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    ADRENAL MYELOLIPOMA: CASE REPORT
    (Aves, 2008) Hakverdi, Sibel; Gorur, Sadik; Temiz, Muhyittin; Akarsu, Bulent; Kiper, Ahmet Namik
    Adrenal myelolipomas are rare occurring benign tumors. They are generally less than 5cm and may not cause symptoms. We discuss a case with adrenal myelolipoma in the light of literature. A 60 year-old female patient had strait flank pain radiate to inguinal region. In the right adrenal gland, a mass about 8 cm was specified by ultrasonography and computerized tomography imaging. In the hystopathological evaluation of the completely resected mass, it was determined that the mass was composed of mature adipose tissue and hematopoetic elements, and the tumor was described as adrenal myelolipoma. In the cases with masses localized in the adrenal gland, adrenal myelolipoma should be considered. Therapy procedure should be planned according to size of the tumor and the presence of symptoms.
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    The analgesic efficacy of preoperative versus postoperative lornoxicam in varicocele repair
    (Elsevier Science Inc, 2007) Inanoglu, Kerem; Gorur, Sadik; Akkurt, Cagla Ozbakis; Guven, Oguz E.; Kararmaz, Alper
    Study Objective: To determine whether intravenous injection of lornoxicam 30 minutes before skin incision provides better pain relief after varicocelectomy than postoperative administration of lornoxicam. Design: Prospective, double-blind, randomized clinical investigation. Setting: Operating room and postoperative recovery area. Patients: 44 ASA physical status I and 11 adult male patients undergoing varicocelectomy. Interventions: Patients were randomized either to receive 8 mg lornoxicam infusion 30 minutes before skin incision, followed by saline infusion immediately after skin closure (group 1), or to receive the identical injections but in reverse order (group 2). All patients received local anesthesia with bupivacame. Measurements: Postoperative pain scores were evaluated hourly for the first 8 hours after surgery, then at 12, 16, 20, and 24 hours after surgery, using a 10-cm visual analog scale. Time to first analgesic request and patient's global assessments also were recorded. Main Results: Patients in group 1 reported significantly lower pain scores (P < 0.05) at all time intervals except at 24 hours and better global assessment (P = 0.001) than did group 2. There were significantly fewer patients in the preemptive group than group 2 who required rescue analgesic within the first 24 hours (0% vs 22.7%; P = 0.024). Mean time to first analgesic request was also significantly longer in the preemptive group (P = 0.001). Conclusion: Intravenous lornoxicam administered before surgery has a better analgesic effect for varicocelectomy than when administered postoperatively. (c) 2007 Elsevier Inc. All rights reserved.
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    Caffeic acid phenethyl ester suppresses oxidative stress in Escherichia coli-induced pyelonephritis in rats
    (Springer, 2007) Celik, Sefa; Gorur, Sadik; Aslantas, Ozkan; Erdogan, Suat; Ocak, Sabahattin; Hakverdi, Sibel
    Although oxidative damage is known to be involved in inflammatory-mediated tissue destruction, modulation of oxygen free radical production represents a new approach to the treatment of inflammatory diseases. Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, has antioxidant, anti-inflammatory and antibacterial properties. For that reason, we aimed to investigate the efficiency of CAPE administration in preventing oxidative damage in pyelonephritis (PYN) caused by Escherichia coli. In this study, 35 Wistar rats were grouped as follows: control, PYN 24 h, PYN 48 h, PYN 72 h, CAPE 24 h, CAPE 48 h and CAPE 72 h. E. coli (1 x 10(9) c.f.u.) were inoculated into the rats in both PYN and CAPE groups via urethral catheterization. Ten mu M/kg-body weight CAPE was injected to the rats in all CAPE groups 24 h before E. coli infection, and injections were repeated at 24-h intervals. Rats were sacrificed 24 h, 48 h and 72 h after infection in both PYN and CAPE groups. Malondialdehyde (MDA) and nitric oxide (NO) levels were significantly increased in kidneys of PYN groups. The activities of the antioxidant enzymes, catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and xanthine oxidase (XO) were also elevated by E. coli. However, CAPE administration reduced MDA and NO levels, as well as XO activity, although it increased SOD and GSH-Px activities. Histopathological examination showed that CAPE reduced the inflammation grade induced by E. coli. In conclusion, CAPE administrations decrease the oxidative damage occurring in PYN and therefore could be used for medical management of bacterial nephropathy.
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    Can effect of finasteride on prostate-specific antigen be used to decrease repeat prostate biopsy?
    (Galenos Yayincilik, 2006) Gorur, Sadik; Bozlu, Murat
    Many patients have had persistently elevated PSA levels and have undergoing multiple negative prostate biopsies. No consensus has been reached on the treatment of patients who continue to have elevated PSA levels despite negative biopsy findings. In the current study, the authors examined the correlation among finasteride treatment, PSA and PSAD to determine patients who could be excluded from repeat prostate biopsy. They found that patients without prostate cancer have a greater decrease in PSAD when taking finasteride for 6 months than those with prostate cancer.
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    Comparison of the postoperative effects of the erector spinae plane block and local infiltration analgesia in patients operated with lumbotomy surgery incision: Randomized clinical study
    (Lippincott Williams & Wilkins, 2024) Hakimoglu, Sedat; Ozdemir, Taner; Comez, Mehmet Selim; Urfali, Senem; Yildirak, Ekrem; Gorur, Sadik; Turhanoglu, Selim
    Background:Our aim was to observe the effects of local infiltration analgesia (LIA) or erector spinae plane block (ESPB) methods, which we applied preemptively in patients who were scheduled for surgery with a lumbotomy surgical incision and on intraoperative remifentanil consumption, and to compare the postoperative numerical rating scale (NRS), morphine demand, consumption, and pain degrees.Methods:Sixty American Society of Anesthesiologists I to III patients aged 18 to 75 years who were due to be operated on with a lumbotomy surgical incision were included in the study. The present study was conducted via prospective, randomized controlled, double-blind trials. After the induction of standard anesthesia, LIA was applied to 30 patients and ESPB was applied to 30 patients preemptively. The dose of remifentanil consumed in the intraoperative period was measured, and the hemodynamic parameters were measured every 5 minutes. Morphine bolus treatment with the postoperative patient-controlled analgesia and rescue analgesia with paracetamol were planned for the patients. Postoperative morphine and additional analgesia consumption, NRS, hemodynamic parameters, and complications were recorded for 48 hours.Results:There was no difference between the groups in terms of demographic and hemodynamic data. The mean consumption of remifentanil was measured as 455 +/- 165.23 mu g in the intraoperative ESPB group and 296.67 +/- 110.59 mu g in the LIA group, and a statistical difference was observed (P = .001). In the postoperative follow-ups, the ESPB group drug consumption and NRS score averages were significantly lower at all times (P = .01; patient-controlled analgesia-morphine, 41.93 +/- 14.47 mg vs 57.23 +/- 15.5 mg and additional analgesic-paracetamol: 2.1 +/- 1.06 vs 4.27 +/- 1.14 g). The mean duration of additional analgesic intake of the groups was 10.6 +/- 8.1 in the LIA group, while it was 19.33 +/- 8.87 in the ESPB group, a significant difference. The patient satisfaction questionnaire was also significantly in favor of ESPB (P = .05).Conclusions:In conclusion, it has been shown that the intraoperative LIA method is more effective in terms of remifentanil consumption and in controlling pain in operations performed with a flank incision, but the ESPB method provides longer and more effective pain control in postoperative follow-ups.
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    Correlation of Multiparametric Prostate MRI with Prostate Biopsy and Radical Prostatectomy Histopathology
    (Galenos Publ House, 2024) Sigva, Hakan; Gorur, Sadik; Gokalp, Fatih; Tamkac, Nezih; Porgali, Sefa Burak; Yildirak, Ekrem
    Objective: Prostate cancer (PCa) is the most common cancer responsible for cancer deaths in men after lung cancer. In this study, we aimed to obtain information about the Gleason score of PCa by prostate image reporting and data system (PIRADS) scoring of multiparametric magnetic resonance imaging (mpMRI) by comparing mpMRI results with the histopathology of prostate biopsy and radical prostatectomy specimen. Materials and Methods: A total of 214 patients who applied to the outpatient clinic of Hatay Mustafa Kemal University Faculty of Medicine, Department of Urology between January 2019 and April 2021 with elevated prostate-specific antigen (PSA) levels were included in the study. All patients underwent mpMRI before the biopsy procedure. PIRADS scoring was performed by the same radiologist. Prostate biopsy was systematically performed by experienced urologists as 12 quadrant biopsies. Results: When the mpMRI results of the patients are evaluated; the most common patterns are seen as PIRADS 2 and PIRADS 4, followed by PIRADS 3 lesions, followed by PIRADS 5 lesions, and PIRADS 1 lesions, which were the least frequent. When the analysis was applied to predict PCa over the pyrans value, the receiver operating characteristics analysis result for the diagnosis of the disease showed statistically significant levels of area under the curve (0.860; p<0.001), with a sensitivity of 81% and a sensitivity of 3 and above PIRADS 3 and above. It can predict cancer with 75 specificity. In the correlation analysis, there was a low but significant correlation between PIRADS and PSA value (r=0.252; p<0.001). Conclusion: We found that patients presenting with elevated PSA levels and mpMRI had a high power in detecting PCa. We also found a strong relationship between ISUP rating and PIRADS. As a result, it is thought that the pathology of the patients can be predicted using mpMRI.
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    EEG abnormalities during treatment with tadalafil, a phosphodiesterase type 5 inhibitor
    (Taylor & Francis Ltd, 2009) Okuyucu, Esra E.; Guven, Oguz; Duman, Taskin; Gorur, Sadik; Melek, Ismet M.; Akcin, Soner; Yilmazer, Serkan
    Objective: Tadalafil is a selective phosphodiesterase type 5 (PDE-5) inhibitor approved for the treatment of erectile dysfunction. Less is known about the electroencephalography (EEG) effects of PDE-5 inhibitors, and the present study, therefore, examined the risk of EEG abnormalities associated with tadalafil. Method: EEG recordings from 35 erectile dysfunction patients taking tadalafil (20 mg) were graded for severity of EEG abnormalities (at admission, 2 and 48 hours after tadalafil administration). Results: At admission, there were no EEG abnormalities. At second EEG, abnormalities occurred in 12 (34.3%) of the 35 patients. Eight (22.9%) patients had mild and four (11.4%) patients had moderate EEG abnormalities. At third EEG, one (2.9%) patient had mild and one (2.9%) patient had moderate EEG abnormalities. Conclusion: PDE-5 inhibitors may produce EEG abnormalities. Although the exact role of PDE in altering susceptibility to seizure remains unclear, epileptic seizures may occur during treatment with PDE inhibitors. [Neurol Res 2009; 31: 313-315]
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    The effect of caffeic acid phenethyl ester (CAPE) on histopathological changes in testicular ischemia-reperfusion injury
    (Academic Press Ltd Elsevier Science Ltd, 2006) Atik, Esin; Gorur, Sadik; Kiper, Ahmet Namik
    Testicular torsion causes an enhanced formation of reactive oxygen species which contributes to the pathophysiology of ischemia-reperfusion injury in the testis. We evaluated here the effect of caffeic acid phenethyl ester (CAPE), a new antioxidant and anti-inflammatory agent on histopathological changes in testicular ischemia-reperfusion injury. Adult male Wistar rats were divided into six groups of five each: control group I (n = 5), sham operation group 2 (n = 5), torsion/detorsion (T/D) group 3 (it = 5), T/D + saline group 4 (n = 5), T/D + CAPE group 5 (n = 5) and T/D + CAPE group 6 (n = 5). Group I served to determine baseline values of histopathological parameters, group 2 animals that underwent sham operation served as a control, while groups 3-6 animals were subjected to left unilateral torsion (2 h) and detorsion (24 h) periods. All the groups were sacrified 24 h later except group 6. CAPE was injected 2 days with the same dose to the group 6 and it was sacrified 48 h later. One testis removed and fixed in Bouin's solution. After routine tissue processing myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS) immunohistochemical methods were studied from paraffin embedded tissues. Treating rats with CAPE (applied at 10 mu mol/kg, 30 min prior to T/D) attenuated the testicular injury and as well as the tissue levels of MPO. At the same time testis tissue showed a decrease in iNOS activity. Our results suggest that CAPE treatment have a protective role on testicular T/D and this effect may be due to inhibiting the neutrophil mediated cellular injury. (c) 2006 Elsevier Ltd. All rights reserved.
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    EFFECT OF TAMSULOSIN THERAPY ON LOWER URINARY TRACT SYMPTOMS IN PARKINSON'S DISEASE
    (Aves, 2008) Gorur, Sadik; Melek, Ismet Murat; Okuyucu, Esra; Helli, Ali; Duman, Taskin; Kiper, Ahmet Namik
    Introduction: The aim of this study is to evaluate the intensity of lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH) with and without Parkinson's disease (PD). We also investigated the efficacy of tamsulosin therapy in the management of the subjective and objective symptoms in these patients. Materials and Methods: This study included 80 (40 patients with and 40 without PD) clinically diagnosed BPH patients treated with tamsulosin. International Prostate Symptom score (IPSS), quality of life (QoL), maximum flow rate (Qmax) and post-void residual urine volume (PVR) were determined at baseline and after the 3 months of therapy. The PD group also evaluated with Unified Parkinson's Disease Rating Scale (UPDRS). All patients had received tamsulosin 0.4 mg/per day for 3 months period. The relationship between PD duration and UPDRS and mean changes of IPSS, QoL, Qmax and PVR after tamsulosin therapy were also investigated in PD group. Results: Three patients (7.5%) in PD group were discontinuied the therapy due to the severe hypotension attack. Initial data of IPSS, QoL, Qmax and PVR were different between two groups (p<0.001). After tamsulosin treatment, LUTS improved significantly in both groups (p<0.05). Improvement rates of the IPSS, QoL, Qmax and PVR were significantly higher in non-PD group (p<0.05). When relationship were investigated between PD duration and UPDRS and mean changes of IPSS, QoL, Qmax and PVR after tamsulosin therapy, all parameters were found in correlation except PVR. Conclusion: Tamsulosin therapy appears to useful in PD patient with BPH. But its efficacy is changed with PD duration and severity. After all, tamsulosin therapy can be given to these patients group with close follow-up.
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    Elastic properties of the aorta in patients with erectile dysfunction: assessment by conventional and color tissue Doppler echocardiography
    (Turkish Soc Cardiology, 2006) Seyfeli, Ergun; Gorur, Sadik; Akgul, Ferit; Gur, Mustafa; Seydaliyeva, Tunzale; Yalcin, Fatih; Kiper, Ahmet Namik
    Objectives: It has been suggested that erectile dysfunction (ED) may be the first clinical reflection of vascular disease. We investigated the stiffness and elastic properties of the aorta by conventional and color tissue Doppler echocardiography (TDE) in patients with ED of vascular origin. Study design: Thirty male patients with ED (mean age 52 +/- 8 years; range 41 to 73 years) were studied. Systolic and diastolic aortic diameters were measured by M-mode echocardiography to asses elastic properties of the aorta. Tissue Doppler velocities (S, E, and A cm/sec) of the upper and inferior aortic wall were measured by color TDE. Aortic strain and elasticity, and aortic stiffness index (ASI) were calculated. The results were compared with those of 30 healthy male controls (mean age 49 years). Results: Systolic and diastolic pressures and aortic systolic and diastolic diameters differed significantly between the two groups (p=0.001, p=0.034, p=0.045, p=0.004, respectively). Compared to controls, ASI was significantly higher (p=0.007), and aortic strain (p=0.002) and S wave velocity of the upper wall (p=0.001) were significantly lower in patients with ED. Significant correlations were found between S wave velocity of the upper wall with ASI (r=0.389, p=0.004), aortic strain (r=0.444, p=0.001) and elasticity (r=0.504, p<0.001), and between S wave velocity of the mitral lateral annulus and ASI (r=-0. 472, p<0.001) and aortic elasticity (r=0.533, p<0.001). Conclusion: Erectile dysfunction of vascular origin is associated with increased aortic stiffness and decreased aortic elasticity, this may foreshadow other vascular system diseases having a silent course.
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    Elastographic evaluation of the effect of sickle cell anemia on testicles: a prospective study
    (Wiley, 2022) Koras, Omer; Gorur, Sadik; Bayramogullari, Hanifi; Ilhan, Gul; Gokalp, Fatih; Kacmaz, Murat; Ilgezdi, Alican
    To quantitatively determine testicular tissue stiffness values using shear wave elastography (SWE) in males that have sickle cell anemia (SCA) and to evaluate the relationship between elastography results and semen analysis parameters and hormone levels. Fifty patients diagnosed with SCA and followed up in the hematology outpatient clinic were evaluated in the urology outpatient clinic as the study group. In addition, there were 88 patients without any SCA-related complaints in the control group. We compared these groups with respect to their values, spermiogram parameters, testicular volume, and SWE values. Among patients in the SCA group, 28% had impaired sperm parameters. When testicular elastography was assessed, the testicular volumes were materially lower in the SCA group in comparison to the control group [right testicular volume: 14.76 (12.77-18.12) and 19.68 (15.12-24.18), respectively, p < 0.001; left testicular volume: 14.11 (11.06-17.32) and 16.59 (13.38-20.13), respectively, p = 0.015]. Additionally, the left testis central stiffness and the left testis inferior stiffness were significantly higher in the SCA group (p < 0.001 and p = 0.014, respectively). The age and hydroxyurea use had a worse effect on sperm parameters in patients with SCA (odds ratio: -0.161 and -1.914, standard deviation: 0.071 and 0.921, and p = 0.024 and p = 0.038, respectively). We consider that the technique utilized in this study for SWE values is fast and can be adopted as a reliable diagnostic tool and follow-up practice in routine clinical practice to evaluate the acuteness of damage to the testicles in patients having SCA.
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    Endovascular Treatment of Acute Renal Artery Hemorrhages: Efficacy and Effect on Renal Functions
    (Duzce Univ, Fac Medicine, 2022) Kayali, Alperen; Gorur, Sadik
    Aim: The aim of this study was to investigate the efficacy and complications of endovascular treatment of acute renal artery hemorrhage and the etiology of the condition. Material and Methods: Twenty-two patients who underwent endovascular embolization with renal acute artery hemorrhage between 2016 and 2020 were evaluated retrospectively. Etiologies of the acute renal artery hemorrhage were investigated. Laboratory and clinical follow-up information were analyzed for the efficacy and the complication of the treatment. The serum creatinine levels of the patients before and after the procedure were compared. Results: Selective renal artery embolization procedures were performed in a total of 22 patients. Of the 22 patients, 10 (45.5%) were male and 12 (54.5%) were female. The patients' ages ranged from 5 to 79 years, and the mean age of the patients was 51.5 +/- 18.6 years. Clinical success was achieved in 91.7% of embolization procedures. A statistically significant increase was seen in the serum creatinine levels of the patients after the procedure compared to 24 hours before the angiography procedure (median: 0.97 vs. 0.93, p=0.046). No significant change was observed in serum blood urea nitrogen and the estimated glomerular filtration rate levels (p=0.338, and p=0.067, respectively). Acute renal failure and postembolization syndrome were observed in only one patient as complications. The complication rate was found to be 4.5%. Conclusion: Selective embolization of the renal artery has high clinical success in acute renal artery hemorrhages without impairing renal function. The treatment has advantages such as no need for general anesthesia, and low complication rates.
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    Glomerular hyperfiltration in hypogonadotropic hypogonadic patients: Overlooking a cache?
    (Springer, 2015) Gozukara, Kerem Han; Arslan, Abdulmuttalip; Gorur, Sadik; Rifaioglu, Mehmet Murat; Carlioglu, Ayse
    To investigate renal function in idiopathic hypogonadotropic hypogonadic (IHH) patients by measuring glomerular filtration rate (GFR) using modification of diet in renal disease formula, and determine whether there is any relationship between GFR and testosterone levels. Thirty-three patients with IHH and 37 healthy control subjects participated in this study. The IHH group showed statistically significant higher GFR and proteinuria with respect to the control group (163.1 +/- A 46.9 to 117.9 +/- A 30.5 mL/min, p < 0.001; 0.2 +/- A 0.1 to 0.08 +/- A 0.02 mg/dL, p = 0.041, respectively). Uric acid and creatinine levels were statistically lower than in the control group (4.6 +/- A 0.5-3.6 +/- A 0.9 mg/dL, p = 0.02; 0.7 +/- A 0.2 to 0.9 +/- A 0.2 mg/dL, p < 0.001, respectively). Hyperfiltration positively correlated with IHH in multivariate linear regression analyses (beta = 0.591, p < 0.001). In addition, in the IHH group, we found that the GFR increased independently of body mass index and age. Our study confirms that low testosterone in IHH patients is associated with glomerular hyperfiltration. Patients with IHH should be carefully monitored with respect to their GFR.
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    Long-term effect of varicocele repair on intratesticular arterial resistance index
    (John Wiley & Sons Inc, 2008) Balcı, Ali; Karazincir, Sinem; Gorur, Sadik; Sumbas, Haldun; Egilmez, Ertugrul; Inandi, Tacettin
    Purpose. To investigate the long-term effect of varicocele repair on ipsilateral intratesticular arterial resistance index (RI) using color Doppler sonography (CDS). Methods. A total of 26 infertile patients with left varicocele who underwent a testicular artery and lymphatic-sparing subinguinal varicocelectomy were examined with CDS for intratesticular flow parameters before and at least 6 months after surgery. We also evaluated preoperative and postoperative semen parameters. Results. The mean values of RI, end-diastolic velocity and pulsatility index decreased significantly after surgery, whereas no significant change was observed in peak systolic velocity. Repair of the varicocele resulted in a statistically significant increase in the total sperm count, motility, morphology, and total motile sperm count. However, no significant correlation was found between sperm parameters and RI values (p > 0.05). Conclusions. Our data show that a significant improvement occurs in testicular blood supply and sperm parameters after surgical varicocele repair, without significant correlation between these 2 changes. (C) 2007 Wiley Periodicals, Inc.
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    Periprostatic nerve blockage reduces postoperative analgesic consumption and pain scores of patients undergoing transurethral prostate resection
    (Karger, 2007) Gorur, Sadik; Inanoglu, Kerem; Akkurt, B. Cagla O.; Candan, Yasar; Kiper, Ahmet N.
    Introduction: To evaluate the effects of periprostatic bupivacaine administration on pain control and analgesic consumption after transurethral prostate resection (TURP). Materials and Methods: The study included 40 male patients with benign prostatic hyperplasia who underwent TURP, and they were divided randomly into two groups. All patients were operated under general anesthesia. The study group patients (n = 20) received periprostatic bupivacaine (0.5% 20 ml) injection (group I), and the control patients (n = 20) received only saline (NaCl 0.9% 20 ml) injection (group II). All injections were performed bilaterally into the periprostatic areas immediately after the TURP procedure via the transperineal route. In the postoperative period, all patients (groups I and II) received tramadol using a patient-controlled analgesia device. Postoperative pain was assessed and recorded using the visual analog scale (VAS) at postoperative hours 1, 2, 3, 4, 5, 6, 7, 8, 12, 16, 20, 24, and 48. Total tramadol consumptions and additional analgesic requirements were also recorded and compared between groups. Results: There was no difference in demographic data between the two groups (p > 0.05). VAS scores of the patients at hours 1, 3, 4, 5, 7, 8, and 12 were found to be significantly lower in group I than in group II (p < 0.05). Total tramadol consumption and patient-controlled analgesia demands of groups I and II were 153.5 +/- 8 52.4 vs. 465.0 +/- 55.1 mg and 17.1 +/- 7.7 vs. 77.8 +/- 7.5 mg, respectively (p < 0.001). No side effect was observed regarding bupivacaine injections. Conclusions: Periprostatic bupivacaine administration was a useful and safe method for postoperative pain control and reduced analgesic consumption in patients undergoing TURP. Copyright (c) 2007 S. Karger AG, Basel.
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    THE PREVALENCE AND RISK FACTORS OF ENURESIS IN CHILDREN AGED BETWEEN 6 AND 18 YEARS IN HATAY
    (Aves, 2008) Gorur, Sadik; Inandi, Tacettin; Turhan, Ebru; Helli, Ali; Kiper, Ahmet Namik
    Introduction: Aim of this study was to determine the prevalence and associated socio-demographic factors of enuresis among children aged between 6-18 years in Hatay. Materials and Methods: Five districts were selected in different geographic directions (east, west, north, south, and central) of Hatay. Five mother schools, twelve primary schools and twelve high schools were selected randomly from schools in these districts. The questionnaire was distributed to the students in order to fill by the parents. A total of 4000 questionaire were sent and re-collected one week later. Results: The percentage of the response rate was 74.6%. Age of the children ranges from 6 to 18 years (mean+/-SD; 11.26+/-3.03). Of the participants, 51.8% were girls and 48.2% were boys. Prevalence of enuresis were 7.4% in girls and 10.7% in boys (p= 0.002). Mean age, body mass index and parents age were lower in the children with enuresis than the nonenuretics (p<0.001). Deficiency disorders, problems in friendship relation, failure in school, difficult aurosal, tonsillitis history, snoring and apnea were more frequent in the groups of enuresis (p<0.001). It was found that enuresis were more common in the children whose parents and siblings have enuresis history (p<0.001). The percentage of enuresis among the children with another urological problems was 27.4% (p<0.001). On the other hand, no relation was determined among the writing hand, birth place and birth type with enuresis. Child and mother age, bad friendship relations, low school success, enuresis history in siblings and parents and apnea period in sleeping were associated with enuresis in multipl logistic regression analysis. Conclusion: Enuresis seems associated with familial and behavioral factors. We suggest that evaluation of urinary and other systems in addition to physico-social behaviors of children and adolescence with enuresis may provide some benefit for management and therapy.
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    PROSTATE ADENOCARCINOMA WITH HEMORRHAGIC CYST FORMATION: A CASE REPORT AND REVIEW OF THE LITERATURE
    (Aves, 2006) Gorur, Sadik; Balcı, Ali; Karazincir, Sinem; Guven, Esref Oguz; Sumbas, Haldun; Kiper, Ahmet Namik
    Introduction: Prostate adenocarcinoma accompanied with hemorrhagic cyst formation is a rare entity. It is usually diagnosed incidentally in patients who represent to urology clinics with compliant of lower urinary tract symptoms (LUTS). Here, we presented a 70-year-old man who has LUTS and serum PSA level of 102.35 ng/ml.
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    Protective effects of caffeic acid phenethyl ester, vitamin C, vitamin E and N-acetylcysteine on vancomycin-induced nephrotoxicity in rats
    (Wiley, 2007) Ocak, Sabahattin; Gorur, Sadik; Hakverdi, Sibel; Celik, Sefa; Erdogan, Suat
    The objective of this study was to compare the beneficial effects of caffeic acid phenethyl ester (CAPE), vitamin C, vitamin E and N-acetylcysteine on vancomycin-induced nephrotoxicity. Thirty rats were randomly devided into six groups: (i) control; (ii) vancomycin, 200 mg/kg administrated via intraperitoneal route; (iii) vancomycin plus CAPE - vancomycin with 10 mu mol/kg CAPE; (iv) vancomycin plus vitamin C - vancomycin (intraperitoneally) with 200 mg/dl vitamin C in drinking water; (iv) vancomycin plus vitamin E - vancomycin with 1000 mg/kg body weight vitamin E (intramuscularly); and (vi) vancomycin plus N-acetylcysteine - vancomycin with 10 mg/kg body weight (intraperitoneally) of N-acetylcysteine. Vancomycin treatments were started I day after the first administrations of these agents and continued for 7 days. At the end of the experiments, catalase activity was significantly decreased by vancomycin in kidney homogenates (P < 0.05). Vitamin E, vitamin C, N-acetylcysteine and CAPE administrations decreased the blood urea nitrogen levels increased by vancomycin, although significant differences were detected only in the vitamins E and C groups (P < 0.05). Increased renal malondialdehyde and nitric oxide levels by vancomycin were significantly suppressed by agents used in the study (P < 0.05). Histopathological examination demonstrated prominent damages in the vancomycin-treated group. Vitamin E was the most beneficial agent on vancomycin-induced tubular damage, followed by vitamin C, N-acetyleysteine and CAPE treatments, respectively. The data suggest that vitamin E, as well as vitamin C, N-acetyleysteine and CAPE, could be useful for reducing the detrimental effects on vancomycin-induced toxicity in kidneys.
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    Recent Advances in Elongated and Round Spermatid Injection
    (Galenos Yayincilik, 2021) Gokalp, Fatih; Gorur, Sadik
    Azoospermia is commonly identified in patients with infertility. Non-obstructive azoospermia (NOA) includes primary or secondary and incomplete testicular failure. Before testicular sperm extraction (TESE), donor insemination is the only option available in men with NOA. The combination of microTESE and intracytoplasmic sperm injection has considerably increased the fertilization rate. However, mature spermatozoa can be found in half of the patients. This situation prompted experts to use spermatids to assist in reproductive techniques. Elongated spermatid injection (ELSI) and round spermatid injection (ROSI) are among the possible treatments for couples who cannot find mature spermatozoa after microTESE in patients with NOA. This review provides an updated summary of the most recent available topics on ELSI and ROSI in the literature.