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Öğe Does transcutaneous nerve stimulation have effect on sympathetic skin response?(Elsevier Sci Ltd, 2018) Okuyucu, E. Esra; Turhanoglu, Ayse Dicle; Guntel, Murat; Yilmazer, Serkan; Savas, Nazan; Mansuroglu, AyhanObjective: This study examined the effects of transcutaneous electrical nerve stimulation (TENS) on the sympathetic nerve system by sympathetic skin response test. Methods: Fifty-five healthy volunteers received either: (i) 30 minutes TENS (25 participants) (ii) 30 minutes sham TENS (30 participants) and SSR test was performed pre- and post-TENS. The mean values of latency and peak-to-peak amplitude of five consecutive SSRs were calculated. Results: A significant amplitude difference was found between TENS and sham TENS group both in right and left hand (p = 0.04, p = 0.01, respectively). However there was no significant latancy difference between two groups (p>0.05). Conclusion: TENS has an inhibitory effect on elicited SNS responses when compared with sham TENS control group. (C) 2017 Elsevier Ltd. All rights reserved.Öğe Investigation of the Association between Headache Type, Frequency, and Clinical and Radiological Findings in Patients with Multiple Sclerosis(Wolters Kluwer Medknow Publications, 2020) Demetgul, Ozcan; Duman, Taskin; Guntel, MuratAim: In this study, we aimed to investigate the prevalence of primary headaches in patients with multiple sclerosis (MS), to determine the type of headache according to the criteria of International Headache Society and to investigate the relationship between primary headache type and MS subtype, and the relationship between the localization of plaques in the brain magnetic resonance imaging (MRI) with MS clinic. Methods: In this study, we include the patients diagnosed with MS according to the Mc Donald criteria and functional loss determined with Expanded Disability Status Scale (EDSS). We include the patients who were questioned about headache characteristics in detail and the patients who have MRI previously. MRI evaluations of plaque localization of the patients were classified retrospectively. Findings: Headache in 54.4% of 320 patients participated in the study are available (23.8% tension-type headache (TTH), 30.6% migraine). When we look at the first three initial symptoms of MS patients, the patients who have polysymptomatic symptoms at the beginning are 25.3%, those with motor symptoms are 23.1%, and patients with optical symptoms are 19.7%. The mean EDSS was 2.6 +/- 1.9. When we look the lesion localization, at most pericallosal lesions are present. Mean disease duration was 9.9 years in patients with TTH and 4.5 years in patients with migraine. The difference was statistically significant (P < 0.05). The mean EDSS score was 4.7 in patients with TTH and 1.8 in patients with migraine, and the difference was statistically significant (P < 0.001). The average number of lesions in the brain was 22.07 in patients with TTH and 15.79 in patients with migraine. The difference was statistically significant (P < 0.001). Results: In this study, the frequency of headache in MS patients was found to be greater than the general population and we found a higher incidence of migraine-type headache in these patients. We observed that the tension type of headache is more frequent in MS patients with higher ages, longer disease duration, more plaque numbers, and high EDSS scores.Öğe Multiple Sclerosis and Migraine; Coincidence or Co Morbidity?(Sage Publications Ltd, 2017) Duman, Taskin; Uluduz, Derya; Guntel, Murat; Demetgul, Ozcan; Melek, Ismet; Okuyucu, Esra[Abstract Not Available]Öğe Patients With Neuropathic Pain Have Poor Sleep Quality(Lippincott Williams & Wilkins, 2021) Guntel, Murat; Huzmeli, Esra Dogru; Melek, IsmetAlthough sleep disorders have been studied many times in neuropathic pain (NP), the effect of pain level, depression, and quality of life (QOL) on sleep quality in NP has been rarely investigated. In the present study, we aimed to investigate associations between possible quality of sleep (QOS) impairment and pain level, depression, and QOL. Average daily pain intensity, QOL, QOS, and depression status of the patients were evaluated using a 100-mm visual analog scale (VAS), the RAND 36-Item Health Survey 1.0, the Pittsburgh Sleep Quality Index, and Beck Depression Inventory (BDI), respectively. In 83.1% of patients QOS was found to be poor. We found that there was a significant difference between good and poor QOS in BDI, VAS, and RAND 36-Item Health Survey 1.0 scale's parameters, and patients with NP have poor sleep quality. Depression status is the main predictor for QOS, so pain level and QOL affect the QOS in NP. Physicians who aim healthy QOS must evaluate all characteristics of pain, depression status, and QOL in patients with NP.Öğe Polisomographic Investigation of Sleep Disorders in Patients with Sickle Cell Anemia and Evaluation of the Effect on the Prognosis(Aves, 2022) Dikmen, Nursel; Okuyucu, Emine Esra; Guntel, Murat; Ucar, Edip; Ilhan, Gul; Babayigit, Cenk; Karadag, MehmetOBJECTIVE: The aim of this study is to identify sleep disorders in adults with sickle cell disease and to examine the effects of accompanying sleep disorders on the prognosis of sickle cell disease. MATERIAL AND METHODS: Twenty-eight patients followed up with a diagnosis of sickle cell disease and 22 healthy volunteers were included in our study. RESULTS: Both groups had similar characteristics in terms of age, gender, and body mass index. More obstructive sleep apnea syndrome was detected in the sickle cell group than in healthy volunteers. Statistically, the sickle cell patient group had higher apnea-hypopnea index and lower nighttime oxygen desaturation. As the degree of obstructive sleep apnea syndrome increased in the sickle cell group, it was found that there were more emergency admissions and hospitalization due to painful crises and/or acute chest syndrome in the last 1 year. Also, lower sleep efficiency was found in the sickle cell disease patient group. In the sickle cell group, it was found that the restless leg syndrome severity was statistically significantly more. CONCLUSION: As hypoxia deepens in sickle cell patients, mortality and morbidity due to the disease increase significantly. Comorbid sleep disturbances in sickle cell patients exacerbate nocturnal hypoxia and negatively affect the prognosis of the disease. Therefore, patients with sickle cell disease should be questioned in detail in terms of obstructive sleep apnea syndrome and, if necessary, polysomnographic evaluation should be performed to provide treatment for sleep disorders in the early period.Öğe The relationship between cartilage thickness and muscle thickness or leg length discrepancy in poliomyelitis sequelae(Jmni, 2023) Uysal, Alper; Guntel, Murat; Dede, Hava OezlemObjectives: To evaluate the relationship between cartilage loss and differences in muscle thickness and/or leg length in poliomyelitis sequelae (PMS). Our study is the first to evaluate the relationship between cartilage loss and both muscle atrophy and leg length discrepancy in the same population. Methods: 37 patients with PMS and 38 healthy controls were included. Talar and distal femoral cartilage thicknesses and gastrocnemius medialis and quadriceps femoris muscle thicknesses were measured via ultrasound. Leg length differences and manual muscle strength were also evaluated. Results: The mean muscle thicknesses and cartilage thicknesses were thinner in the more affected legs than in the less affected legs in the patient group. All of the ultrasonographic measurements were thinner in the less affected legs of the patient group than in the right legs of the control group, except for the knee cartilage thicknesses. While there was a correlation between the cartilage thickness difference and the muscle thickness difference between the less and more affected legs in the patient group, there was no correlation between the cartilage thickness difference and leg length differences. Conclusions: Patients with PMS are predisposed to osteoarthritis. Talar and knee cartilage thicknesses may be more associated with the muscle thickness than the leg length discrepancy in PMS.Öğe Relationship of restless legs syndrome with blood parameters(Cukurova Univ, Fac Medicine, 2022) Guntel, Murat; Uysal, Alper; Melek, Ismet MuratPurpose: We aimed to investigate the factors affecting the etiopathogenesis by comparing the restless legs syndrome patients with the healthy control group in terms of some laboratory parameters. Materials and Methods: Patients who were diagnosed with restless legs syndrome were included in the study. A control group that was similar in terms of age and gender was formed. Both groups were compared in terms of iron, ferritin, iron-binding capacity, folate, vitamin B12, vitamin D, calcium, magnesium, ALT, AST, hemogram, creatinine, fasting blood sugar, and thyroid hormone levels. Results: 37 patients with restless legs syndrome and 41 controls were included in the study. In the restless legs syndrome group hemoglobin, ferritin, iron, fasting blood sugar, vitamin D, and fT4 values were 12.7 (10.3-16.0) g/dL, 37.3 (3.7-89.4) mg/L, 62 (21-195) mu g/dL, 96 (65-250) mg/L, 11.26 (4.20-41.57) ug/L and 1.24 (0.73-2.14) mu g/dL respectively, they were 14.8 (12.3-16.1) g/dL, 56 (9-189) mg/L, 90 (30-245) mu g/dL, 91 (70-107) mg/L, 17.31 (5.73-32.90) mu g/L and 1.08 (0.63-2.04) mu g/dL respectively in the control group.There were statistically significant differences between the groups in terms of hemoglobin, ferritin, iron, fasting blood sugar, vitamin D, and fT4 levels. Conclusion: Hemoglobin and iron parameters, vitamin D levels, fasting blood sugar and T4 levels should be evaluated in patients with restless legs syndrome and should be replaced if necessary. Correction of deficiencies may be beneficial for patients' clinics.Öğe Relationship of the lunar cycle and seasonality with stroke(Asean Neurological Assoc, 2021) Altunisik, Erman; Guntel, Murat; Yavuz, Erdal; Arik, AliBackground & Objective: Stroke is one of the leading causes of death. It is also one of the most important factors of long-term disability. We aimed to reveal the relationship of the lunar cycle and seasonality with stroke characteristics. Methods: Data, including the demographic characteristics of the patients, stroke types, stroke severity, etiological factors, accompanying diseases, intensive care needs, and mortality rate were evaluated, recorded, and compared according to seasonality and lunar phases. Results: The study included 538 patients. The stroke type of 468 patients was ischemic. The stroke severity of 231 patients was determined as minor. The ischemic stroke rate was higher in winter than in spring and summer. In spring, the rate of severe stroke was lower than in summer and winter. Posterior system strokes were found at a higher rate in the summer months. During the winter months, middle cerebral artery infarctions were detected more frequently. The intensive care needs of the patients were observed mostly in summer and winter in ischemic stroke patients. When the National Institutes of Health Stroke Scale (NIHSS) scores were compared according to season, no significant difference was found between the groups. There was also no significant difference in gender, age, stroke severity, involved arterial system, etiology, and NIHSS score according to moon phases. But the transient ischemic attack (HA) rate was higher in the full moon than in the last quarter moon. Conclusion: Seasonal variations may affect ischemic stroke characteristics, such as type, severity and involved arterial system, but in our study, the lunar cycle was not found related to the investigated features.Öğe Relationship of vitamin D level, fasting blood sugar, andbody mass index, to carpal tunnel syndrome severity(2021) Uysal, Alper; Guntel, MuratAim: This study aims to investigate the relationship between Idiopathic Carpal Tunnel Syndrome (CTS) and Vitamin D Level, BodyMass Index (BMI), and Fasting Blood Sugar.Materials and Methods: 54 CTS patients diagnosed electrophysiologically were included in the study. These patients' ages, genders,height and body weights, and body mass index values were recorded. Laboratory tests including vitamin D levels and fasting blood sugars were performed for each participant. The CTS stage was determined electrophysiologically and the Boston questionnaire and the visual analogue scale (VAS) were filled to assess total pain scores, symptom severities (CNS), and functional states (FSS).Results: There was a statistically significant difference between the distribution of CTS stages in female patients and male patients (p = 0.008). There was no statistically significant difference between mild, moderate, and severe CTS stages in terms of age, body mass index, and fasting blood glucose (p = 0.459; p = 0.232; p = 0.413, respectively). There is a statistically significant difference between CTS stages in terms of vitamin D levels (p<0.001). Vitamin D averages were observed to decline from mild to severe stages of CTS. According to the Boston Carpal Tunnel Syndrome functional status scale, it was determined that there is marginal statistical significance between the stages of CTS. It was observed that the mean functional status scale scores increased from the mild stage to the severe stage (p = 0.055). There was no statistically significant difference between mild, moderate, and severe CTS stages in terms of VAS pain and paresthesia scores and the Boston Carpal Tunnel Syndrome symptom severity scale (p = 0.340; p = 0.359; p = 0.250, respectively).Conclusion: We found a significant relationship between the vitamin D level and the CTS stage. According to Boston Carpal TunnelSyndrome Questionnaire, we found that there is a marginal statistical significance between the stages of CTS.Öğe Sleep Quality in Neurodegenerative Diseases(Academic Press Ltd-Elsevier Science Ltd, 2020) Okuyucu, Esra; Urfali, Boran; Guntel, Murat[Abstract Not Available]Öğe Ultrasonographic Evaluation of the Distal Femoral Cartilage Thickness in Parkinson's Patients(Jmni, 2023) Uysal, Alper; Guntel, Murat; Demetgul, Ozcan; Cicek, UlacObjectives: Both Parkinson's disease (PD) and osteoarthritis (OA) are characterized by chronic inflammation and tissue degeneration. The aim of this study is to investigate the relationship between PD and distal femoral cartilage thickness (DFCT). Our study is the first in the literature to measure DFCT in PD. Methods: 68 patients with PD and 30 healthy individuals participated. The patient group was divided into three subgroups, according to the Hoehn Yahr stages (HYS): mild, moderate and severe. Patient subgroups and the control group were compared with each other in terms of neutrophillymphocyte ratio (NLR), C-reactive protein (CRP), and DFCT. Results: The NLR and CRP levels of the PD patients were higher than the values of the healthy people. The DFCT values of the mild PD subgroup were significantly higher than those of the control group, except for one value. The DFCT values of the moderate PD subgroup and the healthy group were similar. The DFCT values of the severe PD subgroup were lower than the values of the healthy group. Conclusions: Our study showed the presence of ultrasonographic evidence consistent with early signs of cartilage destruction in early-stage PD disease. As the PD stage progressed, the cartilage thickness decreased accordingly.Öğe Ultrasonographic Evaluation of the Distal Femoral Cartilage Thickness in Parkinson’s Patients(International Society of Musculoskeletal and Neuronal Interactions, 2023) Uysal, Alper; Guntel, Murat; Demetgül, Özcan; Çiçek, UlaşObjectives: Both Parkinson’s disease (PD) and osteoarthritis (OA) are characterized by chronic inflammation and tissue degeneration. The aim of this study is to investigate the relationship between PD and distal femoral cartilage thickness (DFCT). Our study is the first in the literature to measure DFCT in PD. Methods: 68 patients with PD and 30 healthy individuals participated. The patient group was divided into three subgroups, according to the Hoehn Yahr stages (HYS): mild, moderate and severe. Patient subgroups and the control group were compared with each other in terms of neutrophil-lymphocyte ratio (NLR), C-reactive protein (CRP), and DFCT. Results: The NLR and CRP levels of the PD patients were higher than the values of the healthy people. The DFCT values of the mild PD subgroup were significantly higher than those of the control group, except for one value. The DFCT values of the moderate PD subgroup and the healthy group were similar. The DFCT values of the severe PD subgroup were lower than the values of the healthy group. Conclusions: Our study showed the presence of ultrasonographic evidence consistent with early signs of cartilage destruction in early-stage PD disease. As the PD stage progressed, the cartilage thickness decreased accordingly. © 2023, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved.
