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Öğe Can olive oil prevent distal colon mucosal atrophy caused by disuse in rats with colostomy? An experimental animal study(Index Copernicus Int, 2021) Atia, Ahmet; Demir, Emel; Gursoy, Didar; Celikkaya, Mehmet Emin; Akcora, BulentAim: This study aims to investigate the effects of pure olive oil on mucosal atrophy of the distal colon in rats. Material and methods: The study included 28 male albino Wistar rats weighing 300-350 g. A total of 28 animals were randomly allocated to four groups: group 1: control group (n = 6); group 2: ostomy group (n = 6); group 3: ostomy + saline group (n = 8); group 4: ostomy + olive oil group (n = 8). By definition, group 1 did not undergo any procedure. The same surgical procedure was performed for groups 2, 3, and 4 as described below. In all animals from these groups, a two-centimeter-long mid-line incision was made and the colon was divided into 5 cm sections, measured from the distal colon to the caecum. Proximal and distal stomas were created 2 cm apart in the midline with the use of single-layer interrupted sutures. All rats were kept under close daily observation until they were terminated postoperatively after the 1st month. Animals from group 2 did not undergo any additional procedures, while those fromgroups 3 and 4 were given 2 mL of saline and olive oil twice a day, respectively. At the end of the 1st month, the rats were re-operated through the same approach. Biopsies were taken from the proximal and distal stomas of all rats in the same manner for further histopathological analysis. Results: Group 1 showed no significant differences in terms of mucosal thickness, muscular thickness, wall thickness or colonic lumen diameter between the proximal and distal segments of the colon. Although there were significant differences between the proximal and distal colostomies for each parameter in groups 2, 3, and 4, the mucosal thickness, muscular thickness, wall thickness, and colonic lumen diameter differences for proximal and distal ostomies were very small in group 4 when compared to groups 2 and 3. Conclusion: The administration of pure olive oil through the distal colon before colostomy closure may reduce the difference in diameter between the proximal and distal intestinal segments. As a result, a more straightforward surgical procedure may be achieved.Öğe Comparison of Head and Neck Cancer Distribution in Turkish and Syrian Populations(Iranian Scientific Society Medical Entomology, 2019) Serindere, Gozde; Bolgul, Behiye; Gursoy, Didar; Hakverdi, Sibel; Savas, NazanBackground: Although oral health improves in several countries, global problems are still present. Predictably, the disadvantaged and poor population groups in both developing and developed countries have high rate of malign disease. The aim of this study was to evaluate the prevalence of head and neck cancers (HNCs) and to compare them between Syrian and Turkish population. Methods: A total of 4570 patients confirmed to have HNC histopathologically from Hatay Mustafa Kemal University Hospital Pathology report archive were retrospectively evaluated. Among them, 452 were Syrian patients while 4118 were Turkish patients. Data were collected from 2010 to 2017. Gender and age information were taken from medical records. According to the pathological results, HNCs were classified. Results: In 474 patients, HNCs were inscriprived, of which 317 were in males and 157 in females aged 23-80 years with histologically approved cancer of head and neck area. Overall, 100 were Syrian patients while 374 were Turkish patients. In both Syrian and Turkish patients, the most observed HNC was squamous cell carcinoma (SCC). Conclusion: Nowadays, the prevalence of cancer is higher because of the excessive consumption of alcohol, tobacco, chewing, and smoking. For the higher cancer incidence in Syrian refugees, we thought that the impact of war such as stress may have been effective as well as the known several etiologic factors of cancer. For the increased risk of cancer, the early diagnosis of this become more important.Öğe Comparison of Ultrasonography and Cone Beam Computed Tomography in the Differential Diagnosis of Periapical Lesions: A Prospective Radiopathological Study(Univ Indonesia, Fac Dentistry, 2022) Serindere, Gozde; Belgin, Ceren Aktuna; Bulte, Mert; Gursoy, Didar; Salimov, FarizObjective: The aim of this study is to evaluate the correlation between ultrasonography (USG) and cone beam computed tomography (CBCT) and the accuracy between histopathological diagnosis and preliminary diagnosis in the diagnosis of periapical lesion. Methods: 20 patients with periapical lesion in the jaw, were included in the study. The presence of expansion or perforation and dimensions of the lesion were performed with CBCT. In the examination of the lesion with USG, shape, echogenicity, vascularization of the lesion and the presence of buccal expansion and perforation, were determined. Subsequently, a biopsy was taken from the lesion for histopathological examination and the final result was compared with the accuracy of the preliminary diagnoses. Results: Kolmogorov-Smirnov test, Wilcoxon test (w) and Cohen's kappa coefficient (kappa) was used to analyze the data. Three of the 4 lesions diagnosed as periapical granuloma as a preliminary diagnosis were confirmed as periapical granuloma in histopathological examination. Periapical cyst was confirmed in histopathological examination of 14 of 16 lesions diagnosed as periapical cyst as a preliminary diagnosis. Mesiodistal (MD) measurements in CBCT measurements were significantly higher than the USG group (p <0.05). There was 100% agreement (p = 0.000) between the evaluation of buccal expansion, buccal perforation, and palatal-lingual perforation between CBCT and USG. Conclusion: It was concluded that the combined use of USG and CBCT can provide the clinician with important information in the diagnosis of periapical lesion.Öğe Hemostatic effects of traditional Inula viscosa and Capsella bursa-pastoris plant mixture extract on rat liver parenchymal bleeding model(Turkish Assoc Trauma Emergency Surgery, 2022) Ozturk, Ozan Utku; Ugur, Mustafa; Guzel, Yelda; Ozturk, Mehmet Ali; Gursoy, Didar; Dogan, Serdar; Temiz, MuhyittinBACKGROUND: Failure to achieve effective bleeding control and problems related to transfusion in liver surgery are the most common causes of post-operative mortality and morbidity. Various methods/drugs including topical hemostatic agents have been employed for bleeding control in liver surgery. This study was aimed to investigate the hemostatic properties of the herb mixture extract of Inula viscosa and Capsella bursa-pastoris (IvCbp) in rat liver laceration model, which have been traditionally used as antiseptic and hemostatic agents public in Hatay/Tukey. METHODS: Thirty rats were divided into three groups equally and blood samples were taken from all rats for preoperative hemoglobin (Hb) measurements. Then, the standard liver resection model was applied to all rats. Sponge for the first rat group, Ankaferd Blood Stopper (R) Trend-Tech for the second rat group and IvCbp plant extract mixture for the third group were applied to resection areas for 3 minutes. Liver samples of all rats were evaluated in terms of inflammation and necrosis intensity on the 5th post-operative day. RESULTS: operative Hb values were found as 11.0 +/- 1.1 g/dL in the sponge group, 11.9 +/- 2.0 g/dL in the Ankaferd group, and 14.I +/- 1.2 g/dL in the IvCbp herb mixture group (p<0.001). In the histopathological examination, less necrosis was observed in the herb mixture group compared to the sponge and Ankaferd groups (p=0.001). In addition, no statistically significant necrosis difference was observed between sponge and Ankaferd groups. While less inflammation was observed in the herb mixture group compared to the other groups, Ankaferd group had the highest inflammation score (p<0.001). CONCLUSION: IvCbp herb mixture extract group provide effective hemostatic control, caused less Hb decrease and resulted in less inflammation and necrosis compared to Ankaferd and sponge groups in a rat liver resection model.Öğe A novel enema method can prevent infectious complications of transrectal ultrasound-guided prostate biopsy: A single-centre experience(Wiley, 2021) Gokalp, Fatih; Koras, Omer; Gursoy, Didar; Sigva, Hakan; Porgali, Sefa Burak; Tamkac, Nezih; Kulak, BilalBackground TRUS biopsy is the preferred method for diagnosing prostate cancer, but it can cause infectious complications that arise with the contribution of fluoroquinolone resistance. We aimed to explore the potential protective effect of a second rectal enema before biopsy. Methods From January 2015 to December 2020, 419 patients were assessed retrospectively. Patients with a history of anticoagulant use, uncontrolled diabetes, urological surgery, prostate biopsy or recent hospitalisation or overseas travel, as well as those with the previous prostatitis, were excluded from the study. The patients were subsequently divided into two groups: Group 1 (n = 223) had received one enema, on the morning of the biopsy and Group 2 (n = 196) had received two, with the additional enema administered half an hour before the procedure. Results There was no significant difference between the groups in terms of age(P = .076), BMI (P = .489), diabetes (P = .265), prostate-specific antigen (PSA) level (P = .193), free/total PSA (f/t PSA) ratio (P = .518) and prostate size (P = .661) or in relation to cancer detection (P = .428). The median hospitalisation date was significantly higher in Group 1 (P = .003) as was urinary tract infection (UTI) development (P = .004). However, there was no significant difference in terms of fever and sepsis (P = .524 and P = .548, respectively). Additionally, subgroup analysis demonstrated that UTI was significantly lower in patients with diabetes mellitus who had received a second enema (P = .004), though there was no significant difference in UTI between the groups in those without diabetes mellitus (P = .215). Multivariable analysis showed that age and diabetes were significant risk factors for the development of UTI (OR: 1.074, 95% CI: 1.027-1.130, P = .002 and OR: 1.220, 95% CI: 0.131-0.665, P = .003, respectively). Furthermore, the second enema was a significant protective factor for preventing UTI (OR: -1.794, 95% CI: 2.208-16.389, P < .001). Conclusion Older age and the presence of diabetes mellitus are independent risk factors for UTI after prostate biopsy. A second enema procedure before biopsy may protect patients from related infectious complications and could therefore be used as an alternative preventative method.Öğe Renal Angiomyolipoma: A Clinicopathological Study of Seven Cases and Review of the Literature(Galenos Yayincilik, 2020) Gursoy, Didar; Secinti, Ilke Evrim; Hakverdi, Sibel; Gorur, SadikObjective: Renal angiomyolipomas (AMLs) are mesenchymal kidney tumours that have triphasic histology. This study aimed to present the clinical, pathological and immunohistochemical features of seven AML cases along with a review of the relevant literature. Materials and Methods: Seven cases of pathologically diagnosed AML were included in the study. The presence of fat tissues, smooth muscle cells, blood vessels and epithelioid components were determined for all cases. Tumour necrosis, haemorrhage, mitosis, lymphovascular and perineural invasion were also recorded. Immune markers [human melanoma black-45 (HMB45), Melan-A, smooth muscle actin (SMA), cytokeratin], previously applied to the tissue sections, were reevaluated as positive and negative staining. Results: All cases were classic AML types. Five patients had flank pain and two had haematuria. The tumour was located in the left kidney in two cases and in the right kidney in five cases. The mean size of the AMLs was 7.36 +/- 4.23 cm. Tumours were separated from the normal kidney parenchyma with good margins and composed of mature fatty tissues, blood vessels and fusiform spindle smooth muscle cells in varying proportions. Immunohistochemically, all cases were positive with HMB-45, Melan-A and SMA. No case was positive for cytokeratin staining. Conclusion: Correct histological diagnosis of renal AML subtypes is crucial. Incorrect diagnosis of classic renal AML may lead to inadequate postoperative management. Clinicians should be aware of the malignant potential of epithelioid AML and the need for long-term follow-up.Öğe Should a fourth category be added to the international tumor budding consensus conference tumor budding scoring system in colorectal adenocarcinomas?(Wiley, 2022) Secinti, Ilke Evrim; Ozgur, Tumay; Gursoy, Didar; Dede, IsaThe aim of this study was to investigate the relationship between tumor budding (TB) and clinicopathologic prognostic criteria in colorectal adenocarcinomas and to discuss the inclusion of the fourth group in the scoring system. A total of 131 cases were included in the study. TB was scored according to the classical 3-tiered scoring system and our proposed 4-tiered scoring system: BD0 (no buds), BD1* (1-4 buds), BD2 (5-9 buds), and BD3 (>= 10 buds). Cytokeratin staining was applied to 80 randomly selected cases and TB scoring was re-evaluated. TB was not observed in 31 (23.7%) of 131 cases and was categorized as BD0. Patients with BD0 budding had lower pT category, AJCC stage, tumor grade, less lymph node metastasis, lymphovascular invasion, tumor deposits (p < 0.05), and longer overall survival than BD1* patients (log-Rank p: 0.018). There was significant compatibility between the evaluation of TB with H&E and cytokeratin (kappa: 0.727, p < 0.001). In conclusion, we think it is valuable to add the BD0 category to the International Tumor Budding Consensus Conference (ITBCC) scores. However, more research with larger cohorts is needed for clinical applicability. H&E staining is sufficient for the assessment of budding, except in conditions such as increased inflammation where the tumor-stroma interface may be obscured.Öğe Should we report Breslow density, a new concept in cutaneous melanoma?(Malaysian Journal Pathology, 2021) Secinti, Ilke Evrim; Gursoy, Didar; Erturk, Tugce; Dede, Isa; Ozgur, Tumay; Dogan, EsinIntroduction: Breslow density is a newly defined biomarker, independent of Breslow thickness. We aimed to investigate the relationship of Breslow density with other clinicopathological prognostic factors and its effect on the overall survival and disease-free survival in patients with cutaneous melanomas. Materials & Methods: This was a single-centre retrospective study of patients (n = 19) diagnosed with cutaneous malignant melanomas in our hospital between 2011 and 2019 were included in the study. The exclusion criteria were in situ melanomas, punch or incisional biopsies and metastasis at the time of the diagnosis. Breslow density was determined by reevaluating slides obtained at the time of the initial diagnoses. The effect of Breslow density on survival was determined using univariate and multivariate Cox proportional risk analyses. Results: In terms of the overall survival, mortality risk increased as Breslow density increased (p = 0.044). Breslow density was not significantly associated with the overall survival in the multivariate model (p = 0.078). In terms of disease-free survival, the risk of metastasis or recurrence increased 1.229-fold in accordance with an increase in Breslow thickness (CI: 1.057-1.428), whereas increased Breslow density increased the metastasis or recurrence risk 1.059-fold (CI: 1.008-1.112). In the multivariate model, only Breslow density was statistically significant (p = 0.046). Conclusions: As a semi-quantitative and subjective measurement, Breslow density is not a completely accurate representation of the invasive tumour load. However, the measurement is practical and low cost and requires no additional equipment. Therefore, Breslow density can be measured in every laboratory. Considering the value of Breslow density in predicting the prognosis in patients with cutaneous melanomas and strong inter-observer compliance observed in the present study, we believe that it would be useful to include this measurement in pathology reports.
