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    Elastic properties of the aorta in patients with erectile dysfunction: assessment by conventional and color tissue Doppler echocardiography
    (Turkish Soc Cardiology, 2006) Seyfeli, Ergun; Gorur, Sadik; Akgul, Ferit; Gur, Mustafa; Seydaliyeva, Tunzale; Yalcin, Fatih; Kiper, Ahmet Namik
    Objectives: It has been suggested that erectile dysfunction (ED) may be the first clinical reflection of vascular disease. We investigated the stiffness and elastic properties of the aorta by conventional and color tissue Doppler echocardiography (TDE) in patients with ED of vascular origin. Study design: Thirty male patients with ED (mean age 52 +/- 8 years; range 41 to 73 years) were studied. Systolic and diastolic aortic diameters were measured by M-mode echocardiography to asses elastic properties of the aorta. Tissue Doppler velocities (S, E, and A cm/sec) of the upper and inferior aortic wall were measured by color TDE. Aortic strain and elasticity, and aortic stiffness index (ASI) were calculated. The results were compared with those of 30 healthy male controls (mean age 49 years). Results: Systolic and diastolic pressures and aortic systolic and diastolic diameters differed significantly between the two groups (p=0.001, p=0.034, p=0.045, p=0.004, respectively). Compared to controls, ASI was significantly higher (p=0.007), and aortic strain (p=0.002) and S wave velocity of the upper wall (p=0.001) were significantly lower in patients with ED. Significant correlations were found between S wave velocity of the upper wall with ASI (r=0.389, p=0.004), aortic strain (r=0.444, p=0.001) and elasticity (r=0.504, p<0.001), and between S wave velocity of the mitral lateral annulus and ASI (r=-0. 472, p<0.001) and aortic elasticity (r=0.533, p<0.001). Conclusion: Erectile dysfunction of vascular origin is associated with increased aortic stiffness and decreased aortic elasticity, this may foreshadow other vascular system diseases having a silent course.
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    Relationship between elastic properties of the aorta and uric acid levels in newly diagnosed hypertensive patients
    (Turkish Soc Cardiology, 2006) Gur, Mustafa; Yilmaz, Remzi; Demirbag, Recep; Seyfeli, Ergun; Ozdogru, Ibrahim; Altiparmak, Ibrahim Halil; Dogan, Ali
    Objectives: The association between elastic properties of the aorta and uric acid levels was investigated in patients with newly diagnosed hypertension. Study design: The study included 109 patients (68 females, 41 males; mean age 51.6+/-6.9 years) with newly diagnosed hypertension. Echocardiographic examination was performed. Systolic and diastolic diameters were measured by M-mode echocardiography, and elastic indices (aortic strain and distensibility) were calculated. Pulse pressure was obtained by a sphygmomanometer. Blood samples were obtained to determine serum uric acid levels and other biochemical parameters. The results were compared with those of a control group consisting of 21 age-and sex-matched healthy volunteers. Results: Compared to the control group, aortic strain and distensibility were significantly lower (p<0.001) and uric acid levels were significantly higher (p=0.044) in hypertensive patients. In multivariate regression analysis, aortic strain and distensibility showed independent relationships with uric acid levels (p=0.010 and p=0.009, respectively), age (p=0.001 and p<0.001), and left ventricular mass index (p=0.002 and p<0.001) in the patient group. Multivariate analysis according to gender showed that aortic strain and distensibility were in independent relationship with uric acid levels, age, and left ventricular mass index only in female patients. Conclusion: These data support the view that increased uric acid levels may have a role in the pathogenesis of impaired elastic properties of the aorta especially in hypertensive women.