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  • Küçük Resim
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    Effects of glucosamine-chondroitin combination on synovial fluid IL-1?, IL-6, TNF-? and PGE2 levels in internal derangements of temporomandibular joint
    (Medicina Oral S L, 2015) Damlar, Ibrahim; Esen, Emin; Tatli, Ufuk
    Background: The aim of the present study was to evaluate the effects of glucosamine-chondroitin sulphate combination on internal derangements of temporomandibular joint in clinical and biochemical manners. Material and Methods: This randomized clinical study included 31 cases reporting joint tenderness, in which disc displacement was detected on MR imaging. In all patients, synovial fluid sampling was performed under local anesthesia. In the study group, the patients were prescribed a combination of 1500 mg glucosamine and 1200 mg chondroitin sulphate, while patients in the control group were only prescribed 50 mg tramadol HCl (twice daily) for pain control. After 8 weeks, synovial fluid sampling was repeated in the same manner. The levels of pain, maximum mouth opening (MMO), synovial fluid IL-1 beta, IL-6, TNF-alpha and PGE(2) measured before and after pharmacological intervention were compared. Results: The reduction in pain levels was significant in both groups. There was no significant difference between two groups in terms of pain reduction. The improvement in MMO was significant in the study group but it was not in the control group. The MMO improvement was significantly higher in the study group compared to the control group. In the study group, significant decrease was observed in PGE(2) level, while the decreases in IL-1 beta, IL-6 and TNF-alpha levels were not significant. In the control group, no significant decrease was observed in any of the inflammatory cytokines after 8 weeks, moreover IL-1 beta and IL-6 levels were increased. Alterations of IL-1 beta and IL-6 levels were significant in study group while TNF-alpha and PGE(2) levels were not, compared to control group. Conclusions: In conclusion, these results might suggest that glucosamine-chondroitin combination significantly increases the MMO and decreases the synovial fluid IL1 beta and IL6 levels in internal derangements of TMJ compared to tramadol. The modifications of synovial fluid TNF-alpha and PGE(2) levels do not reach statistical significance. This combination also provides efficient pain relief in similar level with tramadol, a narcotic analgesic.
  • Küçük Resim
    Öğe
    Effects of Smoking on Periimplant Health Status and IL-1?, TNF-?, and PGE2 Levels in Periimplant Crevicular Fluid: A Cross-Sectional Study on Well-Maintained Implant Recall Patients
    (Lippincott Williams & Wilkins, 2013) Tatli, Ufuk; Damlar, Ibrahim; Erdogan, Ozgur; Esen, Emin
    Purpose:The aim of this cross-sectional study was to evaluate the effects of smoking on periimplant health status and inflammatory cytokines interleukin-1, tumor necrosis factor-, and prostaglandin E2 levels in periimplant crevicular fluid (PICF) and to determine their correlation with clinical parameters in well-maintained implant recall patients.Material and Methods:A total of 60 dental implants placed in 60 patients (27 patients were smoker and 33 were nonsmoker) were included in the study. Plaque index, gingival index, probing depth, periimplant bone loss, PICF volume, and biochemical cytokine levels in PICF were determined and analyzed statistically. The correlation between PICF cytokine levels and clinical parameters were also analyzed.Results:All clinical parameters with the exception of plaque scores were significantly higher in the smoker group. Significantly increased levels of cytokines were observed in the smoker group. The correlation between the cytokine levels and clinical parameters were more marked in smokers.Conclusions:Although the implants of the smoker patients seem to be clinically healthy, the results demonstrate that the implants are relatively at risk even if in a well-maintained population.