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Öğe Apoptosisinbovineocularsquamousecellcarcinomas(2022) Kutlu, Tuncer; Karakurt, Emin; Aydın, Uğur; Beytut, Enver; Özaydın, İsa; Dağ, Serpil; Aksoy, ÖzgürAim: Cell death, especially apoptosis, is one of the most studied topics regarding cells. Understanding the mechanism of apoptosis in\rdiseases will help understand the pathogenesis of diseases, as well\ras the treatment. This study aims to grade the Bovine ocular squamous cell carcinoma (BOSCC) and to evaluate apoptosis in tumors\rwith different anaplastic features.\rMaterials and Methods: A total of 30 formalin-fixed tumor tissues\rconsisting of 10 poorly-differentiated, 10 moderately-differentiated,\rand 10 well-differentiated tissues were used to examine apoptosis in\rBOSCCs. Hematoxylin & eosin (HE) was performed for histopathological examination and TUNEL staining was performed for detection\rof apoptosis in all BOSCCs.\rResults: It was determined that apoptosis decreased as the malignancy increased in BOSCCs (p<0.001). Although all the tumors\rexamined were malignant, apoptosis, i.e. controlled cell death, was\rfound to be severe in well-differentiated type and mild in moderate\rand poorly-differentiated types.\rConclusion: It was concluded that this case observed in bovines\rshould be considered in studies on the pathogenesis of cancer and\rtreatment.Öğe Cell proliferation and apoptosis in canine oral papillomatosis(Urmia Univ, 2024) Karakurt, Emin; Coskun, Nuvit; Aydin, Ugur; Dag, Serpil; Beytut, Enver; Ataseven, Veysel Soydal; Yilmaz, VolkanThis study was aimed at the evaluation of cell proliferation, p53 level and apoptotic index by immunohistochemical methods in canine oral papillomatosis. The study material comprised of tumor tissue samples taken from six dogs being admitted to the Pathology Department of Faculty of Veterinary Medicine, Kafkas University, Kars, Turkiye. Choice of immunohistochemical staining was avidin-biotin peroxidase method. Cases of canine oral papillomatosis, determined to have been caused by canine papillomavirus-1, were found to have a rather high cell proliferation index. Furthermore, all cases were immunohistochemically demonstrated to carry a mutant p53 gene. Despite the mutation of p53 gene, the shift in the Bax/Bcl-2 ratio of dogs diagnosed with tumor was in favor of the pro-apoptotic Bax gene. The apoptotic mechanism was determined to occur through both the caspasedependent and caspase-independent pathways. While the lesions occupied the entire oral cavity in some cases, histopathologically, malignant transformation was not detected in any of the six cases.Öğe Molecular detection of Papillomavirus and immunohistochemical investigation of p53 gene expressions in bovine papillomas and fibropapillomas (vol 204, 278, 2022)(Springer, 2022) Karakurt, Emin; Coskun, Nuvit; Dag, Serpil; Beytut, Enver; Ataseven, Veysel Soydal; Yilmaz, Volkan; Dogan, Firat[Abstract Not Available]
