking was significantly associated with postadolescent acne (P<0.001). No significant differences were observed between patients with postadolescent acne and control subjects in triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels, thyroid hormone profiles, and thyroid ultrasound scans. High-density lipoprotein cholesterol levels were significantly decreased with postadolescent acne (P=0.01). ConclusionsTo our knowledge, this is the first study to investigate the thyroid functions and lipid profile in men and women with postadolescent acne. In this study, there was no relationship between thyroid functions and postadolescent acne. However, an association with low high-density lipoprotein cholesterol levels and postadolescent acne was detected. Further investigations with more patients in different populations are needed to determine the causes of postadolescent acne.Öğe The Association Between Inflammatory Markers and the Degree of Psoriasis Vulgaris(Sage Publications Inc, 2014) Balta, Ilknur; Balta, Sevket; Demirkol, Sait; Ekiz, Ozlem; Sarlak, Hakan; Cakar, Mustafa[Abstract Not Available]Öğe A case of atypical scleromyxedema mimicking angioedema which responded well to acitretin treatment(Deri Zuhrevi Hastaliklar Dernegi, 2015) Ekiz, Ozlem; Sen, Bilge Bulbul; Rifaioglu, Emine Nur; Yaldiz, MehmetA 37-year-old male patient was admitted our clinic with the complaints of edema and mild pruritus of the eyelids, ears, and the neck. On dermatological examination, there were edema and pale erythema on the eyelids and ears as well as coarsening of the facial features and lines grooving the forehead. His medical history revealed that the patients received systemic corticosteroids, antihistamines and epinephrine treatments for about two months with the diagnosis of urticaria and angioedema, however, he did not benefit from these treatments. A diagnosis of atypical scleromyxedema without monoclonal gammopathy was established according to the clinical, histopathological and laboratory findings. Acitretin treatment with a dose of 35 mg/day was started. Marked regression in the lesions was observed two months later.Öğe A Case Report: Lichen Simplex Chronics Mimicking Bowen's Disease(Derman Medical Publ, 2014) Balta, Ilknur; Simsek, Gulcin Guler; Ekiz, Ozlem; Balta, Sevkat; Demirkol, SaitLichen simplex chronicus (LSC), also known as neurodermatitis. It can present clinically as isolated or multiple lichenified thickened plaques that are usually hyper pigmented and excoriated with accentuated skin markings. The diagnosis of LSC is usually easily made from characteristic lesions. In more difficult cases histopathological study is useful. A 59-year-old male patient had a one-year history of erythema and crusts beginning on the left lumbar region and enlarging peripherally. His past medical history was unremarkable. Dermatological examination revealed 3x4 cm sharply demarcated, erytherhatous, slightly scaling and crusted solitary plaque on the left lumbar region. Because of the clinical characteristics of the lesions, Bowen's disease was suspected clinically in the diagnosis of the disease. Histological exam sat was compatible with the diagnosis of LSC. Thus, a diagnosis of Bowen's disease was eliminated. Our case is presented in order to remind that LSC should be kept in mind, in differential diagnosis of Bowen's disease.Öğe Dermoscopy in the Diagnosis of Cutaneous Leishmaniasis(Int Dermoscopy Society, 2019) Serarslan, Gamze; Ekiz, Ozlem; Ozer, Cahit; Sarikaya, GokhanBackground: Cutaneous leishmaniasis (CL) is a protozoan infectious disease. Dermoscopy is a noninvasive diagnostic tool that has been applied to several skin diseases, including infestations. Objectives: To determine the dermoscopic patterns of CL lesions and to investigate whether a relationship exists between dermoscopic characteristics and the disease duration, localization, and type of CL lesions. Methods: Seventy-nine patients (48 male, 31 female) from Hatay, Turkey, were enrolled in the study and a dermoscopic evaluation was performed on 139 lesions. Images of CL lesions were taken via polarized light contact dermoscopy. Chi-square and Fisher exact tests were used for statistical analyses and P values <0.05 were considered significant. Results: Generalized erythema was seen in all CL lesions. Vascular structures (94.2%), yellow tears (75.5%), and a white starburst-like pattern (58.3%) were the other most common dermoscopic features. Hyperkeratosis (P = 0.001) and white starburst-like pattern (P < 0.001) were more prevalent in the extremities than elsewhere. Among vascular structures, linear irregular (45.8%), hairpin (43.5%), and comma-shaped (25.9%) patterns were the most common dermoscopic findings. Linear irregular (P = 0.023) and arborizing vessels (P = 0.001) were observed in the head-neck region. Dotted (P = 0.009), hairpin (P < 0.001), and glomerular-like (P = 0.016) morphological findings were more prevalent in the extremities. Statistical significances in disease duration were detected in microarborizing (P = 0.027) and arborizing (P = 0.004) vessels and were most prevalent with a disease duration of >6 months. Hairpin vessels were prevalent in the plaque and nodulo-ulcerative type of lesions. Dotted vessels were most commonly seen in the plaque type (47.4%) of lesions. Conclusions: Generalized erythema, yellow tears, and starburst-like patterns, as well as linear irregular, hairpin, comma-shaped, and arborizing vessels, were the most commonly detected dermoscopic features of CL lesions. We suggest that the presence of these features can be helpful when diagnosing CL lesions by dermoscopy.Öğe Erythematous indurated plaque lesions Net Quiz on the breast(Scientific Scholar Llc, 2013) Sen, Bilge Bulbul; Rifaioglu, Emine Nur; Ekiz, Ozlem; Ozgur, Tumay; Akkucuk, Seckin; Inan, Mehmet Ugur; Dogramaci, Asena Cigden[Abstract Not Available]Öğe The Etiology of Behcet Disease: Is It Really Inflammation or Not!(Sage Publications Inc, 2014) Ekiz, Ozlem; Balta, Ilknur; Sen, Bilge Bulbul; Rifaioglu, Emine Nur; Balta, Sevket; Demirkol, Sait[Abstract Not Available]Öğe Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris(Taylor & Francis Ltd, 2014) Ozuguz, Pinar; Kacar, Seval Dogruk; Ekiz, Ozlem; Takci, Zennure; Balta, Ilknur; Kalkan, GoknurBackground: Although hyperseborrhea, follicular hyperkeratinization, Propionibacterium acnes colonization and inflammation are found to be responsible in the pathogenesis of acne, the exact mechanisms are unknown. Vitamin A and E are basic antioxidants vital for health. Zinc is also an essential element for human. But these parameters of the effects on skin are not fully understood. We aimed to evaluate plasma levels of vitamin A, E and zinc in acne patients in relation to the severity of the disease. Material and method: There were 94 acne patients who were referred to our clinic, all new diagnosed, and 56 age and sex matched healthy volunteers as control group. All patients are assessed according to Global Acne Grading System and grouped as mild, moderate, severe and very severe. Acne patients further grouped as group 1 consist of patients with mild to moderate disease; and group 2 consist of patients with severe to very severe acne. The patients with the controls and group 1 with group 2 was compared. Results: The level of vitamin E, vitamin A and zinc were significantly lower than the control group (Table 1, p<0.001). When the patient group is compared among each other there was no statistically significant difference for plasma vitamin A levels between group 1 and 2 whereas vitamin E and zinc levels were significantly low in group 2 than group 1. Thus there was a negative correlation between acne severity and vitamin E and zinc levels. Conclusion: Our study marks the importance of diet in patients with acne. We offer supportive dietary measures with foods rich in vitamin A and E and zinc in the acne prophylaxis and treatment. Supportive treatment with these vitamins and zinc in severe acne may lead to satisfactory results.Öğe Generalized Hair Casts Due to Traction(Wiley-Blackwell, 2013) Ozuguz, Pinar; Kacar, Seval; Takci, Zennure; Ekiz, Ozlem; Kalkan, Goknur; Sen, Bilge BulbulPeripilar keratin casts, also called pseudonits or hair casts, are thin, elongated, greyish-white, cylindrical, sleeve-like structures that encircle the hair shaft and can easily be slid along the hair. They may be clinically misdiagnosed as nits. In addition to physical removal, keratolytic lotions or shampoos are helpful. We report an 11-year-old girl with pseudonits. Although it is not a rare condition, underdiagnosis is common.Öğe Graham-Little-Piccardi-Lassueur Syndrome: A Case Report(Galenos Yayincilik, 2015) Rifaioglu, Emine Nur; Sen, Tuba; Ozgur, Tumay; Sen, Bilge Bulbul; Ekiz, OzlemA rare type of liken pilanopilaris, Graham-Little-Piccardi-Lassueur syndrome (GLPLS), is characterized by cicatricial alopecia of the scalp, follicular hyperkeratosis of trunk and extremities and non-cicatricial alopecia of axilla and pubis. A forty year-old woman admitted with hair loss and palpabl wheals on her body. On her dermatologic examination alopecic plaques with irregular border and atrophic appearance and milimetric papules around follicules on fronto-parietal part of scalp were detected. Also there were purple like-brown milimetric papules around follicules on both extensor part of distal arm, axilla, upper and lower back with alopecia on hairy areas. Additionally milimetric purplish papules on flexor area of wrists were accompanied to other signs. In histopathological investigation of the biopsy from scalp and back lesions were demonstrated orthokeratosis on superficial layer of epidermis, vacuolar degeneration and exocytosis on basal layer of epidermis and basal layer of follicular epithelium, perifollicular infiltration of mix type inflammatory cells, a few pigmentation deposited macrophages. The patient was diagnosed as GLPLS based on these symptoms and signs. Early diagnosis and treatment of this chronic, progressive characterized, rare type of lichen planopilaris is important. Treatments modalities could stop progression and provide partial remission, although they can't success complete improvement.Öğe Insulin resistance in patients with post-adolescent acne(Wiley-Blackwell, 2015) Balta, Ilknur; Ekiz, Ozlem; Ozuguz, Pinar; Ustun, Ihsan; Karaca, Semsettin; Kacar, Seval Dogruk; Eksioglu, MeralBackgroundPost-adolescent acne has been defined as acne in a patient aged >25years. Acne vulgaris first develops at the onset of puberty as a result of hormonal changes. During puberty, there is a transient decline in insulin sensitivity. We hypothesized that insulin resistance might persist after puberty in patients with post-adolescent acne. ObjectivesThis study was conducted in order to investigate the relationship between post-adolescent acne and insulin resistance. MethodsThe study population comprised 35 patients with post-adolescent acne and 35 healthy control subjects. The parameters measured were fasting blood glucose, insulin, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), total cholesterol (TC), triglycerides, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). The homeostasis model assessment of insulin resistance (HOMA-IR) index was calculated for each individual. ResultsNo significant differences were observed between patients with post-adolescent acne and control subjects in fasting blood glucose, fasting insulin, AST, ALT, triglyceride and HDL-C levels, and HOMA-IR index. There were also no correlations between these parameters and the severity of acne. ConclusionsThis study suggests that insulin resistance may not play a major role in the pathogenesis of post-adolescent acne. Hormonal changes, genetic susceptibility, stress, the use of cosmetics, drugs, and environmental factors should be considered in the development of post-adolescent acne.Öğe Intralesional Vitamin D Injection May Be an Effective Treatment Option for Warts(Sage Publications Inc, 2016) Aktas, Habibullah; Ergin, Can; Demir, Betul; Ekiz, OzlemBackground: Plantar warts are typically resistant to treatment. In recent years, treatments have included administration of intralesional tuberculin; measles, mumps, rubella vaccine; and Candida albicans antigen immunotherapy. To the best of our knowledge, there are no reports of intralesional vitamin D administration for the treatment of warts. Aim: To evaluate the efficacy and safety of intralesional vitamin D treatment for plantar warts. Methods: Twenty patients with single or multiple plantar warts were included in this study. Vitamin D-3 (0.2 mL, 7.5 mg/mL) was injected into the base of the warts after prilocaine (0.1 mL, 20 mg/mL) injection. A maximum of 5 warts were treated in 1 session, with at maximum 2 injections performed at 4-week intervals. Results: In total, 16 of 20 patients (80%) showed complete resolution of warts, and 1 patient showed partial resolution. Three patients failed to show any response. No recurrence or serious adverse effects were observed. Conclusion: Intralesional vitamin D-3 may be an effective treatment option for warts.Öğe Is there a relationship between disease duration and P-wave dispersion in patients with psoriasis?(Taylor & Francis Ltd, 2013) Sen, Bilge Bulbul; Rifaioglu, Emine Nur; Ekiz, Ozlem; Buyukkaya, Eyup; Sen, Nihat[Abstract Not Available]
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