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    Chromosome Imbalances and Alterations in the p53 Gene in Uterine Myomas from the Same Family Members: Familial Leiomyomatosis in Turkey
    (Asian Pacific Organization Cancer Prevention, 2013) Hakverdi, Sibel; Demirhan, Osman; Tunc, Erdal; Inandiklioglu, Nihal; Uslu, Inayet Nur; Gungoren, Arif; Erdem, Duygu
    Uterine leiomyomas (UL) are extremely common neoplasms in women of reproductive age, and are associated with a variety of characteristic choromosomal aberrations (CAs). The p53 gene has been reported to play a crucial role in suppressing the growth of a variety of cancer cells. Therefore, the present study investigated the effects of CAs and the p53 gene on ULs. We performed cytogenetic analysis by G-banding in 10 cases undergoing myomectomy or hysterectomy. Fluorescence in situ hybridization (FISH) with a p53 gene probe was also used on interphase nuclei to screen for deletions. In patients, CAs were found in 23.4% of 500 cells analysed, significantly more frequent than in the control group (p<0.001). In the patients, 76% of the abnormalities were structural aberrations (deletions, translocations and breaks), and only 24% were numerical. Deletions were the most common structural aberration observed in CAs. Among these CAs, specific changes in five loci 1q11, 1q42, 2p23, 5q31 and Xp22 have been found in our patients and these changes were not reported previously in UL. The chromosome breaks were more frequent in cases, from high to low, 1, 2, 6, 9, 3, 5, 10 and 12. Chromosome 22, X, 3, 17 and 18 aneuploidy was observed to be the most frequent among all numerical aberrations. We observed a low frequency of p53 losses (2-11%) in our cases. The increased incidence of autosomal deletions, translocations, chromatid breaks and aneuploidy, could contribute to the progression of the disease along with other chromosomal alterations.
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    Overlerde neoplastik ve non-neoplastik kistik lezyonların değerlendirilmesi
    (2011) Benk Şilfeler, Dilek; Güngören, Arif; Dolapçıoğlu, Kenan Serdar; Turhan, Ebru; Hakverdi, Sibel; Erdem, Duygu; Hakverdi, Ali Ulvi; Baloğlu, Ali
    Classification of Neoplastic and Non-neoplastic Cystic Lesions in Ovaries Purpose: Determination of the rates of neoplastic and non-neoplastic lesions in ovary cyst cases having been operated. Material and methods: Files of 126 patients being operated with pre-diagnosis of cystic mass in ovary in obstetrics and gynecology service of our hospital between 2005 and 2010 were inspected retrospectively. Findings: TNon-neoplastic cysts in 41 patients (32,5%) and neoplastic tumors in 85 patients (67,4%) were observed out of ovarian masses. 74 benign (58,7%), 3 borderline(2,4%) and 8 malign tumors (6,3%) were observed in neoplastic tumors. All malign ovary tumors cases were operated in elective conditions using laparoscopy. While the average age of patients having these problems was 46±13, average cyst diameter was measured as 18±7.9 cm. 75% of malignancy was resulted from right ovary. The average Ca-125 value was 1420 ± 2079. Discussion: 91 % of cystic masses resulting from ovary were detected as benign in histopathological inspection. Each case has to be evaluated considering ultrasonography, age, tumor determinant and operated in elective conditions if possible. Laparoscopy has to be preferred first of all for the patients that were supposed to suffer from benign and protection of ovary tissue has to be taken care of with minimal invasive approach.