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    Evaluation of oxidative stress, antioxidant status and lipid profile in cattle with displacement of the abomasum
    (Ankara Univ Press, 2016) Durgut, Ramazan; Sagkan Ozturk, Aliye; Ozturk, Oktay Hasan; Guzel, Murat
    The aims of the present study were to evaluate serum oxidative and antioxidant status and oxidative stress index, and lipid metabolism profile in cattle with abomasal displacement. A total of thirty-two dairy cows with right-and left-sided abomasal displacement (LDA (n=11) and RDA without volvulus (n=11)) and 10 healthy controls were used in this study. Serum total oxidative status (TOS) and total antioxidant capacity (TAC) were measured by a colorimetric method. The TOS-to-TAC ratio was also calculated as oxidative stress index (OSI) value. Serum lipid profiles were determined by conventional measurement methods as well. Mean TOS and OSI values were significantly (p<0.001) higher in cows with RDA compared to LDA and healthy controls; however, there was no significant differences in serum TAC values among groups. Serum total cholesterol (TC), high density lipoproteins (HDL) and low density lipoproteins (LDL) levels were significantly (p=0.001) decreased, while serum triglyceride (TG) levels were significantly increased in dairy cows with right-and left-sided abomasal displacement compared to healthy controls. The results of current study showed that dairy cows with RDA forming free radicals than LDA and controls due to abomasal tension and increased intraluminal pressure.
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    Evaluation of oxidative stress, antioxidant status and lipid profile in cattle with displacement of the abomasums
    (Chartered Inst. of Building Services Engineers, 2016) Durgut, Ramazan; Sagkan Ozturk, Aliye; Ozturk, Oktay Hasan; Guzel, Murat
    The aims of the present study were to evaluate serum oxidative and antioxidant status and oxidative stress index, and lipid metabolism profile in cattle with abomasal displacement. A total of thirty-two dairy cows with right- and left-sided abomasal displacement (LDA (n=11) and RDA without volvulus (n=11)) and 10 healthy controls were used in this study. Serum total oxidative status (TOS) and total antioxidant capacity (TAC) were measured by a colorimetric method. The TOS-to-TAC ratio was also calculated as oxidative stress index (OSI) value. Serum lipid profiles were determined by conventional measurement methods as well. Mean TOS and OSI values were significantly (p<0.001) higher in cows with RDA compared to LDA and healthy controls; however, there was no significant differences in serum TAC values among groups. Serum total cholesterol (TC), high density lipoproteins (HDL) and low density lipoproteins (LDL) levels were significantly (p=0.001) decreased, while serum triglyceride (TG) levels were significantly increased in dairy cows with right- and left-sided abomasal displacement compared to healthy controls. The results of current study showed that dairy cows with RDA forming free radicals than LDA and controls due to abomasal tension and increased intraluminal pressure. © 2016, Chartered Inst. of Building Services Engineers. All rights reserved.
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    Investigation of Acute Phase Reactants and Antioxidant Capacity in Calves Infected with Cryptosporidium parvum
    (Kafkas Univ, Veteriner Fakultesi Dergisi, 2017) Cenesiz, Metin; Sagkan Ozturk, Aliye; Dalgin, Duygu; Yarim, Gul Fatma; Ciftci, Gulay; Ozdemir, Ramazan; Guzel, Murat
    Cryptosporidiosis is a zoonotic infection contaminating via fecal-oral route. Cryptosporidium parvum has a wide host prevalance, but is more epidemic in calves. This disease courses with high morbidity and mortality resulting considerable economic losses. In this study, halofuginon (100 mu g /kg/day for 7 days) was applied to calves infected with C. parvum and the effect of this treatment on acute phase proteins and antioxidant capacity were investigated. Study group was comprised of sera of 10 Holstein calves aged 1-3 weeks, infected with C. parvum. Blood samples were obtained from the animals before and after treatment of 7 days and serum amyloid A (SAA), haptoglobin (Hp), C-reactive protein (CRP), ceruloplasmin (CP), malondialdehyde (MDA) levels and superoxide dismutase (SOD) and adenosine deaminase (ADA) activities were measured in sera. Obtained data showed that there was no statistical difference between pre and post treatment SAA, CRP and MDA levels, but a decrease was determined in post treatment Hp (P<0.001) and CP (P<0.05) levels, with ADA (P<0.05) and SOD (P<0.001) activities. Eventually, it was determined that ADA and SOD activities and Hp and CP levels decreases by treatment in calves infected with C. parvum.
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    Prevalence of equine herpesvirus-1 and equine herpesvirus-4 infections in equidae species in Turkey as determined by ELISA and multiplex nested PCR
    (Elsevier Sci Ltd, 2009) Ataseven, Veysel S.; Bilge Dagalp, Seval; Guzel, Murat; Basaran, Zeynep; Tan, Mehmet T.; Geraghty, Bob
    In this report we examined the presence of specific antibodies against equine herpesvirus type 1 (EHV-1 and equine herpesvirus type 4 (EHV-4) in several equidae, including mules, donkeys, horses. The presence of EHV-1 and EHV-4 in respiratory diseases of equids, and ability of multiplex nested polymerase chain reaction (PCR) screening in simultaneous diagnosis of horses acutely infected by EHV-1 and EHV-4 were also investigated. Sera from 504 horses, mules and donkeys sampled were tested for the presence of EHV-1 and EHV-4 specific antibodies. Blood samples taken from 21 symptomatic horses and nasal swabs taken from 40 symptomatic horses were tested for the presence of EHV-1 and EHV-4 by a multiplex nested PCR. A total of 14.3% (3/21) of buffy coat samples and 32.5% (13/40) nasal swab samples were found to contain EHV-1 DNA, while 19% (4/21) buffy coat samples and 22.5% (9/40) nasal swab samples were found to be positive for EHV-4 DNA. By species, 14.5% of horses, 37.2% of mules and 24.2% of donkeys tested were EHV-1 seropositive. EHV-4 specific antibodies were detected in 237 (81.7%) of 290 horse sera tested. Results from this investigation demonstrate that EHV-1 and EHV-4 are prevalent throughout the equid population, and that donkeys and mules might also represent an important source of infection for other equids. We also showed that the multiplex nested PCR assay might be useful for diagnosis of mixed respiratory infections in horses due to EHV-1 and EHV-4. (C) 2008 Elsevier Ltd. All rights reserved.
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    Seroprevalance of toxoplasmosis and babesiosis in Shami goats
    (Indian Veterinary Journal, 2007) Guzel, Murat; Yaman, Mehmet; Babur, Cahit; Duzgun, Ali; Yagci, Sukran; Kilic, Selcuk
    Hatay, located in the south-eastern part of the Mediterranean region, is home to the Shami (Damascus), Kilis and Hatay goats. In this study, the prevalance of toxoplasmosis and babesiosis among Shami goats in Hatay was investigated by serological methods.
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    Serum sialic acids, total antioxidant capacity, and adenosine deaminase activity in cattle with theileriosis and anaplasmosis
    (Natl Veterinary Research Inst, 2008) Guzel, Murat; Askar, Tunay Kontas; Kaya, Galip; Atakisi, Emine; Avci, Gulcan Erbil
    In the present study, we aimed to provide information on the serum content of sialic acids (TSA, LBSA, and PBSA), total antioxidant capacity (TAC), and adenosine deaminase (ADA) activity in cattle affected with naturally acquired theileriosis and anaplasmosis. A total of 55 Holstein cattle, comprising of 15 clinically healthy control animals, 20 cattle with theileriosis, and 20 with anaplasmosis, were used. Diagnosis was based on clinical signs, Giemsa stained blood or lymph node aspirate, and PCR assay. For the PCR assay, Tams I primers were used. The obtained results suggested that the concentration of sialic acids and ADA activity were significantly higher; and TAC were significantly lower in the theileriosis and anaplasmosis groups in contrast to the control group. In conclusion, the increased level of sialic acids and ADA in theileriosis and anaplasmosis may be attributable to the stimulation of the host immune response. In contrast, the reduced level of TAC may reflect a decrease in the antioxidant capacity.
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    Topical retinoic acid in the treatment of feline tail gland hyperplasia (stud tail): A prospective clinical trial
    (Natl Veterinary Research Inst, 2008) Ural, Kerem; Acar, Abuzer; Guzel, Murat; Karakurum, Mehmet Cagri; Cingi, Cenker Cagri
    The purpose of this prospective, double-blinded, and placebo-controlled clinical trial was to investigate the efficacy of topical cream, containing 0.1% retinoic acid for the treatment of tail gland hyperplasia in cats. Nineteen privately owned cats diagnosed with tail gland hyperplasia, based on history and clinical findings were randomly assigned to either a placebo or an active ingredient treatment group. Clinical evaluations were done by the same investigator, who scored clinical healing, at the beginning, during, and at the end of the treatment. Both owners and investigators were blinded to the allocation to the groups. It was demonstrated that retinoic acid gel treatment significantly decreased (P<0.05) the investigator's clinical scores while no significant changes were detected in the placebo treatment group. In conclusion, treatment with 0.1% retinoic acid cream was effective for the topical management of tail gland hyperplasia in the cats included in the study.
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    Use of selamectin for the treatment of psoroptic and sarcoptic mite infestation in rabbits
    (Wiley, 2007) Kurtdede, Arif; Karaer, Zafer; Acar, Abuzer; Guzel, Murat; Cingi, C. Cagri; Ural, Kerem; Ica, Anil
    Selamectin, a novel avermectin compound, was evaluated for its efficacy against naturally occurring infestations of Psoroptes cuniculi and Sarcoptes scabiei. A total of 42 New Zealand rabbits with psoroptic mange and 37 Angora rabbits with sarcoptic mange were used in the present study. On day 0, infested rabbits were treated topically with either selamectin at minimum dose of 6 mg kg(-1) (6-18 mg kg(-1) for New Zealand rabbits, n = 31 and 10-12 mg kg(-1) for Angora rabbits, n = 23) or vehicle only (control groups, n = 11 for New Zealand rabbits, n = 14 for Angora rabbits). The efficacy of selamectin was assessed both clinically and parasitologically by the presence or absence of viable mites. Rabbits were scraped for sarcoptic mites on days 7, 14, 28, 42 and 56 and had otoscopeic and/or microscopic examination for the detection of Psoroptes mites on days 7, 14, 42 and 56. Fisher's exact test was used to assess differences between the vehicle and selamectin treatment in the number of rabbits without mites (cure rates) on each assessment date. It was found that significantly fewer selamectin-treated rabbits had mites detected on skin scrapings (for S. scabiei) or otoscopeic and/or microscopic examination (for P. cuniculi) (P < 0.01) than the vehicle group. Results of the present study suggest that selamectin is effective against naturally infestations of P. cuniculi and S. scabiei in rabbits.