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    Is time of childbirth affected by chronotype of the mother?
    (Taylor & Francis Ltd, 2013) Guler, Ayse; Aydin, Adem; Selvi, Yavuz; Dalbudak, Tuna
    We have investigated if biological rhythms, which affect many physiological and pathological events, influence the time of birth. Two hundred and sixty-three cases who were hospitalized with a diagnosis of active labor and who delivered vaginally were enrolled in the study. Information about the age, gravidity, parity, gestational age on admission, and time of onset of labor and birth was registered. A Morningness-Eveningness Questionnaire (MEQ) was administered for determining the patients' chronotypes and dividing them into a morning- or evening-type group. While 20 (35%) of the morning-types delivered between 18:00 and 24:00h, only 11 (19%) of them delivered between 06:00 and 12:00h. From the evening types, 6 (33%) delivered between 18:00 and 24:00h and 3 (17%) between 06:00 and 12:00h. We conclude that there was no statistically significant difference between the chronotypes in terms of delivery time.
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    Menopausal cardiomyopathy: Does it really exist? A case-control deformation imaging study
    (Wiley, 2014) Kurt, Raziye Keskin; Nacar, Alper B.; Guler, Ayse; Silfeler, Dilek B.; Buyukkaya, Eyup; Karateke, Atilla; Kurt, Mustafa
    Aim We aimed to evaluate and compare the left ventricular (LV) functions of pre- and postmenopausal women at similar ages with none of the known cardiovascular risk factors, by both conventional and advanced echocardiographic methods such as 2-D strain imaging via speckle tracking echocardiography. Methods The study population consisted of 40 healthy postmenopausal women aged 45-50 years and 40 healthy premenopausal women of the same age group. None of the subjects had any cardiovascular risk factors and were on hormone replacement therapy. LV strain and strain rate parameters were measured by 2-D strain imaging. The main outcome measure was effect of menopause on LV function. Results There were no significant differences between the pre- and postmenopausal groups with regard to conventional echocardiographic parameters. LV longitudinal strain and LV early diastolic strain rate values were significantly lower in the postmenopausal group when compared to the premenopausal group. Also, there was a significant negative correlation between LV global strain and serum follicle-stimulating hormone (r=-0.349, P=0.002). Conclusion Our study results demonstrated that healthy postmenopausal women had lower LV longitudinal strain values when compared to the healthy premenopausal women of the same age group by speckle tracking echocardiography.
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    Relation of inflammatory markers with both presence and severity of hyperemesis gravidarum
    (Via Medica, 2014) Kurt, Raziye Keskin; Guler, Ayse; Silfeler, Dilek Benk; Ozcil, Mustafa Dogan; Karateke, Atilla; Hakverdi, Ali Ulvi
    Objectives: The aim of our study is to determine the newly introduced systemic inflammation marker, neutrophil lymphocyte ratio (NLR) in hyperemesis gravidarum (HG) patients and to investigate the association between severity of the disease and NLR. Method: The study population consisted of 55 pregnant patients with HG and 50 pregnant women without complaints matched for gestational age as a control group. The HG patients were grouped as mild (n=16), moderate (n=19) and severe (n=20) according to Modified Pregnancy-Unique Quantification of Emesis and Nausea Scoring Index Questionnaire. Furthermore, hsCRP, neutrophils, lymphocytes, and NLR were evaluated with complete blood count. Results: The HG group had significantly higher NLR values compared to the control group (2.69 +/- 1.81 vs 1.97 +/- 1.34, p=0.004). HsCRP levels were significantly higher among HG patients compared to the control group (1.95 +/- 2.2 vs 0.56 +/- 0.30, p<0.001). The subgroup analysis revealed statistically significant increases in NLR and hsCRP values with increased HG severity (p<0.001, p=0.002). The correlation analysis demonstrated a strong correlation between NLR and hsCRP levels (r: 0.703, p<0.001). Conclusion: Our study results showed that NLR and hsCRP levels are increased in HG disease compared to gestational age matched control group subjects. Furthermore, NLR and hsCRP values are correlated with severity of disease. NLR could be used as a marker for both presence and severity of hyperemesis gravidarum.