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    Clinical efficacy of diclofenac sodium and flunixin meglumine as adjuncts to antibacterial treatment of respiratory disease of calves
    (Wiley-Blackwell, 2010) Guzel, M.; Karakurum, M. C.; Durgut, R.; Mamak, N.
    Objective To compare the efficacy of the non-steroidal antiinflammatory drugs, diclofenac sodium and flunixin meglumine as adjuncts to the antibiotic treatment of bovine respiratory disease (BRD). Procedure We randomly allocated 80 Holstein calves with BRD to three groups. All the calves received a dose of 2.5 mg/kg tulathromycin by single subcutaneous injection and two of the groups received, in addition, either 2.5 mg/kg diclofenac sodium as a single intramuscular injection (diclofenac group, n = 30) or 2.2 mg/kg flunixin meglumine as an intravenous injection on the first three consecutive days after tulathromycin administration (flunixin group, n = 30). All calves were given a clinical score prior to initial treatment (day 0) and after treatment (days 1, 2, 3, 7 and 14) by observing appetite, demeanour, rectal temperature, the rate and type of respiration, presence or absence of coughing, and nasal discharge. Results During the first 48 h, improvement of adverse signs of respiratory disease, such as pyrexia and elevated respiratory rate, and of a high clinical index score was significant in the two adjunct groups compared with the calves receiving antibiotic alone. The reduction in pyrexia was greatest in the diclofenac group. There were no statically significant differences between treatment groups with regard to eventual perceived recovery from respiratory disease in 14 days. Conclusion In this trial, a single intramuscular dose of diclofenac sodium was equally effective as three intravenous injections of flunixin meglumine given on consecutive days as adjunctive therapy for BRD.
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    Evaluation of ivermectin tablets in the treatment of generalized canine demodicosis
    (Ecole Nationale Veterinaire Toulouse, 2007) Karakurum, M. C.; Ural, K.; Cingi, C. C.; Guzel, M.; Haydardedeoglu, A. E.; Borku, M. K.
    Sixteen privately owned dogs with generalized demodicosis included in this study. For the treatment of generalized demodicosis, tablet form of ivermectin (Efektin tablet (R) 10 mg, Sanovel) at a dose of 600 mu g kg(-1) daily was used in study dogs for 6-22 weeks. lvermectin was used at least for 2 weeks more after no mites (dead or alive) seen. All dogs had significant reduction in the in clinical signs and number of mites on skin scrapings during re-evaluations. All dogs became skin scrapings negative. After no mites were seen, treatment was continued for 2 more weeks and then stopped. But three dogs relapsed 5, 8 and 9 months after the therapy lasted. Remained 13 dogs were negative for skin scrapings and clinically normal after 12 months. Oral ivermectin, at a dosage of 600 mu g kg(-1), PO, daily, was found to be effective in resolving generalized demodicosis in 13 of 16 dogs (82,25%.) in one year follow-up after discontinuing of therapy. Although, there were some literatures evaluating the efficacy of the use of injectable formula of ivermectin, to the present authors' knowledge these is the first report evaluating tablet form of ivermectin in the treatment of canine demodicosis.
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    Nimesulide-induced acute biliary tract injury and renal failure in a kitten: a case report
    (Czech Academy Agricultural Sciences, 2008) Borku, M. K.; Guzel, M.; Karakurum, M. C.; Ural, K.; Aktas, S.
    A 3-month-old male kitten was presented to our clinic with malaise, vomiting and jaundice. In the anamnesis, we learned that the cat had a history of anorexia, sneezing, and nasal discharge and that the owner had administered 100 mg/day (t.i.d.) nimesulide orally for three days. In the laboratory study, high levels of serum alkaline phosphatase, gamma-glutamyl transtransferase, total bilirubin, direct bilirubin, indirect bilirubin, urea, and creatinine were detected. All the clinical signs and laboratory abnormalities returned to normal levels after cessation of the nimesulide and supportive treatment. In this case, clinical and laboratory findings were thought to be compatible with nimesulide-induced acute biliary injury and renal failure. This case report indicates that the household pets are at risk of toxic drugs administered by their owners and great caution should be taken in administering NSAIDs in cats.