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    The effects of concomitant giardia intestinalis infection on acute gastrointestinal toxicity in rats undergoing pelvic irradiation
    (2018) Doğan, Zümrüt; Aycan Kaya, Özlem Makbule; Elibol, Ebru; Vardı, Nigar; Erkal, Haldun Şükrü
    INTRODUCTION: Different types of pelvic cancer, such as cervical, endometrial, bladder and prostate, are normally treated by radical radiotherapy, which can be used both alone or in combination with surgery and/or chemotherapy. The aim of this study is to assess the effects of concomitant Giardia intestinalis infection on acute gastrointestinal toxicity in rats that have undergone pelvic irradiation. METHODS: The study group consisted of forty female 6-month-old Wistar rats with the weight of 250 g. The rats were divided into four groups containing ten rats in each group. The study groups are as follows: Group 1 contained rats not infected with Giardia intestinalis and not irradiated, Group 2 contained rats infected with Giardia intestinalis but not irradiated, Group 3 contained rats not infected with Giardia intestinalis but irradiated, Group 4 contained rats infected with Giardia intestinalis and radiated. For the day after the end of radiation, the number of stool pellets was counted, and the operation of weighing rats was performed, and they were sacrificed the following day. The intestinal tissues were taken for histological evaluation. RESULTS: A mucosal damage, such as villus shortening, atrophy of surface epithelium, crypt loss, as well as a decrease in the number of goblet cells of the group 3 and 4, was detected as a result of the light microscopic examination. CONCLUSION: As a result of the present study, the fact that concomitant Giardia intestinalis infection aggravates acute gastrointestinal toxicity in rats that have undergone pelvic irradiation has been verified.
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    Öğe
    Seizures with pentylenetetrazol kindling cause a decrease in the number of pyramidal neurons in the rat hippocampus
    (Science Printers and Publishers Inc., 2016) Kocacan, Süleyman Emre; Sefil, Fatih; Elibol, Ebru; Altunkaynak, Berrin Z.; Acar, Meryem Dilek; Bağirici, Faruk; Marangoz, Cafer
    OBJECTIVE: To investigate the effects of pentylenetetrazole (PTZ) kindling on the number of pyramidal neurons in the rat hippocampus. STUDY DESIGN: Using unbiased stereology, we calculated total pyramidal neuron numbers in the CA1, CA2, and CA3 areas and the whole hippocampus after PTZ-induced kindling. The estimation and the analysis of the number of hippocampal pyramidal cells (areas of CA1-3) were done with the optical fractionator technique, which is a stereological counting technique. RESULTS: Stereological analysis showed that the total number of pyramidal neurons in the whole hippocampus and the number of pyramidal neurons in CA1 were significantly lower in kindled rats as compared to the controls (p < 0.05). However, no significant difference was found in the neuron numbers of CA2 and CA3 (p>0.05). CONCLUSION: PTZ-induced seizures cause a decrease in the amount of pyramidal neurons in the CA area of the rat hippocampus. © Science Printers and Publishers, Inc.