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Öğe Beneficial effect of erdosteine on methotrexate-induced testicular toxicity in mice(Sage Publications Inc, 2010) Oktar, Sueleyman; Gokce, Ahmet; Aydin, Mehmet; Davarci, Muersel; Meydan, Sedat; Ozturk, Oktay Hasan; Koc, AhmetMethotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. Methotrexate can cause serious or life-threatening side effects on liver, lungs, kidneys, and immune system. Methotrexate chemotherapy causes testicular damage in humans. The aim of this study was to investigate the possible protective role of erdosteine on testicular toxicity of methotrexate in mice. Twenty-six male mice were divided into four groups as follows: group 1, control; group 2, erdosteine-treated; group 3, methotrexate-treated; and group 4, methotrexate + erdosteine treated. On the first day of experiment, a single dose of methotrexate was intraperitoneally administered to groups 3 and 4, although a daily single dose of erdosteine was orally administered to group 2 and 4 for 7 days. At the end of the experiment, the testes of the animals were removed and weighed. The levels of total antioxidant capacity and total oxidative stress, and myeloperoxidase activity in the methotrexate group were higher than the control group (p<0.05). Lipid peroxidation levels were not changed in methotrexate group compared with control group. In conclusion, erdosteine could effectively protect the testes in methotrexate-induced toxicity.Öğe Childhood Enuresis is Associated with Shorter Intravaginal Ejaculatory Latency Time in Healthy Men(Elsevier Science Inc, 2013) Gokce, Ahmet; Halis, FikretPurpose: In our previous study we showed that there was a significant increase in the prevalence of monosymptomatic enuresis among lifelong premature ejaculators. In this study we compared the intravaginal ejaculatory latency time of men with and without a history of monosymptomatic enuresis, and determined the association between the severity and duration of monosymptomatic enuresis and intravaginal ejaculatory latency time in healthy men. Materials and Methods: Between March and September 2012 we designed a prospective study in 49 healthy men who had a history of monosymptomatic enuresis and in age matched 49 control cases without a history of monosymptomatic enuresis. All subjects were asked about their history of monosymptomatic enuresis. Each subject was then evaluated using the premature ejaculation diagnostic tool and asked to measure their intravaginal ejaculatory latency times with their female sexual partner using a calibrated stopwatch. Results: Men with a history of monosymptomatic enuresis and control cases had a mean age of 33.6 (SD 4.7, range 25 to 43) and 33.8 (SD 5.4, range 25 to 48) years, respectively (p = 0.97). Mean/median intravaginal ejaculatory latency times of men with and without a history of monosymptomatic enuresis were 196.9/126.2 and 426.6/343.2 seconds, respectively (p = 0.001). Mean/median premature ejaculation diagnostic tool scores of men with and without a history of monosymptomatic enuresis were 7.1/6 and 2.3/2, respectively (p < 0.001). In correlation matrix analysis, intravaginal ejaculatory latency times and premature ejaculation diagnostic tool scores were correlated significantly with monosymptomatic enuresis history, duration and severity (p < 0.001). Conclusions: We found that intravaginal ejaculatory latency time in men with a history of monosymptomatic enuresis is significantly shorter than that of controls. We have also shown that there is a strong negative correlation between having a history of monosymptomatic enuresis and intravaginal ejaculatory latency time.Öğe Effect of Thymoquinone on Oxidative Stress in Escherichia coli-Induced Pyelonephritis in Rats(Elsevier Science Inc, 2011) Evirgen, Omer; Gokce, Ahmet; Ozturk, Oktay Hasan; Nacar, Emel; Onlen, Yusuf; Ozer, Burcin; Motor, Vicdan KoksaldiBACKGROUND: Recurrent urinary tract infections are important in children and adults with diabetes mellitus and/or incontinence due to risk of pyelonephritis (PYN) and renal damage. There is a positive correlation released free radicals during PYN and renal damage. Experimental studies showed that antioxidant agents improve renal damage when used immediately after bacterial inoculation. OBJECTIVE: The aim of the present study was to evaluate whether treatment by thymoquinone (TQ) before or during Escherichia coli inoculation prevents oxidative damage in acute pyelonephritis (PYN) in an ascending obstructive rat model. METHODS: In this study, 42 Wistar rats were grouped as follows: control, PYN (24, 48, and 72 hours), and TQ-PYN (24, 48, and 72 hours). E. coli (1 x 10(9) colony forming units) was inoculated into the bladder via urethral catheterization in both the PYN and TQ groups. TQ injections were performed 24 hours before bacteria inoculation and repeated at 24-hour intervals during the indicated time at a dose of 10 mg/kg body weight intraperitoneally in TQ groups. RESULTS: Superoxide dismutase activity was statistically lower in the TQ-PYN-48 and -72 groups than the PYN-48 and -72 groups (P < 0.001, P = 0.004, respectively). Catalase activity was significantly higher in PYN-24, -48, and -72 groups than the control group (P < 0.001). In addition, there was a significant difference between the TQ-PYN-24, -48, and -72 groups and PYN groups in terms of glutathione peroxidase activity (P < 0.001, P = 0.026, P = 0.046, respectively). When the TQ-PYN-72 group was compared with the PYN-72 group, malondialdehyde levels were significantly lower in the TQ-PYN-72 group than in the PYN-72 group (P = 0.033). A histologic examination also confirmed the protective effect of TQ. In statistical analysis of histopathologic findings, there were significant differences between the PYN-24 and TQ-PYN-24, PYN-48 and TQ-PYN-48, and PYN-72 and TQ-PYN-72 groups (P = 0.008, P < 0.001, P < 0.001, respectively). CONCLUSIONS: The results indicate that TQ administration attenuated the oxidative damage that occurred in PYN and, therefore, could be used as a supportive agent to protect the kidneys from oxidative damage caused by PYN. (Curr Ther Res Clin Exp. 2011;72:204-215) (C) 2011 Elsevier HS Journals, Inc. All rights reserved.Öğe Hereditary Behavior of Varicocele(Amer Soc Andrology, Inc, 2010) Gokce, Ahmet; Davarci, Muersel; Yalcinkaya, Fatih Ruetue; Guven, Esref Oguz; Kaya, Yusuf Selim; Helvaci, Mehmet Rami; Balbay, Mevlana DeryaThe inheritance of varicoceles and the potential transmission to first-degree relatives has rarely been investigated. In the present study, we examined the first-degree relatives of men with known varicocele to reveal the familial risk for varicocele. Of the patients with clinical varicocele who presented with infertility, testicular pain, or asymmetrical swelling of the scrotum between June 1, 2008 and May 31, 2009, 49 agreed to have their available first-degree relatives contacted for screening of varicoceles (n = 66). A cohort of 100 consecutive men who applied to the department of internal medicine between 2008 and 2009 for checkup procedure without a history of subfertility or a varicocele were used as a control population. Of the 92 first-degree relatives contacted, 66 (71.7%) decided to participate in this study. Of these 66 men, 21 (33.9%) had a palpable varicocele on physical examination. Compared with a control population (12%), the prevalence of palpable varicocele in the first-degree relatives of patients with known varicocele (33.9%) was approximately 3-fold greater (P < .005). Among the first-degree relatives, 4 (21.1%) of 19 fathers and 17 (36.2%) of 47 brothers had palpable varicocele. As a conclusion, a significant increase in varicocele prevalence is present in the first-degree relatives of men with known varicoceles. Patients should be counseled about this increased risk in male relatives of patients.Öğe Intracorporeal pneumatic shock application for the treatment of chronic plantar fasciitis: a randomized, double blind prospective clinical trial(Springer, 2010) Dogramaci, Yunus; Kalacı, Aydıner; Emir, Anil; Yanat, Ahmet Nedim; Gokce, AhmetPlantar fasciitis (PF) is a common clinical condition that usually resolves with non-operative treatments. Extracorporeal shock wave therapy (ESWT) has been used in the treatment of chronic PF not responding to other conservative measures; however, ESWT devices are expensive and available for daily practice in only few centers (In developing countries). A pneumatic lithotripter is a cheap and readily available device which uses pneumatic shock application for the intracorporeal lithotripsy. The aim of this study was to investigate the clinical efficacy of intracorporeal pneumatic shock therapy (IPST) application for the treatment of chronic PF using a cheap and readily available pneumatic lithotripter. A randomized, double-blind, placebo-controlled study was conducted. A total of 50 patients with clinically and radiologically confirmed PF were randomly allocated to either an active- (treatment) (n = 25) or inactive (placebo) (n = 25) group. Under local anesthesia and posterior tibial nerve block, a rigid probe was directly introduced into the calcaneal spur under fluoroscopic control; a standard protocol of 1,000 shock was applied during a single session into the calcaneal spur. The main outcome measure was the patients' subjective assessment of pain by means of a Visual Analog Scale (VAS) and the Roles and Maudsley Score before the treatment and 6 months later. At the 6 months, the rate of successful outcomes (excellent + good results) in the treatment group (92%) were significantly higher comparing to the control group (24%) (P < 0.001). Heel pain measured 6 months after using the VAS were 2.04 +/- A 1.67 in treatment group and 7.16 +/- A 1.57 in control group as compared to 8.92 +/- A 1.22 and 9.12 +/- A 1.23 before the commencement of the treatment. No complications attributable to the procedure such as rupture of the planter fascia, hematoma, or infection were observed during the study. This pilot study showed that IPST is an effective and safe method of treatment of patients with chronic PF not responding to conservative measures. IPST application should be considered before surgical intervention when the extracorporeal shock devices are not available for daily practice. However, further evaluation of this novel treatment is necessary to understand the exact mechanism of action.Öğe Intraurethral Utterbasti Application for Urethral Injury in Rats(Medwell Online, 2012) Yalcinkaya, Fatih Rustu; Davarci, Mursel; Gokce, Ahmet; Guven, Esref Oguz; Inci, Mehmet; Kerem, Mustafa; Ayyildiz, AliUrethral stricture is an illness that can be repeated and that has a troublous treatment process. Uttarbasti which is used in traditional Indian wound healing is a mixture consisting of rock salt, honey and sesame oil. In traditional treatment, there are studies about the effects of honey, wax and sesame oil on wound healing. Researchers aimed at searching the efficiency of the treatment by using uttarbasti in urethral stenosis. In the experiment 18 Wistar Albino type rats which are around 200-250 g were used. These rats were divided into 3 groups and each has 6 rats. Urethra was marked till external meatus with 18G sting. To the 1st group, not any drug was given. To the 2nd group, for 3 weeks saline (1 cc) was given into urethra. To the 3rd group for 3 weeks uttarbasti (1 cc) was applied into urethra. At the end of the 3rd week, all the groups were decapitated. They were taken into histopathological search with their penis tissue and urethra.Öğe Intraurethral utterbasti application for urethral injury in rats(2012) Yalcinkaya, Fatih Rustu; Davarci, Mursel; Gokce, Ahmet; Guven, Esref Oguz; Inci, Mehmet; Kerem, Mustafa; Ayyildiz, AliUrethral stricture is an illness that can be repeated and that has a troublous treatment process. Uttarbasti which is used in traditional Indian wound healing is a mixture consisting of rock salt, honey and sesame oil. In traditional treatment, there are studies about the effects of honey, wax and sesame oil on wound healing. Researchers aimed at searching the efficiency of the treatment by using uttarbasti in urethral stenosis. In the experiment 18 Wistar Albino type rats which are around 200-250 g were used. These rats were divided into 3 groups and each has 6 rats. Urethra was marked till external meatus with 18G sting. To the 1 st group, not any drug was given. To the 2nd group, for 3 weeks saline (1 cc) was given into urethra. To the 3rd group for 3 weeks uttarbasti (1 cc) was applied into urethra. At the end of the 3rd week, all the groups were decapitated. They were taken into histopathological search with their penis tissue and urethra. © Medwell Journals, 2012.Öğe Metastatic prostate adenocarcinoma presenting as supraclavicular lymphadenopathy: a report of two cases(Termedia Publishing House Ltd, 2012) Davarci, Mursel; Gokce, Ahmet; Guven, E. Oguz; Yalcinkaya, Fatih R.; Esen, Hasan; Sevinc, AlperClinical examination is very important in the practice of medicine. In patients presenting with a supraclavicular mass, a number of diseases including cancer should be ruled out. Two patients who presented with a bulky left supraclavicular mass were evaluated. Their medical history revealed complaints attributed to lower urinary tract infection. We performed histopathological examination of the lymph nodes with radiological evaluation of the thorax and abdomen. The final diagnoses were prostate cancer in both patients. It should always be kept in mind that prostate cancer is the most frequent cancer in elderly men, and although very unusual, the presenting finding can be cervical or supraclavicular lymphadenopathy; thus clinicians should be aware of urological examinations in such cases.Öğe Protective Effect of Thymoquinone in Experimental Testicular Torsion(Karger, 2010) Gokce, Ahmet; Oktar, Suleyman; Koc, Ahmet; Gonenci, Ramazan; Yalcinkaya, Fatih; Yonden, Zafer; Duru, MehmetObjectives: To investigate the protective role of thymoquinone (TQ) on unilateral testicular ischemia-reperfusion (I/R) injury in mice. Materials and Methods: Experiments were performed on male C57BL/6 mice (8 weeks old, 20-25 g). The animals were divided into 3 groups including 6 mice in each group: control (sham), torsion/detorsion (TD) and TD+TQ. Mice, except the sham-operated group, were subjected to left unilateral torsion (720 degrees rotation in the clockwise direction). The experiments were finished after sham operation time for controls, 120 min torsion and 240 min detorsion for the other groups. In the TD+TQ group 10 mg TQ was injected intraperitoneally 30 min before detorsion. Results: In the TD group total oxidative stress (TOS), oxidative stress index (OSI) and malondialdehyde (MDA) levels were higher than in the controls. TQ treatment decreased MDA, TOS and OSI values, but did not affect the total antioxidant capacity and myeloperoxidase activity in the TD+TQ group. Upon histological examination, mice in the TD group displayed moderate-to-severe disruption of the seminiferous epithelium. Treatment with TQ resulted in significantly reduced histological damage associated with I/R injury. Conclusion: Our results suggested that TQ treatment may have a protective effect on testicular I/R injury. Copyright (C) 2010 S. Karger AG, BaselÖğe Protective effects of thymoquinone against methotrexate-induced testicular injury(Sage Publications Ltd, 2011) Gokce, Ahmet; Oktar, Suleyman; Koc, Ahmet; Yonden, ZaferThymoquinone is the major active component derived from Nigella sativa. Methotrexate is a folic acid antagonist widely used in clinic. Aim of this study was to investigate the possible protective role of thymoquinone on testicular toxicity of methotrexate. Experiments were performed on male C57BL/6 mice (6 weeks old, 20 +/- 2 g). The animals were divided into four groups with six mice in each group. Equivalent volumes of saline were injected intraperitoneally (i.p.) in the control group. In the thymoquinone group, mice received thymoquinone i.p. with a dose of 10 mg/kg/day for 4 days. Mice in the methotrexate group received single dose of methotrexate i.p., with a dose of 20 mg/kg. Finally, in the methotrexate plus thymoquinone group, in the first and the following 3 days after methotrexate administration, thymoquinone was injected with a dose of 10 mg/kg/day, i.p. At the end of the experiment, the left testis was quickly removed and divided into two parts for histological examination and biochemical analysis. Methotrexate alone increased total antioxidant capacity and myeloperoxidase activity compared to the controls. Thymoquinone treatment decreased total antioxidant capacity and prevented the increase in the myeloperoxidase activity. Light microscopy showed in mice that receiving methotrexate resulted in interstitial space dilatation, edema, severe disruption of the seminiferous epithelium and reduced diameter of the seminiferous tubules. Administration of thymoquinone reversed histological changes of methotrexate significantly. We suggest that thymoquinone use may decrease the destructive effects of methotrexate on testicular tissue of patients using this agent.Öğe Re: Is Varicocele Associated With Underlying Venous Abnormalities? Varicocele and the Prostatic Venous Plexus(Elsevier Science Inc, 2009) Gokce, Ahmet; Balbay, M. Derya[Abstract Not Available]Öğe The Relationship between Lifelong Premature Ejaculation and Monosymptomatic Enuresis(Wiley-Blackwell, 2010) Gokce, Ahmet; Ekmekcioglu, OguzIntroduction. Although both biological and psychological factors are important in the etiologies, the underlying physiopathologies of lifelong premature ejaculation (PE) and monosymptomatic enuresis (ME) are not completely understood. Aim. The aim of this study is to evaluate the prevalence of ME in men diagnosed with lifelong PE and relationships of these two conditions. Methods. Between December 2008 and November 2009, we designed a prospective randomized study in 51 patients who had presented with lifelong PE and in age-matched 106 healthy control cases without PE. If the patient declared that he ejaculated less than 1 minute more than half of his intercourse attempts, he was enrolled in the study. Main Outcome Measures. All subjects included in this study underwent general and urological physical examinations and were asked about their history of ME. The frequency of enuresis was graded using the following criteria: (i) 1-2 times/week as infrequent; (ii) 3-5 times/week as moderate; and (iii) 6-7 times/week as severe. Only patients with primary ME were evaluated. Results. Of the 51 premature ejaculator men, 19 (37.2%) had a history of ME. Among these 19 men, five (26.3%) had severe, six (31.6%) had moderate, and eight (42.1%) had infrequent enuresis. Of the 106 control cases, 16 (15.1%) had a history of ME and of these 16 patients, three (18.7%) had severe, five (31.2%) had moderate, and eight (50%) had infrequent enuresis. Compared with control population (15.1%), the prevalence of ME in the premature ejaculators (37.2%) was more than twofold higher (P < 0.005). Conclusion. We have found a significant increase in ME prevalence in lifelong premature ejaculators. A common deficiency of inhibitory signal processing in the central nervous system may underlie both inability to inhibit the ejaculation and micturition in these patients or genetic predisposition may play a significant role. Further prospective studies are needed to explain the relationship between lifelong PE and ME. Gokce A, and Ekmekcioglu O. The relationship between lifelong premature ejaculation and monosymptomatic enuresis. J Sex Med 2010;7:2868-2872.Öğe Salt and Nitric Oxide Synthase Inhibition-Induced Hypertension: Kidney Dysfunction and Brain Anti-Oxidant Capacity(Taylor & Francis Inc, 2010) Oktar, Suleyman; Ilhan, Selcuk; Meydan, Sedat; Aydin, Mehmet; Yonden, Zafer; Gokce, AhmetThe specific aim of this study was to examine the effects of salt-loading on kidney function and brain antioxidant capacity. Wistar rats were divided into four groups: Control rats were given normal drinking water and no drug treatment for 2 weeks. LNNA group: rats were given normal drinking water and the nitric oxide (NO) inhibitor NG-nitro-L-arginine (L-NNA), 3 mg/kg/day. LNNA + Salt group: rats were given drinking water containing salt 2% and 3 mg/kg L-NNA. Salt group: rats were given drinking water containing salt 2% and no drug treatment. Basal blood pressure and the levels of serum BUN, creatinine, uric acid, cortisol, electrolyte, serum antioxidant capacity, and oxidative stress were measured. NO, superoxide dismutase (SOD), and catalase (CAT) levels were measured in the hypothalamus, brainstem, and cerebellum. Salt overload increased the blood pressure of the LNNA + Salt group. Salt-loading enhanced BUN, creatinine, sodium retention. High salt produced an increase in uric acid levels and a decrease in cortisol levels in serum. Additionally, the oxidative stress index in serum increased in the LNNA + Salt group. Salt-loading enhanced brain NO levels, but not SOD and CAT activity. L-NNA increased brain SOD activity, but not CAT and NO levels. In conclusion, salt-loading causes hypertension, kidney dysfunction, and enhances oxidative stress in salt-sensitive rats.Öğe Urodynamic evaluation of acute effects of sildenafil on voiding among males with erectile dysfunction and symptomatic benign prostate(Tubitak Scientific & Technological Research Council Turkey, 2012) Yalcinkaya, Fatih Rustu; Davarci, Mursel; Akcin, Soner; Gokce, Ahmet; Guven, Esref Oguz; Inci, Mehmet; Balbay, Mevlana DeryaAim: To evaluate the acute effects of sildenafil citrate on micturition of men with erectile dysfunction and symptomatic benign prostatic hyperplasia using urodynamic parameters. Materials and methods: Between June and December 2009, a total of 50 patients over the age of 40 participated in the study. The patients were admitted to our hospital with erectile dysfunction and moderate to severe lower urinary symptoms with benign prostatic hyperplasia. To examine the sexual function of the participants, we used the IIEF-5 Sexual Health Inventory for Men questionnaire. Patients were randomly divided into 2 groups: a treatment group and a control group. A basal urodynamic evaluation was performed in both groups. After the urodynamic evaluation, 50 mg of sildenafil was given to the patients in the control group and 1 h later a second evaluation was performed. Following the urodynamic evaluation, a placebo was given to the patients in the control group and then a second evaluation was performed after 1 h. Results: A statistically significant increase was seen in maximal flow and average flow (Qmax and Qave) after 1 h in the treatment group. The increase in the control group was not significant. Conclusion: Based on the study findings, we suggest that sildenafil has an effect on micturition in the short term. However, to determine the role of sildenafil in the treatment of BPH/LUTS, further studies with larger patient groups are needed.
