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Öğe Effect of Sickle Cell Anemia on Pelvic Dimensions: A Magnetic(Kowsar Publ, 2017) Atci, Nesrin; Gozukara, Ilay; Ozturk, Fatma; Burakgazi, Gulen; Kurt, Raziye Keskin; Karazincir, SinemBackground: The cesarean delivery rate tends to be higher in women with sickle cell anemia (SCA) and sickle cell trait (SCT) for various reasons. However, pelvic contracture, which may lead to cesarean sections, has never before been studied in these groups. Objectives: The aim of this study was to investigate magnetic resonance (MR) pelvimetry findings of women with SCA and SCT. Patients and Methods: We studied 66 women who underwent MR pelvimetry between March and June 2015 at our center. Our prospective study included 21 women with SCA, 20 women with SCT, and 25 control women. Sagittal inlet, sagittal mid-pelvis, transverse inlet, transverse mid-pelvis and transverse outlet diameters were measured on MR images. The mean diameters were compared with each other and with the control group Results: Sagittal inlet and transverse inlet were not significantly different between the groups. Also, mid-pelvic diameters for the sagittal and transvers mid-pelvis were similar between the groups. Even though the transverse outlet seems to be lesser in the SCA group compared with other groups, it was not statistically significant. Conclusion: Our study demonstrated that the pelvic roofs of women with SCA and SCT are indistinguishable from healthy women. Thereby, maternal pelvic structures that impact delivery types may not be significantly changed in SCA and SCT diseases. We believe that when making decisions about modes of delivery, these results should be taken into consideration.Öğe Histopathologic and metabolic effect of ursodeoxycholic acid treatment on PCOS rat model(Taylor & Francis Ltd, 2016) Gozukara, Ilay; Dokuyucu, Recep; Ozgur, Tumay; Ozcan, Oguzhan; Pinar, Neslihan; Kurt, Raziye Keskin; Kucur, Suna KabilThe aim of this study was to determine the effect of ursodeoxycholic acid (UDCA) treatment on a polycystic ovary syndrome (PCOS) rat model. Thirty-two female Wistar-Albino rats were randomly divided into four groups as follows - group 1: sham group (n: 8), group 2: letrozole-induced PCOS group (n: 8), group 3: letrozole-induced PCOS plus metformin-treated (500 mg/kg) group (n: 8) and group 4: letrozole-induced PCOS plus UDCA (150 mg/kg)-treated group (n: 8). Histopathologic examination of the ovaries, circulating estrone (E1), estradiol (E2), testosterone, androstenedione, glucose, insulin and lipid profiles were evaluated. Histopathologic examination results revealed that groups 3 and 4 had significantly lower cystic and atretic follicles compared to group 2. Besides, group 4 had significantly higher antral follicles than group 2 (8.5 +/- 2.9 versus 5.4 +/- 1.1; p: 0.001). Furthermore, total testosterone (4.9 +/- 2.8 versus 8.8 +/- 2.9; p=0.004) and insulin levels were significantly lower in group 4 compared to group 2 (1.7 +/- 0.08 versus 2.1 +/- 0.5; p = 0.02). However, lipid parameters, E1, E2, glucose and HOMA-IR were comparable between the groups. Our study results demonstrated that UDCA therapy improves ovarian morphology and decreases total testosterone and insulin levels.Öğe Investigation of the presence of Trichomonas vaginalis in infertile Turkish women(Walter De Gruyter Gmbh, 2015) Kaya, Ozlem Aycan; Silfeler, Dilek Benk; Kurt, Raziye Keskin; Gozukara, Ilay; Yengil, Erhan; Bayramoglu, NeslihanBackground: Trichomoniasis is a sexually transmitted vaginal infection caused by a protozoan called Trichomonas vaginalis. Its prevalence ranges between 3-40% among randomly tested women. Objectives: To investigate the presence of T vaginalis in infertile women presenting to a Turkish gynecology outpatient clinic using parasitological methods. Methods: The study population comprised 51 patient participants who attended the gynecology clinic of Mustafa Kemal University Hospital between March and August 2013. The women were divided into those presenting with infertility (n = 22) and a patient control group (n = 29). Women in the control group had complaints other than infertility. Microscopic examination, Giemsa staining, and cysteine peptone liver maltose culture were performed on samples taken from posterior fornix tested for T vaginalis. Results: T vaginalis was observed in 18% (n = 4) of infertile patients and in none of the control group (P = 0.03). Conclusions: Asymptomatic infertile women should be examined for T vaginalis infection, which may play a role as a cause or contributing factor in infertility.Öğe Mean Platelet Volume, a Novel Biomarker in Adolescents with Severe Primary Dysmenorrhea(Elsevier Science Inc, 2016) Kucur, Suna Kabil; Seven, Ali; Yuksel, Kadriye Beril; Sencan, Halime; Gozukara, Ilay; Keskin, NadiStudy Objective: To evaluate whether mean platelet volume (MPV) would be a profitable marker in predicting disease severity in adolescents with severe primary dysmenorrhea (PD). Design, Setting, Participants, Interventions, and Main Outcome Measures: A total of 67 patients diagnosed with PD and 37 healthy adolescents with regular menstrual cycles were included in the study. Hemoglobin, MPV, and white blood cell, platelet, lymphocyte, and neutrophil counts were measured as part of the automated complete blood examination. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio were obtained from the absolute neutrophil or platelet count, respectively, divided by the absolute lymphocyte count. The visual analog scale was used to assess the level of pain, as mild (<40 mm), moderate (40-60 mm) and severe ( >60 mm) PD. Results: The MPV level of the combined severity of PD and control groups were similar. However, the MPV was significantly lower in the severe PD group compared with the control group (P = .04). There were no significant differences in the other hematological parameters between the groups. The mean visual analog scale score of the PD and control subjects were 7.35 +/- 2.25 and 1.07 +/- 1.96, respectively (P < .01). There was a poor negative correlation, which was statistically insignificant, between MPV and white blood cell count. Conclusion: The present study showed that MPV is decreased in adolescents with severe PD. Further studies with larger numbers of subjects are necessary to clarify the roles of platelets in the pathogenesis of severe PD and evaluate the changes in MPV value in response to treatment.Öğe YKL-40 expression in abnormal invasive placenta cases(Walter De Gruyter Gmbh, 2017) Gozukara, Ilay; Ozgur, Tumay; Dolapcioglu, Kenan; Gungoren, Arif; Karapinar, Oya SoyluObjective: YKL-40 is a secreted glycoprotein and has been implicated in the proliferation and differentiation of malignant cells, extracellular tissue remodelling, neovascularisation, inhibition of cancer cell apoptosis and stimulation of tumour-associated fibroblasts. The purpose of this study was to evaluate YKL-40 tissue expression in extravillous trophoblast invasion and its possible implication in placenta creta. Methods: A total of 35 placenta creta cases and six control cases were included in the study, of which eight cases were placenta accreta, 12 were increta and 15 were percreta. Histological YKL-40 staining was scored in tissue as weak (1), medium (2) and strong (3). Results: YKL-40 immunoreactivity intensity in the percreta group was significantly higher compared to the increta and accreta groups (2.47 +/- 0.74, 1.33 +/- 0.49 and 1.37 +/- 0.52, respectively; P = 0.000). YKL-40 immunoreactivity intensity was positively correlated with creta (r = 0.6; P = 0.000), depth of invasion (r = 0.49; P = 0.003) and depth of invasion to full thickness ratio (r = 0.58; P = 0.000). Conclusion: This study demonstrated that YKL-40 is strongly expressed in placenta percreta and is correlated with extravillous trophoblast invasion. These findings may be informative for understanding the pathophysiology of placenta creta.
