Yazar "Karadag, Mehmet" seçeneğine göre listele
Listeleniyor 1 - 20 / 27
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Association of MEFV mutations and vascular involvement in Behcet's disease: a study from Hatay, Turkey(Termedia Publishing House Ltd, 2022) Serarslan, Gamze; Cura, Sibel Elmacioglu; Kimyon, Gezmis; Ucgul, Goekhan; Karadag, MehmetIntroduction: In this study, we aimed to determine the frequency of MEFV mutations in Behcet's disease (BD) and to investigate the relationship between clinical findings of the disease and the MEFV mutations. Material and methods: A total of 66 participants (30 BD patients, 36 healthy subjects) were included in this study. The MEFV gene was analyzed by using DNA sequence analysis. Results: The distribution of MEFV mutations was not significantly different between the patients and the control group (p = 0.373). However, individuals with R202Q mutation had a risk of OR 4 times (95% CI: 1.1-14.5) higher than those without the mutation (p = 0.035). The rate of vascular involvement was statistically significantly higher in patients with the mutation than in patients without the mutation (p = 0.005). Conclusions: MEFV mutation was associated with vascular involvement in patients with BD. This is also the first study to indicate that the R202Q mutation may have a role in BD. However large series from different regions are required to compare these results.Öğe Classical versus non-classical EGFR mutations: Erlotinib response and impact of renal insufficiency(Sage Publications Ltd, 2021) Celik, Emir; Samanci, Nilay Sengul; Karadag, Mehmet; Demirci, Nebi Serkan; Cikman, Duygu Ilke; Derin, Sumeyra; Bedir, SahinIntroduction Erlotinib is an effective treatment option for EGFR-mutant non-small cell lung cancer. It is important to predict patients who will respond better to erlotinib. We designed this study to investigate the effect of renal insufficiency (RI) on erlotinib treatment outcomes. Methods All patients receiving erlotinib were stratified into 3 groups. Group 1 consisted of non-RI subjects with classical epidermal growth factor receptor (EGFR) mutations, Group 2 consisted of those with RI (Estimated glomerular filtration rate <60 mL/min) and classical EGFR mutations, and Group 3 consisted of those with non-classical EGFR mutations. Results 82 patients were included in the study. Median progression-free survival (PFS) in patients with classical mutation was approximately 6 months shorter in those with RI, although not statistically significant. Median overall survival (OS) in Group 1, 2 and 3 was 34.1 months, 35.2 months, and 15 months, respectively and although not statistically significant, median OS was 20 months shorter in Group 3. Univariate and multivariate cox-regression analysis revealed shorter PFS and OS in males and those with ECOG >= 2 while PFS and OS were longer in those with recurrent lung tumors and generating rash during erlotinib treatment. There was no difference between RI and non-RI patients in terms of adverse events except for fatigue and appetite loss. Conclusions This research showed OS in patients with and without RI was comparable. Although not statistically significant, PFS in patients with classical mutation was approximately 6 months shorter in those with RI patients.Öğe Effects of cognitive tasks on eye movements(Springer Heidelberg, 2022) Sarac, Elif Tugba; Batuk, Merve Ozbal; Yarali, Mehmet; Karadag, Mehmet; Aksoy, Songul; Akoglu, ErtapEye movements are guided by vestibular and visual information. The vestibulo-ocular knowledge of the vestibule includes eye movements in the opposite direction of head movements. This study investigated the effect of auditory what and where tasks on the visual where to evaluate the effects of cognitive tasks on eye movements. All subjects underwent testing with videonystagmography (VNG). The VNG battery of saccade and tracking oculomotor tests were performed. The study design was planned in three stages: (1) without any cognitive tasks, eye movements were recorded with VNG, (2) participants were asked to tell what sound they heard during VNG recording, and (3) the subject was asked to tell from what direction, or where, the sound had come from during VNG recording. Providing individuals with a cognitive task changed the test results negatively in all parameters. Giving cognitive tasks to individuals spoils all VNG parameters. The VNG oculomotor tests are affected by the dual tasks. Daily tasks such as sound object localization and recognition have a significant effect on scanning the visual environment in daily life such as during driving or walking in a crowded environment.Öğe Electric scooters as a silent source of danger in increasing use among young people: a single-center in-depth accident analysis(Turkish Assoc Trauma Emergency Surgery, 2023) Demir, Necdet; Dokur, Mehmet; Agdogan, Ozgur; Koc, Suna; Karadag, Mehmet; Dokur, Ibrahim FikriBACKGROUND: The reasons for the increase in accidents involving shared stand-up e-scooters in recent years may be the wide-spread use of e-scooters among young people, especially in metropolitan areas with heavy traffic, non-compliance with traffic rules, and insufficient legal regulations. In this study, we analyzed in detail the typical features of rider-sharing e-scooter-related injuries brought to the emergency department of our hospital in the light of current literature.METHODS: The clinical and accident characteristics of 60 patients with surgical requirements who were brought to the emergency department of our hospital due to e-scooter-related accidents between 2020 and 2020 were analyzed using statistical methods ret-rospectively.RESULTS: The majority of the victims were university students and the number of victims of the male gender was slightly higher and the mean age was 25.3 +/- 13.0 years. Most e-scooter accidents occur on weekdays. Most of the e-scooter-related accidents happen on weekdays and are non-collision type accidents. The majority of e-scooter-related accident victims were in the minor trauma group (injury severity score <9), predominantly had extremity and soft-tissue injuries and needed radiological examination (44 patients, 73.3%), and only eight victims (13.3%) required surgical operation and also all of the e-scooter victims were discharged fully healed.CONCLUSION: Among the more common collision-free e-scooter-related accidents that have a lower trauma severity score or cause minor soft-tissue injury, mono-trauma occurs more commonly than multisystem trauma; likewise, radius and nasal-weighted monofractures occur more commonly than multiple fractures, according to this study. Besides, effective measures and legal regulations should be put in place to prevent e-scooter-related accidents.Öğe Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats(Kare Publ, 2022) Sener, Dila; Kocak, Mihrican; Saracoglu, Ramazan; Deveci, Ugur; Karadag, MehmetBackground and Aim: In this study, we aimed to assess the hemostatic and histopathological impacts of the Algan hemostatic agent (AHA) with the liver injury model. Materials and Methods: 24 male rats, 10-12 week old, were randomly divided into three equal groups (n=8) as control (physiological saline solution), AHA liquid and AHA powder. A total of three iatrogenic cut injuries were performed on the anterior surface of the left liver lobe. After bleeding started, sponges soaked with physiological saline, AHA liquid, AHA powder were gently pressed on the injured area for 20 seconds in corresponding groups, respectively. The bleeding time was measured with a timer. Failure to stop bleeding after three consecutive applications was considered as a failure. Animals were euthanized at the tenth minute of the procedure. Left liver lobes were removed for histopathological examination. Results: Bleeding control success rates of AHA liquid were significantly higher than that of the AHA powder group, and both forms were more effective than physiological saline. A superficial thick granulation tissue with entrapped powder residual materials was detected in the AHA powder group. Liver parenchyma was intact in liquid and powder groups. Conclusion: AHA is a fast-acting and applicable hemostatic agent in the liver bleeding model. However, further comparative studies in various organs are needed.Öğe In-hospital and short-term predictors of mortality in patients with intermediate-high risk pulmonary embolism(Tabriz Univ Medical Sciences & Health Services, 2020) Gok, Gulay; Karadag, Mehmet; Cinar, Tufan; Nurkalem, Zekeriya; Duman, DursunIntroduction: The aim of this study was to evaluate the in-hospital and short-term predictive factors of mortality in intermediate-high risk acute pulmonary embolism (PE) patients with right ventricle (RV) dysfunction and myocardial injury. Methods: In this retrospective study, the medical records of 187 patients with a diagnosis of intermediatehigh risk acute PE were evaluated. A contrast-enhanced multi-detector pulmonary angiography was used to confirm diagnosis in all cases. All-cause mortality was determined by obtaining both in-hospital and 30 days follow-up data of patients from medical records. Results: During the in-hospital stay (9.5 +/- 4.72 days), 7 patients died, resulting in an acute PE related in-hospital mortality of 3.2%. Admission heart rate (HR), (Odds ratio (OR), 1.028 95% Confidence interval (CI), 0.002-1.121; P = 0.048) and blood urea nitrogen (BUN) (OR, 1.028 95% CI, 0.002-1.016; P = 0.044) were found to be independent predictors for in-hospital mortality in a multivariate logistic regression analysis. In total, 32 patients (20.9%) died during 30 days follow-up.The presence of congestive heart failure (OR, 0.015, 95%CI, 0.001-0.211; P = 0.002) and dementia (OR, 0.029, 95%CI, 0.002-0.516; P = 0.016) as well as low albumin level (OR, 0.049 95%CI, 0.006-0.383; P = 0.049) were associated with 30 days mortality. Conclusion: HR and BUN were independent predictors of in-hospital mortality and the presence of congestive heart failure, dementia, and low albumin levels were associated with higher 30 days mortality.Öğe Investigating the Levels of Brain-Specific Proteins in Hydrocephalus Patients(Bentham Science Publ Ltd, 2021) Guzelcicek, Ahmet; Gonel, Ataman; Koyuncu, Ismail; Cigdem, Gulyara; Kose, Dogan; Karadag, Mehmet; Cadirci, DursunBackground: Hydrocephalus, a common brain disorder in children, can cause permanent brain damage. A timely diagnosis of this disorder is crucial. Objective: The aim of this study was to evaluate the levels of S-100, CK-18, and NSE brain-specific proteins in patients with hydrocephalus. We examined the levels of these proteins in the blood samples of hydrocephalic patients. Methods: The study was conducted on the hydrocephalus (n = 31) patients and a healthy control group (n = 30). A Receiver Operating Characteristic (ROC) curve was used to assess the validity of the NSE, CK-18, and S100B to differentiate between the hydrocephalus and the control groups. The suitability of the data to the normal distribution was tested with the Shapiro Wilk test, and the Student t-test was used to compare the characteristics of the normal distribution in two independent groups. The individuals in the hydrocephalus and control groups had similar values in terms of age, height, and weight. Results: It was observed that NSE, CK-18, and S100B mean values of the individuals in the hydrocephalus group were significantly higher than NSE, CK-18, and S100B mean values of the control group. Conclusion: Experiments have shown that the levels of these proteins increase significantly in hydrocephalus patients compared to the healthy group. These three parameters can be considered as important markers in the diagnosis of hydrocephalus.Öğe An investigation of potential coronaphobia-related factors in adults and sleep quality relations(Elsevier, 2021) Karaaslan, Yasemin; Mete, Oguzhan; Karadag, Mehmet; Kaya, Derya Ozer; Celenay, Seyda ToprakBackground: The study aimed to investigate potential coronaphobia-related factors in adults and to assess the relationship between coronaphobia and sleep quality. Methods: This cross-sectional study was conducted in 1262 participants. The Covid-19 Phobia Scale (C19P-S) and Jenkins Sleep Scale (JSS) were used to measure outcomes. Univariate and multivariate logistic regression analyses were constructed to determine risk factors for coronaphobia. Pearson correlation coefficient was used to assess the correlation between C19P-S and JSS. Results: The following risk factors were found to be associated with coronaphobia: gender, marital status, presence of chronic disease, staying home, and sleep disturbances. Female gender (OR = 2.23 and OR = 2.12), being married (OR = 1.31 and OR = 1.45), chronic disease status (OR = 1.39 and OR = 1.27), staying home (OR = 1.72 and OR = 1.35) and sleep disturbances (OR = 2.63 and OR = 2.49) were found to be associated with the likelihood of having a higher coronaphobia score (p < 0.05). Weak positive correlations were found between C19P-S and its subscales and JSS scores (p < 0.001). Conclusions: Female gender, being married, having chronic diseases, staying home, and having sleep disturbances were found to be risk factors for having high coronaphobia scores. Moreover, the severity of coronaphobia was associated with sleep disturbances. These results should be considered in the management of coronaphobia. (C) 2021 Elsevier B.V. All rights reserved.Öğe Lower urinary tract symptoms and toileting behaviors in Turkish adult women(Routledge Journals, Taylor & Francis Ltd, 2023) Celenay, Seyda Toprak; Dusgun, Elif Sena; Karaaslan, Yasemin; Urus, Gulcin; Karadag, Mehmet; Ozdemir, EnverThis study aimed to investigate lower urinary tract symptoms (LUTS) in Turkish adult women and to compare toileting behaviors in women with and without LUTS. This cross-sectional study was conducted in 815 women. The International Consultation on Incontinence Modular Questionnaire - Female LUTS and a toileting behaviors form, created by the authors, were used in evaluations. Nearly 50 % of the women had at least one LUTS, 45.8 % had storage symptoms, 7.4 % had voiding symptoms, and 20.2 % had incontinence symptoms. The rates of premature urination, straining during urination, delayed urination, and sitting on the toilet while urinating were higher in women with LUTS than in women without LUTS (p < .05). The rate of squatting on the toilet while urinating was lower in women with LUTS than those without LUTS (p < .05). Various LUTS were common in adult women. Some toileting behaviors such as premature urination, straining during urination, delayed urination, and sitting on the toilet while urinating were higher in women with LUTS compared to women without LUTS. Since the rate of unhealthy toilet behaviors is higher in women with LUTS, it is important to know unhealthy toilet behaviors in the management of LUTS and to organize training programs to prevent these behaviors and LUTS.Öğe Most notable 100 articles of COVID-19: an Altmetric study based on bibliometric analysis(Springer London Ltd, 2021) Borku Uysal, Betul; Islamoglu, Mehmet Sami; Koc, Suna; Karadag, Mehmet; Dokur, MehmetObjective The purpose of this study is to guide researchers in the COVID-19 pandemic by evaluating the 100 most cited articles of COVID-19 in terms of bibliometric analysis, Altmetric scores, and dimension badges. Methods COVID-19 was entered as the search term in Thomson Reuter's Web of Science database. The 100 most cited articles (T100) were analyzed bibliometrically. Altmetric attention scores (AASs) and dimension badge scores of the articles were evaluated. Results T100 articles were published from January to September 2020. The average citation of the top 100 articles on COVID-19 was 320 +/- 344.3 (143-2676). The language of all articles was English. The average Altmetric value of T100 is 3246 +/- 3795 (85-16,548) and the mean dimension badge value was 670 +/- 541.6 (176-4232). Epidemiological features (n = 22) and treatment (n = 21) were at the top of the main topics of T100 articles. Conclusion The more citations an article is made, the more it indicates the contribution of that article to science. However, the number of citations is not always the only indicator of article quality. The existence of methods that measure the impact of the article outside the academia to measure the value of the article arises more in an issue that affects the whole world, such as the COVID-19 pandemic.Öğe A New Risk Score to Predict In-Hospital Mortality in Elderly Patients With Acute Heart Failure: On Behalf of the Journey HF-TR Study Investigators(Sage Publications Inc, 2020) Gok, Gulay; Karadag, Mehmet; Sinan, Umit Yasar; Zoghi, MehdiWe aimed to predict in-hospital mortality of elderly patients with heart failure (HF) by using a risk score model which could be easily applied in routine clinical practice without using an electronic calculator. The study population (n = 1034) recruited from the Journey HF-TR (Patient Journey in Hospital with Heart Failure in Turkish Population) study was divided into a derivation and a validation cohort. The parameters related to in-hospital mortality were first analyzed by univariate analysis, then the variables found to be significant in that analysis were entered into a stepwise multivariate logistic regression (LR) analysis. Patients were classified as low, intermediate, and high risk. A risk score obtained by taking into account the regression coefficients of the significant variables as a result of the LR analysis was tested in the validation cohort using receiver operating characteristic curve analysis. In total, 6 independent variables (age, blood urea nitrogen, previous history of hemodialysis/hemofiltration, inotropic agent use, and length of intensive care stay) associated with in-hospital mortality were included in the analysis. The risk score had a good discrimination in both the derivation and validation cohorts. A new validated risk score to determine the risk of in-hospital mortality of elderly hospitalized patients with HF was developed by including 6 independent predictors.Öğe Pelvic floor dysfunction symptoms and knowledge level in obese women(Routledge Journals, Taylor & Francis Ltd, 2022) Karaaslan, Yasemin; Karadag, Mehmet; Celenay, Seyda ToprakThis study compared the pelvic floor dysfunction (PFD) symptoms and knowledge levels in obese and non-obese women. The study included 40 obese and 41 non-obese women. The presence of PFD and the severity of its symptoms were questioned with the Pelvic Floor Distress Inventory-20 (PFDI20) (its sub-scales: Pelvic Organ Prolapse Distress Inventory-6 (POPDI-6), Colorectal-Anal Distress Inventory-8 (CRADI-8), Urinary Distress Inventory-6 (UDI-6)). Participants' PFD knowledge levels were evaluated with the Prolapse and Incontinence Knowledge Questionnaire (PIKQ) and the Anal Incontinence Knowledge Questionnaire (AIKQ). The rates of urinary incontinence (UI) and pelvic organ prolapse (POP) symptoms were higher in the obese group compared to the control group (p = .001). The POPDI-6, CRADI-8, UDI-6, and PFDI-20 scores were higher in the obese group compared to the control group (p < .001). Moreover, the knowledge level related to treatment methods for PFD was lower in the obese women compared to the non-obese women (p < .05). PFD symptom incidence and severity were higher and knowledge levels related to PFD were lower in the obese women compared to the non-obese women. Informative teaching programs on this issue would be beneficial as part of preventive health services.Öğe Polisomographic Investigation of Sleep Disorders in Patients with Sickle Cell Anemia and Evaluation of the Effect on the Prognosis(Aves, 2022) Dikmen, Nursel; Okuyucu, Emine Esra; Guntel, Murat; Ucar, Edip; Ilhan, Gul; Babayigit, Cenk; Karadag, MehmetOBJECTIVE: The aim of this study is to identify sleep disorders in adults with sickle cell disease and to examine the effects of accompanying sleep disorders on the prognosis of sickle cell disease. MATERIAL AND METHODS: Twenty-eight patients followed up with a diagnosis of sickle cell disease and 22 healthy volunteers were included in our study. RESULTS: Both groups had similar characteristics in terms of age, gender, and body mass index. More obstructive sleep apnea syndrome was detected in the sickle cell group than in healthy volunteers. Statistically, the sickle cell patient group had higher apnea-hypopnea index and lower nighttime oxygen desaturation. As the degree of obstructive sleep apnea syndrome increased in the sickle cell group, it was found that there were more emergency admissions and hospitalization due to painful crises and/or acute chest syndrome in the last 1 year. Also, lower sleep efficiency was found in the sickle cell disease patient group. In the sickle cell group, it was found that the restless leg syndrome severity was statistically significantly more. CONCLUSION: As hypoxia deepens in sickle cell patients, mortality and morbidity due to the disease increase significantly. Comorbid sleep disturbances in sickle cell patients exacerbate nocturnal hypoxia and negatively affect the prognosis of the disease. Therefore, patients with sickle cell disease should be questioned in detail in terms of obstructive sleep apnea syndrome and, if necessary, polysomnographic evaluation should be performed to provide treatment for sleep disorders in the early period.Öğe Positron emission tomography/ computed tomography (PET/CT) findings in lung nodules and masses: A single-center experience(Kare Publ, 2023) Akgun, Kadir Burak; Atilgan, Hasan Ikbal; Karadag, Mehmet; Dikmen, NurselBACKGROUND AND AIM: Positron Emission Tomography/Computed Tomography (PET/CT) is utilized as a guide for sampling lung lesions and for staging lung cancer. In this study, we exam-ined the importance of mass size and Standardized Uptake Value maximum (SUVmax) values in predicting cancer in lesions identified on PET/CT.METHODS: We analyzed PET/CT results from patients diagnosed with newly discovered lung cancer or those presenting lung lesions in other radiological imaging. The lesion's longest diameter and the areas with the highest SUVmax values were recorded. Lesion-nodule categorization, as well as benign-malignant differentiation and cancer subtypes, were separately examined with respect to diameter and SUVmax involvement.RESULTS: Separate diameter and SUVmax cut-off values were determined for predicting can-cer in lesions and nodules. For all lesions, the likelihood of malignancy increases when the size exceeds 27.5 mm and the SUVmax value surpasses 5.428 (p<0.001, p<0.001). Concern -ing nodules, the malignancy threshold lies at a size of 15.5 mm and an SUVmax value of 4.54 (p<0.001, p=0.022). It was observed that lesion size and SUV(max)value in primary lung cancers were significantly higher than in metastatic lung cancers (p=0.002, p=0.04). SUVmax uptake was lower in small cell lung cancer (SCLC) lesions compared to non-small cell lung cancer (NSCLC) lesions (p=0.001). The longest diameter was higher in adenocarcinoma than in squamous cell carcinoma (p=0.028).CONCLUSIONS: PET/CT plays a crucial role in staging patients diagnosed with lung cancer. In cases where cancer is suspected but diagnosis is challenging, PET/CT findings, along with the individual's risk factors, will aid in clinical decision-making.Öğe The relationship between eGFR and capecitabine efficacy/toxicity in metastatic breast cancer(Humana Press Inc, 2021) Celik, Emir; Samanci, Nilay Sengul; Karadag, Mehmet; Demirci, Nebi Serkan; Demirelli, Fuat Hulusi; Ozguroglu, MustafaThe objective of this study was to evaluate the efficacy and toxicity of capecitabine in metastatic breast cancer (mBC) according to the estimated glomerular filtration rate (eGFR). A total of 135 patients included in the final analysis were stratified into 3 categories according to baseline eGFR, i.e., eGFR <60 mL/min/1.73 m(2) (Group 1), eGFR 60-90 mL/min/1.73 m(2) (Group 2) and eGFR >90 mL/min/1.73 m(2) (Group 3). If a patient developed a level of toxicity that would lead to capecitabine dose reduction, this was recognized as dose-limiting toxicity (DLT). The dose was reduced due to toxicity in 95 cycles. A total of 95 DLTs were seen in 76 (56.2%) of the 135 patients. When 76 patients with DLT were evaluated according to eGFR, DLT was observed in 93.3% of those in Group 1, 72.5% of those in Group 2 and 41.3% of those in Group 3 (p < 0.001). The median time to progression (TTP) of all patients was 7.4 months. No significant difference in TTP was observed in patients stratified into 3 groups according to eGFR. When the patients were divided into two groups as DLT and without DLT, the median TTP was 8.68 months (95% CI, 7.53-9.81 months) in those with toxicity and 6.23 months (95% CI, 4.04-8.43 months) in those without toxicity (log-rank p = 0.004). We found a significant relationship between low eGFR and increased risk of DLT. Having a DLT was associated with a longer TTP. It indicates the need for more data/larger study investigating these discrepancies.Öğe Relationship Between Oxidative Stress, Tau Level and Antioxidant Mechanisms of the KEAP-1/NRF-2/HO-1 in Children with Hydrocephalus(Bentham Science Publishers, 2021) Guzelcicek, Ahmet; Koyuncu, Ismail; Gönel, Ataman; Cigdem, Gulyara; Karadag, MehmetBackground: Hydrocephalus is a complex neurologic disorder that has a widespread impact on the central nervous system and a multifactor disease which affects the CSF dynamics and causes severe neurological impairments in children. The pathophysiology of hydrocephalus is not fully understood. However, increasing evidence suggests that oxidative stress may be an important factor in the pathogenesis of hydrocephalus. Objective: The purpose of this study is to investigate the relationship of the KEAP-1/NRF-2/HO-1 pathway, one of the main regulators of the antioxidant system in the hydrocephalus pathology, on oxidative stress and tau protein level. Methods: The study included 32 patients with hydrocephalus and 32 healthy controls. KEAP-1, NRF-2, HO-1, TAU, and MPO levels are measured using ELISA method TAS, TOS, and Total THIOL colorimetric method. Results: KEAP-1, TAS, and Total THIOL levels were found significantly lowerer in the hydrocephalus group than in the control group. Nevertheless, it was identified that in the hydrocephalus group that the NRF-2, HO-1, TAU, MPO, TOS, and OSI levels were significantly elevated. Conclusion: In conclusion, although the KEAP-1/NRF-2/HO-1 pathway is activated in patients with hydrocephalus, it is identified that the antioxidant defense system is insufficient and ultimately leads to elevated oxidative stress. The elevation in the tau level may be an indicator of oxidative stress induced neurodegenerative damage. © 2021 Bentham Science Publishers.Öğe The Relationship Between Symptom Severity and Caregiver Burden in Cancer Patients Under Palliative Care: A Cross-Sectional Study(Sage Publications Inc, 2022) Celik, Emir; Aslan, Muhammed Samil; Samanci, Nilay Sengul; Karadag, Mehmet; Saglam, Tarik; Celik, Yasemin Cakan; Demirci, Nebi SerkanIntroduction Hospitalization is a stressful experience both for primary caregivers (PCs) and cancer patients alike. Although there is significant evidence that PCs of cancer patients can experience significant caregiver burden (CB), less is known about the relationships between PCs and patient symptom severity that influence CB. Methods: In this cross-sectional study, measures of the symptom severity were obtained from cancer patients. The PCs were assessed for CB. Associations between patients' symptoms and demographic characteristics and CB were investigated using multivariate analyses. Results: A total of 98 participants (patient-caregiver dyads) filled the questionnaires. According to the Zarit Burden Interview results, 65.3% of PCs had a high CB. Pain, tiredness, nausea, depression, drowsiness, well-being, and dyspnea had significantly higher mean values in those with high CB (p < .05). Financial difficulties, first-degree relationships with the patient, higher anxiety levels, and more pronounced tiredness appear to be the variables most predictive with high CB. Conclusion: In conclusion, the present study showed CB of PCs among a group of hospitalized incurable cancer patients. PCs of more symptomatic cancer patients had a higher CB, according to our findings. This emphasized the significance of palliative care. Appropriate guidance should be provided for the psychostress caused by the CB.Öğe Reliability and Validity Study of the Turkish Version of the COVID-19 Peritraumatic Distress Index(Aves, 2021) Karadag, Mehmet; Kokacya, Mehmet HanifiObjective: The Coronavirus Disease 2019 (COVID-19) pandemic, affecting people worldwide, negatively affects the mental health of people. During this situation, accurate and reliable tools are needed to evaluate mental state. The aim of this study was to translate the COVID-19 Peritraumatic Distress Index (CPDI) into Turkish, and analyze it for validity and reliability. Methods: The original form of the CPDI was translated into Turkish using the back translation method. It was then applied to over 400 individuals, randomly selected from patients and their relatives, between the ages of 18 and 70, who presented to the outpatient clinics of Mustafa Kemal University Research Hospital. Data were collected with a demographic data form. Exploratory and confirmatory factor analyses were done. Construct validity, item content validity index, and content validity were analyzed. Cronbach's alpha vs. Spearman-Brown reliability analyses were done. Results: Cronbach's alpha coefficient for the CPDI was found to be 0.842, which is quite high. Cronbach's alpha coefficient for the subscales ranged from 0.670 to 0.780. The SpearmanBrown reliability coefficient was 0.730. The confirmatory factor analysis revealed good fit indices (.2/df = 1.94; root mean square error of approximation = 0.05; Comparative Fit Index = 0.93; Adjusted Goodness of Fit Index and Tucker-Lewis Index = 0.91). The mean total score was 27.26 (SD = 12.28), while the mean subscale scores ranged from 4.83 to 10.26. Conclusion: The Turkish version of the CPDI is valid and reliable, and can be used in studies evaluating the COVID-19 peritraumatic stress.Öğe Reply to Letter to the Editor-Treatment of Hepatic Hydatid Disease-Role of Surgery, ERCP, and Percutaneous Drainage: A Retrospective Study(Lippincott Williams & Wilkins, 2021) Muhammedoglu, Bahtiyar; Pircanoglu, Eyup M.; Piskin, Erol; Torun, Serkan; Karadag, Mehmet; Topuz, Sezgin; Koktas, Suleyman[Abstract Not Available]Öğe Role of adiponectin and leptin in patients with alopecia areata with scalp hair loss(Springer London Ltd, 2021) Serarslan, Gamze; Ozcan, Oguzhan; Okyay, Ebru; Unlu, Bahar; Karadag, MehmetBackground/aims Alopecia areata (AA) is considered an organ-specific autoimmune disease of hair follicles. Adipose tissue plays a role in lipid metabolism and glucose metabolism and secretes adipokines such as leptin and adiponectin. Dysregulation in the adipokine balance may be associated with metabolic syndrome. We aimed to determine serum adipokine levels in AA patients and compare them with healthy controls, and to determine whether there was metabolic syndrome and insulin resistance in the AA patients. Methods A total of 70 participants were included in the study. Patients were divided into two subgroups: patients with scalp hair loss were in subgroup 1 (AA1). Patients with beard and eyebrow hair loss were in subgroup 2 (AA2). Serum adiponectin, leptin, TNF-alpha, insulin, fasting glucose, TG, and HDL were analyzed. Results Thirty-six (25 male, 11 female) patients with AA and 34 (18 male, 16 female) healthy subjects were included in the study. Metabolic syndrome was detected in three of the AA patients and in two of the healthy subjects. Serum leptin, adiponectin, TNF-alpha, TG, HDL, and insulin levels and HOMA-IR scores were not statistically significant in patients compared with control subjects, except fasting glucose levels (p = 0.035). However, serum leptin and adiponectin levels were significantly higher in AA1 (n = 25) subgroup compared with the control group (p = 0.029,p = 0.026 respectively). There was a statistically significant increase in the fasting glucose level, while there were no differences in other parameters between the AA2 (n = 11) subgroup and the control group. Conclusions To our knowledge, this is the first report indicating that adiponectin and leptin probably has a role in the pathogenesis of AA with scalp hair involvement.
