Yazar "Karateke, A." seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    Antioxidant effect of erdosteine and lipoic acid in ovarian ischemia-reperfusion injury
    (Elsevier Science Bv, 2014) Dokuyucu, Recep; Karateke, A.; Gokce, H.; Kurt, R. K.; Ozcan, O.; Ozturk, S.; Tas, Z. A.
    Objective: To investigate the effects of erdosteine and alpha lipoic acid (ALA) in a rat model of ovarian ischaemia-reperfusion injury. Study design: Forty-eight female Wistar albino rats were separated, at random, into six groups of eight rats. The groups were classified as: sham, torsion, detorsion, detorsion + erdosteine 100 mg/kg, detorsion + alpha lipoic acid (ALA) 100 mg/kg, and detorsion + erdosteine + ALA. The investigators executing the biochemical and histological analyses were blinded to the randomization until the end of the study. Results: The TOS (Total Oxidant Status) and OSI (Oxidative Stress Index) levels are higher in the Torsion and Detorsion groups when compared with the ones in the Sham group (p < 0.05). Strong correlation was found between OSI and total histological score in the sham, torsion and detorsion groups (r = 0.765, p < 0.001). The mean levels of TOS and OSI in the rats that received erdosteine and/or ALA were significantly lower compared with the sham, torsion and detorsion groups (p < 0.05). Mean TOS and mean OSI were lower in the detorsion + erdosteine + ALA group compared with the detorsion + erdosteine and detorsion + ALA groups (p < 0.05). In comparison with the detorsion group, the numbers of primordial follicles (p = 0.006) and primary follicles (p = 0.036) were increased in the groups that received erdosteine and/or ALA. Conclusions: Erdosteine and ALA decreased ischaemia-reperfusion injury in an experimental rat ovarian torsion model; combination treatment had a greater effect than either agent alone. Treatment with erdosteine and/or ALA was found to preserve the loss of reproductive capacity normally observed after ovarian torsion. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
  • [ N/A ]
    Öğe
    Relation of red cell distribution width to the presence and severity of endometriosis
    (Imr Press, 2014) Kurt, R. Keskin; Dogan, A. Citil; Yesilyurt, H.; Karateke, A.; Okyay, A. Guler
    Aim: Although the exact pathogenesis of endometriosis is not known, it is proposed to be a chronic inflammatory disease. The association between red cell distribution width (RDW) and inflammation is well established. Therefore, in the present study, the authors aimed to investigate the association between presence and severity of endometriosis and RDW. Materials and Methods: Fifty endometriosis patients and 48 controls were included in the study. The endometriosis group was categorized in two subgroups as mild-to-moderate (n=35) and moderate-to-severe disease (n=15). CA-125 and RDW values of all participants were measured. Results: Both RDW (17.7 +/- 2.2 vs 14.9 +/- 1.5, p < 0.001) and CA-125 (50.6 +/- 35.1 vs 27.9 +/- 4.8) levels were significantly higher in the endometriosis patients when compared to the control group. Moreover the authors found a significant positive correlation between RDW and CA-125 levels (r: 0.495, p < 0.001). Conclusion: The present study results demonstrated that RDW levels were significantly increased in endometriosis patients and associated with the severity of endometriosis.