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Öğe ACUTE CYANIDE POISONING AND CHALLENGES IN THE DIAGNOSIS(Bmj Publishing Group, 2019) El, Cigdem; Celikkaya, Mehmet Emin[Abstract Not Available]Öğe Association of childhood obesity with retinal microvasculature and corneal endothelial cell morphology(Walter De Gruyter Gmbh, 2021) Kurtul, Bengi Ece; Cakmak, Ayse Idil; Elbeyli, Ahmet; Karaaslan, Abdulkerim; El, CigdemObjectives: To investigate the optical coherence tomography angiography (OCTA) and specular microscopy (SM) findings in obese children and compare them with healthy ones. Methods: In this prospective study, 50 eyes of 25 obese children [body mass index (BMI) >= 95th percentile], 36 eyes of 18 control age- and sex- matched healthy subjects (BMI <85th percentile) were included. Demographic features and ophthalmological examination including OCTA measurements as well as SM findings were assessed. Cellular morphology was observed by noncontact SM and results for corneal endothelial cell density (cells/mm(2)), coefficient of variation of cell size and percentage of hexagonal cells were obtained. The OCTA was performed with 6 x 6 mm sections for macula and 4.5 x 4.5 mm sections for optic disc in all eyes. Foveal retinal thickness (FRT), retinal nerve fiber layer (RNFL) thickness, vessel density in different sections of retina and optic nerve head were analyzed. Results: All SM parameters, RNFL thickness for average, and all quadrants and optic disc radial peripapillary capillary densities were similar between groups. However, FRT, flow area for choriocapillaris, superficial and deep foveal capillary densities were significantly higher in obese group when compared to controls (242.4 +/- 18.2 mu m vs. 232.1 +/- 16.5 mu m, p=0.024, 2.2 +/- 0.1 mm(2) vs, 2.2 +/- 0.0 mm(2), p=0.042, 22.4 +/- 6.9% vs. 15.6 +/- 5.5%, p=0.001, and 38.9 +/- 7.5% vs. 31.1 +/- 8.6 %, p=0.001, respectively). Conclusions: Obese children seem to have higher values of FRT, flow area for choriocapillaris, superficial and deep foveal capillary densities. These results may have significant implications for understanding of how childhood obesity could affect retinal microvasculature.Öğe THE CAUSE OF FEVER THAT SHOULD BE KEPT IN MIND IN FAMILY MEDICINE IN SETTLEMENTS WHERE LIVESTOCK FARMING IS WIDESPREAD: BRUCELLOSIS(Bmj Publishing Group, 2019) El, Cigdem; Celikkaya, Mehmet Emin[Abstract Not Available]Öğe A common public health problem: corrosive ingestion in children(Dr Behcet Uz Cocuk Hastaliklari Ve Cerrahisi, 2018) Celikkaya, Mehmet Emin; Atici, Ahmet; El, Cigdem; Akcora, BulentObjective: Corrosive substances are both histologically and functionally damaging agents when contacted with the mucosa. Corrosive substance ingestion is still one of the most important and frequent home accidents because of the reasons such as the storage of corrosives in food containers, colored packages, and places where children can reach easily. Methods: The medical records of 125 patients who were followed up because of intake of corrosive substances between 2014 and 2017 were retrospectively reviewed. Patients were evaluated according to age, gender, type of corrosive substance ingested and type of treatment. Results: Of 125 cases 63 were girls (50.4%), 62 were males (49.6%). The median age of the cases was 4.1 years. Among the corrosive substances, most frequently laundry bleach (48%; n=61), vinegar (17%; n=21), drain opener (12.8%; n=16), washing liquid (9%; n=11), olive sweetener (caustic) (n=3; 2.4%), lime dissolver (n=4; 3.2%), salicylic acid (n=3; 2.4%), oil solvent (n=2; 1.6%), wart drug (n=2; 1.6%), and acetonide (n=2; 1.6%) were ingested in respective number of patients. Esophagoscopy was performed only in patients with symptoms. Conclusion: Prevention of the intake of corrosives is much simpler and more economical when compared with long and expensive treatment processes. It is necessary that everyone who cares about children must be carefull. Corrosive substances must kept in sealed packages even in locked cabinets. Also, packages containing corrosive substances should not contain interesting colors and designs for children.Öğe A Comparative Analysis of Pediatric Emergency Department Admissions Before and During the COVID-19 Pandemic(Springernature, 2024) Caliskan, Osman Firat; Trabzon, Gul; Gullu, Ufuk Utku; Yazarli, Esra Gezmen; Sari, Ferhat; Ipek, Sevcan; El, CigdemObjectives This study aims to evaluate the outbreak's impact on emergency services, with findings obtained from patients who applied to our pediatric emergency service before and during the pandemic period. Methods In this study, the Pediatric Emergency Polyclinic of Hatay Mustafa Kemal University (MKU) Department of Pediatrics was evaluated during the COVID-19 pre -pandemic period and the COVID-19 pandemic period. Demographic features, complaints, discharge situations, diagnostic groups, and diagnoses of 16,730 nontraumatic patients one month to 18 years old were compared retrospectively. Results Comparing the pre -pandemic period and the pandemic period, it was determined that there was a statistically significant difference in the average age of patients, age groups, admission hours, triage classification, complaints, and diagnoses seen. Conclusion According to the findings obtained in the study, pediatric emergency department admissions decreased significantly during the pandemic period. As a result of the pandemic measures taken, the incidence of diseases caused by infectious agents, such as respiratory tract infections, decreased. The change in pediatric emergency service habits with the pandemic highlights the importance of conducting more comprehensive epidemiological studies in terms of more efficient and effective use of pediatric emergency health services in Turkey.Öğe Differences in steep quality and body mass index in asthmatic children and healthy control group(Codon Publications, 2021) Gokcek, Ozden; Yurdalan, Ufuk; Huzmeli, Esra Dogru; El, CigdemIntroduction: Childhood asthma has become a serious public health problem. Obesity has been determined to be one of the risk factors of asthma. Aim: We aimed to determine the difference in body mass index (BMI) and sleep quality in pediatric asthmatic individuals compared to their peers. Method: Thirty children aged 8-17 years were followed up in the Pediatric Outpatient Clinic for asthma along with 30 healthy children. The BMI percentile values of the children were recorded. The Pittsburgh Sleep Quality Index was used to assess sleep quality. Results: Each group in our study had 10 girls and 20 boys. The mean age was found to be 11.76 +/- 2.69 years in asthma group and 11.33 +/- 2.29 years in the healthy group. The asthma group were found to be more obese than the healthy group (P = 0.033). There was a significant difference between groups interested in a sport (P = 0.028) and steep quality (P = 0.007). Conclusion: It was observed that the asthma group had more obesity and poorer sleep quality than the healthy group. Further, it was determined that in the asthma group, the level of interest in any sport was less than that in the healthy group. We think that high obesity in the asthma group reduces the effect of corticosteroids, and the continuity of nighttime cough symptoms causes deterioration in sleep quality. We conclude that participation in sports activities should be encouraged to reduce the level of obesity in asthmatic children. (C) 2021 Codon Publications. Published by Codon Publications.Öğe DOES EARLY STABILIZATION APPLICATIONS AFFECT CLINICAL PROGRESSION IN POISONING LINKED TO SNAKE BITES?(Bmj Publishing Group, 2019) El, Cigdem; Celikkaya, Mehmet Emin[Abstract Not Available]Öğe Evaluation of the possible effect of inspiratory muscle training on inflammation markers and oxidative stress in childhood asthma(Springer, 2023) Gokcek, Ozden; Yurdalan, Ufuk; Tugay, Baki Umut; El, Cigdem; Dogan, SerdarAirway inflammation characterized as asthma is one of the most common chronic diseases in the world. The aim of this study was to evaluate the possible effect of inspiratory muscle training on inflammation markers and oxidative stress levels in childhood asthma. A total of 105 children (age range 8-17 years), including 70 asthmatics and 35 healthy children, participated in the study. The 70 asthma patients were randomly assigned to the inspiratory muscle training (IMT) group (n = 35) and control group (n = 35), and healthy children were assigned to the healthy group (n = 35). The IMT group was treated with the threshold IMT device for 7 days/6 weeks at 30% of maximum inspiratory pressure. Respiratory muscle strength was evaluated with a mouth pressure measuring device, and respiratory function was evaluated with a spirometer. In addition, CRP, periostin, TGF-beta, and oxidative stress levels were analyzed. The evaluation was performed only once in the healthy group and twice (at the beginning and end of 6 weeks) in asthma patients. In the study, there were significant differences between asthma patients and the healthy group in terms of MIP and MEP values, respiratory function, oxidative stress level, periostin, and TGF-beta. Post-treatment, differences were observed in the oxidative stress level, periostin, and TGF-beta of the IMT group (p <.05). Conclusion: After 6 weeks of training, IMT positively contributed to reducing the inflammation level and oxidative stress. This suggests that IMT should be used as an alternative therapy to reduce inflammation and oxidative stress.Öğe Investigation of the optic disc and retinal microvasculature by optical coherence tomography angiography in children with asthma(Wolters Kluwer Medknow Publications, 2023) Karaaslan, Abdulkerim; Kurtul, Bengi Ece; Cakmak, Ayse Idil; El, CigdemPURPOSE: To assess the optic disc and retinal microvasculature by optical coherence tomography angiography (OCTA) in asthmatic children. MATERIALS AND METHODS: Thirty asthmatic children (asthma group) and 30 control age- and sex-matched healthy controls (control group) were included in this cross-sectional study. The asthma group was then divided into two subgroups according to the presence of inhaled steroid use. Demographic findings were noted. Retinal nerve fiber layer (RNFL) thickness and vessel density in different sections of the retina and optic nerve head were analyzed by OCTA. RESULTS: RNFL thickness for temporal quadrants and flow area for outer retina levels were significantly lower in the asthma group than the control group (72.58 +/- 10.99 mu m vs 77.73 +/- 9.73 mu m, P = 0.015, and 0.60 +/- 0.31mm(2 vs.) 0.72 +/- 0.31mm(2), P = 0.047, respectively). However, inside disc vascular densities were significantly higher in the asthma group when compared to controls (55.16% +/- 3.71% vs. 52.08% +/- 3.79%, P < 0.001). Inside disc vascular densities were also significantly higher, and RNFL thickness for temporal quadrants was significantly lower in the asthmatic patients without steroid use subgroup when compared to others (P < 0.001, P = 0.012, respectively). CONCLUSION: Lower values of temporal quadrant RNFL, and flow area for outer retina, but higher levels of inside disc vascular density seem to be associated with asthmatic children. OCTA findings in asthmatic children appear to be regardless of inhaled steroid use.Öğe IS IT THE NEGATIVE EFFECTS OF SERUM VITAMIN DEFICIENCY OF PREGNANT AND LACTATING WOMEN ON DEVELOPMENT OF NEWBORN NEUROLOGICAL SYSTEM CAN BE AVOIDED(Bmj Publishing Group, 2019) El, Cigdem; Celikkaya, Mehmet Emin[Abstract Not Available]Öğe IS THE SECOND DOSE ANTIVENOM IN SCORPION STINGS: IS IT EFFECTIVE?(Bmj Publishing Group, 2019) El, Cigdem; Celikkaya, Mehmet Emin[Abstract Not Available]Öğe Pediatric esophageal perforation due to firearm injuries during the Syrian war and a new suture technique(Elsevier, 2018) Atici, Ahmet; Celikkaya, Mehmet Emin; El, Cigdem; Akcora, BulentThe incidence of esophageal perforation (EP) due to firearm injury (FAI) is markedly low compared with that occurring in other organs. The most frequently reported cause of EP is iatrogenic injuries. The incidence of EP due to penetrating injuries, such as FAI, is very rare and highly destructive. Here we report cases of EP due to FAI in childhood during the Syrian war and elucidate a new suture technique.Öğe Presentation of a new mutation in FMF and evaluating the frequency of distribution of the MEFV gene mutation in our region with clinical findings(Springer, 2021) Arpaci, Abdullah; Dogan, Serdar; Erdogan, Hazal Fatma; El, Cigdem; Cura, Sibel ElmaciogluFamilial Mediterranean Fever (FMF), which is an autosomal recessive disease characterized by recurrent self-limiting fever, peritonitis, pleuritis, arthritis and erysipelas-like erythemas, has been common among ethnic groups such as Turkish, Armenian, Arabic and Jewish. The clinical presentation is caused by mutations in the MEFV gene encoding the Pyrin protein. In this study, we aimed to present a new mutation that has not been previously defined from the mutations in the MEFV gene which is responsible for the genetic pathology of familial Mediterranean fever and to evaluate the frequency of distribution of the MEFV gene mutation among different ethnic groups living in our region. In present retrospective study, a total of 2639 clinically suspected FMF patients who were referred to Hatay Mustafa Kemal University Hospital between 2010 and 2017 were recorded. MEFV gene mutations were observed using DNA sequence analysis. MEFV mutations were found in 2079 of the 2639 patients (78.7%) Among these patients 184 (6.97%) were homozygous, while 1365 (51.72%) were heterozygous. The most frequently observed mutation was R202Q (1319, 19.55%) followed by E148Q (n = 476, 7.05%), M694V (n = 439, 6.51%), V726A (n = 146, 2.16%) and M680I (n = 135, 2%). In a case clinically diagnosed as FMF, a new mutation called S145G (p. Ser145Gly, c.433A > G) was identified in exon 2 of the MEFV gene. Besides, addition of a new pathogenic MEFV variant to the literature, the relationship between the FMF clinic and homozygous form of R202Q, which was previously considered as a polymorphism, was highlighted.Öğe Presentation of two new mutations in the 3?untranslated region of the ?-globin gene and evaluating the molecular spectrum of thalassemia mutations in the Mediterranean region of Turkey(Springer, 2021) Arpaci, Abdullah; Gul, Bahar Unlu; Ozcan, Oguzhan; Ilhan, Gul; El, Cigdem; Dirican, Emre; Elmacioglu, SibelThalassemia is a common genetic disorder. We aimed to present thalassemia mutation data that covers a period of 7 years from the Mediterranean region of Turkey by comparing with hemoglobin indices and to contribute to prenatal diagnosis and genetic counseling studies which should be decided very quickly. In this study, in which a retrospective archive was scanned, the cases were first grouped as alpha and beta thalassemia, and then beta thalassemia mutations were examined in a total of 5 groups as UTR-Pro, Codon, IVS, beta(0), and beta(+). We have reached the family of the proband that analyzed their Hb indices and genetic mutation. All mutations were statistically compared with Hb indices, HbF, and HbA(2). We have identified two new beta thalassemia mutations that have the feature of not being defined previously [HBB:C*62 A>G. (3 ' UTR+1536 A>G) and HBB:C*1 G>A (3 ' UTR+1475 G>A)]. The most commonly encountered 23 mutations account for 74.7% of all mutations which is unlike the literature. In the beta thalassemia group, 73 different mutations were detected. The most common beta thalassemia mutation was HBB: c.93-21 G>A (IVS I-110 G>A) with a frequency of 19.72%. A statistically significant difference was found when comparing the mutation groups with Hb indices. We think that it may be useful to evaluate the mutations we have newly identified too together with the Hb indices especially in evaluating the carriers of thalassemia and it will contribute to prenatal diagnosis and genetic counseling studies which should be decided very quickly.Öğe Pyloric perforation due to stress disorders in an adolescent girl(Elsevier Science Bv, 2018) Atici, Ahmet; Celikkaya, Mehmet Emin; El, Cigdem; Akcora, BulentGastroduodenal perforation is a serious emergency condition. The predominance of duodenal perforation in pediatric age group shifts towards gastric perforation at later ages. However, due to thick muscle tissue pyloric perforation is seen very rarely in all age groups [3]. A 14-year-old female patient with abdominal pain lasting for one day admitted to our pediatric emergency room. During the physical examination, generalized abdominal tenderness and muscular defense were observed in all quadrants of the abdomen. Laparotomy was performed with an upper abdominal median incision. A large amount of serous, non-biliary fluid was observed in the abdomen. A perforation area of nearly 3 mm was identified on the anterior of the pylorus. Primary repair with omentopexy of the pyloric perforation was performed. On postoperative day 7, the patient was discharged without any complication. Pyloric perforation should be considered in the differential diagnosis of patients presented with epigastric pain.Öğe A significant cause of constipation and growth retardation: hirschsprung's disease(Bayrakol Medical Publisher, 2019) El, Cigdem; Celikkaya, Mehmet Emin; Atici, Ahmet; Akcora, BulentAim: In this study we aimed to draw attention to HD which may lead to mortal complications if early diagnosis and treatment are not provided for infants with gastrointestinal symptoms. Material and Method: In Mustafa Kemal University, Faculty of Medicine, Department of Pediatrics between September 2016 and March 2018 the data of the patients who were diagnosed with Hirschsprung's disease were retrospectively analyzed. In this study age, gender, percentile values of growth and development (height, weight, head circumference), neurodevelopment stages (ability to tonic neck reflex, ability to sit supported and unsupported ability to sit), first meconium time, the most common complaints and physical examination findings were examined. Results: The mean age of the 19 patients was 7.42 months (48 days-40 months). Sixteen (%84) of the patients were male and 3 (%16) of the patients were female. Growth and development values were detected in 8 of the patients in the range of 10-25, 6 of the patients in the 3-10 percentile range and 5 of the patients were under the 3rd percentile. The first meconium excretion time of the patients was an average of 3 days (49 hours-5 days). Discussion: It should be kept in mind that organic causes such as HD should be considered in children with history of delayed meconium passage in the anamnesis and if complaints have been present before the age of one year and in whom growth retardation is detected in theft examinations. In this way, late diagnosis, complications, unnecessary and costly tests and treatments can be prevented in the HD.Öğe Sirenomelia/mermaid syndrome without imperforate anus in a premature infant(Elsevier Science Bv, 2018) Atici, Ahmet; Celikkaya, Mehmet Emin; Arslan, Selda; El, Cigdem; Akcora, Bulent[Abstract Not Available]Öğe TRAUMA OF THE LIVER IN CHILDREN WITH FIREARM INJURIES DUE TO WAR: WHEN IT SHOULD BE OPERATED?(Bmj Publishing Group, 2019) Celikkaya, Mehmet; Atici, Ahmet; El, Cigdem; Akcora, Bulent[Abstract Not Available]Öğe AN UNCOMMON CAUSE OF SPONTANEOUS ECCHYMOSIS IN CHILDREN: ACUTE IDIOPATHIC THROMBOCYTOPENIC PURPURA(Bmj Publishing Group, 2019) El, Cigdem; Celikkaya, Mehmet Emin[Abstract Not Available]
