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  • Küçük Resim
    Öğe
    Effect of exenatide on aortic stiffness and blood pressure parameters
    (2017) Gürkan, Eren
    Amaç: Eksenatid ile insülin glarjinin sistolik ve diyastolik kan basıncı, nabız basıncı ve aortik sertlik parametreleri üzerine etkinliğini değerlendirmek.Gereç ve Yöntemler: Başlangıçta en az 2 ay metformin tedavisi alan, insülin ve inkretin bazlı tedaviler için naif, vücut kitle indeksi (VKİ) =25-45 kg/m2aralığında olan 34 tip 2 diyabetli hasta, glukagon like peptit-1 (GLP-1) analogu olan eksenatid ve insülin glarjin kollarına randomize edildi. 26 hafta boyunca izlendi. Aortik sertlik ölçümü transtorasik ekokardiogra? ve hemodinamik veriler kullanılarak hesaplandı.Vücut ağırlığı ve total vücut yağ kütlesi biyoimpedansla ölçüldü. Bulgular: Her iki çalışma kolunda sistolik ve diyastolik kan basıncında anlamlı değişiklik görülmedi. Aortik serlik parametrelerine etkileri değerlendirildiğinde başlangıç ve sonuç değerlerinde anlamlı farklılık tespit edilmedi. Aortik sertlik ?-indeksi ile kilo değişimi arasında negatif(r=-0.322) ve aortik distansibilite ile kilo değişimi arasında pozitif korelasyon tespit edildi (r=0.386).Tartışma: Eksenatid ve insulin glarjin çalışma periyodu boyunca kan basıncı parametrelerine nötral etki göstermiştir. Eksenatid aortik sertlik parametrelerinde değişikliğe neden olmamıştır. 26 haftalık eksenatid tedavisi glisemik regülasyon yanında, vücut ağırlığı ve yağ kütlesikaybına neden olmaktadır. Vücut ağırlığı ve yağ kütlesi kaybı aortic sertlik belirteçlerine olumlu etmektedir
  • Küçük Resim
    Öğe
    Effects of dapagliflozin on serum low-density lipoprotein cholesterol and triglyceride levels
    (Gaziantep Üniversitesi, 2020) Gürkan, Eren
    Objective: The aim of this study is to assess the effects of dapagliflozin, a sodium/glucose cotransporter 2 (SGLT2) inhibitor, on serum triglyceride and low-density lipoprotein (LDL) cholesterol levels in patients with type 2 diabetes mellitus (DM).Methods: A total of 40 patients with type 2 DM, who were followed up regularly in the Endocrinology and Metabolism Out-patient Clinic of State Hospital, were evaluated retrospectively. In these patients, dapagliflozin was added to their regular treatment for glycemic control. The patients’ anthropometric measurements, glycemic regulation status, and serum LDL cho-lesterol and triglyceride levels were retrieved from the system records. A statistical analysis of drug effects was performed using the repeated measures analysis of covariance test, keeping the effects of HbA1c and body mass index (BMI) covariates constant.Results: In addition to the improvement in fasting blood glucose levels, HbA1c, and body weight of the patients, a reduction by 10 mg/dL and 43.04 mg/dL was observed in serum LDL cholesterol and triglyceride levels, respectively. The evaluation of BMI and HbA1c covariates together revealed a statistically significant reduction in triglyceride levels (p=0.032 and p=0.008, respectively).Conclusion: Besides glycemic control and weight loss, addition of dapagliflozin to the type 2 DM therapy is associated with an improvement in serum triglyceride levels, suggesting that together with other benefits, SGLT2 inhibitors appear to pro-vide an additional benefit of reducing the risk of cardiovascular diseases.
  • Küçük Resim
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    Evaluation of Liver Fibrosis in Polycystic Ovary Syndrome by Shear Wave Elastography, FIB-4 Score, and Serum Periostin Levels
    (2023) Gürkan, Eren; Aslan, Gökçen; Burakgazi, Gülen; Özcan, Oğuzhan
    Objective: In this study, we aimed to demonstrate the presence of liver fibrosis in patients with poly- cystic ovary syndrome at a relatively early stage of the disease using biochemical data and 2-dimen- sional shear wave elastography techniques. Methods: The study included 33 women with polycystic ovary syndrome and 33 healthy women volunteers. Serum androgen and sex hormone binding globulin levels were measured, and then free androgen index was calculated. Periostin and matrix metalloproteinase-3 levels were measured by ELISA method. Sterling formula was used to calculate FIB-4 score. Liver elasticity was evaluated using shear wave elastography. Results: Periostin and matrix metalloproteinase-3 levels were found to be significantly higher in the polycystic ovary syndrome group compared to the control group (P < .001 and P < .001, respectively). Serum testosterone level and free androgen index were also significantly higher in the polycystic ovary syndrome group (P = .044 and P = .037, respectively). However, there was no significant differ- ence between the groups in terms of liver velocity and elasticity (P = .185 and P = .172, respectively). A positive correlation was found between FIB-4 score and periostin (r = 0.433, P = .012) and between FIB-4 score and liver elasticity in the PCOS group (r = 0.374, P = .032). Conclusion: FIB-4 score was positively correlated with periostin and liver elasticity. These data sug- gest that in addition to FIB-4 score, serum periostin level and shear wave elastography may help us clinically in the detection of liver fibrosis at patients with polycystic ovary syndrome.
  • Küçük Resim
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    Importance of magnetic resonance imaging in pituitary stalk interruption syndrome
    (Türkiye Klinikleri Yayınevi, 2019) Gürkan, Eren; Anık, Yonca; Çizmecioğlu, Filiz Mine; Akyay, Özlem Zeynep; Çetinarslan, Berrin
    Objective: To evaluate the importance of magnetic resonance imaging in the treatment and follow-up of patients with pituitary stalk interruption syndrome. Material and Methods: The study included patients who were admitted to the Endocrinology and Metabolism Clinic of our hospital from 2009 to 2013. Pituitary functions, growth and development curves, and magnetic resonance imaging findings of the patients were evaluated during the follow-up period. Results: The study included three men and two women. Four patients had multiple pituitary hormone deficiency. All cases were diagnosed with short stature with respect to their chronological age. Four patients were diagnosed with pituitary stalk interruption syndrome in their childhood. Isolated growth hormone deficiency was observed only in one patient. Conclusion: Pituitary insufficiency should be considered when evaluating pituitary stalk interruption syndrome. The presence of pituitary stalk and the change in the size of the anterior pituitary gland are crucial magnetic resonance imaging findings in monitoring pituitary functions. In addition, evaluating the size of the pituitary gland may allow early detection of pituitary insufficiency in adult patients with pituitary stalk interruption syndrome