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    Effect of Cutaneous Leishmaniasis Treatment on Serum Adenosine/Deoxyadenosine Deaminase Activities
    (Asian Journal Of Chemistry, 2012) Culha, Gulnaz; Berkoz, Mehmet; Yalin, Serap; Gulkan, Burcu
    Adenosine deaminase is an enzyme present in a great number of plants and animals, found from simple intervebrates to human beings. Adenosine deaminase and deoxyadenosine deaminase activities increase substantially during mitogenic and antigenic responses of lymphocytes and conversely lymphocytes blastogenesis. Various diseases characterized by the alteration of cell-mediated immunity can be effected by the serum activity of adenosine deaminase. Cutaneous leishmania is an intracellular parasite that targets and multiplies within phagocytic cells of the innate immune system such as the macrophage, dendritic cell and neutrophil. In this study, we investigated the role of treatment on adenosine deaminase and deoxyadenosine deaminase activities in the cutaneous leishmaniasis patients. For this aim, 25 treated cutaneous leishmaniasis patients, 19 untreated patients and 25 healthy control subjects were enrolled in this study. The clinical diagnosis was parasitologically confirmed Giemsa stain and by culture NNN medium. Adenosine deaminase and deoxyadenosine deaminase activities were measured spectrophotometrically by the method of Giusti. Serum adenosine deaminase and deoxyadenosine deaminase activities were higher in cutaneous leishmaniasis patients than the controls and also, adenosine deaminase and deoxyadenosine deaminase activities decreased in treated patients as compare with non-treated cutaneous leishmaniasis patients. According to these results, it is suggested that evaluation of adenosine deaminase activity in serum of patients with cutaneous leishmaniasis could be considered a useful monitoring tool for their infection status. Therefore, adenosine deaminase can be a predictive and sensitive parameter of leishmaniasis treatment.
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    Öğe
    Imported Cutaneous Leishmaniasis Cases Detected in Truck Drivers in Hatay
    (Ankara Microbiology Soc, 2018) Culha, Gulnaz; Cigdem Dogramaci, Asena; Kaya, Tugba; Cavus, Ibrahim; Gulkan, Burcu; Ozbilgin, Ahmet
    Leishmaniasis, seen in tropical and subtropical regions, is an infectious disease caused by the protozoan parasite Leishmania species. There are three main forms of leishmaniasis: cutaneous, mucocutaneous and visceral leishmaniasis. Cutaneous leishmaniasis (CL) has become an increasing problem as the number of travels around the world increases and people go to work in endemic areas. Turkey has received great numbers of immigrants in recent years, from its neighboring countries like Iraq, Islamic Republic of Iran, Afghanistan, Turkmenistan and the Syrian Arab Republic because of the political instabilities in these countries as well as the job opportunities caused by large-scale development projects undertaken by Turkey. In this report, imported CL cases detected in five truck drivers transporting from Hatay to Turkmenistan, Syria, Saudi Arabia, Iran and Georgia, Uzbekistan and Azarbaijan countries were presented. The patients admitted to Mustafa Kemal University, Faculty of Medicine Dermatology Policlinic, with wound complaints on their bodies were directed to the Department of Parasitology to obtain smear samples from their wounds. The age range of the patients were 38 to 43 years. Patients with wound trail for a period ranging from one month to one year had a number of lesions varying between 2-7 and in all cases, a smear preparation was prepared from the lesions for diagnostic purposes. Clinical material obtained from five patients with pre-diagnosis of CL was firstly examined with Giemsa stain. Samples taken from the patients were inoculated into modified NNN (Novy-MacNeal-Nicolle) medium for the evaluation of the presence of the promastigotes. Promastigotes obtained from the inoculated medium were also genotyped using the ITS1 region. In all of the slides prepared from the clinical material taken from the patients amastigotes were determined. The growth of promastigotes were observed in only three of the clinical specimen inoculated media. The genotyped three species were Leishmania tropica, Leishmania infantum/donovani and Leishmania major. In this study, the importance of support for the diagnosis of different microbiological methods used in the diagnosis of leishmaniasis infection which occurred during the outbreaks of the disease has been put forward. In addition, it was aimed to draw attention to the importance of imported CL cases in our country diagnosed in five truck drivers making transportation from Hatay to Turkmenistan, Syria, Saudi Arabia, Iran, Georgia, Uzbekistan and Azerbaijan.
  • Küçük Resim
    Öğe
    Search of house mite's fauna and investigation of relationship between house dust mite and allergy in the province of Hatay, Turkey
    (Kuwait Medical Assoc, 2019) Gulkan, Burcu; Degerli, Serpil; Culha, Gulnaz; Savas, Nazan; Ozcelik, Semra
    Objective: This study aims to search house mite's fauna and to investigate the relationship between house dust mite prevalence and house-related risk factors and allergic diseases. Design: Cross sectional study Setting : Two hundred houses in 25 different neigborhoods in Hatay province of Turkey. Hatay province is located in East Mediterranean Region with a population of 1,519,836. It has the border with Syria. The sample was selected by clustered sociodemographic region systematic random sampling method. Subjects: Two hundred samples of house dust Intervention: A survey was used. Pearson Chi-Square test was used. Main outcome measure(s): Samples of house dust in total were analyzed according to Spieksma-Boezman method of lactic acid precipitation; and the identification of the samples in which mites were detected was made according to the Coloff's type identification key. Results: Out of 200 samples of house dust, mite was detected in 57.5% of them. The most frequently found type of mite was determined as D. pteronyssinus (72.2%). There was no significant relationship found between the mite prevalence and other criteria, except the number of rooms when the ground clearance of houses, the case of garden, carpet type, washing temperature and duration of duvets, times of the insolation of pillows and quilts, heating devices, cleaning times, insolation conditions, presence of a pet and the economic situation of the family were analyzed (p > 0.05). Conclusion It is determined that mite prevalence in the province of Hatay, Turkey is higher than many regions.
  • [ N/A ]
    Öğe
    Search of house mite’s fauna and investigation of relationship between house dust mite and allergy in the province of Hatay, Turkey
    (Kuwait Medical Association, 2019) Gulkan, Burcu; Degerli, Serpil; Culha, Gulnaz; Savas, Nazan; Ozcelik, Semra
    Objective: This study aims to search house mite’s fauna and to investigate the relationship between house dust mite prevalence and house-related risk factors and allergic diseases. Design: Cross sectional study Setting: Two hundred houses in 25 different neigborhoods in Hatay province of Turkey. Hatay province is located in East Mediterranean Region with a population of 1,519,836. It has the border with Syria. The sample was selected by clustered sociodemographic region systematic random sampling method. Subjects: Two hundred samples of house dust Intervention: A survey was used. Pearson Chi-Square test was used. Main outcome measure(s): Samples of house dust in total were analyzed according to Spieksma-Boezman method of lactic acid precipitation; and the identification of the samples in which mites were detected was made according to the Coloff’s type identification key. Results: Out of 200 samples of house dust, mite was detected in 57.5% of them. The most frequently found type of mite was determined as D. pteronyssinus (72.2%). There was no significant relationship found between the mite prevalence and other criteria, except the number of rooms when the ground clearance of houses, the case of garden, carpet type, washing temperature and duration of duvets, times of the insolation of pillows and quilts, heating devices, cleaning times, insolation conditions, presence of a pet and the economic situation of the family were analyzed (p >0.05). Conclusion It is determined that mite prevalence in the province of Hatay, Turkey is higher than many regions. © 2019, Kuwait Medical Association. All rights reserved.