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    Effects of acetylsalicylic acid on rats: An in vivo experimental study in azaserine-rat model
    (Wolters Kluwer Medknow Publications, 2019) Yildiz, Hasan; Kalipci, Erkan; Oztas, Haydar; Yildiz, Deniz
    Aim: The effect of acetylsalicylic acid (ASA) on thiol levels was studied in a rat model of azaserine carcinogenesis. Materials and Methods: ASA and azaserine were applied to the animals to research changes in cellular sulfhydryl (-SH) content and variations in free and protein-bound molecules containing the -SH group. Such effects in rats injected with azaserine were investigated at low (200 ppm) and high (400 ppm) concentrations of ASA over a relatively short (6 months) and a relatively long (12 months) period. Results: Changes in the hepatic, pancreatic, and renal -SH contents were also determined. Conclusion: Compared to the other tissues studied, the liver contained the highest levels of both free and protein-bound -SH.
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    Investigation of Possible Ecotoxic Effects of Acrylamide on Liver with the Azaserine-Rat Model
    (Hard, 2012) Kalipci, Erkan; Yener, Yesim; Yildiz, Hasan; Oztas, Haydar
    In this study, when acrylamide is taken into the body by nutrition, it was aimed to investigate its ecotoxic and/or carcinogenic effects on the liver. The Azaserine-Rat model developed by Longnecker and Curphey was used in this research, and in total 60 Wistar Albino race male rats were used, including 10 rats in each group. The rats were fed for 16 weeks by adding acrylamide at rates of 5 mg/kg/day and 10 mg/kg/day in drinking water. Moreover, neoplastic structures were formed by azaserine application and its effect on the development of these neoplastic structures was also investigated. As a result of this study, it was determined that ecotoxic and histopathological alterations, together with atypical cells, focuses formed in the livers of the rats in the group to which azaserine was applied and in the livers of the rats in the groups that included 5 and 10 mg/kg/day acrylamide in their drinking water. Moreover, it was found that the development (average focus diameter and focus volume) of neoplastic structures formed with azaserine was increased by 5 and 10 mg/kg/day acrylamide. These results make it possible for the probability of acrylamide to be a cancer initiator in the livers of rats.