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Comparison of the efficacy and adverse effects of trospium chloride and tolterodine tartrate in the treatment of overactive bladder symptoms
(Galenos Yayincilik, 2008) Guven, Melih Atahan; Coskun, Ayhan; Gungoren, Arif; Ozdemir, Ozgur; Ercan, Onder; Karakus, Savas
Objective: To compare the efficacy and adverse effects of two antimuscarinic agents (trospium chloride (TCl), tolterodine Ltartrate) in patients having overactive bladder symptoms. Material and Method: During 2005, patients admitted with urge incontinence to Faculty of Medicine, Gynaecology Clinic and answered overactive bladder evaluation questionnaire form, and given Tolterodine-L-Tartrate (Detrusitol (R)) 2 mg, 2x1 (n: 38), Trospium chloride (Spazmex (R)) 30 mg tb 2x1 (n: 41), were retrospectively evaluated. Patients taken both drugs were determined by giving points regarding efficacy and adverse effects as questioned in the questionnaire form at the 1st and 3rd months following the initiation of treatment. Results: Demografic data were similar in both groups (p> 0.05). Points given after treatment were found significantly lower than the points given before treatment in both groups (p<0.001). The efficacy and adverse effects of both drugs were found statisticaly similar (p>0.05). Conclusion: In the highligths of retrospevtive data, we concluded that Trospium chloride and Tolterodine may be used alternatively to each other in treatment of overactive bladder.