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    Spinal arachnoiditis and the axonal degeneration of the spinal nerve roots due to ischemia induced by vasospasm: An experimental study
    (2009) Önder, Arif; Serarslan, Yurdal; Aydın, Mehmet Dumlu; Kanat, Ayhan; Gürsan, Nesrin; Yolaş, Coşkun
    Objective: Various reasons have been ascribed to arachnoiditis development, among which subarachnoid hemorrhage (SAH) may be an important factor in this process. In this experimental study, we investigated the effect of SAH on histopathological findings. The volumetric changes of the radicular arteries and the density of spinal nerve root axons of a SAH model on C4 roots in rabbits were measured. Materials and Methods: In this study, 18 rabbits were used. The animals were randomly divided into three groups: subarachnoid hemorrhage (SAH; n = 10), physiologic serum (SF; n = 4) and control (n = 4) groups. SAH was performed by injecting 0.5 cc of blood into cisterna magna taken from their auricular veins. Cervical spinal nerve roots at the C4 level were examined histopathologically. Results: Meningeal thickening and adhesions, reddish spinal cord and radices were detected macroscopically. Histopathologically, leptomeningeal adhesions, intimal lesions of radicular arteries and axonal injury were detected at the nerve radices. The mean radicular artery volume was found to be low on the arachnoiditis developing animals. The mean alive axon density of the C4 nerve root decreased and axonal degeneration was observed in the SAH group. Conclusion: Our study suggests that SAH may be an important etiologic factor in spinal arachnoiditis.
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    Taste bud-like structures in penile tissues and a predictive neural mechanism of male orgasm: A preliminary hypothesis based on histological evidence
    (Elsevier, 2014) Aydin, Mehmet Dumlu; Aydin, Nazan; Dane, Şenol; Gündo?du, Cemal; Gürsan, Nesrin; Akçay, Fatih; Serarslan, Yurdal
    The basic mechanism of orgasmic pleasure has not yet been elucidated, although there is a broad similarity between taste and orgasmic sensation. Taste buds of the tongue stimulated by tastants have been well described, and taste information has been established as an important regulator of food selection and nutrition. However, very little is known regarding how pleasure sensation is created and perceived in an orgasm. Thus, we investigated whether there were taste bud-like structures stimulated by seminal fructose in the male urethra and glans penis. To confirm this hypothesis, we examined the urethral tissues of 22 male rabbits using modern histological techniques. We discovered that the male urethra and glans penis contained many taste bud-like structures similar to the morphological features of the taste buds of the tongue. Interestingly, these taste bud-like structures resembling those of the tongue were detected in the intramural openings of the urethral lacunae and glandular surfaces. These structures have neuron-like appendages at the apical ends of rose buds in the wall of the urethra and glans. Moreover, each urethral plica contained some taste buds that were particularly more dense in the distal urethra and glans penis. We hypothesized that the pelvic autonomous nerves innervated both the urethral and glans taste buds and conveyed orgasmic sensation from the urethral taste buds to the taste information-computing centers in the brain. We postulated that urethral taste buds are stimulated by seminal fructose, and supplying nerves may play a predominant role in the creation of orgasmic sensation, which has not yet been well studied thus far. © 2014 Elsevier GmbH. All rights reserved.