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    Comparative Study on Phytochemical Profiles, Antiproliferative, Antimicrobial and Antioxidant Activities of Adonis Species from Turkey
    (Springer, 2022) Karahan, Faruk; Avsar, Cumhur; Turkmen, Musa; Gezici, Sevgi; Ilcim, Ahmet
    The present study aimed to determine antiproliferative, antimicrobial, antioxidant activities and also phytochemical composition of different nine Adonis L. species from Turkey. Leaves extracts of the plant samples were used to evaluate antimicrobial activity against 7 bacteria and 2 yeast strains using MICs and disc-diffusion methods. The antioxidant activity of plant samples was determined by using DPPH radical scavenging activity method. MTT assay was used for evaluation antiproliferative activities of the extracts against HL-60, HCA-7 and HUVEC human cells. Chemical composition of plant extracts were determined by Gas Chromatography/Mass Spectrometry. The antimicrobial analyses results showed Gram-negative bacteria more sensitive than Gram-positive against the extracts, and the values were varied from 3.1 to 13.4 mu g/mL. The leaf extract of different Adonis species exhibited remarkable antiproliferative activities towards tested human cancer cells in a dose and time dependently, and they were found to possess more antiproliferative activity against HL-60 cells than that of the HCA-7 cells. As for the chemical composition of Adonis species, they were found to contain many components with antimicrobial and beneficial effects, such as ethyl palmitate, ethyl linoleate. Overall, it was concluded that leaves extracts of Adonis species could have a great potential for use in medicinal drug sources.
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    Öğe
    Exploring the anti-cancer properties of essential oils from some Lamiaceae species against human cancer cells with multivariate analysis
    (Elsevier, 2024) Gezici, Sevgi; Turkmen, Musa; Karahan, Faruk
    The present study was aimed to determine phytochemical characterization, anticancer and antioxidant activities of essential oils obtained from 11 Lamiaceae species, including Clinopodium serpyllifolium subsp. barbatum (P.H.Davis) Braeurouchler, Lavandula angustifolia Miller, Mentha pound piperita L., Mentha pulegium L., Ocimum basilicum L., Rosmarinus officinalis L., Salvia aramiensis Rech.f., Salvia fruticosa Miller, Salvia officinalis L., Satureja thymbra L., and Thymbra spicata L. taxa from Tueurorkiye. The chemical composition of the essential oils (EOs) was identified using GC -MS, and antioxidant activity was determined using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,20- azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) free radical scavenging methods. Furthermore, the anticancer potential of the EOs was evaluated using MTT method against human cell lines, including hepatocellular carcinoma (HepG2), gastric carcinoma (NCI -N87), breast adenocarcinoma (MCF-7), human prostate carcinoma (LNCaP clone FGC-Luc2) cancer cells, and non -cancerous human umbilical vein endothelial cells (HUVECs). The antioxidant activities of the extracts varied from 31.96 to 74.96%. Consistent with antioxidant activities, the anticancer activities of the EOs of S. officinalis, L. angustifolia, and R. officinalis were significantly higher than others. However, almost all EOs were found to inhibit cell viability and induce apoptosis of cancer cells, while the EOs at different concentrations exhibited the highest anticancer activity against NCI -N87, followed by HepG2, MCF-7, and LNCaP cancer cells, with the IC50 value ranging from 10.98 +/- 0.12 to 78.08 +/- 1.21 mg/mL, respectively. Variability in phytochemical components, free radical scavenging and anticancer activities of EOs was revealed by principal component analysis (PCA) and agglomerative hierarchical clustering (AHC). The major components of the EOs distilled from Lamiaceae species were found as eucalyptol, thujone, linalool, linalyl acetate, pulegone, carvone and carvacrol at different concentrations in the EOs. Overall, it can be clearly concluded that the EO samples distilled from some medicinal plants belonging to the Lamiaceae family contain valuable phytochemical compounds and accordingly exhibit remarkable biological activities. (c) 2024 SAAB. Published by Elsevier B.V. All rights reserved.
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    Phytochemical Profiling and In Vitro Antioxidant, Antimicrobial, Cytotoxicity Effects of Some Glycyrrhiza Species from Turkey
    (Springer, 2024) Karahan, Faruk; Tuerkmen, Musa; Avsar, Cumhur; Gezici, Sevgi
    Glycyrrhiza (licorice) species, known as the grandfather of herbs is one of the most popular medicinal plants used in traditional medicines and ethnobotany since ancient times. The present study aimed to determine the chemical composition, anti-cancer, antimicrobial and antioxidant activities of Glycyrrhiza glabra L., G. flavescens Boiss., and G. echinata L. taxa from different ecological conditions in Turkey. Root and leaf extracts of the plant samples were used to evaluate antimicrobial activity against 7 bacteria and 2 yeast strains using MICs and disc-diffusion methods. The antioxidant activity of plant samples was determined by using the DPPH radical scavenging activity method. The antimicrobial analysis results show that Gram-negative bacteria are more sensitive to the extracts than Gram-positive, and antimicrobial values of the root extracts were also more effective than the leaf extracts. The antioxidant activities of the extracts varied from 4.2 to 2196 mu g/mL. Cytotoxicity activities of the Glycyrrhiza extracts were assessed in NCI-N87, LNCaP, and BxPC-3 human cancer cells, and the extracts exhibited remarkable activities towards the cells, with the IC50 value ranging from 16.28 +/- 1.08 to 171.04 +/- 0.68 mu g/mL. Moreover, the chemical contents of the extracts were analyzed, and toluene, phenol, palmitic acid, chroman, butyric acid and lidocaine were determined in both the roots and leaves of the extracts. In the present study, our results also revealed that ecological conditions might affect the chemical content and biological activities of the extracts. Overall, it was found that the tested Glycyrrhiza extracts could have rich sources of medicinal drugs and natural plant products in the future.