Yazar "Isgor, M. M." seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • [ N/A ]
    Öğe
    The effects of Ziziphus jujuba on human glioblastoma cells
    (Wiley-Blackwell, 2016) Duzguner, V.; Kucukgul, A.; Isgor, M. M.; Cellat, M.; Kizilkaya, P.
    [Abstract Not Available]
  • [ N/A ]
    Öğe
    Investigation of the Bioactivity of Escin in Hydrogen Peroxide-Induced Oxidative Stress
    (Hellenic Veterinary Medical Soc, 2023) Kucukgul, A.; Isgor, M. M.; Onel, S. E.
    Escin is a triterpene saponin obtained from the horse chestnut tree Aesculus hippocastanum L. (Hippo-castanaceae). The aim of this study is to investigate the bioactivity of escin against hydrogen peroxide-induced oxida-tive stress in quails. The study was performed in male Japanese quails (n=10) with similar pre-experimental weights (Coturnix japonica) on average. In order to create oxidative stress in quails, hydrogen peroxide was given to drinking water ad libitum for 1 week. At the end of the period, escin was injected intraperitoneally into the quails twice, every other day. The weights of the experimental animals were measured at the beginning and the end of the experiment and compared. In addition, the 10-day live weight change rate and feed intake rates of the experimental animals were also compared. Total antioxidant (TAC), total oxidant (TOC), and oxidative stress index (OSI) were measured colorimet-rically from serum and liver homogenates of animals in the experimental groups. In addition, IL-1 & beta; translation levels from serum samples were investigated by the ELISA method. According to the data obtained from the study, 10-day body weight change rates increased by 33% in the hydrogen peroxide added group compared to the control group, while an increase of 133% was observed in the escin-treated group. Besides, in serum and liver samples, it was found that escin showed strong antioxidant properties by decreasing the amount of TOC and increasing TAC levels in the group escin administered with hydrogen peroxide, compared to the group administered only with hydrogen peroxide. It was also observed that escin significantly suppressed the levels of IL-1 & beta; induced by hydrogen peroxide. As a result, escin was thought to be an alternative molecule in improving growth performance by showing significant antioxidant activity in the prevention of oxidative stress and inflammation in quails. However, multiple trials and detailed molec-ular analyzes are needed to obtain more detailed information on the subject.