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    Effects of vitamin D3 and calcium on fracture healing in rats
    (Turkiye Klinikleri, 2006) Aslan, Bahadir; Kalaci, Aydmer; Bozlar, Murat; Atik, Esin; Yanat, Ahmet Nedim; Taşçi, Arzu
    Objective: We aimed in this study, to evaluate the effects and mechanism of action of single high-dose vitamin D3 and calcium on fracture healing in rats. Material and Methods: A total of 40 rats were divided into four groups; the first group (Group A) was treated with calcium, the second group (Group B) with vitamin D3, the third group (Group C) with calcium and vitamin D3 combination, and the fourth group was the control group (Group D). Tibiae of the rats were osteotomized by a Gigli saw. All rats were sacrificed 3 weeks after surgery. The results obtained were compared by mechanical testing, histological examination and radiographic evaluation. Results: Mean radiographic scores were 1.6 ± 0.8 for group D; 1.7 ± 0.8 for group A; 2.3 ± 0.8 for group B; and 2.4 ± 0.7 for group C. There was a statistically significant difference between the mean radiographic scores of only groups C and D (p = 0.037). There was also a statistically significant difference between the corresponding fracture load values of group D and all the other groups (p = 0.000), but there was no such difference between the corresponding fracture load values of the groups A and B (p = 0.208). Mean histological scores were 5.6 ± 2.7 for group D; 6.0 ± 2.7 for group A; 7.0 ± 2.1 for group B; and 7.2 ± 1.9 for group C (p> 0.05). Conclusion: These results suggested that the real effect of vitamin D on fracture healing was via calcium metabolism. We conclude that calcium and vitamin D given in the early stages of fracture healing gave opportunity for early weight bearing. Copyright © 2006 by Türkiye Klinikleri.
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    Insufficiency fractures of both femoral necks in a young adult caused by osteoporosis
    (Springer, 2008) Kalaci, Aydmer; Yanat, Ahmet Nedim; Sevinc, Teoman Toni; Dogramaci, Yunus
    Insufficiency fractures of femoral necks due to osteoporosis of unknown aetiology occurring coincidentally on both sides in young adults, have not been described in English literature so far. A 18-year-old young girl presented with a 3-month history of gradual onset of bilateral thigh pain and progressive inability to walk. At the first look, plain radiographs of both hips showed no gross abnormal findings other than some tips on reduced bone mineral density of the femoral necks. MRI was ordered upon a high suspicion of fracture and T1-weighed MRI showed a linear low signal on both femoral necks. Dual-energy X-ray absorptiometry of the lumbar spine and femoral neck showed low mineral density. She was treated surgically with in-situ internal fixation using cannulated screws. The bilateral thigh pain was resolved and walking started immediately after the treatment. Insufficiency fracture of the femoral neck due to osteoporosis should be kept in mind even in young adults complaining of atypical pain without evidence of unusual activities. We used both the terms of stress fracture and insufficiency (osteoporotic) fracture interchangeably as the mechanism of fractures resemble each other.
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    METACHRONOUS MULTICENTRIC GIANT CELLTUMOR OF THE UPPER LIMB
    (Istanbul Univ, Faculty Medicine, Publishing Office, 2006) Kalaci, Aydmer; Ozkan, Cenk; Ozbarlas, Serdar
    Metachronous multicentric giant cell tumor (GCT) of bone is a rare entity. The high recurrence rate after curettage may mean that more aggressive surgical management is mandatory, including en-bloc resection when indicated. We report a young woman presenting with metachronous recurrent benign GCT located at the right proximal humerus and a second lesion at the ipsilateral distal radial metaphysis. The case was successfully treated with an aggressive surgical approach (en-bloc resection).