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    EFFECT OF SHORT-TERM CYPERMETHRIN EXPOSURE ON OXIDANT-ANTIOXIDANT BALANCE IN THE WHOLE BODY OF RAINBOW TROUT FRY (Oncorhynchus mykiss)
    (Parlar Scientific Publications (P S P), 2011) Sakin, Fatih; Ispir, Unal; Yonar, Serpil Mise; Yonar, M. Enis; Taysi, M. Resit
    The objective of this study was to investigate the propensity of cypermethrin (CYP) to induce whole body oxidative stress in rainbow trout following exposure. We investigated the effect of CYP (10%, 5%, 2% and 1% of the 4-day rainbow trout now-through LC50 1.46 mu g/L CYP) on antioxidants in rainbow trout fry, Oncorhynchus mykiss, using standard laboratory conditions. 24 h exposure caused induction of malondialdehyde (MDA) and various antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GSH-Px) and reduced glutathione (GSH) in the whole body. Fish were monitored for clinical signs. Results obtained showed that CYP significantly (p < 0.05) increased MDA level. Compared to controls, activities of GSH, GSH-Px, and CAT were significantly (p < 0.05) reduced in the whole bodies of rainbow trout fry exposed to CYP.
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    OXIDATIVE STRESS BIOMARKERS OF EXPOSURE TO DELTAMETHRIN IN RAINBOW TROUT FRY (Oncorhynchus mykiss)
    (Parlar Scientific Publications (P S P), 2011) Yonar, Serpil Mise; Sakin, Fatih; Yonar, M. Enis; Ispir, Unal; Kirici, Muammer
    Deltamethrin (DM) is a widely used pesticide based on pyrethroids, and is reported to be extremely toxic to fish species. We investigated the effect of DM concentrations (0.010, 0.0125 and 0.0250 mu g/L) on antioxidants in rainbow trout, Oncorhynchus mykiss, using standard laboratory conditions. 24 h exposure caused whole body induction of various antioxidant enzymes and nonenzymatic antioxidants. Results showed that DM significantly (p<0.05) increased malondialdehyde (MDA) levels. Catalase (CAT) activity decreased in all experimental groups. Glutathione (GSH) was significantly (p<0.05) increased in the group with DM concentration of 0.0250 mu g/L DM for 24 h. The activity of glutathione peroxidase (GSH-Px) was found to be statistical significantly (p<0.05) decreased in all other experimental groups except the 0.010 mu g/L DM treated group. The parameters studied in this investigation can also be used as biomarkers of exposure to DM. It is suggested that appropriate ecotoxicological risk assessments should be made wherever DM is proposed for use in pest control activities.