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Öğe Hereditary Behavior of Varicocele(Amer Soc Andrology, Inc, 2010) Gokce, Ahmet; Davarci, Muersel; Yalcinkaya, Fatih Ruetue; Guven, Esref Oguz; Kaya, Yusuf Selim; Helvaci, Mehmet Rami; Balbay, Mevlana DeryaThe inheritance of varicoceles and the potential transmission to first-degree relatives has rarely been investigated. In the present study, we examined the first-degree relatives of men with known varicocele to reveal the familial risk for varicocele. Of the patients with clinical varicocele who presented with infertility, testicular pain, or asymmetrical swelling of the scrotum between June 1, 2008 and May 31, 2009, 49 agreed to have their available first-degree relatives contacted for screening of varicoceles (n = 66). A cohort of 100 consecutive men who applied to the department of internal medicine between 2008 and 2009 for checkup procedure without a history of subfertility or a varicocele were used as a control population. Of the 92 first-degree relatives contacted, 66 (71.7%) decided to participate in this study. Of these 66 men, 21 (33.9%) had a palpable varicocele on physical examination. Compared with a control population (12%), the prevalence of palpable varicocele in the first-degree relatives of patients with known varicocele (33.9%) was approximately 3-fold greater (P < .005). Among the first-degree relatives, 4 (21.1%) of 19 fathers and 17 (36.2%) of 47 brothers had palpable varicocele. As a conclusion, a significant increase in varicocele prevalence is present in the first-degree relatives of men with known varicoceles. Patients should be counseled about this increased risk in male relatives of patients.Öğe Intraurethral Utterbasti Application for Urethral Injury in Rats(Medwell Online, 2012) Yalcinkaya, Fatih Rustu; Davarci, Mursel; Gokce, Ahmet; Guven, Esref Oguz; Inci, Mehmet; Kerem, Mustafa; Ayyildiz, AliUrethral stricture is an illness that can be repeated and that has a troublous treatment process. Uttarbasti which is used in traditional Indian wound healing is a mixture consisting of rock salt, honey and sesame oil. In traditional treatment, there are studies about the effects of honey, wax and sesame oil on wound healing. Researchers aimed at searching the efficiency of the treatment by using uttarbasti in urethral stenosis. In the experiment 18 Wistar Albino type rats which are around 200-250 g were used. These rats were divided into 3 groups and each has 6 rats. Urethra was marked till external meatus with 18G sting. To the 1st group, not any drug was given. To the 2nd group, for 3 weeks saline (1 cc) was given into urethra. To the 3rd group for 3 weeks uttarbasti (1 cc) was applied into urethra. At the end of the 3rd week, all the groups were decapitated. They were taken into histopathological search with their penis tissue and urethra.Öğe Intraurethral utterbasti application for urethral injury in rats(2012) Yalcinkaya, Fatih Rustu; Davarci, Mursel; Gokce, Ahmet; Guven, Esref Oguz; Inci, Mehmet; Kerem, Mustafa; Ayyildiz, AliUrethral stricture is an illness that can be repeated and that has a troublous treatment process. Uttarbasti which is used in traditional Indian wound healing is a mixture consisting of rock salt, honey and sesame oil. In traditional treatment, there are studies about the effects of honey, wax and sesame oil on wound healing. Researchers aimed at searching the efficiency of the treatment by using uttarbasti in urethral stenosis. In the experiment 18 Wistar Albino type rats which are around 200-250 g were used. These rats were divided into 3 groups and each has 6 rats. Urethra was marked till external meatus with 18G sting. To the 1 st group, not any drug was given. To the 2nd group, for 3 weeks saline (1 cc) was given into urethra. To the 3rd group for 3 weeks uttarbasti (1 cc) was applied into urethra. At the end of the 3rd week, all the groups were decapitated. They were taken into histopathological search with their penis tissue and urethra. © Medwell Journals, 2012.Öğe PROSTATE ADENOCARCINOMA WITH HEMORRHAGIC CYST FORMATION: A CASE REPORT AND REVIEW OF THE LITERATURE(Aves, 2006) Gorur, Sadik; Balcı, Ali; Karazincir, Sinem; Guven, Esref Oguz; Sumbas, Haldun; Kiper, Ahmet NamikIntroduction: Prostate adenocarcinoma accompanied with hemorrhagic cyst formation is a rare entity. It is usually diagnosed incidentally in patients who represent to urology clinics with compliant of lower urinary tract symptoms (LUTS). Here, we presented a 70-year-old man who has LUTS and serum PSA level of 102.35 ng/ml.Öğe Protective effects of tadalafil on experimental spinal cord injury in rats(Elsevier Sci Ltd, 2010) Serarslan, Yurdal; Yonden, Zafer; Ozgiray, Erkin; Oktar, Sueleyman; Guven, Esref Oguz; Sogut, Sadik; Yilmaz, NebiTadalafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Nitric oxide (NO) functions as a retrograde neurotransmitter in the spinal cord, and postsynaptic structures respond to NO by producing cGMP. The concentrations of cGMP in the spinal cord are controlled by the actions of PDE. The aim of the study was to evaluate and compare the effects of the use of both methylprednisolone and tadalafil on serum and tissue concentrations of NO, malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity, and tissue glutathione peroxidase (GSH-Px) activity in rats with spinal cord injury (SCI). SCI was induced in Wistar albino rats by dropping a 10 g rod from a 5.0 cm height at T8-10. The 28 rats were randomly divided into four equal groups: tadalafil, methylprednisolone, non-treatment and sham groups. Rats were neurologically tested at 24 hours after trauma. At the end of the experiment, blood samples were collected and spinal cord tissue samples were harvested for biochemical evaluation. The tissue level of NO was increased in the tadalafil group compared with the non-treatment and methylprednisolone groups (p < 0.05). The tissue levels of SOD and GSH-Px did not differ between the groups. Serum levels of NO were higher in the tadalafil group than in the non-treatment group (p < 0.05). The increase in serum SOD levels was greater in the tadalafil group than the methylprednisolone group. Serum MDA levels in the tadalafll and methylprednisolone groups tended to be lower than in the non-treatment group (p > 0.05). Tissue MDA levels in the taclalafil and methylprednisolone groups tended to be lower than in the non-treatment group and sham groups (p > 0.05). Although there was no difference in neurological outcome scores between the taclalafil, methylprednisolone and non-treatment groups (p > 0.05), the animals in the taclalafil and methylprednisolone groups tended to have better Scores than the non-treatment group. Thus, tadalafil appears to be beneficial in reducing the effects of injury to the spinal cord by increasing tissue levels of NO and serum activity of SOD. (C) 2009 Elsevier Ltd. All rights reserved.Öğe Robotic and imaging in urological surgery(2009) Teber, Dogu; Baumhauer, Matthias; Guven, Esref Oguz; Rassweiler, JensPurpose of review: New imaging modalities and tissue navigation systems, which are adoptable to minimally invasive robotic urological surgical systems and prone to make the procedures more precise and easy, are reviewed. Recent findings: Image-guided surgery as the general name of combining information of imaging modalities with real-time surgery has already found a place in open and minimally invasive procedures. Soft tissue navigation is a complex type of computer-assisted surgery for soft tissue interventions. Robotic surgery has advantages of superior degrees of freedom and three-dimensional stereotactic user interface. A combination of surgical robotics with image-assisted surgery and soft tissue navigation may offer advantages of more precise anatomical target localization and dissection with minimal damage to the tissue. Solving the problem of organ shift and as a result, unpredictable changing of intraoperative anatomy soft tissue navigation has the potential to increase the precision of minimally invasive robotic surgery. Summary: Apart from less invasiveness, the concomitant use of minimal invasive robotic systems with soft tissue navigation enhances surgical precision. However, at present, abdominal navigation systems are in experimental use and not perfect enough for daily surgical routine. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.Öğe Urodynamic evaluation of acute effects of sildenafil on voiding among males with erectile dysfunction and symptomatic benign prostate(Tubitak Scientific & Technological Research Council Turkey, 2012) Yalcinkaya, Fatih Rustu; Davarci, Mursel; Akcin, Soner; Gokce, Ahmet; Guven, Esref Oguz; Inci, Mehmet; Balbay, Mevlana DeryaAim: To evaluate the acute effects of sildenafil citrate on micturition of men with erectile dysfunction and symptomatic benign prostatic hyperplasia using urodynamic parameters. Materials and methods: Between June and December 2009, a total of 50 patients over the age of 40 participated in the study. The patients were admitted to our hospital with erectile dysfunction and moderate to severe lower urinary symptoms with benign prostatic hyperplasia. To examine the sexual function of the participants, we used the IIEF-5 Sexual Health Inventory for Men questionnaire. Patients were randomly divided into 2 groups: a treatment group and a control group. A basal urodynamic evaluation was performed in both groups. After the urodynamic evaluation, 50 mg of sildenafil was given to the patients in the control group and 1 h later a second evaluation was performed. Following the urodynamic evaluation, a placebo was given to the patients in the control group and then a second evaluation was performed after 1 h. Results: A statistically significant increase was seen in maximal flow and average flow (Qmax and Qave) after 1 h in the treatment group. The increase in the control group was not significant. Conclusion: Based on the study findings, we suggest that sildenafil has an effect on micturition in the short term. However, to determine the role of sildenafil in the treatment of BPH/LUTS, further studies with larger patient groups are needed.
