Yazar "Inci, Mehmet" seçeneğine göre listele
Listeleniyor 1 - 17 / 17
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Association between Body Mass Index, Lipid Profiles, and Types of Urinary Stones(Taylor & Francis Ltd, 2012) Inci, Mehmet; Demirtas, Abdullah; Sarli, Bahadir; Akinsal, Emrecan; Baydilli, NumanObjective: The purpose of this study was to determine the differences in body mass index (BMI), levels of cholesterol, and levels of triglycerides (TGs) among urolithiasis patients with different stone compositions. Materials and methods: Forty-nine patients who had a diagnosis of nephrolithiasis and had undergone open surgery or percutaneous surgery were included, and patients without urolithiasis were randomly selected as controls. Urinary stones were collected and analyzed using infrared spectroscopy. Data relating to patient's age, BMI at diagnosis, serum total cholesterol (TC), high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol (LDL-C) were collected. The stone groups including calcium oxalate monohydrate-calcium oxalate dihydrate (COM-COD), COM, and uric acid were compared with one another and with the control group. In addition, the stone formers group (COM-COD, COM, uric acid, calcium phosphate, and mixed-type stones) was compared to the control group. Results: BMI, TC, and TG levels were significantly higher in stone formers compared with the control group; this association of BMI and TC with stone formation was more prominent in uric acid and COM-COD stone formers, but there was no such prominence for COM stones. LDL-C levels in COM-COD stone formers were significantly higher when compared with COM stone formers. Conclusion: Elevated BMI, hypercholesterolemia, and hyperlipidemia, which are leading components of metabolic syndrome, may be associated with different types of urinary stone formation.Öğe Caffeic acid phenethyl ester (CAPE) protects against acute urogenital injury following pneumoperitoneum in the rat(Taylor & Francis Ltd, 2014) Rifaioglu, Murat Mehmet; Davarci, Mursel; Nacar, Ahmet; Alp, Harun; Celik, Murat; Sefil, Nebihat Kaplan; Inci, MehmetPurpose: Our aim is to determine the biochemical and histologic changes induced in the kidneys, testis and prostate on possible ischemia and reperfusion (I/R) injury caused by pneumoperitoneum (PNP) in a rat model and to evaluate the ability of protective effects of caffeic acid phenethyl ester (CAPE). Methods: Twenty-eight adult male Wistar albino rats were randomly divided to one of three treatment groups, with seven animals in each group. Sham, laparoscopy (L), and laparoscopy plus CAPE (L + C) group were subjected to 60 min of PNP with 15 mmHg one hour before the desufflation period. Total oxidant status (TOS) and total antioxidant status (TAS) levels were determined in kidney, testis, and prostate. Kidney and testis tissues were removed to obtain a histologic score. Also, Johnsen scoring system was used for testicular tissue analysis. Results: L group had significantly higher TOS and lower TAS levels on kidney and testis compared to the other groups. In prostate biochemical analysis, there was not any difference between groups. No difference was found between groups according to kidney and testis tissues' histologic evaluation. In evaluation of Johnsen scoring, L group showed significant lower score compared to the other two groups. Conclusions: Increased intraabdominal pressure (IAP) had an oxidative effect on kidney and testis but not on prostate in rats. Moreover, it could affect the testicular Johnsen score. All these adverse effects of IAP on both kidney and testis could be prevented by CAPE administration.Öğe Does renal parenchymal thickness affect bleeding in percutaneous nephrolithotomy?(Tubitak Scientific & Technological Research Council Turkey, 2013) Rifaioglu, Mehmet Murat; Onem, Kadir; Celik, Huseyin; Davarci, Mursel; Cetinkaya, Mehmet; Inci, Mehmet; Gunesli Yetisken, AylinAim: Blood loss is a major concern during percutaneous nephrolithotomy. The aim of this study was to evaluate the effect of access point parenchymal thickness on bleeding in percutaneous nephrolithotomy procedures. Materials and methods: In this study 85 patients who had undergone a percutaneous nephrolithotomy operation between February 2009 and July 2011 were reviewed retrospectively. All characteristics of the patients were investigated. The details of the operative procedure and the renal parenchymal thickness at the puncture site were also recorded. Blood loss was calculated during the peroperative and postoperative periods. Correlation and multivariate regression analysis were done to detect predictive factors on bleeding. Results: Of the 85 percutaneous nephrolithotomy procedures done, 12 (14.1%) patients had no diminution of hemoglobin value postoperatively and were excluded. This left 73 percutaneous nephrolithotomy procedures that were evaluated. The mean peroperative hemoglobin drop was 1.79 +/- 1.17 mg/dL. Stone size, operation time, and grade of hydronephrosis were correlated with hemoglobin drop significantly (P = 0.047, P = 0.016, and P = 0.034, respectively). There was no correlation between parenchymal thickness and bleeding (P = 0.545). In multivariate regression analysis, only the operation time was found to be a statistically significant independent predictive factor for peroperative bleeding in percutaneous nephrolithotomy (P = 0.005). Conclusion: Renal parenchymal thickness and the grade of hydronephrosis do not predict peroperative hemorrhage in percutaneous nephrolithotomy procedures.Öğe The Effect of Bongardia Chrysogonum on Prostate Tissue in a Rat Model of Streptozotocin-Induced Diabetes(Wiley-Blackwell, 2015) Dokuyucu, Recep; Ozcan, Oguzhan; Sefil, Nebihat Kaplan; Nacar, Ahmet; Inci, Mehmet[Abstract Not Available]Öğe The effect of Bongardia Chrysogonum on prostate tissue in a rat model of STZ-induced diabetes(Springer International Publishing Ag, 2016) Dokuyucu, Recep; Gozukara, Kerem Han; Ozcan, Oguzhan; Sefil, Nebihat Kaplan; Nacar, Ahmet; Dokuyucu, Ahmet; Inci, MehmetBackground: Bongardia chrysogonum is widely used in Turkey for treating urinary tract infections and prostate hypertrophy, and it also has potent hypoglycemic effects and aids glucose homeostasis. Because of the inflammatory conditions in diabetes mellitus (DM), the prostate tissue of men with diabetes is particularly susceptible to developing hypoplasia, and DM produces characteristic pathological changes in prostate tissue. Here, we examined the effects of B. chrysogonum on the prostate tissue of rats with streptozotocin (STZ)-induced diabetes. Results: The glucose levels were statistically significantly higher in the diabetic rats than in healthy controls (P < 0.001). Further, they were significantly lower in the healthy and diabetic rats administered B. chrysogonum than in the untreated diabetic rats (P < 0.001 and 0.05, respectively). The total cholesterol levels were significantly lower in the healthy rats administered B. chrysogonum than the healthy controls (P < 0.05) and diabetic rats (P < 0.01). They were also significantly lower in the diabetic rats administered B. chrysogonum than those that were left untreated (P < 0.05). The testosterone levels were significantly lower in the untreated diabetic rats than in the controls (untreated ones and those administered B. chrysogonum) and diabetic rats administered the herb (P < 0.001, 0.05 and 0.01, respectively). The oxidative stress index was significantly higher in the untreated diabetic rats than the healthy controls (P < 0.05). It was also significantly lower in the healthy and diabetic groups treated with B. chrysogonum than the untreated diabetic rats (P < 0.05). Histological examination showed no changes in the prostate tissue of the non-diabetic rats. In the diabetic group, the glandular lumens were filled with cellular debris and leucocytic infiltrate, and the glandular epithelium was degenerated and thickened. In the diabetic group treated with B. chrysogonum, the epithelium was better preserved and less debris was seen in the glandular lumen. Conclusion: To our knowledge, this is the first study to histologically prove the effects of B. chrysogonum on prostate tissue in diabetes. Our findings may be useful in developing B. chrysogonum into a therapeutic agent against diabetes and benign prostate hyperplasia.Öğe Histopathologic Evaluation of Neurovascular Bundles and Periprostatic Tissue in Interfascial and Intrafascial Nerve-sparing Radical Prostatectomy Technique: A Cadaveric Anatomic Study(Elsevier Science Inc, 2013) Rifaioglu, Murat M.; Davarci, Mursel; Ozgur, Tumay; Ozkanli, Seyma; Ozdes, Taskin; Inci, Mehmet; Onem, KadirOBJECTIVE To compare interfascial (IEF) or intrafascial (IAF) periprostatic nerve dissection technique in prostate tissue using immunohistochemical methods in fresh cadavers. MATERIALS AND METHODS Prostate tissues of 25 fresh cadavers were removed from rectum and other surrounding structures. IEF nerve dissection (n - 25) was performed on the right and IAF nerve (n - 25) dissection on the left side of each prostate under direct visualization. The base, center, and apex of each prostate lobes and fascia dissected were sampled for blind histopathologic evaluation. Total counts of nerve, artery, and vein were performed on hematoxylin and eosin stained sections, whereas sympathetic and parasympathetic nerve counts were performed on immunohistochemical stained sections. Iatrogenic surgical margin injury at base, center, and apex detected were compared between groups. RESULTS Thickness of neurovascular bundle dissected in IAF was found significantly higher than IEF technique. The number of residual sympathetic fibers after dissection of neurovascular bundle was found significantly higher in IAF group. There were significant decreases in total nerve, parasympathetic, and sympathetic nerve counts only at the central region of prostate in IAF group. A significant decrease was found in the number of residual vein left in the fascia only at the apex by IAF dissection. Of surgical margin injury results, no significant difference was detected between IAF and IEF groups at any location. CONCLUSION IAF provides better preservation of sympathetic but not parasympathetic fibers without increasing surgical injury of prostate capsule. (C) 2013 Elsevier Inc.Öğe Increased Femoral Cartilage Thickness in Patients With Klinefelter Syndrome(Sage Publications Inc, 2013) Inci, Mehmet; Akgul, Ozgur; Baydilli, Numan; Ekmekcioglu, Oguz; Ozgocmen, SalihThe objective of this study was to determine femoral cartilage thickness (FCT) in patients with Klinefelter syndrome (KS), which is the most common sex chromosome disorder in men with varying degrees of androgen deficiency. This cross-sectional controlled study was conducted in a tertiary care center. Participants were 33 male patients (mean age = 36.2 years) with KS and 35 aged-matched healthy male controls (mean age = 32.9 years). Femoral condyle cartilage was measured by ultrasonography at three locations in each knee. Total testosterone, estradiol, sex hormone binding globulin, free androgen index, bioavailable testosterone, and albumin levels were measured. Femoral cartilage of patients at right and left knee lateral (3.03 and 2.99 mm), mid (3.81 and 3.74 mm), and medial (3.01 and 3.20 mm) were statistically thicker than in controls (right and left knee lateral 2.29 and 2.36 mm, mid 2.64 and 2.53 mm, medial 2.39 and 2.32 mm, respectively, p < .001). There was no significant correlation between FCT and sex hormones. In conclusion, patients with KS had thicker femoral cartilage. Relatively low testosterone levels in these patients and altered estrogen metabolism may hypothetically explain increased cartilage thickness in these patients.Öğe Intraurethral Utterbasti Application for Urethral Injury in Rats(Medwell Online, 2012) Yalcinkaya, Fatih Rustu; Davarci, Mursel; Gokce, Ahmet; Guven, Esref Oguz; Inci, Mehmet; Kerem, Mustafa; Ayyildiz, AliUrethral stricture is an illness that can be repeated and that has a troublous treatment process. Uttarbasti which is used in traditional Indian wound healing is a mixture consisting of rock salt, honey and sesame oil. In traditional treatment, there are studies about the effects of honey, wax and sesame oil on wound healing. Researchers aimed at searching the efficiency of the treatment by using uttarbasti in urethral stenosis. In the experiment 18 Wistar Albino type rats which are around 200-250 g were used. These rats were divided into 3 groups and each has 6 rats. Urethra was marked till external meatus with 18G sting. To the 1st group, not any drug was given. To the 2nd group, for 3 weeks saline (1 cc) was given into urethra. To the 3rd group for 3 weeks uttarbasti (1 cc) was applied into urethra. At the end of the 3rd week, all the groups were decapitated. They were taken into histopathological search with their penis tissue and urethra.Öğe Intraurethral utterbasti application for urethral injury in rats(2012) Yalcinkaya, Fatih Rustu; Davarci, Mursel; Gokce, Ahmet; Guven, Esref Oguz; Inci, Mehmet; Kerem, Mustafa; Ayyildiz, AliUrethral stricture is an illness that can be repeated and that has a troublous treatment process. Uttarbasti which is used in traditional Indian wound healing is a mixture consisting of rock salt, honey and sesame oil. In traditional treatment, there are studies about the effects of honey, wax and sesame oil on wound healing. Researchers aimed at searching the efficiency of the treatment by using uttarbasti in urethral stenosis. In the experiment 18 Wistar Albino type rats which are around 200-250 g were used. These rats were divided into 3 groups and each has 6 rats. Urethra was marked till external meatus with 18G sting. To the 1 st group, not any drug was given. To the 2nd group, for 3 weeks saline (1 cc) was given into urethra. To the 3rd group for 3 weeks uttarbasti (1 cc) was applied into urethra. At the end of the 3rd week, all the groups were decapitated. They were taken into histopathological search with their penis tissue and urethra. © Medwell Journals, 2012.Öğe [Investigating Demodex folliculorum in patients with urological cancer].(2012) Inci, Mehmet; Kaya, Ozlem Aycan; Inci, Melek; Yula, Erkan; Gökçe, Hasan; Rifaio?lu, M Murat; Demirtaş, OnurIn this study, it was aimed to determine frequency of Demodex folliculorum infestation in patients with urological cancers. This study evaluated 49 patients with urological cancers; 31 sex-matched healthy individuals as a control group were included in the study between March 2011 and April 2012 at the Hospital of Mustafa Kemal University, School of Medicine, Urology Clinic. The demographic characteristics of the patients were recorded. Samples from the perineal region of the subjects were taken by standard method of superficial skin biopsy and evaluated by microscopy. Presence of five or more Demodex sp. in a cm < sup > 2 < /sup > was considered as positive. Mean age was found to be 60.2±18.6 years. D. folliculorum was found to be positive in 11 (22.4%) of the patients with cancer and in 1 (3.2%) of the subjects in the control group. It was found that D. folliculorum frequency was significantly higher in the cancer group compared to the control group. No significant difference was found among the cancer groups in terms of D. folliculorum detection. In the cancer group, mean age was significantly higher in D. folliculorum positive patients than negative ones. It should be kept in mind that D. folliculorum incidence may increase in immunosuppressive states, such as cancer.Öğe The Investigation of Relationship between Coronary Artery Ectasia, Benign Prostatic Enlargement, and Lower Urinary Tract Symptoms(Elsevier Science Inc, 2015) Inci, Mehmet; Baydilli, Numan; Akcay, Adnan Burak; Demirtas, Abdullah; Rifaioglu, Mehmet Murat; Gozukara, Kerem Han; Kaya, Mehmet GungorOBJECTIVE To investigate benign prostatic enlargement (BPE) and lower urinary tract symptoms (LUTS) in patients with coronary artery ectasia (CAE). The relation between CAE, BPE, and LUTS has not been studied so far. METHODS We investigated BPE and LUTS symptoms in 47 men with CAE, 45 men with coronary artery disease (CAD), and 47 male controls with normal coronary arteries. LUTS was evaluated by the International Prostate Symptom Score (IPSS). BPE was evaluated with transabdominal ultrasonography. CAD was defined as myocardial infarction and angiographically diagnosed coronary disease. CAE was defined as being without any stenotic lesions with a visual assessment of the coronary arteries showing a luminal dilatation >= 1.5 fold of the adjacent normal coronary segments. RESULTS Prostate volume was higher in CAE and CAD patients compared with that of the control subjects, respectively (41.0 +/- 10.4 vs 33.5 +/- 9.4 cm(3); 39.1 +/- 10.3 vs 33.5 +/- 9.4 cm3; P = .0001); total IPSS was higher in CAD and CAE patients compared with that of the control subjects (P = .0001). Postmictional residual urine volume was higher in CAE and CAD patients compared with that of the control subjects (P = .002). CONCLUSION We showed that patients with CAE have higher prostate volume, IPSS, and postmictional residual urine volume compared with those of controls with normal coronary angiograms. This study proposes that BPE, LUTS, and CAE maybe different disorders to a common vascular pathology and endothelial dysfunction. This study showed that BPE and LUTS were frequently seen in CAE at least as much as in CAD. Therefore, LUTS and BPE should be kept in mind for CAE patients in follow-ups. (C) 2015 Elsevier Inc.Öğe The Investigation of Total PSA, Free PSA, and Free/Total PSA Ratio in Patients With Liver Cirrhosis Patients According to Child-Pugh Score(Elsevier Science Inc, 2013) Inci, Mehmet; Rifaioglu, Murat Mehmet; Inci, Melek; Celik, Murat; Demir, Mehmet; Ulutas, Turker; Davarci, MurselOBJECTIVE To investigate the total prostate-specific antigen (tPSA), free PSA (fPSA), and free/total PSA (fPSA/tPSA) ratio in patients with liver cirrhosis (LC) according to the severity of hepatic insufficiency. METHODS Eighty-two male patients with LC were studied. The severity of liver disease was categorized by Child-Pugh score (Child-Pugh A, B, and C). Forty-two age-matched healthy subjects were used as a control group. The tPSA, fPSA, fPSA/tPSA ratio, total prostate volume (TPV), total testosterone (TT), and total protein (TP) were measured. The LC group was compared with the control group in terms of these parameters. In addition, intra-comparison and inter-comparison was made between all the Child-Pugh groups and normal subjects, in terms of these parameters. RESULTS The tPSA and fPSA levels in LC cases, Child-Pugh A, Child-Pugh B, and Child-Pugh C groups were significantly decreased compared with the control group. The ratio of fPSA/tPSA in the LC subjects and Child-Pugh A groups significantly increased compared with the control group. TT, TP levels, and TPV in patients with LC were significantly lower compared with the control group and the results were significantly correlated with the Child-Pugh score. CONCLUSION The present study reveals that tPSA and fPSA were decreased in patients with LC in comparison to healthy subjects in terms of 3 mechanisms. First, it might be due to shrunken prostatic volume. Second, it also resulted in decreased levels of testosterone because of the abnormality of hypothalamic-pituitary-testicular axis. Third, it might be the diminished serum protein level in the composition of the PSA. UROLOGY 81: 617-622, 2013. (c) 2013 Elsevier Inc.Öğe OPTIMAL CUT-OFF POINT OF STONE SIZE FOR PREDICTING RESIDUAL STONE IN PERCUTANEOUS NEPHROLITOTOMY(Mary Ann Liebert, Inc, 2012) Rifaioglu, Murat Mehmet; Davarci, Mursel; Inci, Mehmet; Demirbas, Onur; Kaya, Yusuf Selim; Baydinc, Can Yasar[Abstract Not Available]Öğe Relationship between endothelial dysfunction and nocturia with benign prostatic hyperplasia(Taylor & Francis Ltd, 2013) Inci, Mehmet; Sarli, Bahadir; Davarci, Mursel; Yalcinkaya, Fatih Rustu; Rifaioglu, Murat Mehmet; Davran, Ramazan; Arica, SecilObjective. There are limited data on whether there is an association between nocturia, benign prostatic hyperplasia (BPH) and endothelial dysfunction. The aim of the present study was to evaluate whether there is an association between nocturia and endothelial dysfunction in patients with BPH. Material and methods. Forty-two men with a diagnosis of BPH and 42 age-matched controls were enrolled. All patients were assessed for frequency and duration of nocturia, and prostate volume, completed the International Prostate Symptom Score (IPSS) questionnaire, and underwent brachial flow-mediated dilatation (FMD) evaluation. Results. There was a negative correlation between FMD and frequency of nocturia (r = -0.879, p < 0.0001). Moreover, there was a negative correlation between duration of nocturia and FMD (r = -0.890, p < 0.0001). In addition, FMD was significantly decreased in the BPH group compared with the control group (6.0 +/- 0.09 to 7.8 +/- 0.10%) (p = 0.0001). Conclusion. In patients with BPH, nocturia is associated with endothelial dysfunction and may be an insidious risk factor for cardiovascular disease.Öğe Urodynamic evaluation of acute effects of sildenafil on voiding among males with erectile dysfunction and symptomatic benign prostate(Tubitak Scientific & Technological Research Council Turkey, 2012) Yalcinkaya, Fatih Rustu; Davarci, Mursel; Akcin, Soner; Gokce, Ahmet; Guven, Esref Oguz; Inci, Mehmet; Balbay, Mevlana DeryaAim: To evaluate the acute effects of sildenafil citrate on micturition of men with erectile dysfunction and symptomatic benign prostatic hyperplasia using urodynamic parameters. Materials and methods: Between June and December 2009, a total of 50 patients over the age of 40 participated in the study. The patients were admitted to our hospital with erectile dysfunction and moderate to severe lower urinary symptoms with benign prostatic hyperplasia. To examine the sexual function of the participants, we used the IIEF-5 Sexual Health Inventory for Men questionnaire. Patients were randomly divided into 2 groups: a treatment group and a control group. A basal urodynamic evaluation was performed in both groups. After the urodynamic evaluation, 50 mg of sildenafil was given to the patients in the control group and 1 h later a second evaluation was performed. Following the urodynamic evaluation, a placebo was given to the patients in the control group and then a second evaluation was performed after 1 h. Results: A statistically significant increase was seen in maximal flow and average flow (Qmax and Qave) after 1 h in the treatment group. The increase in the control group was not significant. Conclusion: Based on the study findings, we suggest that sildenafil has an effect on micturition in the short term. However, to determine the role of sildenafil in the treatment of BPH/LUTS, further studies with larger patient groups are needed.Öğe Villous adenoma of the urinary bladder: rare location(Termedia Publishing House Ltd, 2012) Atik, Esin; Akansu, Bulent; Davarci, Mursel; Inci, Mehmet; Yalcinkaya, Fatih; Rifaioglu, MuratVillous adenomas are common lesions of the gastrointestinal tract but they are rarely located in the urinary tract including the urinary bladder. There are a few case reports and series in the literature. Here we report a 43-year-old male patient who had a polypoid lesion located on the left lateral wall of the urinary bladder. Transurethral resection was performed. The diagnosis was 'villous adenoma of urinary bladder' with clinical and histopathological findings. Villous adenomas are mostly seen in elderly males. The coexistence of villous adenoma with adenocarcinoma, squamous cell carcinoma, and urothelial carcinoma was observed but there is not clear evidence about progression to carcinoma, in spite of its colonic counterpart. Generally complete surgical resection is accepted as curative but there are no exact data about follow-up and recurrence. By presenting this case, we aim to emphasize that it is a rare but important lesion because of coexistence with malignancies and uncertain malignant potential.Öğe WHAT IS THE CLINICAL IMPORTANCE OF STONE SIZE IN PERCUTANEOUS NEPHROLITOTOMY?(Mary Ann Liebert, Inc, 2012) Rifaioglu, Murat Mehmet; Davarci, Mursel; Inci, Mehmet; Kaya, Yusuf Selim; Demirbas, Onur; Baydinc, Yasar Can[Abstract Not Available]
