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Öğe Characterization of simvastatin-induced structural and functional alterations in the molecules of kidney brush border membrane by ATR-FTIR spectroscopy and chemometric approaches(Federation Amer Soc Exp Biol, 2013) Severcan, Feride; Gocmen, Semire Uzun; Ozek, Nihal Simsek; Severcan, Mete[Abstract Not Available]Öğe Clinical Applications of Biophysics-Clinical Biophysics(Cell Press, 2021) Gocmen, Semire Uzun[Abstract Not Available]Öğe Clinical biophysics and bioinformatics approaches in determination and meeting CBRN safety criterion in nursing clinical applications and services(Cell Press, 2024) Yalcin, Hakan; Yilmaz, Irem Uluisik; Gocmen, Semire Uzun[Abstract Not Available]Öğe Clinical biophysics: complex genetic diseases-inheritance, influence, and occurrence mechanisms of polygenic multifactorial diseases(Cell Press, 2022) Gocmen, Semire Uzun[Abstract Not Available]Öğe Cystic Fibrosis Transmembrane Conductance Regulator Gene Variations in Coding and Noncoding Regions in Congenital Bilateral Absence of the Vas Deferens Dependent Infertility(Cell Press, 2020) Gocmen, Semire Uzun; Wagner, Klaus; Gokce, Sina[Abstract Not Available]Öğe Global safety and health problem of the century: Directed high energy weapons how to defense; how to rescue yourself?(Cell Press, 2024) Gocmen, Semire Uzun[Abstract Not Available]Öğe Introduction of a Cigarette Smoking Cessation Strategy : 'Semire Uzun Gocmen Model' in Smoking Quitting(Cell Press, 2019) Gocmen, Semire Uzun[Abstract Not Available]Öğe Investigation of relationship between IL-6 gene variants and hypertension in Turkish population(Springer, 2015) Karaman, Esin; Kucuk, Meral Urhan; Bayramoglu, Aysegul; Gocmen, Semire Uzun; Ercan, Suleyman; Guler, Halil Ibrahim; Kucukkaya, YunusHypertension (HT) is a common and life threating health problem worldwide leading to stroke, heart attack and renal failure. It is characterized by elevated blood pressure forced heart load. Human interleukin-6 (IL-6) and C- reactive protein (CRP) are known to be involved in inflammatory processes. IL-6 gene is a polymorphic gene which -174 G/C is a common and -572 G/C is a rare polymorphisms identified in promoter region. Publications on IL-6 gene polymorphisms raised the question whether this gene polymorphisms lead to susceptibility to HT or not. To investigate the effects of IL-6 gene -174 G/C (rs 1800795) and -572 G/C (rs1800796) polymorphisms on plasma IL-6 and CRP levels and their associations with hypertension disease in Turkish population we analyzed -174 G/C and -572 G/C polymorphisms and plasma IL-6 and CRP levels in 111 healthy controls and 108 hypertension patients from Adyaman, Turkey. We determined the genotypes using polymerase chain reaction-restriction fragment length polymorphism and analyzed plasma levels of IL-6 by ELISA and CRP by automated standard biochemical methods. We have found no statistically significant differences between IL-6 gene -174 G/C and -572 G/C genotypes and allelic frequencies and IL-6 and CRP plasma levels and HT (p > 0.05). No CC genotype was found in control subjects for -572 G/C polymorphism. In conclusion, we found relation to -174 G/C and -572 G/C gene variants between neither IL-6 and CRP levels nor hypertension. The -572 G allele and GG genotype are predominant in Turkish population in Adyaman, Turkey whereas the CC genotype is very rare.Öğe A New, Rapid, Efficient and Non-Toxic Method for Bacterial DNA Extraction(Cell Press, 2019) Gocmen, Semire Uzun; Aslan, Ahmet; Temiz, Muhyittin[Abstract Not Available]
