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    Increased Femoral Cartilage Thickness in Patients With Klinefelter Syndrome
    (Sage Publications Inc, 2013) Inci, Mehmet; Akgul, Ozgur; Baydilli, Numan; Ekmekcioglu, Oguz; Ozgocmen, Salih
    The objective of this study was to determine femoral cartilage thickness (FCT) in patients with Klinefelter syndrome (KS), which is the most common sex chromosome disorder in men with varying degrees of androgen deficiency. This cross-sectional controlled study was conducted in a tertiary care center. Participants were 33 male patients (mean age = 36.2 years) with KS and 35 aged-matched healthy male controls (mean age = 32.9 years). Femoral condyle cartilage was measured by ultrasonography at three locations in each knee. Total testosterone, estradiol, sex hormone binding globulin, free androgen index, bioavailable testosterone, and albumin levels were measured. Femoral cartilage of patients at right and left knee lateral (3.03 and 2.99 mm), mid (3.81 and 3.74 mm), and medial (3.01 and 3.20 mm) were statistically thicker than in controls (right and left knee lateral 2.29 and 2.36 mm, mid 2.64 and 2.53 mm, medial 2.39 and 2.32 mm, respectively, p < .001). There was no significant correlation between FCT and sex hormones. In conclusion, patients with KS had thicker femoral cartilage. Relatively low testosterone levels in these patients and altered estrogen metabolism may hypothetically explain increased cartilage thickness in these patients.
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    The Relationship between Lifelong Premature Ejaculation and Monosymptomatic Enuresis
    (Wiley-Blackwell, 2010) Gokce, Ahmet; Ekmekcioglu, Oguz
    Introduction. Although both biological and psychological factors are important in the etiologies, the underlying physiopathologies of lifelong premature ejaculation (PE) and monosymptomatic enuresis (ME) are not completely understood. Aim. The aim of this study is to evaluate the prevalence of ME in men diagnosed with lifelong PE and relationships of these two conditions. Methods. Between December 2008 and November 2009, we designed a prospective randomized study in 51 patients who had presented with lifelong PE and in age-matched 106 healthy control cases without PE. If the patient declared that he ejaculated less than 1 minute more than half of his intercourse attempts, he was enrolled in the study. Main Outcome Measures. All subjects included in this study underwent general and urological physical examinations and were asked about their history of ME. The frequency of enuresis was graded using the following criteria: (i) 1-2 times/week as infrequent; (ii) 3-5 times/week as moderate; and (iii) 6-7 times/week as severe. Only patients with primary ME were evaluated. Results. Of the 51 premature ejaculator men, 19 (37.2%) had a history of ME. Among these 19 men, five (26.3%) had severe, six (31.6%) had moderate, and eight (42.1%) had infrequent enuresis. Of the 106 control cases, 16 (15.1%) had a history of ME and of these 16 patients, three (18.7%) had severe, five (31.2%) had moderate, and eight (50%) had infrequent enuresis. Compared with control population (15.1%), the prevalence of ME in the premature ejaculators (37.2%) was more than twofold higher (P < 0.005). Conclusion. We have found a significant increase in ME prevalence in lifelong premature ejaculators. A common deficiency of inhibitory signal processing in the central nervous system may underlie both inability to inhibit the ejaculation and micturition in these patients or genetic predisposition may play a significant role. Further prospective studies are needed to explain the relationship between lifelong PE and ME. Gokce A, and Ekmekcioglu O. The relationship between lifelong premature ejaculation and monosymptomatic enuresis. J Sex Med 2010;7:2868-2872.