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    Is There a Relationship between Statin Use and Corneal Specular Microscopy and Topography Findings?
    (2021) Kurtul, Bengi Ece; Kurtul, Alparslan; Ergashev, Kustharbek
    Objectives: Information about the possible effect of statins on the human corneal endothelium is still not clear. This\rstudy was the first known investigation of the influence of statins on corneal specular microscopy (SM) and topography\rparameters.\rMethods: Thirty-four patients using a statin (atorvastatin) as hyperlipidemia treatment (Group 1) and 34 age- and sexmatched\rhealthy subjects (Group 2) were prospectively included in the study. Demographic data and ophthalmic findings\rof participants were reported and analyzed. Cellular morphology was evaluated using the noncontact SM and corneal endothelial\rcell density (CECD) (cells/mm2), polymegathism (coefficient of variation in cell size [CV], %), and pleomorphism\r(% hexagonal cells [Hex]) data. Anterior chamber depth and volume, iridocorneal angle degree, average keratometry\rdiopters were also measured with corneal topography.\rResults: The mean age was 53.03±7.23 years (range: 38–73 years) for Group 1 and 53.15±10.7 years (range: 34–80 years)\rfor Group 2 (p=0.958). Group 1 consisted of 11 female and 23 male patients and Group 2 included 13 female and 21 male\rparticipants (p=0.798). The mean CECD density was significantly higher in Group 1 when compared with that of Group\r2 (2544.34±244.76 cells/mm2 [range: 2126.60–3107.00 cells/mm2] vs 2404.53±285.46 cells/mm2 [range: 1839.80–2892.30\rcells/mm2], p=0.034). There were no significant statistical differences in the CV and Hex values between the groups\r(p=0.450 and p=0.717, respectively). The corneal topographic measurements were also not significantly different.\rConclusion: The findings of this study revealed higher CECD values in statin users. Statins may have beneficial effects\ron cornea morphology.