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Öğe Anti-inflammatory and antioxidant activity of thymoquinone in a rat model of acute bacterial prostatitis(Sage Publications Ltd, 2013) Inci, M.; Davarci, M.; Inci, M.; Motor, S.; Yalcinkaya, F. R.; Nacar, E.; Aydin, M.Prostatitis plays a major role in morbidity and mortality related to prostate diseases. The aim of this study was to detect whether thymoquinone (TQ) could ameliorate oxidative damage and the proliferative response induced by Escherichia coli (E. coli) in rats. A total of 42 adult male Wistar rats were used. The rats were randomly divided into seven groups (three treatment groups, three infected groups and one control group). Control group received saline and was killed 24 h after saline administration. Infected rats were killed after 24, 48 and 72 h following direct injection of E coli into the prostate. Treatment groups were administered with 10 mg/kg dose of TQ intraperitoneally following E. coli injection and after 24 and 48 h following E. coli injection. The rats were killed at 24, 48 and 72 h after the first drug administration. Each group was compared with each other and with the control group. In addition, infected groups were compared with treatment groups. Our findings show that the treatment with TQ has a protective effect against bacterial prostatitis-induced tissue injury. Increase in malondialdehyde levels and histological damage caused by E. coli were improved markedly with TQ treatment. TQ treatment particularly increased the activity of glutathione peroxidase and decreased the activities of catalase and superoxide dismutase. These observations might be attributed, at least in part, to the antioxidant effect of TQ and suggest that it could be a clinically valuable agent in the prevention of acute prostatitis caused by E. coli.Öğe Assessment of the relationship between coronary artery ectasia and erectile function score(Nature Publishing Group, 2011) Akcay, A. B.; Inci, M.; Bilen, P.; Acele, A.; Sen, N.; Yalcin, F.The relation between coronary artery ectasia (CAE) and erectile dysfunction (ED) has not been studied so far. Hence, we decided to investigate the erectile function score in patients with CAE. We investigated the international index of erectile function (IIEF)-5 score in 34 men with CAE, 38 men with coronary artery disease (CAD), and 30 male controls with normal coronary arteries whose mean ages were 53.2 +/- 5.6, 51.4 +/- 7.8, and 49.6 +/- 8.6 years, respectively. Erectile function was evaluated by the five-item version of the IIEF-5. Each question is scored from 0 to 5. CAE was defined as being without any stenotic lesions with a visual assessment of the coronary arteries showing a luminal dilatation 1.5-fold or more of the adjacent normal coronary segments. IIEF-5 scores in CAE group were found statistically significantly lower than the control group (P < 0.001). There were no statistically significant differences in IIEF-5 scores between CAE and CAD groups (P = 0.13). We have shown for the first time that patients with CAE have lower IIEF-5 scores compared with controls with normal coronary angiograms. Many studies reported that endothelial dysfunction in patients with CAE was more dominant than those with CAD. This study suggests that ED and CAE may be different manifestations of a common underlying vascular pathology and vasculogenic ED is frequently seen in CAE at least as much as in CAD. International Journal of Impotence Research (2011) 23, 128-133; doi:10.1038/ijir.2011.10; published online 28 April 2011Öğe ASSESSMENT OF THE RELATIONSHIP BETWEEN CORONARY ARTERY ECTASIA AND ERECTILE FUNCTION SCORE(Elsevier Ireland Ltd, 2011) Akcay, A. B.; Sen, N.; Inci, M.; Bilen, P.; Yeral, N.; Acele, A.; Yalcin, F.[Abstract Not Available]Öğe Beta-lactamase Enzymes of Clinical Pseudomonas aeruginosa Strains(Univ West Indies Faculty Medical Sciences, 2016) Pasa, O.; Ozer, B.; Duran, N.; Inci, M.; Yula, E.Objectives: In this study, the production of extended spectrum beta-lactamase (ESBL), metallo-betalacatamase (MBL) and AmpC beta-lactamase enzymes of Pseudomonas aeruginosa (P aeruginosa) strains which were isolated from clinical samples were investigated. AmpC gene was also detected by the polymerase chain reaction (PCR) analysis. Methods: A hundred strains of P aeruginosa were included in the study. The presence of ESBL was investigated with combined disk confirmation test, MBL was investigated with E-test method and AmpC beta-lactamase was investigated with disk induction test. In order to detect the production of AmpC beta-lactamase genotypically, the PCR method was used. Results: Only one strain was found to be MBL positive. Four per cent of strains were found to be ESBL positive. AmpC beta-lactamase production was positive in 73% of the strains with disk induction test. AmpC gene was detected in 96% of the studied strains with the PCR method. Conclusion: While ESBL and MBL rates in this study were significantly lower than those found in other studies, the rate of AmpC beta-lactamase was higher. Although AmpC gene was detected in some strains (23%), they were not found to produce AmpC beta-lactamase with disk induction test.Öğe Brucellosis with very high ferritin levels: report of five cases(Sage Publications Ltd, 2012) Arica, V.; Silfeler, I.; Arica, S.; Tutanc, M.; Motor, V. K.; Inci, M.Brucellosis is a zoonotic disease caused by a kind of Brucella bacteria, which commonly appears in humans and rarely causes mortality. In our study, five cases, who were diagnosed by evaluation of clinical findings and serological tests, they also had very high ferritin levels, were reported. Ages of the patients were 16, 12, 10, 16 and 8 years, respectively. Serum ferritin levels were 1200, 985, 886, 748 and 435 ng/ml, respectively. We observed that complaints of the patients reduced after the treatment and ferritin levels returned to its normal range. In the situations of extremely evaluated serum ferritin which is an acute-phase reactant, its levels are able to raise in brucellosis, without existing hemochromatosis and Still's diseaseÖğe Changes in retinal vessels related to varicocele: a pilot investigation(Wiley, 2016) Coskun, M.; Ilhan, N.; Elbeyli, A.; Rifaioglu, M. M.; Inci, M.; Davran, R.; Tuzcu, E. A.The aim of this study was to investigate whether retinal vasculature changes had occurred (retinal artery diameter, retinal vein diameter and artery/vein ratio) in patients with varicocele. This pilot study included 50 healthy subjects with any eye disease apart from slight refractive errors and 55 patients with varicocele. Retinal arteriolar and venular diameters were measured and summarised as central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE). Retinal microvascular diameters and the arteriolar-to-venular ratio (AVR) were assessed with a digital retinal camera. All measurements and calculations were performed using a computer-based program. The mean CRAE value was 151.8 +/- 3.6m in the study group and 150.4 +/- 4.5m in the control group. Mean CRVE value was 209.4 +/- 5.9m in the study group and 200.1 +/- 8.7m in the control group. AVR was found 0.72 +/- 0.02 in the study group and 0.75 +/- 0.03 in the control group. There were significant differences between groups in terms of CRVE and AVR. There were no significant differences between groups in terms of CRAE. The results of this study showed that the patients with varicocele showed significant changes on retinal vascular diameter.Öğe Investigation of Epstein-Barr virus serology and DNA in bone marrow transplant recipients(Academic Journals, 2011) Inci, M.; Gokahmetoglu, S.; Kaynar, L.; Ercal, B. D.; Durmaz, S.; Buyukoglan, R.The aim of this study was to investigate Epstein-Barr virus (EBV) serology and EBV DNA in the patients with bone marrow transplantation. In the current study, 128 patients with bone marrow transplantation (BMT) were included in Hematology-Oncology Department of Medical Faculty, Erciyes University between June 2005 and October 2009. In order to evaluate EBV serology and DNA, 357 samples obtained from the patients were studied with enzyme-linked immunosorbent assay and real-time polymerase chain reaction (PCR). The components of EBV serology were anti-Ebstein-Barr nuclear antigen (EBNA)-1 IgG, anti-viral capsid antigen (VCA) IgG and IgM. EBV seropositivity was found in 98.4% of the samples. EBV DNA positivity was detected in 13.3% of the patients. High viral load was only seen in one patient among all the EBV DNA positivity. No patient showed any symptoms regarding EBV virus and admitted with post-transplant lymphoproliferative disease. In conclusion, for the diagnosis and follow up of EBV infections in patients with BMT, detection of EBV DNA by PCR method is also beneficial in addition to serological tests regarding EBV.Öğe The prevalence of interdigital erythrasma in southern region of Turkey(Wiley-Blackwell, 2012) Inci, M.; Serarslan, G.; Ozer, B.; Inan, M. U.; Evirgen, O.; Alagoz, G. Erkaslan; Duran, N.Background Erythrasma is a skin infection which is caused by Corynebacterium minutissimum. Interdigital erythrasma is the most common form. Objective The aim of this study was to detect the frequency and risk factors of interdigital erythrasma in patients with clinically suspected tinea pedis. Methods This study was conducted between June and December 2010 and included 122 patients who had interdigital foot lesions. All patients were examined using a Woods lamp. The smears were stained using Grams method. Direct examination was performed using 20% potassium hydroxide. Sabouraud dextrose agar and brain heart infusion agar were used for cultures. Moreover, the demographical characteristics of patients, concomitant diseases and clinical findings were also recorded. Cases that were found to be positive on Woods lamp examination and/or Gram staining/culture were considered as erythrasma. Results The rate of erythrasma was found to be 46.7%. The mean age was 43.6 years, and the disease was more prevalent in men. The most common clinical finding was desquamation. Mycological examination was found as positive in 40.35% of the patients. No growth was observed in bacteriological cultures. It was found that using only Woods lamp examination or Gram staining resulted in 11 (9%) and 19 positive patients (15.6%), respectively, whereas using both Woods lamp examination and Gram staining concurrently resulted in 27 positive patients (22.1%). Conclusion Interdigital erythrasma is a commonly seen condition and can clinically mimic tinea pedis. A Woods lamp is a good diagnostic tool, but Gram staining, particularly in those with a negative Woods lamp result, may be a useful method.Öğe Prevalence of Toxoplasmosis, Cytomegalovirus and Rubella IgG Antibodies in Hatay Women and Children(Univ West Indies Faculty Medical Sciences, 2012) Koksaldi-Motor, V.; Evirgen, O.; Azaroglu, I.; Inci, M.; Ozer, B.; Arica, S.Objective: Toxoplasmosis, cytomegalovirus and rubella may cause congenital infections. The aim of this study is to investigate toxoplasmosis, cytomegalovirus and rubella IgG antibodies in women and children who were admitted to the Hatay Women and Children Hospital between January 1 and December 31, 2009. Methods: Levels of IgG antibodies for toxoplasmosis, cytomegalovirus and rubella established with chemiluminescence immunoassay (Architect i2000, Abbott, USA) method were evaluated, retrospectively. Results: The results were obtained from 1103 cases. Seropositivity of IgG antibodies for toxoplasmosis (n = 743), cytomegalovirus (n = 929) and rubella (n = 746) were 59.9%, 98.9% and 93.6%, respectively. Conclusion: Routine serological screening should be recommended in women of childbearing age. Seronegative subjects should be vaccinated for rubella and educated for protection from toxoplasmosis.Öğe A Radiographic Correlation between Renal and Pulp Stones(Univ West Indies Faculty Medical Sciences, 2014) Ertas, E. Tarim; Inci, M.; Demirtas, A.; Ertas, H.; Yengil, Erhan; Sisman, Y.; Gokce, C.Aim: The purpose of this study was to determine the correlation between pulp stones and renal stones. This study also aimed to report associations between the presence of pulp stone and gender, age, tooth type, dental arches and sides. Patients and Methods: Data were collected through examination of bitewing radiographs of 116 kidney stone patients and a similar number of age-matched controls, referred to the Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Erciyes University. Two oral radiologists examined the radiographs to identify pulp stones. The Chi-squared and Mann Whitney U tests were used to investigate the correlations between the presence of pulp chamber calcification and age, gender, dental status and kidney stone. Results: Pulp chamber opacities were detected in 199 (19.3%) out of the 1031 examined teeth, and in 84 (72.4%) out of the 116 kidney stone patients. There was no statistically significant difference between the study and control group (p = 0.882). The occurrence of pulp stones was significantly higher in molars than premolars and similar prevalences were found between dental arches and sides. Conclusion: In this study, no correlation was found between the presence of pulp stones and kidney stones in the investigated group. Therefore, the presence of pulp stones does not seem to be correlated with that of kidney stones.
