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Öğe Ameliorating effect of quercetin on acute pentylenetetrazole induced seizures in rats(E-Century Publishing Corp, 2014) Sefil, Fatih; Kahraman, Ibrahim; Dokuyucu, Recep; Gokce, Hasan; Ozturk, Atakan; Tutuk, Okan; Aydin, MehmetObjective: The aim of the study to elicit effects of pure quercetin in pentylenetetrazole (PTZ) and picrotoxin induced seizures. Materials and methods: Each animal group was divided into six groups and composed of six rats. Rats were assigned to the following experiments and groups (G): (G1) PTZ 45 mg/kg + DMSO; (G2) PTZ 45 mg/kg + 5 mg/kg quercetin; (G3) PTZ 45 mg/kg + 10 mg/kg quercetin; (G4) PTZ 45 mg/kg + 20 mg/kg quercetin; (G5) PTZ 45 mg/kg + 40 mg/kg quercetin; (G6) Picrotoxin 5 mg/kg + DMSO; (G7) Picrotoxin 5 mg/kg + 10 mg/kg quercetin; (G8) Picrotoxin 5 mg/kg + 20 mg/kg quercetin. In all groups quercetin were injected 30 min before PTZ and picrotoxin applications. Results: Compared to PTZ, quercetin significantly prolonged onset of the seizure in 10 mg/kg (P < 0.05) and reduced the seizure stage in 10 mg/kg quercetin injected group (P < 0.01). Compared to PTZ, quercetin also declined the generalized seizure duration at 10 mg/kg (P < 0.01) and 20 mg/kg (P < 0.05) doses. At the doses of 5 mg/kg and 40 mg/kg quercetin there were no significant changes in seizure parameters. Development of picrotoxin induced seizures is slower than in PTZ. Quercetin was found to be unable to prevent seizure in picrotoxin induced seizures. Surprisingly, quercetin also significantly reduced the onset of seizures at the dose of 20 mg/kg (P < 0.05). Conclusion: quercetin (at doses of 10 and 20 mg/kg i.p) prevented seizures in PTZ (45 mg/kg i.p) induced seizures. Especially, 10 mg/kg PTZ prolonged onset of seizures, reduced the seizure duration and seizure severity score in comparison with control group. At a higher (40 mg/kg) dose quercetin failed to prevent PTZ induced seizures. In addition 20 mg/kg quercetin significantly reduced the onset of seizures that suggest a preconvulsive effect. 20 mg/kg quercetin reduced the onset of picrotoxin induced seizures. In picrotoxin model, it may be claimed that quercetin at higher doses accelerate the epileptic activity owing to its antagonistic effect on GABAA. Further investigations are needed to explore the mechanisms of the antiepileptic and preconvulsant effects of quercetin.Öğe Capparis Spinosa L. in an Animal Model of Sciatic Crush Injury(Wiley, 2019) Ishakoglu, Ozlem Kutlu; Tutuk, Okan; Dogan, Hatice; Demir, Enver Ahmet; Secinti, Ilke Evrim; Kara, Mikail; Kahraman, Ibrahim[Abstract Not Available]Öğe An Investigation of Correlation Between Electrophysiological and Functional Recovery After the Sciatic Nerve Injury(Cukurova Univ, Fac Medicine, 2012) Guven, Mustafa; Kahraman, Ibrahim; Gunay, IsmailPurpose: Video or photo assisted footprint analysis method is used to determine the motor and sensorial development instead of classic walking track footprint analysis in experimental peripheral nerve injury. Besides, the sucrose-gap method is used for measuring the electrophysiological activity in the sciatic nerves in-vitro. The aim of this study is to investigate the relationship between functional and electrophysiological recovery during the nerve regeneration in Wistar rats. Methods: In the experiments, after the unilateral sciatic nerve crushing, the rats were evaluated at the preoperative and 2nd, 4th, 6th and 8th weeks postoperative using the sucrose gap method, and photo assisted footprint method. The compound action potentials (CAP), the Peak-time (PT) and the 1/2 Falling-time (1/2FT) were measured, and compared to functional results. Results: Two weeks after being crushed sciatic nerves, complete function loss was seen operated legs in all rats. The amplitude of CAP was determined too small. The PT and the 1/2FT values were three fold longer than intact. However, following 4th - 8th weeks, the amplitude of CAP and other parameters of CAP were closed to intact values. Conclusion: The findings indicated that the results of the functional recovery were correlated to electrophysiological results. However, functional results showed almost full functional recovery in the 4th week, the electrophysiological results did not reach to intact values in the 8th week. We conclude that photo assisted footprint analysis method and sucrose-gap technique, which are useful functional and electrophysiological methods to produce complementary knowledge with each other in the investigation of experimental peripheral nerve regeneration.Öğe Investigation of the Effect of Capari (Capparis spinosa) in Sciatic Nerve Regeneration(Wiley, 2018) Ishakoglu, Ozlem; Tutuk, Okan; Dogan, Hatice; Demir, Enver Ahmet; Kahraman, Ibrahim; Tumer, Cemil[Abstract Not Available]Öğe Investigation of the Effect of Macrophage-Mediated Pulsed Magnetic Field to the Sciatic Nerve Regeneration(Wiley-Blackwell, 2015) Kahraman, Ibrahim; Guven, Mustafa; Dokuyucu, Recep; Sefil, Fatih; Gunay, Ismail[Abstract Not Available]Öğe Investigation of the Efficacy of Vitamin B Complexes on Peripheral Nerve Injuries Treatments in Experimental Models(Wiley-Blackwell, 2015) Temel, Metin; Gokce, Hasan; Dokuyucu, Recep; Kahraman, Ibrahim; Akdag, Abdurrahman; Sefil, Fatih[Abstract Not Available]
