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Öğe Comparison of Mean Platelet Volume Values between Patients with Nasal Polyp and Healthy Individuals(Galenos Yayincilik, 2013) Cevik, Cengiz; Yengil, Erhan; Akbay, Ercan; Arli, Cengiz; Gulmez, Mehmet Ihsan; Akoglu, ErtapObjective: Nasal Polyp (NP) and Allergic Rhinitis (AR) are frequently seen in common. It has been reported that there is an increase in the risk of atherosclerosis in allergic patients. In our study, we aimed to evaluate Mean Platelet Volume (MPV) values in patients with NP, which is used as a marker of atherosclerosis. Methods: Seventy-five patients who underwent functional endoscopic sinus surgery (FESS) with a diagnosis of NP were reviewed. Seventy-five age-matched healthy individuals without AR made up the control group. Val-ues of white blood cell (WBC), platelet (PLT), hemoglobilin (Hb) and MPV were evaluated. Results: MPV values were found to be low in patients with NP 7.89 +/- 1.02 fL compared to control group 8.32 +/- 1.42 fL. This finding was statistically significant. Conclusion: It was found that MPV values are significantly low in patients with NP than control group.Öğe The effect of brochure-assisted education given before septorhinoplasty on surgical fear and anxiety: A randomized controlled trial(Wiley, 2024) Dogan, Sevgi Deniz; Tosunoz, Ipek Kose; Gulmez, Mehmet IhsanThis study is a randomized controlled interventional study aimed to determine the effect of preoperative brochure-assisted education on surgical fear and anxiety in patients scheduled for septorhinoplasty surgery. The study was conducted between May 2022 and February 2023 in the Otorhinolaryngology services and clinics of a training and research hospital in the southern region of Turkey. The study included 61 patients, with 29 in the education group and 32 in the control group. All patients received routine nursing care before surgery, with the education group receiving additional education through an informative brochure. The data were collected using the Personal Information Form, Surgical Fear Questionnaire, and Surgical Anxiety Questionnaire. There was no significant difference in the mean scores of surgical fear between the groups on the morning of the surgery (p > 0.05). However, a significant difference was found in the mean scores of surgical anxiety between the groups (p < 0.05). In conclusion, patients in the education group who received preoperative brochure-assisted education had lower anxiety compared with the control group.Öğe The effect of caffeic acid phenethyl ester and thymoquinone on otitis media with effusion in rats(Elsevier Ireland Ltd, 2017) Gulmez, Mehmet Ihsan; Okuyucu, Emsettin; Dokuyucu, Recep; Gokce, HasanObjective: In this study, we aimed to investigate the effect of CAPE and thymoquinone in experimental rat otitis media with effusion (OME) model. Methods: Intraoral approach of eustachian tube orifice cauterization were administered to 36 of 40 rats participating the study. After application of exclusion criterias, 22 rats with appropriate conditions were determined. Totally 26 rats (44 otitis model ears and 8 normal ears) were randomly divided into 5 groups. While group I was consisted of healthy rats, the other groups were consisted of rats with otitis model. Group I (saline + control group; n = 8 normal ears) and group II (saline + otitis model; n = 10 otitis model ears) received intraperitoneally saline solution. CAPE was given intraperitoneally to group III (CAPE + otitis model; n = 12 otitis model ears) at a concentration of 10 mg/kg for treatment of otitis media. Group IV (thymoquinone + otitis model; n = 12 otitis model ears) was treated orally with 10 mg/kg of thymoquinone. Group V (methylprednisolone + otitis model; n = 10 otitis model ears) was treated intraperitoneally with 1 mg/kg of methylprednisolone. Tympanic bulla samples were excised after 10th day of treatment and examined under light microscopy. Results: Submucosal neutrophil leukocyte count of group 1 was significantly lower than other groups (II, IV, V) (respectively p < 0,0001, p < 0,001, p < 0,0001, Tukey test), while it was not significantly different from group III (p = 0,056, Tukey test). Submucosal neutrophil leukocyte count of group III was significantly lower than group II and group V (p = 0.029 ve p = 0.03, Tukey test). There was no significant difference between group IV and group V (p = 0,28, Tukey test). Conclusion: Based on these findings, it could be suggested that CAPE, anti inflammatory properties proven in the literature, plays an important role in OME treatment. (C) 2017 Elsevier B.V. All rights reserved.Öğe Mean Platelet Volume Evaluation in Patients with Nasal Polyp: Methodological Drawbacks Reply(Galenos Yayincilik, 2015) Cevik, Cengiz; Yengil, Erhan; Akbay, Ercan; Arli, Cengiz; Gulmez, Mehmet Ihsan; Akoglu, Ertap[Abstract Not Available]
